Refined structure (7X9A) of Gi1 - Y1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 215 from structure (60.7%), 139 from model (39.3%)
Residue sidechains - 182 from structure (51.4%), 172 from model (48.6%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 AF2 AF2
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure AF2
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure AF2
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure AF2
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure AF2
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure AF2
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure AF2
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure AF2
G.H1 54 K G.H1.09 Structure AF2
G.H1 55 I G.H1.10 Structure AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure AF2
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure AF2
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure AF2
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure AF2
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure AF2
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 AF2 AF2
G.s4h3 233 V G.s4h3.07 AF2 AF2
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure AF2
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure AF2
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure AF2
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure AF2
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure AF2
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure AF2
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure AF2
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure AF2
G.h4s6 318 E G.h4s6.12 Structure AF2
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure AF2
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure AF2
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure AF2
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 309 from structure (89.6%), 36 from model (10.4%)
Residue sidechains - 286 from structure (82.9%), 59 from model (17.1%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 N - AF2 AF2
N-term 3 S - AF2 AF2
N-term 4 T - AF2 AF2
N-term 5 L - AF2 AF2
N-term 6 F - AF2 AF2
N-term 7 S - AF2 AF2
N-term 8 Q - AF2 AF2
N-term 9 V - AF2 AF2
N-term 10 E - AF2 AF2
N-term 11 N - AF2 AF2
N-term 12 H - AF2 AF2
N-term 13 S - AF2 AF2
N-term 14 V - AF2 AF2
N-term 15 H - AF2 AF2
N-term 16 S - AF2 AF2
N-term 17 N - AF2 AF2
N-term 18 F - AF2 AF2
N-term 19 S - AF2 AF2
N-term 20 E - AF2 AF2
N-term 21 K - AF2 AF2
N-term 22 N - AF2 AF2
N-term 23 A - AF2 AF2
N-term 24 Q - AF2 AF2
N-term 25 L - AF2 AF2
N-term 26 L - AF2 AF2
N-term 27 A - AF2 AF2
N-term 28 F - Structure Structure
N-term 29 E - Structure Structure
N-term 30 N - Structure Structure
N-term 31 D - Structure Structure
N-term 32 D - Structure Structure
N-term 33 C - Structure Structure
N-term 34 H - Structure AF2
N-term 35 L - Structure Structure
TM1 36 P 1.28x28 Structure Structure
TM1 37 L 1.29x29 Structure Structure
TM1 38 A 1.30x30 Structure Structure
TM1 39 M 1.31x31 Structure Structure
TM1 40 I 1.32x32 Structure Structure
TM1 41 F 1.33x33 Structure Structure
TM1 42 T 1.34x34 Structure Structure
TM1 43 L 1.35x35 Structure Structure
TM1 44 A 1.36x36 Structure Structure
TM1 45 L 1.37x37 Structure Structure
TM1 46 A 1.38x38 Structure Structure
TM1 47 Y 1.39x39 Structure Structure
TM1 48 G 1.40x40 Structure Structure
TM1 49 A 1.41x41 Structure Structure
TM1 50 V 1.42x42 Structure Structure
TM1 51 I 1.43x43 Structure Structure
TM1 52 I 1.44x44 Structure Structure
TM1 53 L 1.45x45 Structure Structure
TM1 54 G 1.46x46 Structure Structure
TM1 55 V 1.47x47 Structure Structure
TM1 56 S 1.48x48 Structure Structure
TM1 57 G 1.49x49 Structure Structure
TM1 58 N 1.50x50 Structure Structure
TM1 59 L 1.51x51 Structure Structure
TM1 60 A 1.52x52 Structure Structure
TM1 61 L 1.53x53 Structure Structure
TM1 62 I 1.54x54 Structure Structure
TM1 63 I 1.55x55 Structure Structure
TM1 64 I 1.56x56 Structure Structure
TM1 65 I 1.57x57 Structure Structure
TM1 66 L 1.58x58 Structure Structure
TM1 67 K 1.59x59 Structure Structure
TM1 68 Q 1.60x60 Structure Structure
ICL1 69 K 12.48x48 Structure Structure
ICL1 70 E 12.49x49 Structure Structure
ICL1 71 M 12.50x50 Structure AF2
ICL1 72 R 12.51x51 Structure AF2
TM2 73 N 2.37x37 Structure Structure
TM2 74 V 2.38x38 Structure Structure
TM2 75 T 2.39x39 Structure Structure
TM2 76 N 2.40x40 Structure Structure
TM2 77 I 2.41x41 Structure Structure
TM2 78 L 2.42x42 Structure Structure
TM2 79 I 2.43x43 Structure Structure
TM2 80 V 2.44x44 Structure Structure
TM2 81 N 2.45x45 Structure Structure
TM2 82 L 2.46x46 Structure Structure
TM2 83 S 2.47x47 Structure Structure
TM2 84 F 2.48x48 Structure Structure
TM2 85 S 2.49x49 Structure Structure
TM2 86 D 2.50x50 Structure Structure
TM2 87 L 2.51x51 Structure Structure
TM2 88 L 2.52x52 Structure Structure
TM2 89 V 2.53x53 Structure Structure
TM2 90 A 2.54x54 Structure Structure
TM2 91 I 2.55x55 Structure Structure
TM2 92 M 2.56x551 Structure Structure
TM2 93 C 2.57x56 Structure Structure
TM2 94 L 2.58x57 Structure Structure
TM2 95 P 2.59x58 Structure Structure
TM2 96 F 2.60x59 Structure Structure
TM2 97 T 2.61x60 Structure Structure
TM2 98 F 2.62x61 Structure Structure
TM2 99 V 2.63x62 Structure Structure
TM2 100 Y 2.64x63 Structure Structure
TM2 101 T 2.65x64 Structure Structure
TM2 102 L 2.66x65 Structure Structure
TM2 103 M 2.67x66 Structure Structure
TM2 104 D 2.68x67 Structure Structure
ECL1 105 H 23.49x49 Structure Structure
ECL1 106 W 23.50x50 Structure Structure
ECL1 107 V 23.51x51 Structure Structure
ECL1 108 F 23.52x52 Structure Structure
TM3 109 G 3.21x21 Structure Structure
TM3 110 E 3.22x22 Structure AF2
TM3 111 A 3.23x23 Structure Structure
TM3 112 M 3.24x24 Structure Structure
TM3 113 C 3.25x25 Structure Structure
TM3 114 K 3.26x26 Structure Structure
TM3 115 L 3.27x27 Structure Structure
TM3 116 N 3.28x28 Structure Structure
TM3 117 P 3.29x29 Structure Structure
TM3 118 F 3.30x30 Structure Structure
TM3 119 V 3.31x31 Structure Structure
TM3 120 Q 3.32x32 Structure Structure
TM3 121 C 3.33x33 Structure Structure
TM3 122 V 3.34x34 Structure Structure
TM3 123 S 3.35x35 Structure Structure
TM3 124 I 3.36x36 Structure Structure
TM3 125 T 3.37x37 Structure Structure
TM3 126 V 3.38x38 Structure Structure
TM3 127 S 3.39x39 Structure Structure
TM3 128 I 3.40x40 Structure Structure
TM3 129 F 3.41x41 Structure Structure
TM3 130 S 3.42x42 Structure Structure
TM3 131 L 3.43x43 Structure Structure
TM3 132 V 3.44x44 Structure Structure
TM3 133 L 3.45x45 Structure Structure
TM3 134 I 3.46x46 Structure Structure
TM3 135 A 3.47x47 Structure Structure
TM3 136 V 3.48x48 Structure Structure
TM3 137 E 3.49x49 Structure Structure
TM3 138 R 3.50x50 Structure Structure
TM3 139 H 3.51x51 Structure Structure
TM3 140 Q 3.52x52 Structure Structure
TM3 141 L 3.53x53 Structure Structure
TM3 142 I 3.54x54 Structure Structure
TM3 143 I 3.55x55 Structure Structure
TM3 144 N 3.56x56 Structure Structure
ICL2 145 P - Structure Structure
ICL2 146 R - Structure Structure
ICL2 147 G - Structure Structure
ICL2 148 W - Structure Structure
ICL2 149 R - Structure Structure
ICL2 150 P - Structure Structure
TM4 151 N 4.38x38 Structure Structure
TM4 152 N 4.39x39 Structure Structure
TM4 153 R 4.40x40 Structure Structure
TM4 154 H 4.41x41 Structure Structure
TM4 155 A 4.42x42 Structure Structure
TM4 156 Y 4.43x43 Structure Structure
TM4 157 V 4.44x44 Structure Structure
TM4 158 G 4.45x45 Structure Structure
TM4 159 I 4.46x46 Structure Structure
TM4 160 A 4.47x47 Structure Structure
TM4 161 V 4.48x48 Structure Structure
TM4 162 I 4.49x49 Structure Structure
TM4 163 W 4.50x50 Structure Structure
TM4 164 V 4.51x51 Structure Structure
TM4 165 L 4.52x52 Structure Structure
TM4 166 A 4.53x53 Structure Structure
TM4 167 V 4.54x54 Structure Structure
TM4 168 A 4.55x55 Structure Structure
TM4 169 S 4.56x56 Structure Structure
TM4 170 S 4.57x57 Structure Structure
TM4 171 L 4.58x59 Structure Structure
TM4 172 P 4.59x60 Structure Structure
TM4 173 F 4.60x61 Structure Structure
TM4 174 L 4.61x62 Structure Structure
TM4 175 I 4.62x63 Structure Structure
TM4 176 Y 4.63x64 Structure Structure
TM4 177 Q 4.64x65 Structure Structure
ECL2 178 V - Structure Structure
ECL2 179 M - Structure Structure
ECL2 180 T - Structure Structure
ECL2 181 D - Structure Structure
ECL2 182 E - Structure AF2
ECL2 183 P - Structure Structure
ECL2 184 F - Structure Structure
ECL2 185 Q - Structure AF2
ECL2 186 N - Structure AF2
ECL2 187 V - Structure Structure
ECL2 188 T - Structure Structure
ECL2 189 L - Structure AF2
ECL2 190 D - Structure Structure
ECL2 191 A - Structure Structure
ECL2 192 Y - Structure Structure
ECL2 193 K - Structure AF2
ECL2 194 D - Structure Structure
ECL2 195 K - Structure AF2
ECL2 196 Y - Structure Structure
ECL2 197 V - Structure Structure
ECL2 198 C 45.50x50 Structure Structure
ECL2 199 F 45.51x51 Structure Structure
ECL2 200 D 45.52x52 Structure Structure
ECL2 201 Q - Structure Structure
ECL2 202 F - Structure Structure
ECL2 203 P - Structure Structure
TM5 204 S 5.31x32 Structure Structure
TM5 205 D 5.32x33 Structure Structure
TM5 206 S 5.33x34 Structure Structure
TM5 207 H 5.34x35 Structure Structure
TM5 208 R 5.35x36 Structure Structure
TM5 209 L 5.36x37 Structure Structure
TM5 210 S 5.37x38 Structure Structure
TM5 211 Y 5.38x39 Structure Structure
TM5 212 T 5.39x40 Structure Structure
TM5 213 T 5.40x41 Structure Structure
TM5 214 L 5.41x42 Structure Structure
TM5 215 L 5.42x43 Structure Structure
TM5 216 L 5.43x44 Structure Structure
TM5 217 V 5.44x45 Structure Structure
TM5 218 L 5.45x46 Structure Structure
TM5 219 Q 5.46x461 Structure Structure
TM5 220 Y 5.47x47 Structure Structure
TM5 221 F 5.48x48 Structure Structure
TM5 222 G 5.49x49 Structure Structure
TM5 223 P 5.50x50 Structure Structure
TM5 224 L 5.51x51 Structure Structure
TM5 225 C 5.52x52 Structure Structure
TM5 226 F 5.53x53 Structure Structure
TM5 227 I 5.54x54 Structure Structure
TM5 228 F 5.55x55 Structure Structure
TM5 229 I 5.56x56 Structure Structure
TM5 230 C 5.57x57 Structure Structure
TM5 231 Y 5.58x58 Structure Structure
TM5 232 F 5.59x59 Structure Structure
TM5 233 K 5.60x60 Structure Structure
TM5 234 I 5.61x61 Structure Structure
TM5 235 Y 5.62x62 Structure Structure
TM5 236 I 5.63x63 Structure Structure
TM5 237 R 5.64x64 Structure Structure
TM5 238 L 5.65x65 Structure Structure
TM5 239 K 5.66x66 Structure Structure
TM5 240 R 5.67x67 Structure Structure
TM5 241 R 5.68x68 Structure Structure
TM5 242 N 5.69x69 Structure Structure
TM5 243 N 5.70x70 Structure Structure
TM5 244 M 5.71x71 Structure Structure
TM5 245 M 5.72x72 Structure Structure
TM5 246 D 5.73x73 Structure Structure
ICL3 247 K - Structure AF2
ICL3 248 M - Structure Structure
ICL3 249 R - Structure AF2
TM6 250 D 6.22x22 Structure AF2
TM6 251 N 6.23x23 Structure AF2
TM6 252 K 6.24x24 Structure AF2
TM6 253 Y 6.25x25 Structure Structure
TM6 254 R 6.26x26 Structure AF2
TM6 255 S 6.27x27 Structure Structure
TM6 256 S 6.28x28 Structure Structure
TM6 257 E 6.29x29 Structure Structure
TM6 258 T 6.30x30 Structure Structure
TM6 259 K 6.31x31 Structure Structure
TM6 260 R 6.32x32 Structure Structure
TM6 261 I 6.33x33 Structure Structure
TM6 262 N 6.34x34 Structure Structure
TM6 263 I 6.35x35 Structure Structure
TM6 264 M 6.36x36 Structure Structure
TM6 265 L 6.37x37 Structure Structure
TM6 266 L 6.38x38 Structure Structure
TM6 267 S 6.39x39 Structure Structure
TM6 268 I 6.40x40 Structure Structure
TM6 269 V 6.41x41 Structure Structure
TM6 270 V 6.42x42 Structure Structure
TM6 271 A 6.43x43 Structure Structure
TM6 272 F 6.44x44 Structure Structure
TM6 273 A 6.45x45 Structure Structure
TM6 274 V 6.46x46 Structure Structure
TM6 275 C 6.47x47 Structure Structure
TM6 276 W 6.48x48 Structure Structure
TM6 277 L 6.49x49 Structure Structure
TM6 278 P 6.50x50 Structure Structure
TM6 279 L 6.51x51 Structure Structure
TM6 280 T 6.52x52 Structure Structure
TM6 281 I 6.53x53 Structure Structure
TM6 282 F 6.54x54 Structure Structure
TM6 283 N 6.55x55 Structure Structure
TM6 284 T 6.56x56 Structure Structure
TM6 285 V 6.57x57 Structure Structure
TM6 286 F 6.58x58 Structure Structure
TM6 287 D 6.59x59 Structure Structure
TM6 288 W 6.60x60 Structure Structure
TM6 289 N 6.61x61 Structure AF2
ECL3 290 H - Structure AF2
ECL3 291 Q - Structure AF2
ECL3 292 I - Structure Structure
ECL3 293 I - Structure Structure
ECL3 294 A - Structure Structure
TM7 295 T 7.28x27 Structure Structure
TM7 296 C 7.29x28 Structure Structure
TM7 297 N 7.30x29 Structure Structure
TM7 298 H 7.31x30 Structure Structure
TM7 299 N 7.32x31 Structure Structure
TM7 300 L 7.33x32 Structure Structure
TM7 301 L 7.34x33 Structure Structure
TM7 302 F 7.35x34 Structure Structure
TM7 303 L 7.36x35 Structure Structure
TM7 304 L 7.37x36 Structure Structure
TM7 305 C 7.38x37 Structure Structure
TM7 306 H 7.39x38 Structure Structure
TM7 307 L 7.40x39 Structure Structure
TM7 308 T 7.41x40 Structure Structure
TM7 309 A 7.42x41 Structure Structure
TM7 310 M 7.43x42 Structure AF2
TM7 311 I 7.44x43 Structure Structure
TM7 312 S 7.45x45 Structure Structure
TM7 313 T 7.46x46 Structure Structure
TM7 314 C 7.47x47 Structure Structure
TM7 315 V 7.48x48 Structure Structure
TM7 316 N 7.49x49 Structure Structure
TM7 317 P 7.50x50 Structure Structure
TM7 318 I 7.51x51 Structure Structure
TM7 319 F 7.52x52 Structure Structure
TM7 320 Y 7.53x53 Structure Structure
TM7 321 G 7.54x54 Structure Structure
TM7 322 F 7.55x55 Structure Structure
TM7 323 L 7.56x56 Structure Structure
H8 324 N 8.47x47 Structure Structure
H8 325 K 8.48x48 Structure Structure
H8 326 N 8.49x49 Structure Structure
H8 327 F 8.50x50 Structure Structure
H8 328 Q 8.51x51 Structure Structure
H8 329 R 8.52x52 Structure AF2
H8 330 D 8.53x53 Structure Structure
H8 331 L 8.54x54 Structure Structure
H8 332 Q 8.55x55 Structure AF2
H8 333 F 8.56x56 Structure Structure
H8 334 F 8.57x57 Structure Structure
H8 335 F 8.58x58 Structure AF2
C-term 336 N - Structure Structure
C-term 337 F - AF2 AF2
C-term 338 C - AF2 AF2
C-term 339 D - AF2 AF2
C-term 340 F - AF2 AF2
C-term 341 R - AF2 AF2
C-term 342 S - AF2 AF2
C-term 343 R - AF2 AF2
C-term 344 D - AF2 AF2
C-term 345 D - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 T 75 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 75 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 75 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 146 - G.H5 F 336 G.H5.08
Hydrophobic TM6 Y 253 6x25 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 Y 253 6x25 G.h4s6 D 315 G.h4s6.09
Ionic TM6 E 257 6x29 G.H5 K 345 G.H5.17
Polar TM6 E 257 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 E 257 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM5 M 245 5x72 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 M 245 5x72 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 E 257 6x29 G.H5 F 354 G.H5.26
Polar H8 K 325 8x48 G.H5 K 349 G.H5.21
Hydrophobic H8 K 325 8x48 G.H5 K 349 G.H5.21
Van-der-waals H8 K 325 8x48 G.H5 K 349 G.H5.21
Hydrophobic H8 N 324 8x47 G.H5 F 354 G.H5.26
Hydrophobic TM6 M 264 6x36 G.H5 F 354 G.H5.26
Hydrophobic TM3 L 141 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 L 141 3x53 G.H5 N 347 G.H5.19
Ionic TM6 R 254 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 254 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 254 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 254 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 I 261 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 L 141 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 142 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 W 148 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 W 148 - G.H5 N 347 G.H5.19
Hydrophobic TM5 R 241 5x68 G.H5 I 344 G.H5.16
Polar TM6 N 251 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 N 251 6x23 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 N 251 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic H8 K 325 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 K 325 8x48 G.H5 F 354 G.H5.26
Polar TM3 R 138 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 138 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 138 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 238 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 145 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 145 - G.H5 I 344 G.H5.16
Hydrophobic ICL3 R 249 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL3 R 249 - G.h4s6 K 314 G.h4s6.08
Polar TM6 R 260 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 260 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 260 6x32 G.H5 F 354 G.H5.26
Polar ICL2 R 146 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 R 146 - G.H5 T 340 G.H5.12
Hydrophobic ICL3 M 248 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 M 248 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 I 261 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 261 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM7 L 323 7x56 G.H5 F 354 G.H5.26
Van-der-waals TM7 L 323 7x56 G.H5 F 354 G.H5.26
Polar H8 N 326 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 N 326 8x49 G.H5 K 349 G.H5.21
Hydrophobic ICL2 R 146 - G.S3 L 194 G.S3.01
Hydrophobic ICL2 R 146 - G.H5 I 343 G.H5.15
Hydrophobic TM3 I 142 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 M 264 6x36 G.H5 L 353 G.H5.25
Ionic TM5 R 241 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 241 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM6 I 261 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 I 261 6x33 G.H5 F 354 G.H5.26
Polar TM2 N 73 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 N 73 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 145 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 145 - G.H5 I 343 G.H5.15
Hydrophobic H8 N 324 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 324 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 I 142 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 142 3x54 G.H5 I 344 G.H5.16