Refined structure (7YON) of Gi1 - Y2 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 219 from structure (61.9%), 135 from model (38.1%)
Residue sidechains - 219 from structure (61.9%), 135 from model (38.1%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 Structure Structure
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure Structure
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 AF2 AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 302 from structure (85.1%), 53 from model (14.9%)
Residue sidechains - 300 from structure (84.5%), 55 from model (15.5%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 G - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 I - AF2 AF2
N-term 5 G - AF2 AF2
N-term 6 A - AF2 AF2
N-term 7 E - AF2 AF2
N-term 8 A - AF2 AF2
N-term 9 D - AF2 AF2
N-term 10 E - AF2 AF2
N-term 11 N - AF2 AF2
N-term 12 Q - AF2 AF2
N-term 13 T - AF2 AF2
N-term 14 V - AF2 AF2
N-term 15 E - AF2 AF2
N-term 16 E - AF2 AF2
N-term 17 M - AF2 AF2
N-term 18 K - AF2 AF2
N-term 19 V - AF2 AF2
N-term 20 E - AF2 AF2
N-term 21 Q - AF2 AF2
N-term 22 Y - AF2 AF2
N-term 23 G - AF2 AF2
N-term 24 P - AF2 AF2
N-term 25 Q - AF2 AF2
N-term 26 T - AF2 AF2
N-term 27 T - AF2 AF2
N-term 28 P - AF2 AF2
N-term 29 R - AF2 AF2
N-term 30 G - AF2 AF2
N-term 31 E - AF2 AF2
N-term 32 L - AF2 AF2
N-term 33 V - AF2 AF2
N-term 34 P - AF2 AF2
N-term 35 D - AF2 AF2
N-term 36 P - AF2 AF2
N-term 37 E - AF2 AF2
N-term 38 P - AF2 AF2
N-term 39 E - AF2 AF2
N-term 40 L - Structure Structure
N-term 41 I - Structure Structure
N-term 42 D - Structure Structure
N-term 43 S - Structure Structure
N-term 44 T - Structure Structure
N-term 45 K - Structure Structure
N-term 46 L - Structure Structure
N-term 47 I - Structure Structure
TM1 48 E 1.30x30 Structure Structure
TM1 49 V 1.31x31 Structure Structure
TM1 50 Q 1.32x32 Structure Structure
TM1 51 V 1.33x33 Structure Structure
TM1 52 V 1.34x34 Structure Structure
TM1 53 L 1.35x35 Structure Structure
TM1 54 I 1.36x36 Structure Structure
TM1 55 L 1.37x37 Structure Structure
TM1 56 A 1.38x38 Structure Structure
TM1 57 Y 1.39x39 Structure Structure
TM1 58 C 1.40x40 Structure Structure
TM1 59 S 1.41x41 Structure Structure
TM1 60 I 1.42x42 Structure Structure
TM1 61 I 1.43x43 Structure Structure
TM1 62 L 1.44x44 Structure Structure
TM1 63 L 1.45x45 Structure Structure
TM1 64 G 1.46x46 Structure Structure
TM1 65 V 1.47x47 Structure Structure
TM1 66 I 1.48x48 Structure Structure
TM1 67 G 1.49x49 Structure Structure
TM1 68 N 1.50x50 Structure Structure
TM1 69 S 1.51x51 Structure Structure
TM1 70 L 1.52x52 Structure Structure
TM1 71 V 1.53x53 Structure Structure
TM1 72 I 1.54x54 Structure Structure
TM1 73 H 1.55x55 Structure Structure
TM1 74 V 1.56x56 Structure Structure
TM1 75 V 1.57x57 Structure Structure
TM1 76 I 1.58x58 Structure Structure
TM1 77 K 1.59x59 Structure Structure
TM1 78 F 1.60x60 Structure Structure
ICL1 79 K 12.48x48 Structure Structure
ICL1 80 S 12.49x49 Structure Structure
ICL1 81 M 12.50x50 Structure Structure
ICL1 82 R 12.51x51 Structure Structure
TM2 83 T 2.37x37 Structure Structure
TM2 84 V 2.38x38 Structure Structure
TM2 85 T 2.39x39 Structure Structure
TM2 86 N 2.40x40 Structure Structure
TM2 87 F 2.41x41 Structure Structure
TM2 88 F 2.42x42 Structure Structure
TM2 89 I 2.43x43 Structure Structure
TM2 90 A 2.44x44 Structure Structure
TM2 91 N 2.45x45 Structure Structure
TM2 92 L 2.46x46 Structure Structure
TM2 93 A 2.47x47 Structure Structure
TM2 94 V 2.48x48 Structure Structure
TM2 95 A 2.49x49 Structure Structure
TM2 96 D 2.50x50 Structure Structure
TM2 97 L 2.51x51 Structure Structure
TM2 98 L 2.52x52 Structure Structure
TM2 99 V 2.53x53 Structure Structure
TM2 100 N 2.54x54 Structure Structure
TM2 101 T 2.55x55 Structure Structure
TM2 102 L 2.56x551 Structure Structure
TM2 103 C 2.57x56 Structure Structure
TM2 104 L 2.58x57 Structure Structure
TM2 105 P 2.59x58 Structure Structure
TM2 106 F 2.60x59 Structure Structure
TM2 107 T 2.61x60 Structure Structure
TM2 108 L 2.62x61 Structure Structure
TM2 109 T 2.63x62 Structure Structure
TM2 110 Y 2.64x63 Structure Structure
TM2 111 T 2.65x64 Structure Structure
TM2 112 L 2.66x65 Structure Structure
TM2 113 M 2.67x66 Structure Structure
TM2 114 G 2.68x67 Structure Structure
ECL1 115 E 23.49x49 Structure Structure
ECL1 116 W 23.50x50 Structure Structure
ECL1 117 K 23.51x51 Structure Structure
ECL1 118 M 23.52x52 Structure Structure
TM3 119 G 3.21x21 Structure Structure
TM3 120 P 3.22x22 Structure Structure
TM3 121 V 3.23x23 Structure Structure
TM3 122 L 3.24x24 Structure Structure
TM3 123 C 3.25x25 Structure Structure
TM3 124 H 3.26x26 Structure Structure
TM3 125 L 3.27x27 Structure Structure
TM3 126 V 3.28x28 Structure Structure
TM3 127 P 3.29x29 Structure Structure
TM3 128 Y 3.30x30 Structure Structure
TM3 129 A 3.31x31 Structure Structure
TM3 130 Q 3.32x32 Structure Structure
TM3 131 G 3.33x33 Structure Structure
TM3 132 L 3.34x34 Structure Structure
TM3 133 A 3.35x35 Structure Structure
TM3 134 V 3.36x36 Structure Structure
TM3 135 Q 3.37x37 Structure Structure
TM3 136 V 3.38x38 Structure Structure
TM3 137 S 3.39x39 Structure Structure
TM3 138 T 3.40x40 Structure Structure
TM3 139 I 3.41x41 Structure Structure
TM3 140 T 3.42x42 Structure Structure
TM3 141 L 3.43x43 Structure Structure
TM3 142 T 3.44x44 Structure Structure
TM3 143 V 3.45x45 Structure Structure
TM3 144 I 3.46x46 Structure Structure
TM3 145 A 3.47x47 Structure Structure
TM3 146 L 3.48x48 Structure Structure
TM3 147 D 3.49x49 Structure Structure
TM3 148 R 3.50x50 Structure Structure
TM3 149 H 3.51x51 Structure AF2
TM3 150 R 3.52x52 Structure Structure
TM3 151 C 3.53x53 Structure Structure
TM3 152 I 3.54x54 Structure Structure
TM3 153 V 3.55x55 Structure Structure
TM3 154 Y 3.56x56 Structure Structure
ICL2 155 H - Structure Structure
ICL2 156 L - Structure Structure
ICL2 157 E - Structure Structure
ICL2 158 S - Structure Structure
ICL2 159 K - Structure Structure
ICL2 160 I - Structure Structure
TM4 161 S 4.38x38 Structure Structure
TM4 162 K 4.39x39 Structure Structure
TM4 163 R 4.40x40 Structure Structure
TM4 164 I 4.41x41 Structure Structure
TM4 165 S 4.42x42 Structure Structure
TM4 166 F 4.43x43 Structure Structure
TM4 167 L 4.44x44 Structure Structure
TM4 168 I 4.45x45 Structure Structure
TM4 169 I 4.46x46 Structure Structure
TM4 170 G 4.47x47 Structure Structure
TM4 171 L 4.48x48 Structure Structure
TM4 172 A 4.49x49 Structure Structure
TM4 173 W 4.50x50 Structure Structure
TM4 174 G 4.51x51 Structure Structure
TM4 175 I 4.52x52 Structure Structure
TM4 176 S 4.53x53 Structure Structure
TM4 177 A 4.54x54 Structure Structure
TM4 178 L 4.55x55 Structure Structure
TM4 179 L 4.56x56 Structure Structure
TM4 180 A 4.57x57 Structure Structure
TM4 181 S 4.58x59 Structure Structure
TM4 182 P 4.59x60 Structure Structure
TM4 183 L 4.60x61 Structure Structure
TM4 184 A 4.61x62 Structure Structure
TM4 185 I 4.62x63 Structure Structure
TM4 186 F 4.63x64 Structure Structure
TM4 187 R 4.64x65 Structure Structure
ECL2 188 E - Structure Structure
ECL2 189 Y - Structure Structure
ECL2 190 S - Structure Structure
ECL2 191 L - Structure Structure
ECL2 192 I - Structure Structure
ECL2 193 E - Structure Structure
ECL2 194 I - Structure Structure
ECL2 195 I - Structure Structure
ECL2 196 P - Structure Structure
ECL2 197 D - Structure Structure
ECL2 198 F - Structure Structure
ECL2 199 E - Structure Structure
ECL2 200 I - Structure Structure
ECL2 201 V - Structure Structure
ECL2 202 A - Structure Structure
ECL2 203 C 45.50x50 Structure Structure
ECL2 204 T 45.51x51 Structure Structure
ECL2 205 E 45.52x52 Structure Structure
ECL2 206 K - Structure Structure
ECL2 207 W - Structure Structure
ECL2 208 P - Structure Structure
ECL2 209 G - Structure Structure
ECL2 210 E - Structure Structure
ECL2 211 E - Structure Structure
ECL2 212 K - Structure Structure
TM5 213 S 5.32x33 Structure Structure
TM5 214 I 5.33x34 Structure Structure
TM5 215 Y 5.34x35 Structure Structure
TM5 216 G 5.35x36 Structure Structure
TM5 217 T 5.36x37 Structure Structure
TM5 218 V 5.37x38 Structure Structure
TM5 219 Y 5.38x39 Structure Structure
TM5 220 S 5.39x40 Structure Structure
TM5 221 L 5.40x41 Structure Structure
TM5 222 S 5.41x42 Structure Structure
TM5 223 S 5.42x43 Structure Structure
TM5 224 L 5.43x44 Structure Structure
TM5 225 L 5.44x45 Structure Structure
TM5 226 I 5.45x46 Structure Structure
TM5 227 L 5.46x461 Structure Structure
TM5 228 Y 5.47x47 Structure Structure
TM5 229 V 5.48x48 Structure Structure
TM5 230 L 5.49x49 Structure Structure
TM5 231 P 5.50x50 Structure Structure
TM5 232 L 5.51x51 Structure Structure
TM5 233 G 5.52x52 Structure Structure
TM5 234 I 5.53x53 Structure Structure
TM5 235 I 5.54x54 Structure Structure
TM5 236 S 5.55x55 Structure Structure
TM5 237 F 5.56x56 Structure Structure
TM5 238 S 5.57x57 Structure Structure
TM5 239 Y 5.58x58 Structure Structure
TM5 240 T 5.59x59 Structure Structure
TM5 241 R 5.60x60 Structure Structure
TM5 242 I 5.61x61 Structure Structure
TM5 243 W 5.62x62 Structure Structure
TM5 244 S 5.63x63 Structure Structure
TM5 245 K 5.64x64 Structure Structure
TM5 246 L 5.65x65 Structure Structure
TM5 247 K 5.66x66 Structure Structure
TM5 248 N 5.67x67 Structure Structure
TM5 249 H 5.68x68 Structure Structure
TM5 250 V 5.69x69 Structure Structure
TM5 251 S 5.70x70 Structure Structure
TM5 252 P 5.71x71 Structure Structure
TM5 253 G 5.72x72 Structure Structure
ICL3 254 A - Structure Structure
ICL3 255 A - Structure Structure
TM6 256 N 6.23x23 Structure Structure
TM6 257 D 6.24x24 Structure Structure
TM6 258 H 6.25x25 Structure Structure
TM6 259 Y 6.26x26 Structure Structure
TM6 260 H 6.27x27 Structure Structure
TM6 261 Q 6.28x28 Structure Structure
TM6 262 R 6.29x29 Structure Structure
TM6 263 R 6.30x30 Structure Structure
TM6 264 Q 6.31x31 Structure Structure
TM6 265 K 6.32x32 Structure Structure
TM6 266 T 6.33x33 Structure Structure
TM6 267 T 6.34x34 Structure Structure
TM6 268 K 6.35x35 Structure Structure
TM6 269 M 6.36x36 Structure Structure
TM6 270 L 6.37x37 Structure Structure
TM6 271 V 6.38x38 Structure Structure
TM6 272 C 6.39x39 Structure Structure
TM6 273 V 6.40x40 Structure Structure
TM6 274 V 6.41x41 Structure Structure
TM6 275 V 6.42x42 Structure Structure
TM6 276 V 6.43x43 Structure Structure
TM6 277 F 6.44x44 Structure Structure
TM6 278 A 6.45x45 Structure Structure
TM6 279 V 6.46x46 Structure Structure
TM6 280 S 6.47x47 Structure AF2
TM6 281 W 6.48x48 Structure Structure
TM6 282 L 6.49x49 Structure Structure
TM6 283 P 6.50x50 Structure Structure
TM6 284 L 6.51x51 Structure Structure
TM6 285 H 6.52x52 Structure Structure
TM6 286 A 6.53x53 Structure Structure
TM6 287 F 6.54x54 Structure Structure
TM6 288 Q 6.55x55 Structure Structure
TM6 289 L 6.56x56 Structure Structure
TM6 290 A 6.57x57 Structure Structure
TM6 291 V 6.58x58 Structure Structure
TM6 292 D 6.59x59 Structure Structure
TM6 293 I 6.60x60 Structure Structure
TM6 294 D 6.61x61 Structure Structure
ECL3 295 S - Structure Structure
ECL3 296 Q - Structure Structure
ECL3 297 V - Structure Structure
ECL3 298 L - Structure Structure
TM7 299 D 7.27x26 Structure Structure
TM7 300 L 7.28x27 Structure Structure
TM7 301 K 7.29x28 Structure Structure
TM7 302 E 7.30x29 Structure Structure
TM7 303 Y 7.31x30 Structure Structure
TM7 304 K 7.32x31 Structure Structure
TM7 305 L 7.33x32 Structure Structure
TM7 306 I 7.34x33 Structure Structure
TM7 307 F 7.35x34 Structure Structure
TM7 308 T 7.36x35 Structure Structure
TM7 309 V 7.37x36 Structure Structure
TM7 310 F 7.38x37 Structure Structure
TM7 311 H 7.39x38 Structure Structure
TM7 312 I 7.40x39 Structure Structure
TM7 313 I 7.41x40 Structure Structure
TM7 314 A 7.42x41 Structure Structure
TM7 315 M 7.43x42 Structure Structure
TM7 316 C 7.44x43 Structure Structure
TM7 317 S 7.45x45 Structure Structure
TM7 318 T 7.46x46 Structure Structure
TM7 319 F 7.47x47 Structure Structure
TM7 320 A 7.48x48 Structure Structure
TM7 321 N 7.49x49 Structure Structure
TM7 322 P 7.50x50 Structure Structure
TM7 323 L 7.51x51 Structure Structure
TM7 324 L 7.52x52 Structure Structure
TM7 325 Y 7.53x53 Structure Structure
TM7 326 G 7.54x54 Structure Structure
TM7 327 W 7.55x55 Structure Structure
TM7 328 M 7.56x56 Structure Structure
H8 329 N 8.47x47 Structure Structure
H8 330 S 8.48x48 Structure Structure
H8 331 N 8.49x49 Structure Structure
H8 332 Y 8.50x50 Structure Structure
H8 333 R 8.51x51 Structure Structure
H8 334 K 8.52x52 Structure Structure
H8 335 A 8.53x53 Structure Structure
H8 336 F 8.54x54 Structure Structure
H8 337 L 8.55x55 Structure Structure
H8 338 S 8.56x56 Structure Structure
H8 339 A 8.57x57 Structure Structure
H8 340 F 8.58x58 Structure Structure
H8 341 R 8.59x59 Structure Structure
H8 342 C 8.60x60 AF2 AF2
H8 343 E 8.61x61 AF2 AF2
H8 344 Q 8.62x62 AF2 AF2
H8 345 R 8.63x63 AF2 AF2
C-term 346 L - AF2 AF2
C-term 347 D - AF2 AF2
C-term 348 A - AF2 AF2
C-term 349 I - AF2 AF2
C-term 350 H - AF2 AF2
C-term 351 S - AF2 AF2
C-term 352 E - AF2 AF2
C-term 353 V - AF2 AF2
C-term 354 S - AF2 AF2
C-term 355 V - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic ICL2 K 159 - G.H5 D 350 G.H5.22
Polar ICL2 K 159 - G.H5 D 350 G.H5.22
Hydrophobic ICL3 A 255 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 A 255 - G.h4s6 E 318 G.h4s6.12
Polar H8 S 330 8x48 G.H5 G 352 G.H5.24
Hydrophobic ICL2 H 155 - G.H5 I 344 G.H5.16
Hydrophobic TM6 Y 259 6x26 G.H5 K 345 G.H5.17
Aromatic TM6 R 262 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 262 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM5 P 252 5x71 G.H5 A 338 G.H5.10
Ionic C-term H 350 - G.H5 D 350 G.H5.22
Hydrophobic TM6 Y 259 6x26 G.H5 F 354 G.H5.26
Polar TM3 C 151 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 C 151 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 C 151 3x53 G.H5 C 351 G.H5.23
Polar TM3 C 151 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 C 151 3x53 G.H5 N 347 G.H5.19
Polar C-term E 352 - G.H5 N 346 G.H5.18
Hydrophobic C-term V 355 - G.h2s4 G 217 G.h2s4.03
Van-der-waals C-term V 355 - G.h2s4 G 217 G.h2s4.03
Hydrophobic TM3 R 148 3x50 G.H5 L 353 G.H5.25
Polar TM5 S 251 5x70 G.H5 D 341 G.H5.13
Hydrophobic TM5 S 251 5x70 G.H5 D 341 G.H5.13
Van-der-waals TM5 S 251 5x70 G.H5 D 341 G.H5.13
Van-der-waals TM6 T 266 6x33 G.H5 F 354 G.H5.26
Polar H8 N 331 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 N 331 8x49 G.H5 D 350 G.H5.22
Polar TM5 S 251 5x70 G.H5 K 345 G.H5.17
Polar TM6 T 266 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 266 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 156 - G.S3 L 194 G.S3.01
Ionic C-term E 352 - G.H5 K 349 G.H5.21
Hydrophobic TM5 L 246 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 P 252 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 P 252 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 P 252 5x71 G.S6 Y 320 G.S6.02
Polar H8 N 331 8x49 G.H5 K 349 G.H5.21
Hydrophobic TM5 P 252 5x71 G.H5 D 341 G.H5.13
Hydrophobic C-term S 351 - G.h3s5 T 260 G.h3s5.01
Ionic TM5 H 249 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 249 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 249 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 249 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM3 I 152 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 152 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 152 3x54 G.H5 L 353 G.H5.25
Ionic TM6 R 262 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM5 H 249 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 249 5x68 G.H5 I 344 G.H5.16
Polar C-term S 351 - G.h3s5 D 261 G.h3s5.02
Hydrophobic TM3 R 148 3x50 G.H5 C 351 G.H5.23
Hydrophobic H8 N 329 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 329 8x47 G.H5 G 352 G.H5.24
Hydrophobic C-term V 355 - G.h2s4 E 216 G.h2s4.02
Van-der-waals C-term V 355 - G.h2s4 E 216 G.h2s4.02
Hydrophobic ICL2 H 155 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 H 155 - G.H5 N 347 G.H5.19
Polar H8 S 330 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 S 330 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 S 330 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 263 6x30 G.H5 F 354 G.H5.26
Hydrophobic C-term E 352 - G.h3s5 D 261 G.h3s5.02
Van-der-waals C-term E 352 - G.h3s5 D 261 G.h3s5.02
Hydrophobic TM5 P 252 5x71 G.H5 F 334 G.H5.06
Van-der-waals TM5 P 252 5x71 G.H5 F 334 G.H5.06