Refined structure (7XA3) of Gi1 - CCR2

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 229 from structure (64.7%), 125 from model (35.3%)
Residue sidechains - 227 from structure (64.1%), 127 from model (35.9%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 Structure Structure
G.HN 3 C G.HN.09 Structure Structure
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 Structure Structure
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 Structure Structure
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 Structure Structure
G.s4h3 236 E G.s4h3.10 Structure Structure
G.s4h3 237 D G.s4h3.11 Structure Structure
G.s4h3 238 E G.s4h3.12 Structure Structure
G.s4h3 239 E G.s4h3.13 Structure Structure
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 295 from structure (89.4%), 35 from model (10.6%)
Residue sidechains - 288 from structure (87.3%), 42 from model (12.7%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 L - AF2 AF2
N-term 3 S - AF2 AF2
N-term 4 T - AF2 AF2
N-term 5 S - AF2 AF2
N-term 6 R - AF2 AF2
N-term 7 S - AF2 AF2
N-term 8 R - AF2 AF2
N-term 9 F - AF2 AF2
N-term 10 I - AF2 AF2
N-term 11 R - AF2 AF2
N-term 12 N - AF2 AF2
N-term 13 T - AF2 AF2
N-term 14 N - AF2 AF2
N-term 15 E - AF2 AF2
N-term 16 S - AF2 AF2
N-term 17 G - AF2 AF2
N-term 18 E - AF2 AF2
N-term 19 E - AF2 AF2
N-term 20 V - AF2 AF2
N-term 21 T - AF2 AF2
N-term 22 T - AF2 AF2
N-term 23 F - AF2 AF2
N-term 24 F - AF2 AF2
N-term 25 D - AF2 AF2
N-term 26 Y - AF2 AF2
N-term 27 D - AF2 AF2
N-term 28 Y - AF2 AF2
N-term 29 G - Structure Structure
N-term 30 A - Structure Structure
N-term 31 P - Structure Structure
N-term 32 C - Structure Structure
N-term 33 H - Structure Structure
N-term 34 K - Structure Structure
N-term 35 F - Structure Structure
N-term 36 D - Structure Structure
TM1 37 V 1.27x27 Structure Structure
TM1 38 K 1.28x28 Structure Structure
TM1 39 Q 1.29x29 Structure Structure
TM1 40 I 1.30x30 Structure Structure
TM1 41 G 1.31x31 Structure Structure
TM1 42 A 1.32x32 Structure Structure
TM1 43 Q 1.33x33 Structure Structure
TM1 44 L 1.34x34 Structure Structure
TM1 45 L 1.35x35 Structure Structure
TM1 46 P 1.36x36 Structure Structure
TM1 47 P 1.37x37 Structure Structure
TM1 48 L 1.38x38 Structure Structure
TM1 49 Y 1.39x39 Structure Structure
TM1 50 S 1.40x40 Structure Structure
TM1 51 L 1.41x41 Structure Structure
TM1 52 V 1.42x42 Structure Structure
TM1 53 F 1.43x43 Structure Structure
TM1 54 I 1.44x44 Structure Structure
TM1 55 F 1.45x45 Structure Structure
TM1 56 G 1.46x46 Structure Structure
TM1 57 F 1.47x47 Structure Structure
TM1 58 V 1.48x48 Structure Structure
TM1 59 G 1.49x49 Structure Structure
TM1 60 N 1.50x50 Structure Structure
TM1 61 M 1.51x51 Structure Structure
TM1 62 L 1.52x52 Structure Structure
TM1 63 V 1.53x53 Structure Structure
TM1 64 V 1.54x54 Structure Structure
TM1 65 L 1.55x55 Structure Structure
TM1 66 I 1.56x56 Structure Structure
TM1 67 L 1.57x57 Structure Structure
TM1 68 I 1.58x58 Structure Structure
TM1 69 N 1.59x59 Structure Structure
TM1 70 C 1.60x60 Structure Structure
ICL1 71 K 12.48x48 Structure Structure
ICL1 72 K 12.49x49 Structure Structure
ICL1 73 L 12.50x50 Structure Structure
ICL1 74 K 12.51x51 Structure Structure
TM2 75 C 2.37x37 Structure Structure
TM2 76 L 2.38x38 Structure Structure
TM2 77 T 2.39x39 Structure Structure
TM2 78 D 2.40x40 Structure Structure
TM2 79 I 2.41x41 Structure Structure
TM2 80 Y 2.42x42 Structure Structure
TM2 81 L 2.43x43 Structure Structure
TM2 82 L 2.44x44 Structure Structure
TM2 83 N 2.45x45 Structure Structure
TM2 84 L 2.46x46 Structure Structure
TM2 85 A 2.47x47 Structure Structure
TM2 86 I 2.48x48 Structure Structure
TM2 87 S 2.49x49 Structure Structure
TM2 88 D 2.50x50 Structure Structure
TM2 89 L 2.51x51 Structure Structure
TM2 90 L 2.52x52 Structure Structure
TM2 91 F 2.53x53 Structure Structure
TM2 92 L 2.54x54 Structure Structure
TM2 93 I 2.55x55 Structure Structure
TM2 94 T 2.56x56 Structure Structure
TM2 95 L 2.57x57 Structure Structure
TM2 96 P 2.58x58 Structure Structure
TM2 97 L 2.59x59 Structure Structure
TM2 98 W 2.60x60 Structure Structure
TM2 99 A 2.61x61 Structure Structure
TM2 100 H 2.62x62 Structure Structure
TM2 101 S 2.63x63 Structure Structure
TM2 102 A 2.64x64 Structure Structure
TM2 103 A 2.65x65 Structure Structure
TM2 104 N 2.66x66 Structure Structure
ECL1 105 E 23.49x49 Structure Structure
ECL1 106 W 23.50x50 Structure Structure
ECL1 107 V 23.51x51 Structure Structure
ECL1 108 F 23.52x52 Structure Structure
TM3 109 G 3.21x21 Structure Structure
TM3 110 N 3.22x22 Structure Structure
TM3 111 A 3.23x23 Structure Structure
TM3 112 M 3.24x24 Structure Structure
TM3 113 C 3.25x25 Structure Structure
TM3 114 K 3.26x26 Structure Structure
TM3 115 L 3.27x27 Structure Structure
TM3 116 F 3.28x28 Structure Structure
TM3 117 T 3.29x29 Structure Structure
TM3 118 G 3.30x30 Structure Structure
TM3 119 L 3.31x31 Structure Structure
TM3 120 Y 3.32x32 Structure Structure
TM3 121 H 3.33x33 Structure Structure
TM3 122 I 3.34x34 Structure Structure
TM3 123 G 3.35x35 Structure Structure
TM3 124 Y 3.36x36 Structure Structure
TM3 125 F 3.37x37 Structure Structure
TM3 126 G 3.38x38 Structure Structure
TM3 127 G 3.39x39 Structure Structure
TM3 128 I 3.40x40 Structure Structure
TM3 129 F 3.41x41 Structure Structure
TM3 130 F 3.42x42 Structure Structure
TM3 131 I 3.43x43 Structure Structure
TM3 132 I 3.44x44 Structure Structure
TM3 133 L 3.45x45 Structure Structure
TM3 134 L 3.46x46 Structure Structure
TM3 135 T 3.47x47 Structure Structure
TM3 136 I 3.48x48 Structure Structure
TM3 137 D 3.49x49 Structure Structure
TM3 138 R 3.50x50 Structure Structure
TM3 139 Y 3.51x51 Structure Structure
TM3 140 L 3.52x52 Structure Structure
TM3 141 A 3.53x53 Structure Structure
TM3 142 I 3.54x54 Structure Structure
TM3 143 V 3.55x55 Structure Structure
TM3 144 H 3.56x56 Structure Structure
ICL2 145 A 34.50x50 Structure Structure
ICL2 146 V 34.51x51 Structure Structure
ICL2 147 F 34.52x52 Structure Structure
ICL2 148 A 34.53x53 Structure Structure
ICL2 149 L 34.54x54 Structure Structure
ICL2 150 K 34.55x55 Structure Structure
ICL2 151 A 34.56x56 Structure Structure
ICL2 152 R 34.57x57 Structure Structure
TM4 153 T 4.38x38 Structure Structure
TM4 154 V 4.39x39 Structure Structure
TM4 155 T 4.40x40 Structure Structure
TM4 156 F 4.41x41 Structure Structure
TM4 157 G 4.42x42 Structure Structure
TM4 158 V 4.43x43 Structure Structure
TM4 159 V 4.44x44 Structure Structure
TM4 160 T 4.45x45 Structure Structure
TM4 161 S 4.46x46 Structure Structure
TM4 162 V 4.47x47 Structure Structure
TM4 163 I 4.48x48 Structure Structure
TM4 164 T 4.49x49 Structure Structure
TM4 165 W 4.50x50 Structure Structure
TM4 166 L 4.51x51 Structure Structure
TM4 167 V 4.52x52 Structure Structure
TM4 168 A 4.53x53 Structure Structure
TM4 169 V 4.54x54 Structure Structure
TM4 170 F 4.55x55 Structure Structure
TM4 171 A 4.56x56 Structure Structure
TM4 172 S 4.57x57 Structure Structure
TM4 173 V 4.58x59 Structure Structure
TM4 174 P 4.59x60 Structure Structure
TM4 175 G 4.60x61 Structure Structure
TM4 176 I 4.61x62 Structure Structure
TM4 177 I 4.62x63 Structure Structure
TM4 178 F 4.63x64 Structure Structure
TM4 179 T 4.64x65 Structure Structure
ECL2 180 K - Structure Structure
ECL2 181 C - Structure Structure
ECL2 182 Q - Structure Structure
ECL2 183 K - Structure Structure
ECL2 184 E - Structure Structure
ECL2 185 D - Structure Structure
ECL2 186 S - Structure Structure
ECL2 187 V - Structure Structure
ECL2 188 Y - Structure Structure
ECL2 189 V - Structure Structure
ECL2 190 C 45.50x50 Structure Structure
ECL2 191 G 45.51x51 Structure Structure
ECL2 192 P 45.52x52 Structure Structure
ECL2 193 Y - Structure Structure
ECL2 194 F - Structure Structure
TM5 195 P 5.31x32 Structure Structure
TM5 196 R 5.32x33 Structure Structure
TM5 197 G 5.33x34 Structure Structure
TM5 198 W 5.34x35 Structure Structure
TM5 199 N 5.35x36 Structure Structure
TM5 200 N 5.36x37 Structure Structure
TM5 201 F 5.37x38 Structure Structure
TM5 202 H 5.38x39 Structure Structure
TM5 203 T 5.39x40 Structure Structure
TM5 204 I 5.40x41 Structure Structure
TM5 205 M 5.41x42 Structure Structure
TM5 206 R 5.42x43 Structure Structure
TM5 207 N 5.43x44 Structure Structure
TM5 208 I 5.44x45 Structure Structure
TM5 209 L 5.45x46 Structure Structure
TM5 210 G 5.46x461 Structure Structure
TM5 211 L 5.47x47 Structure Structure
TM5 212 V 5.48x48 Structure Structure
TM5 213 L 5.49x49 Structure Structure
TM5 214 P 5.50x50 Structure Structure
TM5 215 L 5.51x51 Structure Structure
TM5 216 L 5.52x52 Structure Structure
TM5 217 I 5.53x53 Structure Structure
TM5 218 M 5.54x54 Structure Structure
TM5 219 V 5.55x55 Structure Structure
TM5 220 I 5.56x56 Structure Structure
TM5 221 C 5.57x57 Structure Structure
TM5 222 Y 5.58x58 Structure Structure
TM5 223 S 5.59x59 Structure Structure
TM5 224 G 5.60x60 Structure Structure
TM5 225 I 5.61x61 Structure Structure
TM5 226 L 5.62x62 Structure Structure
TM5 227 K 5.63x63 Structure Structure
TM5 228 T 5.64x64 Structure Structure
TM5 229 L 5.65x65 Structure Structure
TM5 230 L 5.66x66 Structure Structure
TM5 231 R 5.67x67 Structure Structure
TM5 232 C 5.68x68 Structure Structure
ICL3 233 R - Structure Structure
TM6 234 N 6.26x26 Structure Structure
TM6 235 E 6.27x27 Structure Structure
TM6 236 K 6.28x28 Structure Structure
TM6 237 K 6.29x29 Structure Structure
TM6 238 R 6.30x30 Structure Structure
TM6 239 H 6.31x31 Structure Structure
TM6 240 R 6.32x32 Structure Structure
TM6 241 A 6.33x33 Structure Structure
TM6 242 V 6.34x34 Structure Structure
TM6 243 R 6.35x35 Structure Structure
TM6 244 V 6.36x36 Structure Structure
TM6 245 I 6.37x37 Structure Structure
TM6 246 F 6.38x38 Structure Structure
TM6 247 T 6.39x39 Structure Structure
TM6 248 I 6.40x40 Structure Structure
TM6 249 M 6.41x41 Structure Structure
TM6 250 I 6.42x42 Structure Structure
TM6 251 V 6.43x43 Structure Structure
TM6 252 Y 6.44x44 Structure Structure
TM6 253 F 6.45x45 Structure Structure
TM6 254 L 6.46x46 Structure Structure
TM6 255 F 6.47x47 Structure Structure
TM6 256 W 6.48x48 Structure Structure
TM6 257 T 6.49x49 Structure Structure
TM6 258 P 6.50x50 Structure Structure
TM6 259 Y 6.51x51 Structure Structure
TM6 260 N 6.52x52 Structure Structure
TM6 261 I 6.53x53 Structure Structure
TM6 262 V 6.54x54 Structure Structure
TM6 263 I 6.55x55 Structure Structure
TM6 264 L 6.56x56 Structure Structure
TM6 265 L 6.57x57 Structure Structure
TM6 266 N 6.58x58 Structure Structure
TM6 267 T 6.59x59 Structure Structure
TM6 268 F 6.60x60 Structure Structure
TM6 269 Q 6.61x61 Structure Structure
TM6 270 E 6.62x62 Structure Structure
TM6 271 F 6.63x63 Structure Structure
TM6 272 F 6.64x64 Structure Structure
TM6 273 G 6.65x65 Structure Structure
ECL3 274 L - Structure Structure
ECL3 275 S - Structure Structure
ECL3 276 N - Structure Structure
ECL3 277 C - Structure Structure
TM7 278 E 7.26x25 Structure Structure
TM7 279 S 7.27x26 Structure Structure
TM7 280 T 7.28x27 Structure Structure
TM7 281 S 7.29x28 Structure Structure
TM7 282 Q 7.30x29 Structure Structure
TM7 283 L 7.31x30 Structure Structure
TM7 284 D 7.32x31 Structure Structure
TM7 285 Q 7.33x32 Structure Structure
TM7 286 A 7.34x33 Structure Structure
TM7 287 T 7.35x34 Structure Structure
TM7 288 Q 7.36x35 Structure Structure
TM7 289 V 7.37x36 Structure Structure
TM7 290 T 7.38x37 Structure Structure
TM7 291 E 7.39x38 Structure Structure
TM7 292 T 7.40x39 Structure Structure
TM7 293 L 7.41x40 Structure Structure
TM7 294 G 7.42x41 Structure Structure
TM7 295 M 7.43x42 Structure Structure
TM7 296 T 7.44x43 Structure Structure
TM7 297 H 7.45x45 Structure Structure
TM7 298 C 7.46x46 Structure Structure
TM7 299 C 7.47x47 Structure Structure
TM7 300 I 7.48x48 Structure Structure
TM7 301 N 7.49x49 Structure Structure
TM7 302 P 7.50x50 Structure Structure
TM7 303 I 7.51x51 Structure Structure
TM7 304 I 7.52x52 Structure Structure
TM7 305 Y 7.53x53 Structure Structure
TM7 306 A 7.54x54 Structure Structure
TM7 307 F 7.55x55 Structure Structure
TM7 308 V 7.56x56 Structure Structure
H8 309 G 8.47x47 Structure Structure
H8 310 E 8.48x48 Structure Structure
H8 311 K 8.49x49 Structure Structure
H8 312 F 8.50x50 Structure Structure
H8 313 R 8.51x51 Structure Structure
H8 314 S 8.52x52 Structure AF2
H8 315 L 8.53x53 Structure AF2
H8 316 F 8.54x54 Structure AF2
H8 317 H 8.55x55 Structure AF2
H8 318 I 8.56x56 Structure AF2
H8 319 A 8.57x57 Structure AF2
H8 320 L 8.58x58 Structure AF2
C-term 321 G - Structure Structure
C-term 322 C - Structure Structure
C-term 323 R - Structure Structure
C-term 324 I - AF2 AF2
C-term 325 A - AF2 AF2
C-term 326 P - AF2 AF2
C-term 327 L - AF2 AF2
C-term 328 Q - AF2 AF2
C-term 329 K - AF2 AF2
C-term 330 P - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 N 234 6x26 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 N 234 6x26 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 A 145 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 149 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 R 138 3x50 G.H5 L 353 G.H5.25
Ionic ICL3 R 233 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 233 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 233 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 233 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 A 145 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 V 244 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 A 141 3x53 G.H5 C 351 G.H5.23
Polar H8 G 309 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 G 309 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 G 309 8x47 G.H5 G 352 G.H5.24
Polar TM3 A 141 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 141 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 T 228 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM3 R 138 3x50 G.H5 C 351 G.H5.23
Ionic H8 K 311 8x49 G.H5 D 350 G.H5.22
Polar H8 K 311 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 K 311 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 K 311 8x49 G.H5 D 350 G.H5.22
Polar TM2 C 75 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 C 75 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 C 75 2x37 G.H5 D 350 G.H5.22
Ionic TM5 R 231 5x67 G.H5 D 341 G.H5.13
Polar TM5 R 231 5x67 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 231 5x67 G.H5 D 341 G.H5.13
Hydrophobic TM3 I 142 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 149 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM6 I 245 6x37 G.H5 L 353 G.H5.25
Polar TM6 R 240 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 240 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 240 6x32 G.H5 F 354 G.H5.26
Polar H8 E 310 8x48 G.H5 F 354 G.H5.26
Hydrophobic ICL2 L 149 34x54 G.S3 L 194 G.S3.01
Van-der-waals TM5 R 231 5x67 G.H5 I 344 G.H5.16
Hydrophobic TM2 T 77 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 K 237 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 237 6x29 G.H5 F 354 G.H5.26
Polar TM6 R 240 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 240 6x32 G.H5 L 353 G.H5.25
Hydrophobic ICL3 R 233 - G.S6 Y 320 G.S6.02
Hydrophobic TM5 L 229 5x65 G.H5 F 354 G.H5.26
Hydrophobic ICL2 V 146 34x51 G.H5 F 336 G.H5.08
Ionic ICL2 K 150 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL2 K 150 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 K 150 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 K 150 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 L 229 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 229 5x65 G.H5 L 348 G.H5.20
Ionic H8 E 310 8x48 G.H5 K 349 G.H5.21
Hydrophobic TM3 I 142 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 142 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 241 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL2 K 150 34x55 G.hns1 R 32 G.hns1.03