Refined structure (7XBW) of Gi1 - CX3CR1

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 216 from structure (61.0%), 138 from model (39.0%)
Residue sidechains - 189 from structure (53.4%), 165 from model (46.6%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 AF2 AF2
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure AF2
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure AF2
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure AF2
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure AF2
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure AF2
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure AF2
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure AF2
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure AF2
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure AF2
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure AF2
G.H2 206 S G.H2.02 Structure AF2
G.H2 207 E G.H2.03 Structure AF2
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure AF2
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 AF2 AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure AF2
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure AF2
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure AF2
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure AF2
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure AF2
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure AF2
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure AF2
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure AF2
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 281 from structure (87.8%), 39 from model (12.2%)
Residue sidechains - 246 from structure (76.9%), 74 from model (23.1%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 Q - AF2 AF2
N-term 4 F - AF2 AF2
N-term 5 P - AF2 AF2
N-term 6 E - AF2 AF2
N-term 7 S - AF2 AF2
N-term 8 V - AF2 AF2
N-term 9 T - AF2 AF2
N-term 10 E - AF2 AF2
N-term 11 N - AF2 AF2
N-term 12 F - AF2 AF2
N-term 13 E - AF2 AF2
N-term 14 Y - AF2 AF2
N-term 15 D - AF2 AF2
N-term 16 D - AF2 AF2
N-term 17 L - AF2 AF2
N-term 18 A - AF2 AF2
N-term 19 E - AF2 AF2
N-term 20 A - AF2 AF2
N-term 21 C - AF2 AF2
N-term 22 Y - AF2 AF2
TM1 23 I 1.24x24 AF2 AF2
TM1 24 G 1.25x25 AF2 AF2
TM1 25 D 1.26x26 AF2 AF2
TM1 26 I 1.27x27 AF2 AF2
TM1 27 V 1.28x28 AF2 AF2
TM1 28 V 1.29x29 AF2 AF2
TM1 29 F 1.30x30 AF2 AF2
TM1 30 G 1.31x31 Structure Structure
TM1 31 T 1.32x32 Structure Structure
TM1 32 V 1.33x33 Structure Structure
TM1 33 F 1.34x34 Structure AF2
TM1 34 L 1.35x35 Structure Structure
TM1 35 S 1.36x36 Structure Structure
TM1 36 I 1.37x37 Structure Structure
TM1 37 F 1.38x38 Structure Structure
TM1 38 Y 1.39x39 Structure Structure
TM1 39 S 1.40x40 Structure Structure
TM1 40 V 1.41x41 Structure Structure
TM1 41 I 1.42x42 Structure Structure
TM1 42 F 1.43x43 Structure Structure
TM1 43 A 1.44x44 Structure Structure
TM1 44 I 1.45x45 Structure Structure
TM1 45 G 1.46x46 Structure Structure
TM1 46 L 1.47x47 Structure Structure
TM1 47 V 1.48x48 Structure Structure
TM1 48 G 1.49x49 Structure Structure
TM1 49 N 1.50x50 Structure Structure
TM1 50 L 1.51x51 Structure Structure
TM1 51 L 1.52x52 Structure Structure
TM1 52 V 1.53x53 Structure Structure
TM1 53 V 1.54x54 Structure Structure
TM1 54 F 1.55x55 Structure AF2
TM1 55 A 1.56x56 Structure Structure
TM1 56 L 1.57x57 Structure Structure
TM1 57 T 1.58x58 Structure Structure
TM1 58 N 1.59x59 Structure Structure
TM1 59 S 1.60x60 Structure Structure
ICL1 60 K 12.48x48 Structure AF2
ICL1 61 K 12.49x49 Structure AF2
ICL1 62 P 12.50x50 Structure Structure
ICL1 63 K 12.51x51 Structure AF2
TM2 64 S 2.37x37 Structure Structure
TM2 65 V 2.38x38 Structure Structure
TM2 66 T 2.39x39 Structure Structure
TM2 67 D 2.40x40 Structure Structure
TM2 68 I 2.41x41 Structure Structure
TM2 69 Y 2.42x42 Structure Structure
TM2 70 L 2.43x43 Structure Structure
TM2 71 L 2.44x44 Structure Structure
TM2 72 N 2.45x45 Structure Structure
TM2 73 L 2.46x46 Structure Structure
TM2 74 A 2.47x47 Structure Structure
TM2 75 L 2.48x48 Structure Structure
TM2 76 S 2.49x49 Structure Structure
TM2 77 D 2.50x50 Structure Structure
TM2 78 L 2.51x51 Structure Structure
TM2 79 L 2.52x52 Structure Structure
TM2 80 F 2.53x53 Structure Structure
TM2 81 V 2.54x54 Structure Structure
TM2 82 A 2.55x55 Structure Structure
TM2 83 T 2.56x56 Structure Structure
TM2 84 L 2.57x57 Structure Structure
TM2 85 P 2.58x58 Structure Structure
TM2 86 F 2.59x59 Structure AF2
TM2 87 W 2.60x60 Structure Structure
TM2 88 T 2.61x61 Structure Structure
TM2 89 H 2.62x62 Structure Structure
TM2 90 Y 2.63x63 Structure Structure
TM2 91 L 2.64x64 Structure Structure
TM2 92 I 2.65x65 Structure Structure
TM2 93 N 2.66x66 Structure Structure
ECL1 94 E - Structure AF2
ECL1 95 K - Structure AF2
ECL1 96 G - Structure Structure
ECL1 97 L - Structure AF2
ECL1 98 H - Structure AF2
ECL1 99 N - Structure AF2
ECL1 100 A - Structure Structure
TM3 101 M 3.24x24 Structure Structure
TM3 102 C 3.25x25 Structure Structure
TM3 103 K 3.26x26 Structure Structure
TM3 104 F 3.27x27 Structure Structure
TM3 105 T 3.28x28 Structure Structure
TM3 106 T 3.29x29 Structure Structure
TM3 107 A 3.30x30 Structure Structure
TM3 108 F 3.31x31 Structure Structure
TM3 109 F 3.32x32 Structure Structure
TM3 110 F 3.33x33 Structure Structure
TM3 111 I 3.34x34 Structure Structure
TM3 112 G 3.35x35 Structure Structure
TM3 113 F 3.36x36 Structure Structure
TM3 114 F 3.37x37 Structure Structure
TM3 115 G 3.38x38 Structure Structure
TM3 116 S 3.39x39 Structure Structure
TM3 117 I 3.40x40 Structure Structure
TM3 118 F 3.41x41 Structure Structure
TM3 119 F 3.42x42 Structure Structure
TM3 120 I 3.43x43 Structure AF2
TM3 121 T 3.44x44 Structure Structure
TM3 122 V 3.45x45 Structure Structure
TM3 123 I 3.46x46 Structure Structure
TM3 124 S 3.47x47 Structure Structure
TM3 125 I 3.48x48 Structure Structure
TM3 126 D 3.49x49 Structure Structure
TM3 127 R 3.50x50 Structure Structure
TM3 128 Y 3.51x51 Structure Structure
TM3 129 L 3.52x52 Structure Structure
TM3 130 A 3.53x53 Structure Structure
TM3 131 I 3.54x54 Structure Structure
TM3 132 V 3.55x55 Structure Structure
TM3 133 L 3.56x56 Structure Structure
ICL2 134 A 34.50x50 Structure Structure
ICL2 135 A 34.51x51 Structure Structure
ICL2 136 N 34.52x52 Structure Structure
ICL2 137 S 34.53x53 Structure Structure
ICL2 138 M 34.54x54 Structure Structure
ICL2 139 N 34.55x55 Structure Structure
ICL2 140 N 34.56x56 Structure Structure
ICL2 141 R 34.57x57 Structure AF2
TM4 142 T 4.38x38 Structure Structure
TM4 143 V 4.39x39 Structure Structure
TM4 144 Q 4.40x40 Structure Structure
TM4 145 H 4.41x41 Structure Structure
TM4 146 G 4.42x42 Structure Structure
TM4 147 V 4.43x43 Structure Structure
TM4 148 T 4.44x44 Structure Structure
TM4 149 I 4.45x45 Structure Structure
TM4 150 S 4.46x46 Structure Structure
TM4 151 L 4.47x47 Structure Structure
TM4 152 G 4.48x48 Structure Structure
TM4 153 V 4.49x49 Structure Structure
TM4 154 W 4.50x50 Structure Structure
TM4 155 A 4.51x51 Structure Structure
TM4 156 A 4.52x52 Structure Structure
TM4 157 A 4.53x53 Structure Structure
TM4 158 I 4.54x54 Structure Structure
TM4 159 L 4.55x55 Structure Structure
TM4 160 V 4.56x56 Structure Structure
TM4 161 A 4.57x57 Structure Structure
TM4 162 A 4.58x59 Structure Structure
TM4 163 P 4.59x60 Structure Structure
TM4 164 Q 4.60x61 Structure Structure
TM4 165 F 4.61x62 Structure Structure
TM4 166 M 4.62x63 Structure Structure
TM4 167 F 4.63x64 Structure Structure
TM4 168 T 4.64x65 Structure Structure
ECL2 169 K - Structure AF2
ECL2 170 Q - Structure Structure
ECL2 171 K - Structure Structure
ECL2 172 E - Structure AF2
ECL2 173 N - Structure AF2
ECL2 174 E - Structure AF2
ECL2 175 C 45.50x50 Structure Structure
ECL2 176 L 45.51x51 Structure Structure
ECL2 177 G 45.52x52 Structure Structure
ECL2 178 D - Structure Structure
ECL2 179 Y - Structure Structure
ECL2 180 P - Structure Structure
ECL2 181 E - Structure AF2
ECL2 182 V - Structure AF2
TM5 183 L 5.30x31 Structure Structure
TM5 184 Q 5.31x32 Structure AF2
TM5 185 E 5.32x33 Structure AF2
TM5 186 I 5.33x34 Structure AF2
TM5 187 W 5.34x35 Structure Structure
TM5 188 P 5.35x36 Structure Structure
TM5 189 V 5.36x37 Structure Structure
TM5 190 L 5.37x38 Structure Structure
TM5 191 R 5.38x39 Structure Structure
TM5 192 N 5.39x40 Structure Structure
TM5 193 V 5.40x41 Structure Structure
TM5 194 E 5.41x42 Structure Structure
TM5 195 T 5.42x43 Structure Structure
TM5 196 N 5.43x44 Structure Structure
TM5 197 F 5.44x45 Structure AF2
TM5 198 L 5.45x46 Structure Structure
TM5 199 G 5.46x461 Structure Structure
TM5 200 F 5.47x47 Structure Structure
TM5 201 L 5.48x48 Structure Structure
TM5 202 L 5.49x49 Structure Structure
TM5 203 P 5.50x50 Structure Structure
TM5 204 L 5.51x51 Structure Structure
TM5 205 L 5.52x52 Structure Structure
TM5 206 I 5.53x53 Structure Structure
TM5 207 M 5.54x54 Structure Structure
TM5 208 S 5.55x55 Structure Structure
TM5 209 Y 5.56x56 Structure Structure
TM5 210 C 5.57x57 Structure Structure
TM5 211 Y 5.58x58 Structure Structure
TM5 212 F 5.59x59 Structure Structure
TM5 213 R 5.60x60 Structure Structure
TM5 214 I 5.61x61 Structure Structure
TM5 215 I 5.62x62 Structure Structure
TM5 216 Q 5.63x63 Structure Structure
TM5 217 T 5.64x64 Structure Structure
TM5 218 L 5.65x65 Structure Structure
TM5 219 F 5.66x66 Structure Structure
TM5 220 S 5.67x67 Structure Structure
TM5 221 C 5.68x68 Structure AF2
ICL3 222 K - Structure AF2
ICL3 223 N - Structure Structure
TM6 224 H 6.28x28 Structure Structure
TM6 225 K 6.29x29 Structure Structure
TM6 226 K 6.30x30 Structure Structure
TM6 227 A 6.31x31 Structure Structure
TM6 228 K 6.32x32 Structure Structure
TM6 229 A 6.33x33 Structure Structure
TM6 230 I 6.34x34 Structure Structure
TM6 231 K 6.35x35 Structure Structure
TM6 232 L 6.36x36 Structure Structure
TM6 233 I 6.37x37 Structure Structure
TM6 234 L 6.38x38 Structure Structure
TM6 235 L 6.39x39 Structure Structure
TM6 236 V 6.40x40 Structure Structure
TM6 237 V 6.41x41 Structure Structure
TM6 238 I 6.42x42 Structure Structure
TM6 239 V 6.43x43 Structure Structure
TM6 240 F 6.44x44 Structure Structure
TM6 241 F 6.45x45 Structure Structure
TM6 242 L 6.46x46 Structure Structure
TM6 243 F 6.47x47 Structure Structure
TM6 244 W 6.48x48 Structure Structure
TM6 245 T 6.49x49 Structure Structure
TM6 246 P 6.50x50 Structure Structure
TM6 247 Y 6.51x51 Structure Structure
TM6 248 N 6.52x52 Structure Structure
TM6 249 V 6.53x53 Structure Structure
TM6 250 M 6.54x54 Structure AF2
TM6 251 I 6.55x55 Structure Structure
TM6 252 F 6.56x56 Structure Structure
TM6 253 L 6.57x57 Structure Structure
TM6 254 E 6.58x58 Structure Structure
TM6 255 T 6.59x59 Structure Structure
TM6 256 L 6.60x60 Structure Structure
TM6 257 K 6.61x61 Structure AF2
TM6 258 L 6.62x62 Structure Structure
TM6 259 Y 6.63x63 Structure AF2
TM6 260 D 6.64x64 Structure Structure
ECL3 261 F - Structure AF2
ECL3 262 F - Structure Structure
ECL3 263 P - Structure Structure
TM7 264 S 7.24x23 Structure Structure
TM7 265 C 7.25x24 Structure Structure
TM7 266 D 7.26x25 Structure Structure
TM7 267 M 7.27x26 Structure AF2
TM7 268 R 7.28x27 Structure AF2
TM7 269 K 7.29x28 Structure AF2
TM7 270 D 7.30x29 Structure Structure
TM7 271 L 7.31x30 Structure Structure
TM7 272 R 7.32x31 Structure AF2
TM7 273 L 7.33x32 Structure Structure
TM7 274 A 7.34x33 Structure Structure
TM7 275 L 7.35x34 Structure Structure
TM7 276 S 7.36x35 Structure Structure
TM7 277 V 7.37x36 Structure Structure
TM7 278 T 7.38x37 Structure Structure
TM7 279 E 7.39x38 Structure Structure
TM7 280 T 7.40x39 Structure Structure
TM7 281 V 7.41x40 Structure Structure
TM7 282 A 7.42x41 Structure Structure
TM7 283 F 7.43x42 Structure Structure
TM7 284 S 7.44x43 Structure Structure
TM7 285 H 7.45x45 Structure Structure
TM7 286 C 7.46x46 Structure Structure
TM7 287 C 7.47x47 Structure Structure
TM7 288 L 7.48x48 Structure Structure
TM7 289 N 7.49x49 Structure Structure
TM7 290 P 7.50x50 Structure Structure
TM7 291 L 7.51x51 Structure Structure
TM7 292 I 7.52x52 Structure Structure
TM7 293 Y 7.53x53 Structure Structure
TM7 294 A 7.54x54 Structure Structure
TM7 295 F 7.55x55 Structure Structure
TM7 296 A 7.56x56 Structure Structure
H8 297 G 8.47x47 Structure Structure
H8 298 E 8.48x48 Structure AF2
H8 299 K 8.49x49 Structure Structure
H8 300 F 8.50x50 Structure Structure
H8 301 R 8.51x51 Structure Structure
H8 302 R 8.52x52 Structure AF2
H8 303 Y 8.53x53 Structure Structure
H8 304 L 8.54x54 Structure Structure
H8 305 Y 8.55x55 Structure Structure
H8 306 H 8.56x56 Structure Structure
H8 307 L 8.57x57 Structure Structure
H8 308 Y 8.58x58 Structure Structure
H8 309 G 8.59x59 Structure Structure
H8 310 K 8.60x60 Structure Structure
C-term 311 C - AF2 AF2
C-term 312 L - AF2 AF2
C-term 313 A - AF2 AF2
C-term 314 V - AF2 AF2
C-term 315 L - AF2 AF2
C-term 316 C - AF2 AF2
C-term 317 G - AF2 AF2
C-term 318 R - AF2 AF2
C-term 319 S - AF2 AF2
C-term 320 V - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 218 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 T 217 5x64 G.H5 I 344 G.H5.16
Van-der-waals ICL3 N 223 - G.H5 K 345 G.H5.17
Hydrophobic TM6 A 227 6x31 G.H5 L 348 G.H5.20
Van-der-waals TM6 A 227 6x31 G.H5 L 348 G.H5.20
Hydrophobic TM6 K 226 6x30 G.H5 K 345 G.H5.17
Hydrophobic ICL2 M 138 34x54 G.S3 L 194 G.S3.01
Hydrophobic ICL2 A 135 34x51 G.S3 L 194 G.S3.01
Ionic ICL2 R 141 34x57 G.HN E 28 G.HN.52
Polar ICL2 R 141 34x57 G.HN E 28 G.HN.52
Hydrophobic ICL2 R 141 34x57 G.HN E 28 G.HN.52
Van-der-waals ICL2 R 141 34x57 G.HN E 28 G.HN.52
Hydrophobic TM1 A 55 1x56 G.H5 L 353 G.H5.25
Van-der-waals TM1 A 55 1x56 G.H5 L 353 G.H5.25
Hydrophobic ICL2 A 134 34x50 G.H5 T 340 G.H5.12
Hydrophobic H8 K 299 8x49 G.H5 L 353 G.H5.25
Hydrophobic ICL2 A 134 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 232 6x36 G.H5 F 354 G.H5.26
Hydrophobic H8 F 300 8x50 G.H5 L 353 G.H5.25
Van-der-waals H8 F 300 8x50 G.H5 L 353 G.H5.25
Polar TM2 S 64 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 S 64 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 64 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM1 V 52 1x53 G.H5 L 353 G.H5.25
Hydrophobic TM7 Y 293 7x53 G.H5 L 353 G.H5.25
Van-der-waals TM7 Y 293 7x53 G.H5 L 353 G.H5.25
Hydrophobic ICL2 M 138 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 M 138 34x54 G.hns1 R 32 G.hns1.03
Polar TM2 D 67 2x40 G.H5 L 353 G.H5.25
Polar TM2 T 66 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM6 K 226 6x30 G.H5 L 348 G.H5.20
Hydrophobic TM4 Q 144 4x40 G.HN E 28 G.HN.52
Van-der-waals TM4 Q 144 4x40 G.HN E 28 G.HN.52
Hydrophobic ICL3 N 223 - G.H5 I 344 G.H5.16
Hydrophobic TM6 K 228 6x32 G.H5 F 354 G.H5.26
Hydrophobic H8 K 299 8x49 G.H5 F 354 G.H5.26
Van-der-waals H8 K 299 8x49 G.H5 F 354 G.H5.26
Polar ICL2 R 141 34x57 G.HN E 25 G.HN.49
Van-der-waals ICL2 R 141 34x57 G.HN E 25 G.HN.49
Hydrophobic TM2 T 66 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 131 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 131 3x54 G.H5 I 344 G.H5.16
Polar TM2 D 67 2x40 G.H5 C 351 G.H5.23
Hydrophobic TM2 D 67 2x40 G.H5 C 351 G.H5.23
Van-der-waals TM2 D 67 2x40 G.H5 C 351 G.H5.23
Hydrophobic TM2 L 70 2x43 G.H5 L 353 G.H5.25
Van-der-waals TM2 L 70 2x43 G.H5 L 353 G.H5.25
Ionic TM3 R 127 3x50 G.H5 D 350 G.H5.22
Polar TM3 R 127 3x50 G.H5 D 350 G.H5.22
Hydrophobic TM3 R 127 3x50 G.H5 D 350 G.H5.22
Van-der-waals TM3 R 127 3x50 G.H5 D 350 G.H5.22
Hydrophobic ICL2 R 141 34x57 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 141 34x57 G.hns1 R 32 G.hns1.03
Polar ICL2 N 139 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 139 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM1 L 56 1x57 G.H5 L 353 G.H5.25
Van-der-waals TM1 L 56 1x57 G.H5 L 353 G.H5.25
Polar ICL2 N 139 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 N 139 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 N 139 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 A 135 34x51 G.H5 F 336 G.H5.08
Polar TM3 R 127 3x50 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 127 3x50 G.H5 N 347 G.H5.19
Van-der-waals TM3 R 127 3x50 G.H5 N 347 G.H5.19
Polar TM2 D 67 2x40 G.H5 G 352 G.H5.24
Hydrophobic TM2 D 67 2x40 G.H5 G 352 G.H5.24
Van-der-waals TM2 D 67 2x40 G.H5 G 352 G.H5.24
Hydrophobic TM2 L 70 2x43 G.H5 C 351 G.H5.23
Van-der-waals TM2 L 70 2x43 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 131 3x54 G.H5 L 348 G.H5.20
Ionic TM4 H 145 4x41 G.HN E 28 G.HN.52
Polar TM4 H 145 4x41 G.HN E 28 G.HN.52
Hydrophobic TM4 H 145 4x41 G.HN E 28 G.HN.52
Van-der-waals TM4 H 145 4x41 G.HN E 28 G.HN.52
Polar H8 K 299 8x49 G.H5 C 351 G.H5.23
Van-der-waals H8 K 299 8x49 G.H5 C 351 G.H5.23
Hydrophobic ICL2 M 138 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 M 138 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL2 R 141 34x57 G.HN K 29 G.HN.53
Van-der-waals ICL2 R 141 34x57 G.HN K 29 G.HN.53
Hydrophobic H8 G 297 8x47 G.H5 F 354 G.H5.26
Van-der-waals H8 G 297 8x47 G.H5 F 354 G.H5.26
Hydrophobic ICL2 M 138 34x54 G.S1 V 34 G.S1.02
Van-der-waals ICL2 M 138 34x54 G.S1 V 34 G.S1.02
Polar TM3 A 130 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 130 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 130 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 A 134 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 134 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 I 230 6x34 G.H5 L 348 G.H5.20
Hydrophobic ICL3 N 223 - G.H5 L 348 G.H5.20
Hydrophobic TM3 I 131 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 N 140 34x56 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 M 138 34x54 G.S1 E 33 G.S1.01
Ionic TM6 K 226 6x30 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 226 6x30 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 K 226 6x30 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 226 6x30 G.h4s6 E 318 G.h4s6.12
Hydrophobic H8 K 299 8x49 G.H5 G 352 G.H5.24
Van-der-waals H8 K 299 8x49 G.H5 G 352 G.H5.24
Hydrophobic TM6 A 229 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 A 229 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM6 A 229 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 229 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM4 Q 144 4x40 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 Q 144 4x40 G.hns1 R 32 G.hns1.03