Refined structure (7XXI) of Gi2 - P2Y12 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 218 from structure (61.4%), 137 from model (38.6%)
Residue sidechains - 200 from structure (56.3%), 155 from model (43.7%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 V G.HN.11 AF2 AF2
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure AF2
G.HN 9 D G.HN.33 Structure AF2
G.HN 10 K G.HN.34 Structure AF2
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 A G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure AF2
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 K G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure AF2
G.H1 56 I G.H1.11 Structure Structure
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 D G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 R H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 R H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 M H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 V H.HA.23 AF2 AF2
H.HA 86 K H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 N H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 Q H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 A H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 P H.hahb.09 AF2 AF2
H.HB 99 S H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 A H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 S H.HB.13 AF2 AF2
H.HB 112 C H.HB.14 AF2 AF2
H.hbhc 113 T H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 Q H.hbhc.11 AF2 AF2
H.hbhc 118 G H.hbhc.12 AF2 AF2
H.hbhc 119 V H.hbhc.13 AF2 AF2
H.hbhc 120 L H.hbhc.14 AF2 AF2
H.hbhc 121 P H.hbhc.15 AF2 AF2
H.HC 122 D H.HC.01 AF2 AF2
H.HC 123 D H.HC.02 AF2 AF2
H.HC 124 L H.HC.03 AF2 AF2
H.HC 125 S H.HC.04 AF2 AF2
H.HC 126 G H.HC.05 AF2 AF2
H.HC 127 V H.HC.06 AF2 AF2
H.HC 128 I H.HC.07 AF2 AF2
H.HC 129 R H.HC.08 AF2 AF2
H.HC 130 R H.HC.09 AF2 AF2
H.HC 131 L H.HC.10 AF2 AF2
H.HC 132 W H.HC.11 AF2 AF2
H.HC 133 A H.HC.12 AF2 AF2
H.hchd 134 D H.hchd.01 AF2 AF2
H.HD 135 H H.HD.01 AF2 AF2
H.HD 136 G H.HD.02 AF2 AF2
H.HD 137 V H.HD.03 AF2 AF2
H.HD 138 Q H.HD.04 AF2 AF2
H.HD 139 A H.HD.05 AF2 AF2
H.HD 140 C H.HD.06 AF2 AF2
H.HD 141 F H.HD.07 AF2 AF2
H.HD 142 G H.HD.08 AF2 AF2
H.HD 143 R H.HD.09 AF2 AF2
H.HD 144 S H.HD.10 AF2 AF2
H.HD 145 R H.HD.11 AF2 AF2
H.HD 146 E H.HD.12 AF2 AF2
H.hdhe 147 Y H.hdhe.01 AF2 AF2
H.hdhe 148 Q H.hdhe.02 AF2 AF2
H.hdhe 149 L H.hdhe.03 AF2 AF2
H.hdhe 150 N H.hdhe.04 AF2 AF2
H.hdhe 151 D H.hdhe.05 AF2 AF2
H.HE 152 S H.HE.01 AF2 AF2
H.HE 153 A H.HE.02 AF2 AF2
H.HE 154 A H.HE.03 AF2 AF2
H.HE 155 Y H.HE.04 AF2 AF2
H.HE 156 Y H.HE.05 AF2 AF2
H.HE 157 L H.HE.06 AF2 AF2
H.HE 158 N H.HE.07 AF2 AF2
H.HE 159 D H.HE.08 AF2 AF2
H.HE 160 L H.HE.09 AF2 AF2
H.HE 161 E H.HE.10 AF2 AF2
H.HE 162 R H.HE.11 AF2 AF2
H.HE 163 I H.HE.12 AF2 AF2
H.HE 164 A H.HE.13 AF2 AF2
H.hehf 165 Q H.hehf.01 AF2 AF2
H.hehf 166 S H.hehf.02 AF2 AF2
H.hehf 167 D H.hehf.03 AF2 AF2
H.hehf 168 Y H.hehf.04 AF2 AF2
H.hehf 169 I H.hehf.05 AF2 AF2
H.hehf 170 P H.hehf.06 AF2 AF2
H.hehf 171 T H.hehf.07 AF2 AF2
H.HF 172 Q H.HF.01 AF2 AF2
H.HF 173 Q H.HF.02 AF2 AF2
H.HF 174 D H.HF.03 AF2 AF2
H.HF 175 V H.HF.04 AF2 AF2
H.HF 176 L H.HF.05 AF2 AF2
H.HF 177 R H.HF.06 AF2 AF2
G.hfs2 178 T G.hfs2.01 AF2 AF2
G.hfs2 179 R G.hfs2.02 AF2 AF2
G.hfs2 180 V G.hfs2.03 AF2 AF2
G.hfs2 181 K G.hfs2.04 AF2 AF2
G.hfs2 182 T G.hfs2.05 AF2 AF2
G.hfs2 183 T G.hfs2.06 Structure Structure
G.hfs2 184 G G.hfs2.07 Structure Structure
G.S2 185 I G.S2.01 Structure Structure
G.S2 186 V G.S2.02 Structure Structure
G.S2 187 E G.S2.03 Structure Structure
G.S2 188 T G.S2.04 Structure Structure
G.S2 189 H G.S2.05 Structure Structure
G.S2 190 F G.S2.06 Structure Structure
G.S2 191 T G.S2.07 Structure Structure
G.S2 192 F G.S2.08 Structure Structure
G.s2s3 193 K G.s2s3.01 Structure Structure
G.s2s3 194 D G.s2s3.02 Structure Structure
G.S3 195 L G.S3.01 Structure Structure
G.S3 196 H G.S3.02 Structure Structure
G.S3 197 F G.S3.03 Structure Structure
G.S3 198 K G.S3.04 Structure Structure
G.S3 199 M G.S3.05 Structure Structure
G.S3 200 F G.S3.06 Structure Structure
G.S3 201 D G.S3.07 Structure Structure
G.S3 202 V G.S3.08 Structure Structure
G.s3h2 203 G G.s3h2.01 Structure Structure
G.s3h2 204 G G.s3h2.02 Structure AF2
G.s3h2 205 Q G.s3h2.03 Structure Structure
G.H2 206 R G.H2.01 Structure AF2
G.H2 207 S G.H2.02 Structure Structure
G.H2 208 E G.H2.03 Structure Structure
G.H2 209 R G.H2.04 Structure Structure
G.H2 210 K G.H2.05 Structure Structure
G.H2 211 K G.H2.06 Structure Structure
G.H2 212 W G.H2.07 Structure Structure
G.H2 213 I G.H2.08 Structure Structure
G.H2 214 H G.H2.09 Structure Structure
G.H2 215 C G.H2.10 Structure Structure
G.h2s4 216 F G.h2s4.01 Structure Structure
G.h2s4 217 E G.h2s4.02 Structure Structure
G.h2s4 218 G G.h2s4.03 Structure Structure
G.h2s4 219 V G.h2s4.04 Structure Structure
G.h2s4 220 T G.h2s4.05 Structure Structure
G.S4 221 A G.S4.01 Structure Structure
G.S4 222 I G.S4.02 Structure Structure
G.S4 223 I G.S4.03 Structure Structure
G.S4 224 F G.S4.04 Structure Structure
G.S4 225 C G.S4.05 Structure Structure
G.S4 226 V G.S4.06 Structure Structure
G.S4 227 A G.S4.07 Structure Structure
G.s4h3 228 L G.s4h3.01 Structure Structure
G.s4h3 229 S G.s4h3.02 Structure Structure
G.s4h3 230 A G.s4h3.03 Structure Structure
G.s4h3 231 Y G.s4h3.04 Structure Structure
G.s4h3 232 D G.s4h3.05 Structure Structure
G.s4h3 233 L G.s4h3.06 Structure Structure
G.s4h3 234 V G.s4h3.07 Structure Structure
G.s4h3 235 L G.s4h3.08 AF2 AF2
G.s4h3 236 A G.s4h3.09 AF2 AF2
G.s4h3 237 E G.s4h3.10 AF2 AF2
G.s4h3 238 D G.s4h3.11 AF2 AF2
G.s4h3 239 E G.s4h3.12 AF2 AF2
G.s4h3 240 E G.s4h3.13 AF2 AF2
G.s4h3 241 M G.s4h3.14 Structure Structure
G.s4h3 242 N G.s4h3.15 Structure Structure
G.H3 243 R G.H3.01 Structure Structure
G.H3 244 M G.H3.02 Structure Structure
G.H3 245 H G.H3.03 Structure Structure
G.H3 246 E G.H3.04 Structure AF2
G.H3 247 S G.H3.05 Structure Structure
G.H3 248 M G.H3.06 Structure Structure
G.H3 249 K G.H3.07 Structure Structure
G.H3 250 L G.H3.08 Structure Structure
G.H3 251 F G.H3.09 Structure Structure
G.H3 252 D G.H3.10 Structure Structure
G.H3 253 S G.H3.11 Structure Structure
G.H3 254 I G.H3.12 Structure Structure
G.H3 255 C G.H3.13 Structure Structure
G.H3 256 N G.H3.14 Structure Structure
G.H3 257 N G.H3.15 Structure Structure
G.H3 258 K G.H3.16 Structure Structure
G.H3 259 W G.H3.17 Structure Structure
G.H3 260 F G.H3.18 Structure Structure
G.h3s5 261 T G.h3s5.01 Structure Structure
G.h3s5 262 D G.h3s5.02 Structure Structure
G.h3s5 263 T G.h3s5.03 Structure Structure
G.S5 264 S G.S5.01 Structure Structure
G.S5 265 I G.S5.02 Structure Structure
G.S5 266 I G.S5.03 Structure Structure
G.S5 267 L G.S5.04 Structure Structure
G.S5 268 F G.S5.05 Structure Structure
G.S5 269 L G.S5.06 Structure Structure
G.S5 270 N G.S5.07 Structure Structure
G.s5hg 271 K G.s5hg.01 Structure Structure
G.HG 272 K G.HG.01 Structure Structure
G.HG 273 D G.HG.02 Structure Structure
G.HG 274 L G.HG.03 Structure Structure
G.HG 275 F G.HG.04 Structure Structure
G.HG 276 E G.HG.05 Structure Structure
G.HG 277 E G.HG.06 Structure Structure
G.HG 278 K G.HG.07 Structure Structure
G.HG 279 I G.HG.08 Structure Structure
G.HG 280 T G.HG.09 Structure Structure
G.HG 281 H G.HG.12 Structure Structure
G.HG 282 S G.HG.13 Structure Structure
G.HG 283 P G.HG.14 Structure Structure
G.HG 284 L G.HG.15 Structure Structure
G.HG 285 T G.HG.16 Structure Structure
G.HG 286 I G.HG.17 Structure Structure
G.hgh4 287 C G.hgh4.01 Structure Structure
G.hgh4 288 F G.hgh4.02 Structure Structure
G.hgh4 289 P G.hgh4.03 Structure Structure
G.hgh4 290 E G.hgh4.04 Structure AF2
G.hgh4 291 Y G.hgh4.05 Structure Structure
G.hgh4 292 T G.hgh4.06 Structure Structure
G.hgh4 293 G G.hgh4.07 Structure Structure
G.hgh4 294 A G.hgh4.08 Structure Structure
G.H4 295 N G.H4.01 Structure Structure
G.H4 296 K G.H4.02 Structure AF2
G.H4 297 Y G.H4.03 Structure Structure
G.H4 298 D G.H4.04 Structure Structure
G.H4 299 E G.H4.05 Structure AF2
G.H4 300 A G.H4.06 Structure Structure
G.H4 301 A G.H4.07 Structure Structure
G.H4 302 S G.H4.08 Structure Structure
G.H4 303 Y G.H4.10 Structure Structure
G.H4 304 I G.H4.11 Structure Structure
G.H4 305 Q G.H4.12 Structure Structure
G.H4 306 S G.H4.13 Structure AF2
G.H4 307 K G.H4.14 Structure Structure
G.H4 308 F G.H4.15 Structure Structure
G.H4 309 E G.H4.16 Structure Structure
G.H4 310 D G.H4.17 Structure Structure
G.h4s6 311 L G.h4s6.01 Structure Structure
G.h4s6 312 N G.h4s6.02 Structure Structure
G.h4s6 313 K G.h4s6.03 Structure Structure
G.h4s6 314 R G.h4s6.04 Structure Structure
G.h4s6 315 K G.h4s6.08 Structure Structure
G.h4s6 316 D G.h4s6.09 Structure Structure
G.h4s6 317 T G.h4s6.10 Structure Structure
G.h4s6 318 K G.h4s6.11 Structure Structure
G.h4s6 319 E G.h4s6.12 Structure AF2
G.S6 320 I G.S6.01 Structure Structure
G.S6 321 Y G.S6.02 Structure Structure
G.S6 322 T G.S6.03 Structure Structure
G.S6 323 H G.S6.04 Structure Structure
G.S6 324 F G.S6.05 Structure Structure
G.s6h5 325 T G.s6h5.01 Structure Structure
G.s6h5 326 C G.s6h5.02 Structure Structure
G.s6h5 327 A G.s6h5.03 Structure AF2
G.s6h5 328 T G.s6h5.04 Structure Structure
G.s6h5 329 D G.s6h5.05 Structure AF2
G.H5 330 T G.H5.01 Structure Structure
G.H5 331 K G.H5.02 Structure Structure
G.H5 332 N G.H5.03 Structure Structure
G.H5 333 V G.H5.04 Structure Structure
G.H5 334 Q G.H5.05 Structure Structure
G.H5 335 F G.H5.06 Structure Structure
G.H5 336 V G.H5.07 Structure Structure
G.H5 337 F G.H5.08 Structure Structure
G.H5 338 D G.H5.09 Structure Structure
G.H5 339 A G.H5.10 Structure Structure
G.H5 340 V G.H5.11 Structure Structure
G.H5 341 T G.H5.12 Structure Structure
G.H5 342 D G.H5.13 Structure Structure
G.H5 343 V G.H5.14 Structure Structure
G.H5 344 I G.H5.15 Structure Structure
G.H5 345 I G.H5.16 Structure Structure
G.H5 346 K G.H5.17 Structure Structure
G.H5 347 N G.H5.18 Structure Structure
G.H5 348 N G.H5.19 Structure Structure
G.H5 349 L G.H5.20 Structure Structure
G.H5 350 K G.H5.21 Structure Structure
G.H5 351 D G.H5.22 Structure Structure
G.H5 352 C G.H5.23 Structure Structure
G.H5 353 G G.H5.24 Structure Structure
G.H5 354 L G.H5.25 Structure Structure
G.H5 355 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 291 from structure (90.4%), 31 from model (9.6%)
Residue sidechains - 270 from structure (83.9%), 52 from model (16.1%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 Q - AF2 AF2
N-term 3 A - AF2 AF2
N-term 4 V - AF2 AF2
N-term 5 D - AF2 AF2
N-term 6 N - AF2 AF2
N-term 7 L - AF2 AF2
N-term 8 T - AF2 AF2
N-term 9 S - AF2 AF2
N-term 10 A - AF2 AF2
N-term 11 P - AF2 AF2
N-term 12 G - AF2 AF2
N-term 13 N - AF2 AF2
N-term 14 T - AF2 AF2
N-term 15 S - AF2 AF2
N-term 16 L - AF2 AF2
N-term 17 C - AF2 AF2
N-term 18 T - AF2 AF2
N-term 19 R - AF2 AF2
N-term 20 D - AF2 AF2
TM1 21 Y 1.28x28 AF2 AF2
TM1 22 K 1.29x29 AF2 AF2
TM1 23 I 1.30x30 Structure Structure
TM1 24 T 1.31x31 Structure Structure
TM1 25 Q 1.32x32 Structure Structure
TM1 26 V 1.33x33 Structure Structure
TM1 27 L 1.34x34 Structure Structure
TM1 28 F 1.35x35 Structure Structure
TM1 29 P 1.36x36 Structure Structure
TM1 30 L 1.37x37 Structure AF2
TM1 31 L 1.38x38 Structure Structure
TM1 32 Y 1.39x39 Structure Structure
TM1 33 T 1.40x40 Structure Structure
TM1 34 V 1.41x41 Structure Structure
TM1 35 L 1.42x42 Structure Structure
TM1 36 F 1.43x43 Structure Structure
TM1 37 F 1.44x44 Structure AF2
TM1 38 V 1.45x45 Structure Structure
TM1 39 G 1.46x46 Structure Structure
TM1 40 L 1.47x47 Structure Structure
TM1 41 I 1.48x48 Structure Structure
TM1 42 T 1.49x49 Structure Structure
TM1 43 N 1.50x50 Structure Structure
TM1 44 G 1.51x51 Structure Structure
TM1 45 L 1.52x52 Structure Structure
TM1 46 A 1.53x53 Structure Structure
TM1 47 M 1.54x54 Structure AF2
TM1 48 R 1.55x55 Structure AF2
TM1 49 I 1.56x56 Structure Structure
TM1 50 F 1.57x57 Structure Structure
TM1 51 F 1.58x58 Structure Structure
TM1 52 Q 1.59x59 Structure Structure
TM1 53 I 1.60x60 Structure Structure
ICL1 54 R - Structure AF2
ICL1 55 S - Structure Structure
ICL1 56 K - Structure Structure
TM2 57 S 2.37x37 Structure Structure
TM2 58 N 2.38x38 Structure Structure
TM2 59 F 2.39x39 Structure Structure
TM2 60 I 2.40x40 Structure Structure
TM2 61 I 2.41x41 Structure Structure
TM2 62 F 2.42x42 Structure Structure
TM2 63 L 2.43x43 Structure Structure
TM2 64 K 2.44x44 Structure Structure
TM2 65 N 2.45x45 Structure Structure
TM2 66 T 2.46x46 Structure Structure
TM2 67 V 2.47x47 Structure Structure
TM2 68 I 2.48x48 Structure Structure
TM2 69 S 2.49x49 Structure Structure
TM2 70 D 2.50x50 Structure Structure
TM2 71 L 2.51x51 Structure Structure
TM2 72 L 2.52x52 Structure Structure
TM2 73 M 2.53x53 Structure Structure
TM2 74 I 2.54x54 Structure Structure
TM2 75 L 2.55x55 Structure Structure
TM2 76 T 2.56x56 Structure Structure
TM2 77 F 2.57x57 Structure Structure
TM2 78 P 2.58x58 Structure Structure
TM2 79 F 2.59x59 Structure Structure
TM2 80 K 2.60x60 Structure Structure
TM2 81 I 2.61x61 Structure Structure
TM2 82 L 2.62x62 Structure Structure
TM2 83 S 2.63x63 Structure Structure
TM2 84 D 2.64x64 Structure AF2
TM2 85 A 2.65x65 Structure Structure
TM2 86 K 2.66x66 Structure AF2
ECL1 87 L - Structure AF2
ECL1 88 G - Structure Structure
ECL1 89 T - Structure Structure
TM3 90 G 3.18x18 Structure Structure
TM3 91 P 3.19x19 Structure Structure
TM3 92 L 3.20x20 Structure Structure
TM3 93 R 3.21x21 Structure Structure
TM3 94 T 3.22x22 Structure Structure
TM3 95 F 3.23x23 Structure Structure
TM3 96 V 3.24x24 Structure Structure
TM3 97 C 3.25x25 Structure Structure
TM3 98 Q 3.26x26 Structure AF2
TM3 99 V 3.27x27 Structure Structure
TM3 100 T 3.28x28 Structure Structure
TM3 101 S 3.29x29 Structure Structure
TM3 102 V 3.30x30 Structure Structure
TM3 103 I 3.31x31 Structure Structure
TM3 104 F 3.32x32 Structure Structure
TM3 105 Y 3.33x33 Structure Structure
TM3 106 F 3.34x34 Structure Structure
TM3 107 T 3.35x35 Structure Structure
TM3 108 M 3.36x36 Structure Structure
TM3 109 Y 3.37x37 Structure Structure
TM3 110 I 3.38x38 Structure Structure
TM3 111 S 3.39x39 Structure Structure
TM3 112 I 3.40x40 Structure Structure
TM3 113 S 3.41x41 Structure Structure
TM3 114 F 3.42x42 Structure Structure
TM3 115 L 3.43x43 Structure Structure
TM3 116 G 3.44x44 Structure Structure
TM3 117 L 3.45x45 Structure Structure
TM3 118 I 3.46x46 Structure Structure
TM3 119 T 3.47x47 Structure Structure
TM3 120 I 3.48x48 Structure Structure
TM3 121 D 3.49x49 Structure Structure
TM3 122 R 3.50x50 Structure Structure
TM3 123 Y 3.51x51 Structure Structure
TM3 124 Q 3.52x52 Structure Structure
TM3 125 K 3.53x53 Structure Structure
TM3 126 T 3.54x54 Structure Structure
TM3 127 T 3.55x55 Structure Structure
TM3 128 R 3.56x56 Structure Structure
ICL2 129 P 34.50x50 Structure Structure
ICL2 130 F 34.51x51 Structure Structure
ICL2 131 K 34.52x52 Structure Structure
ICL2 132 T 34.53x53 Structure Structure
ICL2 133 S 34.54x54 Structure Structure
ICL2 134 N 34.55x55 Structure Structure
ICL2 135 P 34.56x56 Structure Structure
ICL2 136 K 34.57x57 Structure AF2
TM4 137 N 4.38x38 Structure Structure
TM4 138 L 4.39x39 Structure Structure
TM4 139 L 4.40x40 Structure Structure
TM4 140 G 4.41x41 Structure Structure
TM4 141 A 4.42x42 Structure Structure
TM4 142 K 4.43x43 Structure Structure
TM4 143 I 4.44x44 Structure Structure
TM4 144 L 4.45x45 Structure Structure
TM4 145 S 4.46x46 Structure Structure
TM4 146 V 4.47x47 Structure Structure
TM4 147 V 4.48x48 Structure Structure
TM4 148 I 4.49x49 Structure Structure
TM4 149 W 4.50x50 Structure Structure
TM4 150 A 4.51x51 Structure Structure
TM4 151 F 4.52x52 Structure Structure
TM4 152 M 4.53x53 Structure Structure
TM4 153 F 4.54x54 Structure Structure
TM4 154 L 4.55x55 Structure Structure
TM4 155 L 4.56x56 Structure Structure
TM4 156 S 4.57x57 Structure Structure
TM4 157 L 4.58x58 Structure Structure
TM4 158 P 4.59x59 Structure Structure
TM4 159 N 4.60x60 Structure Structure
TM4 160 M 4.61x61 Structure Structure
TM4 161 I 4.62x62 Structure Structure
TM4 162 L 4.63x63 Structure Structure
TM4 163 T 4.64x64 Structure Structure
ECL2 164 N - Structure Structure
ECL2 165 R - Structure Structure
ECL2 166 Q - Structure AF2
ECL2 167 P - Structure Structure
ECL2 168 R - Structure AF2
ECL2 169 D - Structure AF2
ECL2 170 K - Structure Structure
ECL2 171 N - Structure AF2
ECL2 172 V - Structure Structure
ECL2 173 K - Structure Structure
ECL2 174 K - Structure Structure
ECL2 175 C 45.50x50 Structure Structure
ECL2 176 S 45.51x51 Structure Structure
ECL2 177 F 45.52x52 Structure Structure
ECL2 178 L - Structure Structure
ECL2 179 K - Structure Structure
ECL2 180 S - Structure Structure
TM5 181 E 5.30x30 Structure Structure
TM5 182 F 5.31x31 Structure Structure
TM5 183 G 5.32x32 Structure Structure
TM5 184 L 5.33x33 Structure Structure
TM5 185 V 5.34x34 Structure Structure
TM5 186 W 5.35x35 Structure Structure
TM5 187 H 5.36x36 Structure Structure
TM5 188 E 5.37x37 Structure AF2
TM5 189 I 5.38x38 Structure Structure
TM5 190 V 5.39x39 Structure Structure
TM5 191 N 5.40x40 Structure Structure
TM5 192 Y 5.41x41 Structure Structure
TM5 193 I 5.42x42 Structure Structure
TM5 194 C 5.43x43 Structure Structure
TM5 195 Q 5.44x44 Structure Structure
TM5 196 V 5.45x45 Structure Structure
TM5 197 I 5.46x46 Structure Structure
TM5 198 F 5.47x47 Structure Structure
TM5 199 W 5.48x48 Structure Structure
TM5 200 I 5.49x49 Structure Structure
TM5 201 N 5.50x50 Structure Structure
TM5 202 F 5.51x51 Structure Structure
TM5 203 L 5.52x52 Structure Structure
TM5 204 I 5.53x53 Structure Structure
TM5 205 V 5.54x54 Structure Structure
TM5 206 I 5.55x55 Structure Structure
TM5 207 V 5.56x56 Structure Structure
TM5 208 C 5.57x57 Structure Structure
TM5 209 Y 5.58x58 Structure Structure
TM5 210 T 5.59x59 Structure Structure
TM5 211 L 5.60x60 Structure Structure
TM5 212 I 5.61x61 Structure Structure
TM5 213 T 5.62x62 Structure Structure
TM5 214 K 5.63x63 Structure Structure
TM5 215 E 5.64x64 Structure Structure
TM5 216 L 5.65x65 Structure Structure
TM5 217 Y 5.66x66 Structure Structure
TM5 218 R 5.67x67 Structure Structure
TM5 219 S 5.68x68 Structure Structure
TM5 220 Y 5.69x69 Structure Structure
TM5 221 V 5.70x70 Structure Structure
TM5 222 R 5.71x71 Structure Structure
TM5 223 T 5.72x72 Structure Structure
ICL3 224 R - Structure Structure
ICL3 225 G - Structure Structure
ICL3 226 V - Structure Structure
ICL3 227 G - Structure Structure
ICL3 228 K - Structure AF2
ICL3 229 V - Structure AF2
TM6 230 P 6.29x30 Structure Structure
TM6 231 R 6.30x31 Structure AF2
TM6 232 K 6.31x32 Structure AF2
TM6 233 K 6.32x33 Structure AF2
TM6 234 V 6.33x34 Structure Structure
TM6 235 N 6.34x35 Structure Structure
TM6 236 V 6.35x36 Structure Structure
TM6 237 K 6.36x37 Structure Structure
TM6 238 V 6.37x38 Structure Structure
TM6 239 F 6.38x39 Structure Structure
TM6 240 I 6.39x40 Structure Structure
TM6 241 I 6.40x41 Structure Structure
TM6 242 I 6.41x42 Structure Structure
TM6 243 A 6.42x43 Structure Structure
TM6 244 V 6.43x44 Structure Structure
TM6 245 F 6.44x45 Structure Structure
TM6 246 F 6.45x46 Structure Structure
TM6 247 I 6.46x461 Structure Structure
TM6 248 C 6.47x47 Structure Structure
TM6 249 F 6.48x48 Structure Structure
TM6 250 V 6.49x49 Structure Structure
TM6 251 P 6.50x50 Structure Structure
TM6 252 F 6.51x51 Structure Structure
TM6 253 H 6.52x52 Structure Structure
TM6 254 F 6.53x53 Structure Structure
TM6 255 A 6.54x54 Structure Structure
TM6 256 R 6.55x55 Structure Structure
TM6 257 I 6.56x56 Structure Structure
TM6 258 P 6.57x57 Structure Structure
TM6 259 Y 6.58x58 Structure Structure
TM6 260 T 6.59x59 Structure Structure
TM6 261 L 6.60x60 Structure Structure
TM6 262 S 6.61x61 Structure Structure
TM6 263 Q 6.62x62 Structure Structure
TM6 264 T 6.63x63 Structure Structure
TM6 265 R 6.64x64 Structure Structure
ECL3 266 D - Structure AF2
ECL3 267 V - Structure Structure
ECL3 268 F - Structure Structure
TM7 269 D 7.24x23 Structure Structure
TM7 270 C 7.25x24 Structure Structure
TM7 271 T 7.26x25 Structure Structure
TM7 272 A 7.27x26 Structure Structure
TM7 273 E 7.28x27 Structure Structure
TM7 274 N 7.29x28 Structure Structure
TM7 275 T 7.30x29 Structure Structure
TM7 276 L 7.31x30 Structure Structure
TM7 277 F 7.32x31 Structure Structure
TM7 278 Y 7.33x32 Structure Structure
TM7 279 V 7.34x33 Structure Structure
TM7 280 K 7.35x34 Structure Structure
TM7 281 E 7.36x35 Structure Structure
TM7 282 S 7.37x36 Structure Structure
TM7 283 T 7.38x37 Structure Structure
TM7 284 L 7.39x38 Structure Structure
TM7 285 W 7.40x39 Structure Structure
TM7 286 L 7.41x40 Structure Structure
TM7 287 T 7.42x41 Structure Structure
TM7 288 S 7.43x42 Structure Structure
TM7 289 L 7.44x43 Structure Structure
TM7 290 N 7.45x45 Structure Structure
TM7 291 A 7.46x46 Structure Structure
TM7 292 C 7.47x47 Structure Structure
TM7 293 L 7.48x48 Structure Structure
TM7 294 D 7.49x49 Structure Structure
TM7 295 P 7.50x50 Structure Structure
TM7 296 F 7.51x51 Structure Structure
TM7 297 I 7.52x52 Structure Structure
TM7 298 Y 7.53x53 Structure Structure
TM7 299 F 7.54x54 Structure Structure
TM7 300 F 7.55x55 Structure Structure
TM7 301 L 7.56x56 Structure Structure
H8 302 C 8.47x47 Structure Structure
H8 303 K 8.48x48 Structure Structure
H8 304 S 8.49x49 Structure Structure
H8 305 F 8.50x50 Structure Structure
H8 306 R 8.51x51 Structure Structure
H8 307 N 8.52x52 Structure Structure
H8 308 S 8.53x53 Structure Structure
H8 309 L 8.54x54 Structure Structure
H8 310 I 8.55x55 Structure Structure
H8 311 S 8.56x56 Structure Structure
H8 312 M 8.57x57 Structure Structure
C-term 313 L - Structure Structure
C-term 314 K - AF2 AF2
C-term 315 C - AF2 AF2
C-term 316 P - AF2 AF2
C-term 317 N - AF2 AF2
C-term 318 S - AF2 AF2
C-term 319 A - AF2 AF2
C-term 320 T - AF2 AF2
C-term 321 S - AF2 AF2
C-term 322 L - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 F 59 2x39 G.H5 D 351 G.H5.22
Van-der-waals TM2 F 59 2x39 G.H5 D 351 G.H5.22
Polar H8 K 303 8x48 G.H5 F 355 G.H5.26
Polar TM5 T 223 5x72 G.H5 D 342 G.H5.13
Hydrophobic TM5 T 223 5x72 G.H5 D 342 G.H5.13
Ionic TM6 K 233 6x33 G.h4s6 E 319 G.h4s6.12
Polar TM6 K 233 6x33 G.h4s6 E 319 G.h4s6.12
Polar H8 C 302 8x47 G.H5 K 350 G.H5.21
Van-der-waals H8 C 302 8x47 G.H5 K 350 G.H5.21
Hydrophobic ICL2 F 130 34x51 G.H5 I 344 G.H5.15
Hydrophobic ICL2 F 130 34x51 G.H5 T 341 G.H5.12
Van-der-waals ICL2 F 130 34x51 G.H5 T 341 G.H5.12
Hydrophobic ICL2 P 129 34x50 G.H5 T 341 G.H5.12
Polar TM5 S 219 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 S 219 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 S 219 5x68 G.H5 D 342 G.H5.13
Hydrophobic ICL2 T 132 34x53 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 T 223 5x72 G.S6 Y 321 G.S6.02
Van-der-waals TM5 T 223 5x72 G.S6 Y 321 G.S6.02
Polar TM3 R 122 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 122 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 122 3x50 G.H5 C 352 G.H5.23
Polar TM5 Y 220 5x69 G.H5 D 342 G.H5.13
Polar TM6 K 237 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM6 K 237 6x37 G.H5 L 354 G.H5.25
Van-der-waals TM6 K 237 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM5 T 223 5x72 G.H5 A 339 G.H5.10
Hydrophobic ICL2 T 132 34x53 G.hns1 A 31 G.hns1.02
Hydrophobic TM3 R 122 3x50 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 129 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 129 34x50 G.H5 I 345 G.H5.16
Hydrophobic TM5 Y 220 5x69 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM5 Y 220 5x69 G.h4s6 E 319 G.h4s6.12
Polar ICL2 N 134 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 N 134 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 N 134 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 P 129 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 129 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM3 K 125 3x53 G.H5 L 349 G.H5.20
Hydrophobic TM2 F 59 2x39 G.H5 G 353 G.H5.24
Hydrophobic TM6 K 233 6x33 G.H5 K 346 G.H5.17
Polar TM3 K 125 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 K 125 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 R 122 3x50 G.H5 L 349 G.H5.20
Hydrophobic TM2 F 59 2x39 G.H5 C 352 G.H5.23
Van-der-waals TM2 F 59 2x39 G.H5 C 352 G.H5.23
Hydrophobic ICL2 F 130 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 F 130 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM5 L 216 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM6 V 234 6x34 G.H5 F 355 G.H5.26
Aromatic ICL2 F 130 34x51 G.H5 F 337 G.H5.08
Hydrophobic ICL2 F 130 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 F 130 34x51 G.H5 F 337 G.H5.08
Hydrophobic TM5 L 216 5x65 G.H5 K 346 G.H5.17
Hydrophobic TM5 T 223 5x72 G.H5 D 338 G.H5.09
Van-der-waals TM5 T 223 5x72 G.H5 D 338 G.H5.09
Hydrophobic TM3 K 125 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM5 T 223 5x72 G.H5 F 335 G.H5.06
Van-der-waals TM5 T 223 5x72 G.H5 F 335 G.H5.06
Ionic ICL3 R 224 - G.h4s6 E 319 G.h4s6.12
Polar ICL3 R 224 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 R 224 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 R 224 - G.h4s6 E 319 G.h4s6.12
Polar ICL3 R 224 - G.S6 I 320 G.S6.01
Hydrophobic ICL3 R 224 - G.S6 I 320 G.S6.01
Van-der-waals ICL3 R 224 - G.S6 I 320 G.S6.01
Hydrophobic TM5 L 216 5x65 G.H5 I 345 G.H5.16
Van-der-waals TM5 L 216 5x65 G.H5 I 345 G.H5.16
Aromatic ICL3 R 224 - G.S6 Y 321 G.S6.02
Van-der-waals TM3 T 126 3x54 G.H5 L 349 G.H5.20
Polar ICL2 P 129 34x50 G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 129 34x50 G.H5 N 348 G.H5.19
Hydrophobic TM7 L 301 7x56 G.H5 L 354 G.H5.25
Hydrophobic TM3 T 126 3x54 G.H5 I 345 G.H5.16
Polar H8 C 302 8x47 G.H5 F 355 G.H5.26
Hydrophobic H8 C 302 8x47 G.H5 F 355 G.H5.26
Van-der-waals H8 C 302 8x47 G.H5 F 355 G.H5.26
Hydrophobic TM5 I 212 5x61 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 135 34x56 G.HN R 24 G.HN.48
Van-der-waals ICL2 P 135 34x56 G.HN R 24 G.HN.48
Hydrophobic TM6 I 241 6x41 G.H5 L 354 G.H5.25
Hydrophobic TM7 L 301 7x56 G.H5 G 353 G.H5.24
Van-der-waals TM7 L 301 7x56 G.H5 G 353 G.H5.24
Polar TM3 D 121 3x49 G.H5 C 352 G.H5.23
Van-der-waals TM3 D 121 3x49 G.H5 C 352 G.H5.23
Ionic TM5 R 222 5x71 G.H5 D 338 G.H5.09
Polar TM5 R 222 5x71 G.H5 D 338 G.H5.09
Hydrophobic TM5 R 222 5x71 G.H5 D 338 G.H5.09
Polar H8 C 302 8x47 G.H5 G 353 G.H5.24
Hydrophobic H8 C 302 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 C 302 8x47 G.H5 G 353 G.H5.24