Refined structure (7XTA) of Gi1 - 5-HT4 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 219 from structure (61.9%), 135 from model (38.1%)
Residue sidechains - 215 from structure (60.7%), 139 from model (39.3%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 AF2 AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 283 from structure (83.5%), 56 from model (16.5%)
Residue sidechains - 23 from structure (6.8%), 316 from model (93.2%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 K - AF2 AF2
N-term 4 L - AF2 AF2
N-term 5 D - AF2 AF2
N-term 6 A - AF2 AF2
N-term 7 N - AF2 AF2
N-term 8 V - AF2 AF2
N-term 9 S - AF2 AF2
N-term 10 S - AF2 AF2
N-term 11 E - AF2 AF2
N-term 12 E - AF2 AF2
N-term 13 G - AF2 AF2
N-term 14 F - AF2 AF2
N-term 15 G - AF2 AF2
N-term 16 S - AF2 AF2
TM1 17 V 1.30x30 AF2 AF2
TM1 18 E 1.31x31 Structure AF2
TM1 19 K 1.32x32 Structure AF2
TM1 20 V 1.33x33 Structure Structure
TM1 21 V 1.34x34 Structure AF2
TM1 22 L 1.35x35 Structure Structure
TM1 23 L 1.36x36 Structure AF2
TM1 24 T 1.37x37 Structure AF2
TM1 25 F 1.38x38 Structure AF2
TM1 26 L 1.39x39 Structure AF2
TM1 27 S 1.40x40 Structure AF2
TM1 28 T 1.41x41 Structure AF2
TM1 29 V 1.42x42 Structure AF2
TM1 30 I 1.43x43 Structure AF2
TM1 31 L 1.44x44 Structure AF2
TM1 32 M 1.45x45 Structure AF2
TM1 33 A 1.46x46 Structure AF2
TM1 34 I 1.47x47 Structure AF2
TM1 35 L 1.48x48 Structure AF2
TM1 36 G 1.49x49 Structure AF2
TM1 37 N 1.50x50 Structure AF2
TM1 38 L 1.51x51 Structure Structure
TM1 39 L 1.52x52 Structure AF2
TM1 40 V 1.53x53 Structure AF2
TM1 41 M 1.54x54 Structure AF2
TM1 42 V 1.55x55 Structure AF2
TM1 43 A 1.56x56 Structure AF2
TM1 44 V 1.57x57 Structure AF2
TM1 45 C 1.58x58 Structure AF2
TM1 46 W 1.59x59 Structure AF2
TM1 47 D 1.60x60 Structure AF2
ICL1 48 R 12.48x48 Structure AF2
ICL1 49 Q 12.49x49 Structure AF2
ICL1 50 L 12.50x50 Structure AF2
ICL1 51 R 12.51x51 Structure AF2
ICL1 52 K 12.52x52 Structure AF2
TM2 53 I 2.37x37 Structure AF2
TM2 54 K 2.38x38 Structure AF2
TM2 55 T 2.39x39 Structure AF2
TM2 56 N 2.40x40 Structure AF2
TM2 57 Y 2.41x41 Structure AF2
TM2 58 F 2.42x42 Structure AF2
TM2 59 I 2.43x43 Structure AF2
TM2 60 V 2.44x44 Structure AF2
TM2 61 S 2.45x45 Structure AF2
TM2 62 L 2.46x46 Structure AF2
TM2 63 A 2.47x47 Structure AF2
TM2 64 F 2.48x48 Structure AF2
TM2 65 A 2.49x49 Structure AF2
TM2 66 D 2.50x50 Structure AF2
TM2 67 L 2.51x51 Structure Structure
TM2 68 L 2.52x52 Structure AF2
TM2 69 V 2.53x53 Structure AF2
TM2 70 S 2.54x54 Structure AF2
TM2 71 V 2.55x55 Structure AF2
TM2 72 L 2.56x551 Structure AF2
TM2 73 V 2.57x56 Structure AF2
TM2 74 M 2.58x57 Structure AF2
TM2 75 P 2.59x58 Structure AF2
TM2 76 F 2.60x59 Structure AF2
TM2 77 G 2.61x60 Structure AF2
TM2 78 A 2.62x61 Structure AF2
TM2 79 I 2.63x62 Structure AF2
TM2 80 E 2.64x63 Structure AF2
TM2 81 L 2.65x64 Structure AF2
TM2 82 V 2.66x65 Structure AF2
TM2 83 Q 2.67x66 Structure AF2
TM2 84 D 2.68x67 Structure AF2
ECL1 85 I 23.49x49 Structure AF2
ECL1 86 W 23.50x50 Structure AF2
ECL1 87 I 23.51x51 Structure AF2
ECL1 88 Y 23.52x52 Structure AF2
TM3 89 G 3.21x21 Structure AF2
TM3 90 E 3.22x22 Structure AF2
TM3 91 V 3.23x23 Structure AF2
TM3 92 F 3.24x24 Structure AF2
TM3 93 C 3.25x25 Structure AF2
TM3 94 L 3.26x26 Structure AF2
TM3 95 V 3.27x27 Structure AF2
TM3 96 R 3.28x28 Structure AF2
TM3 97 T 3.29x29 Structure AF2
TM3 98 S 3.30x30 Structure AF2
TM3 99 L 3.31x31 Structure AF2
TM3 100 D 3.32x32 Structure AF2
TM3 101 V 3.33x33 Structure AF2
TM3 102 L 3.34x34 Structure Structure
TM3 103 L 3.35x35 Structure AF2
TM3 104 T 3.36x36 Structure Structure
TM3 105 T 3.37x37 Structure AF2
TM3 106 A 3.38x38 Structure AF2
TM3 107 S 3.39x39 Structure AF2
TM3 108 I 3.40x40 Structure AF2
TM3 109 F 3.41x41 Structure AF2
TM3 110 H 3.42x42 Structure AF2
TM3 111 L 3.43x43 Structure AF2
TM3 112 C 3.44x44 Structure Structure
TM3 113 C 3.45x45 Structure AF2
TM3 114 I 3.46x46 Structure AF2
TM3 115 S 3.47x47 Structure AF2
TM3 116 L 3.48x48 Structure AF2
TM3 117 D 3.49x49 Structure AF2
TM3 118 R 3.50x50 Structure AF2
TM3 119 Y 3.51x51 Structure Structure
TM3 120 Y 3.52x52 Structure AF2
TM3 121 A 3.53x53 Structure AF2
TM3 122 I 3.54x54 Structure AF2
TM3 123 C 3.55x55 Structure Structure
TM3 124 C 3.56x56 Structure AF2
ICL2 125 Q - Structure AF2
ICL2 126 P 34.50x50 Structure AF2
ICL2 127 L 34.51x51 Structure AF2
ICL2 128 V 34.52x52 Structure AF2
ICL2 129 Y 34.53x53 Structure AF2
ICL2 130 R 34.54x54 Structure AF2
ICL2 131 N 34.55x55 Structure AF2
ICL2 132 K 34.56x56 Structure AF2
ICL2 133 M 34.57x57 Structure AF2
TM4 134 T 4.38x38 Structure AF2
TM4 135 P 4.39x39 Structure AF2
TM4 136 L 4.40x40 Structure AF2
TM4 137 R 4.41x41 Structure AF2
TM4 138 I 4.42x42 Structure AF2
TM4 139 A 4.43x43 Structure AF2
TM4 140 L 4.44x44 Structure AF2
TM4 141 M 4.45x45 Structure AF2
TM4 142 L 4.46x46 Structure AF2
TM4 143 G 4.47x47 Structure Structure
TM4 144 G 4.48x48 Structure AF2
TM4 145 C 4.49x49 Structure AF2
TM4 146 W 4.50x50 Structure AF2
TM4 147 V 4.51x51 Structure AF2
TM4 148 I 4.52x52 Structure AF2
TM4 149 P 4.53x53 Structure AF2
TM4 150 T 4.54x54 Structure AF2
TM4 151 F 4.55x55 Structure AF2
TM4 152 I 4.56x56 Structure AF2
TM4 153 S 4.57x57 Structure AF2
TM4 154 F 4.58x58 Structure AF2
TM4 155 L 4.59x59 Structure AF2
TM4 156 P 4.60x60 Structure AF2
TM4 157 I 4.61x61 Structure AF2
TM4 158 M 4.62x62 Structure AF2
TM4 159 Q 4.63x63 Structure AF2
TM4 160 G 4.64x64 Structure AF2
ECL2 161 W - Structure AF2
ECL2 162 N - Structure Structure
ECL2 163 N - Structure AF2
ECL2 164 I - Structure AF2
ECL2 165 G - Structure AF2
ECL2 166 I - Structure Structure
ECL2 167 I - Structure AF2
ECL2 168 D - Structure AF2
ECL2 169 L - Structure AF2
ECL2 170 I - Structure AF2
ECL2 171 E - Structure AF2
ECL2 172 K - Structure AF2
ECL2 173 R - Structure AF2
ECL2 174 K - Structure AF2
ECL2 175 F - Structure AF2
ECL2 176 N - Structure AF2
ECL2 177 Q - Structure AF2
ECL2 178 N - Structure AF2
ECL2 179 S - Structure AF2
ECL2 180 N - Structure AF2
ECL2 181 S - Structure AF2
ECL2 182 T - Structure AF2
ECL2 183 Y - Structure AF2
ECL2 184 C 45.50x50 Structure AF2
ECL2 185 V 45.51x51 Structure AF2
ECL2 186 F 45.52x52 Structure AF2
ECL2 187 M - Structure AF2
ECL2 188 V - Structure AF2
TM5 189 N 5.35x36 Structure AF2
TM5 190 K 5.36x37 Structure AF2
TM5 191 P 5.37x38 Structure AF2
TM5 192 Y 5.38x39 Structure AF2
TM5 193 A 5.39x40 Structure AF2
TM5 194 I 5.40x41 Structure AF2
TM5 195 T 5.41x42 Structure AF2
TM5 196 C 5.42x43 Structure AF2
TM5 197 S 5.43x44 Structure AF2
TM5 198 V 5.44x45 Structure Structure
TM5 199 V 5.45x46 Structure AF2
TM5 200 A 5.46x461 Structure AF2
TM5 201 F 5.47x47 Structure AF2
TM5 202 Y 5.48x48 Structure AF2
TM5 203 I 5.49x49 Structure AF2
TM5 204 P 5.50x50 Structure AF2
TM5 205 F 5.51x51 Structure AF2
TM5 206 L 5.52x52 Structure Structure
TM5 207 L 5.53x53 Structure AF2
TM5 208 M 5.54x54 Structure AF2
TM5 209 V 5.55x55 Structure AF2
TM5 210 L 5.56x56 Structure AF2
TM5 211 A 5.57x57 Structure AF2
TM5 212 Y 5.58x58 Structure Structure
TM5 213 Y 5.59x59 Structure AF2
TM5 214 R 5.60x60 Structure AF2
TM5 215 I 5.61x61 Structure AF2
TM5 216 Y 5.62x62 Structure AF2
TM5 217 V 5.63x63 Structure AF2
TM5 218 T 5.64x64 Structure AF2
TM5 219 A 5.65x65 Structure AF2
TM5 220 K 5.66x66 Structure AF2
TM5 221 E 5.67x67 Structure AF2
TM5 222 H 5.68x68 Structure AF2
TM5 223 A 5.69x69 Structure AF2
TM5 224 H 5.70x70 Structure Structure
TM5 225 Q 5.71x71 Structure Structure
TM5 226 I 5.72x72 AF2 AF2
TM5 227 Q 5.73x73 AF2 AF2
TM5 228 M 5.74x74 AF2 AF2
TM5 229 L 5.75x75 AF2 AF2
TM5 230 Q 5.76x76 AF2 AF2
TM5 231 R 5.77x77 AF2 AF2
TM5 232 A 5.78x78 AF2 AF2
TM5 233 G 5.79x79 AF2 AF2
ICL3 234 A - AF2 AF2
ICL3 235 S - AF2 AF2
ICL3 236 S - AF2 AF2
ICL3 237 E - AF2 AF2
ICL3 238 S - AF2 AF2
ICL3 239 R - AF2 AF2
ICL3 240 P - AF2 AF2
ICL3 241 Q - AF2 AF2
ICL3 242 S - AF2 AF2
ICL3 243 A - AF2 AF2
ICL3 244 D - AF2 AF2
ICL3 245 Q - AF2 AF2
ICL3 246 H - AF2 AF2
ICL3 247 S - AF2 AF2
TM6 248 T 6.24x24 AF2 AF2
TM6 249 H 6.25x25 AF2 AF2
TM6 250 R 6.26x26 AF2 AF2
TM6 251 M 6.27x27 AF2 AF2
TM6 252 R 6.28x28 AF2 AF2
TM6 253 T 6.29x29 AF2 AF2
TM6 254 E 6.30x30 Structure AF2
TM6 255 T 6.31x31 Structure AF2
TM6 256 K 6.32x32 Structure AF2
TM6 257 A 6.33x33 Structure Structure
TM6 258 A 6.34x34 Structure AF2
TM6 259 K 6.35x35 Structure AF2
TM6 260 T 6.36x36 Structure AF2
TM6 261 L 6.37x37 Structure AF2
TM6 262 C 6.38x38 Structure AF2
TM6 263 I 6.39x39 Structure Structure
TM6 264 I 6.40x40 Structure AF2
TM6 265 M 6.41x41 Structure AF2
TM6 266 G 6.42x42 Structure AF2
TM6 267 C 6.43x43 Structure AF2
TM6 268 F 6.44x44 Structure AF2
TM6 269 C 6.45x45 Structure AF2
TM6 270 L 6.46x46 Structure AF2
TM6 271 C 6.47x47 Structure AF2
TM6 272 W 6.48x48 Structure AF2
TM6 273 A 6.49x49 Structure AF2
TM6 274 P 6.50x50 Structure AF2
TM6 275 F 6.51x51 Structure Structure
TM6 276 F 6.52x52 Structure AF2
TM6 277 V 6.53x53 Structure AF2
TM6 278 T 6.54x54 Structure AF2
TM6 279 N 6.55x55 Structure AF2
TM6 280 I 6.56x56 Structure AF2
TM6 281 V 6.57x57 Structure AF2
TM6 282 D 6.58x58 Structure AF2
TM6 283 P 6.59x59 Structure AF2
TM6 284 F 6.60x60 Structure AF2
TM6 285 I 6.61x61 Structure AF2
ECL3 286 D - Structure AF2
ECL3 287 Y - Structure AF2
ECL3 288 T - Structure AF2
ECL3 289 V - Structure AF2
TM7 290 P 7.31x30 Structure AF2
TM7 291 G 7.32x31 Structure AF2
TM7 292 Q 7.33x32 Structure AF2
TM7 293 V 7.34x33 Structure AF2
TM7 294 W 7.35x34 Structure AF2
TM7 295 T 7.36x35 Structure AF2
TM7 296 A 7.37x36 Structure AF2
TM7 297 F 7.38x37 Structure AF2
TM7 298 L 7.39x38 Structure AF2
TM7 299 W 7.40x39 Structure AF2
TM7 300 L 7.41x40 Structure AF2
TM7 301 G 7.42x41 Structure AF2
TM7 302 Y 7.43x42 Structure AF2
TM7 303 I 7.44x43 Structure AF2
TM7 304 N 7.45x45 Structure AF2
TM7 305 S 7.46x46 Structure AF2
TM7 306 G 7.47x47 Structure AF2
TM7 307 L 7.48x48 Structure AF2
TM7 308 N 7.49x49 Structure AF2
TM7 309 P 7.50x50 Structure AF2
TM7 310 F 7.51x51 Structure AF2
TM7 311 L 7.52x52 Structure AF2
TM7 312 Y 7.53x53 Structure AF2
TM7 313 A 7.54x54 Structure AF2
TM7 314 F 7.55x55 Structure AF2
TM7 315 L 7.56x56 Structure AF2
H8 316 N 8.47x47 Structure AF2
H8 317 K 8.48x48 Structure AF2
H8 318 S 8.49x49 Structure AF2
H8 319 F 8.50x50 Structure AF2
H8 320 R 8.51x51 Structure Structure
H8 321 R 8.52x52 Structure AF2
H8 322 A 8.53x53 Structure AF2
H8 323 F 8.54x54 Structure AF2
H8 324 L 8.55x55 Structure AF2
H8 325 I 8.56x56 Structure Structure
H8 326 I 8.57x57 Structure AF2
H8 327 L 8.58x58 Structure AF2
H8 328 C 8.59x59 Structure Structure
H8 329 C 8.60x60 AF2 AF2
C-term 330 D - AF2 AF2
C-term 331 D - AF2 AF2
C-term 332 E - AF2 AF2
C-term 333 R - AF2 AF2
C-term 334 Y - AF2 AF2
C-term 335 R - AF2 AF2
C-term 336 R - AF2 AF2
C-term 337 P - AF2 AF2
C-term 338 S - AF2 AF2
C-term 339 I - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 226 5x72 G.H5 K 345 G.H5.17
Van-der-waals TM5 I 226 5x72 G.H5 K 345 G.H5.17
Hydrophobic TM5 L 229 5x75 G.S6 Y 320 G.S6.02
Van-der-waals TM5 L 229 5x75 G.S6 Y 320 G.S6.02
Polar TM5 G 233 5x79 G.S6 F 323 G.S6.05
Hydrophobic TM5 G 233 5x79 G.S6 F 323 G.S6.05
Van-der-waals TM5 G 233 5x79 G.S6 F 323 G.S6.05
Hydrophobic ICL3 S 238 - G.H4 A 301 G.H4.08
Van-der-waals ICL3 S 238 - G.H4 A 301 G.H4.08
Polar ICL2 Q 125 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 Q 125 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 Q 125 - G.H5 N 347 G.H5.19
Hydrophobic ICL3 S 235 - G.S6 F 323 G.S6.05
Van-der-waals ICL3 S 235 - G.S6 F 323 G.S6.05
Hydrophobic TM5 T 218 5x64 G.H5 L 348 G.H5.20
Hydrophobic TM5 A 232 5x78 G.H5 F 334 G.H5.06
Van-der-waals TM5 A 232 5x78 G.H5 F 334 G.H5.06
Polar TM6 K 256 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM6 K 256 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 K 256 6x32 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Q 125 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 Q 125 - G.H5 I 343 G.H5.15
Polar ICL3 E 237 - G.H4 E 297 G.H4.04
Hydrophobic ICL3 E 237 - G.H4 E 297 G.H4.04
Van-der-waals ICL3 E 237 - G.H4 E 297 G.H4.04
Polar ICL3 S 235 - G.H4 A 300 G.H4.07
Hydrophobic ICL3 S 235 - G.H4 A 300 G.H4.07
Van-der-waals ICL3 S 235 - G.H4 A 300 G.H4.07
Ionic ICL3 H 246 - G.H4 E 308 G.H4.16
Polar ICL3 H 246 - G.H4 E 308 G.H4.16
Van-der-waals ICL3 H 246 - G.H4 E 308 G.H4.16
Polar TM5 I 226 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM5 I 226 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 I 226 5x72 G.H5 D 341 G.H5.13
Polar ICL2 R 130 34x54 G.HN G 27 G.HN.51
Van-der-waals ICL2 R 130 34x54 G.HN G 27 G.HN.51
Hydrophobic TM5 I 226 5x72 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 I 226 5x72 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 L 229 5x75 G.H5 A 338 G.H5.10
Van-der-waals TM5 L 229 5x75 G.H5 A 338 G.H5.10
Polar ICL3 R 239 - G.H4 C 305 G.H4.13
Hydrophobic ICL3 R 239 - G.H4 C 305 G.H4.13
Van-der-waals ICL3 R 239 - G.H4 C 305 G.H4.13
Hydrophobic TM3 Y 120 3x52 G.H5 C 351 G.H5.23
Polar TM5 R 214 5x60 G.H5 C 351 G.H5.23
Polar TM3 D 117 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 D 117 3x49 G.H5 C 351 G.H5.23
Van-der-waals TM3 D 117 3x49 G.H5 C 351 G.H5.23
Polar ICL3 S 238 - G.H4 E 298 G.H4.05
Hydrophobic ICL3 S 238 - G.H4 E 298 G.H4.05
Van-der-waals ICL3 S 238 - G.H4 E 298 G.H4.05
Polar ICL3 A 234 - G.H4 Q 304 G.H4.12
Hydrophobic ICL3 A 234 - G.H4 Q 304 G.H4.12
Van-der-waals ICL3 A 234 - G.H4 Q 304 G.H4.12
Hydrophobic ICL3 A 234 - G.S6 F 323 G.S6.05
Van-der-waals ICL3 A 234 - G.S6 F 323 G.S6.05
Ionic ICL3 R 239 - G.H4 D 309 G.H4.17
Polar ICL3 R 239 - G.H4 D 309 G.H4.17
Van-der-waals ICL3 R 239 - G.H4 D 309 G.H4.17
Polar ICL3 A 234 - G.S6 T 321 G.S6.03
Hydrophobic ICL3 A 234 - G.S6 T 321 G.S6.03
Van-der-waals ICL3 A 234 - G.S6 T 321 G.S6.03
Hydrophobic TM5 I 226 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 I 226 5x72 G.S6 Y 320 G.S6.02
Polar TM5 E 221 5x67 G.H5 D 341 G.H5.13
Hydrophobic TM5 E 221 5x67 G.H5 D 341 G.H5.13
Van-der-waals TM5 E 221 5x67 G.H5 D 341 G.H5.13
Polar TM5 E 221 5x67 G.H5 T 340 G.H5.12
Van-der-waals TM5 E 221 5x67 G.H5 T 340 G.H5.12
Hydrophobic TM5 R 214 5x60 G.H5 L 353 G.H5.25
Van-der-waals ICL3 A 234 - G.S6 H 322 G.S6.04
Polar ICL3 S 235 - G.H4 A 301 G.H4.08
Van-der-waals ICL3 S 235 - G.H4 A 301 G.H4.08
Hydrophobic TM5 V 217 5x63 G.H5 I 344 G.H5.16
Van-der-waals TM5 V 217 5x63 G.H5 I 344 G.H5.16
Polar TM5 Q 230 5x76 G.S6 T 321 G.S6.03
Hydrophobic TM5 Q 230 5x76 G.S6 T 321 G.S6.03
Van-der-waals TM5 Q 230 5x76 G.S6 T 321 G.S6.03
Hydrophobic ICL2 R 130 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 130 34x54 G.hns1 A 31 G.hns1.02
Polar TM2 K 54 2x38 G.H5 C 351 G.H5.23
Hydrophobic TM2 K 54 2x38 G.H5 C 351 G.H5.23
Van-der-waals TM2 K 54 2x38 G.H5 C 351 G.H5.23
Polar TM5 L 229 5x75 G.S6 T 321 G.S6.03
Van-der-waals TM5 L 229 5x75 G.S6 T 321 G.S6.03
Hydrophobic TM7 L 315 7x56 G.H5 C 351 G.H5.23
Van-der-waals TM7 L 315 7x56 G.H5 C 351 G.H5.23
Polar TM5 Q 225 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 Q 225 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 Q 225 5x71 G.H5 D 337 G.H5.09
Ionic ICL1 K 52 12x52 G.H5 D 350 G.H5.22
Polar ICL1 K 52 12x52 G.H5 D 350 G.H5.22
Hydrophobic ICL1 K 52 12x52 G.H5 D 350 G.H5.22
Van-der-waals ICL1 K 52 12x52 G.H5 D 350 G.H5.22
Polar ICL2 Q 125 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 Q 125 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 Q 125 - G.H5 I 344 G.H5.16
Polar TM3 Y 120 3x52 G.H5 N 347 G.H5.19
Van-der-waals TM3 Y 120 3x52 G.H5 N 347 G.H5.19
Polar ICL3 S 242 - G.H4 E 308 G.H4.16
Hydrophobic ICL2 L 127 34x51 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 L 127 34x51 G.hns1 A 31 G.hns1.02
Hydrophobic TM5 M 228 5x74 G.H5 F 334 G.H5.06
Van-der-waals TM5 M 228 5x74 G.H5 F 334 G.H5.06
Polar TM5 G 233 5x79 G.S6 T 321 G.S6.03
Hydrophobic TM5 G 233 5x79 G.S6 T 321 G.S6.03
Van-der-waals TM5 G 233 5x79 G.S6 T 321 G.S6.03
Hydrophobic ICL3 R 239 - G.H4 A 301 G.H4.08
Van-der-waals ICL3 R 239 - G.H4 A 301 G.H4.08
Hydrophobic TM7 L 315 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 L 315 7x56 G.H5 G 352 G.H5.24
Polar ICL3 R 239 - G.H4 Y 302 G.H4.10
Aromatic ICL3 R 239 - G.H4 Y 302 G.H4.10
Hydrophobic ICL3 R 239 - G.H4 Y 302 G.H4.10
Van-der-waals ICL3 R 239 - G.H4 Y 302 G.H4.10
Hydrophobic TM6 K 259 6x35 G.H5 L 353 G.H5.25
Van-der-waals TM6 K 259 6x35 G.H5 L 353 G.H5.25
Polar TM6 K 259 6x35 G.H5 C 351 G.H5.23
Polar TM5 Q 230 5x76 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 Q 230 5x76 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 Q 230 5x76 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 Q 225 5x71 G.H5 D 341 G.H5.13
Hydrophobic TM5 L 229 5x75 G.H5 D 337 G.H5.09
Van-der-waals TM5 L 229 5x75 G.H5 D 337 G.H5.09
Hydrophobic ICL3 E 237 - G.H4 A 301 G.H4.08
Polar TM5 A 232 5x78 G.S6 H 322 G.S6.04
Hydrophobic TM5 A 232 5x78 G.S6 H 322 G.S6.04
Van-der-waals TM5 A 232 5x78 G.S6 H 322 G.S6.04
Polar TM5 G 233 5x79 G.S6 H 322 G.S6.04
Hydrophobic TM5 G 233 5x79 G.S6 H 322 G.S6.04
Van-der-waals TM5 G 233 5x79 G.S6 H 322 G.S6.04
Polar ICL3 S 238 - G.H4 Y 302 G.H4.10
Polar ICL3 Q 245 - G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL3 Q 245 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL3 Q 245 - G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 T 253 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 T 253 6x29 G.H5 F 354 G.H5.26
Van-der-waals ICL3 R 239 - G.H4 Q 306 G.H4.14
Polar TM5 Q 230 5x76 G.S6 I 319 G.S6.01
Hydrophobic TM5 Q 230 5x76 G.S6 I 319 G.S6.01
Van-der-waals TM5 Q 230 5x76 G.S6 I 319 G.S6.01
Polar ICL3 S 238 - G.H4 E 297 G.H4.04
Hydrophobic ICL3 S 238 - G.H4 E 297 G.H4.04
Van-der-waals ICL3 S 238 - G.H4 E 297 G.H4.04
Polar TM5 A 232 5x78 G.S6 F 323 G.S6.05
Hydrophobic TM5 A 232 5x78 G.S6 F 323 G.S6.05
Van-der-waals TM5 A 232 5x78 G.S6 F 323 G.S6.05
Polar TM6 K 259 6x35 G.H5 G 352 G.H5.24
Hydrophobic TM6 K 259 6x35 G.H5 G 352 G.H5.24
Van-der-waals TM6 K 259 6x35 G.H5 G 352 G.H5.24
Ionic TM6 H 249 6x25 G.h4s6 E 318 G.h4s6.12
Polar TM6 H 249 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 H 249 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 H 249 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 R 214 5x60 G.H5 L 348 G.H5.20
Hydrophobic TM6 K 256 6x32 G.H5 L 348 G.H5.20
Van-der-waals TM6 K 256 6x32 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 229 5x75 G.H5 F 334 G.H5.06
Van-der-waals TM5 L 229 5x75 G.H5 F 334 G.H5.06
Hydrophobic TM5 E 221 5x67 G.H5 I 344 G.H5.16
Van-der-waals TM5 E 221 5x67 G.H5 I 344 G.H5.16
Hydrophobic TM5 Q 230 5x76 G.H5 F 334 G.H5.06
Hydrophobic TM3 D 117 3x49 G.H5 L 353 G.H5.25
Van-der-waals TM3 D 117 3x49 G.H5 L 353 G.H5.25
Hydrophobic TM5 A 232 5x78 G.S6 T 321 G.S6.03
Hydrophobic TM5 Q 230 5x76 G.S6 Y 320 G.S6.02
Van-der-waals TM5 Q 230 5x76 G.S6 Y 320 G.S6.02
Hydrophobic ICL2 L 127 34x51 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 127 34x51 G.hns1 R 32 G.hns1.03
Polar ICL3 S 235 - G.H4 Q 304 G.H4.12
Hydrophobic ICL3 S 235 - G.H4 Q 304 G.H4.12
Van-der-waals ICL3 S 235 - G.H4 Q 304 G.H4.12
Aromatic TM6 H 249 6x25 G.H5 F 354 G.H5.26
Hydrophobic TM6 H 249 6x25 G.H5 F 354 G.H5.26
Van-der-waals TM6 H 249 6x25 G.H5 F 354 G.H5.26