Refined structure (8E3X) of Gs - PAC1 receptor

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 232 from structure (58.9%), 162 from model (41.1%)
Residue sidechains - 224 from structure (56.9%), 170 from model (43.1%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 AF2 AF2
G.HN 11 D G.HN.28 AF2 AF2
G.HN 12 Q G.HN.29 Structure Structure
G.HN 13 R G.HN.30 Structure Structure
G.HN 14 N G.HN.31 Structure Structure
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure Structure
G.s1h1 50 E G.s1h1.04 Structure Structure
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure AF2
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure Structure
G.H1 58 K G.H1.06 Structure Structure
G.H1 59 Q G.H1.07 Structure Structure
G.H1 60 M G.H1.08 Structure Structure
G.H1 61 R G.H1.09 Structure Structure
G.H1 62 I G.H1.10 AF2 AF2
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 Structure Structure
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure AF2
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 Structure Structure
G.s4h3 253 Y G.s4h3.04 AF2 AF2
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 Structure Structure
G.s4h3 262 Q G.s4h3.13 Structure Structure
G.s4h3 263 T G.s4h3.14 Structure Structure
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure AF2
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure AF2
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure AF2
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure AF2
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure AF2
G.h3s5 285 I G.h3s5.03 Structure AF2
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure Structure
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 Structure Structure
G.HG 305 K G.HG.12 Structure Structure
G.HG 306 S G.HG.13 Structure Structure
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure Structure
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 362 from structure (82.5%), 77 from model (17.5%)
Residue sidechains - 329 from structure (74.9%), 110 from model (25.1%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 A - AF2 AF2
N-term 3 G - AF2 AF2
N-term 4 V - AF2 AF2
N-term 5 V - AF2 AF2
N-term 6 H - AF2 AF2
N-term 7 V - AF2 AF2
N-term 8 S - AF2 AF2
N-term 9 L - AF2 AF2
N-term 10 A - AF2 AF2
N-term 11 A - AF2 AF2
N-term 12 L - AF2 AF2
N-term 13 L - AF2 AF2
N-term 14 L - AF2 AF2
N-term 15 L - AF2 AF2
N-term 16 P - AF2 AF2
N-term 17 M - AF2 AF2
N-term 18 A - AF2 AF2
N-term 19 P - AF2 AF2
N-term 20 A - AF2 AF2
N-term 21 M - AF2 AF2
N-term 22 H - AF2 AF2
N-term 23 S - AF2 AF2
N-term 24 D - Structure Structure
N-term 25 C - Structure Structure
N-term 26 I - Structure Structure
N-term 27 F - Structure Structure
N-term 28 K - Structure Structure
N-term 29 K - Structure Structure
N-term 30 E - Structure Structure
N-term 31 Q - Structure Structure
N-term 32 A - Structure Structure
N-term 33 M - Structure Structure
N-term 34 C - Structure Structure
N-term 35 L - Structure Structure
N-term 36 E - Structure Structure
N-term 37 K - Structure Structure
N-term 38 I - Structure Structure
N-term 39 Q - Structure Structure
N-term 40 R - Structure AF2
N-term 41 A - Structure Structure
N-term 42 N - Structure AF2
N-term 43 E - Structure AF2
N-term 44 L - Structure AF2
N-term 45 M - Structure AF2
N-term 46 G - Structure Structure
N-term 47 F - Structure AF2
N-term 48 N - Structure AF2
N-term 49 D - Structure AF2
N-term 50 S - Structure Structure
N-term 51 S - Structure Structure
N-term 52 P - Structure AF2
N-term 53 G - Structure Structure
N-term 54 C - Structure Structure
N-term 55 P - Structure AF2
N-term 56 G - Structure Structure
N-term 57 M - Structure AF2
N-term 58 W - Structure Structure
N-term 59 D - Structure Structure
N-term 60 N - Structure Structure
N-term 61 I - Structure Structure
N-term 62 T - Structure Structure
N-term 63 C - Structure Structure
N-term 64 W - Structure Structure
N-term 65 K - Structure AF2
N-term 66 P - Structure AF2
N-term 67 A - Structure Structure
N-term 68 H - Structure AF2
N-term 69 V - Structure AF2
N-term 70 G - Structure Structure
N-term 71 E - Structure AF2
N-term 72 M - Structure AF2
N-term 73 V - Structure AF2
N-term 74 L - Structure AF2
N-term 75 V - Structure AF2
N-term 76 S - Structure Structure
N-term 77 C - Structure Structure
N-term 78 P - Structure Structure
N-term 79 E - Structure Structure
N-term 80 L - Structure Structure
N-term 81 F - Structure Structure
N-term 82 R - Structure Structure
N-term 83 I - Structure Structure
N-term 84 F - Structure Structure
N-term 85 N - Structure Structure
N-term 86 P - Structure Structure
N-term 87 D - Structure Structure
N-term 88 Q - AF2 AF2
N-term 89 V - AF2 AF2
N-term 90 W - AF2 AF2
N-term 91 E - AF2 AF2
N-term 92 T - AF2 AF2
N-term 93 E - AF2 AF2
N-term 94 T - AF2 AF2
N-term 95 I - AF2 AF2
N-term 96 G - AF2 AF2
N-term 97 E - AF2 AF2
N-term 98 S - AF2 AF2
N-term 99 D - AF2 AF2
N-term 100 F - AF2 AF2
N-term 101 G - AF2 AF2
N-term 102 D - AF2 AF2
N-term 103 S - AF2 AF2
N-term 104 N - AF2 AF2
N-term 105 S - AF2 AF2
N-term 106 L - AF2 AF2
N-term 107 D - AF2 AF2
N-term 108 L - AF2 AF2
N-term 109 S - AF2 AF2
N-term 110 D - AF2 AF2
N-term 111 M - AF2 AF2
N-term 112 G - AF2 AF2
N-term 113 V - AF2 AF2
N-term 114 V - Structure AF2
N-term 115 S - Structure Structure
N-term 116 R - Structure AF2
N-term 117 N - Structure AF2
N-term 118 C - Structure Structure
N-term 119 T - Structure AF2
N-term 120 E - Structure AF2
N-term 121 D - Structure AF2
N-term 122 G - Structure Structure
N-term 123 W - Structure AF2
N-term 124 S - Structure Structure
N-term 125 E - Structure AF2
N-term 126 P - Structure AF2
N-term 127 F - Structure AF2
N-term 128 P - Structure AF2
N-term 129 H - Structure AF2
N-term 130 Y - Structure AF2
N-term 131 F - Structure Structure
N-term 132 D - Structure Structure
N-term 133 A - Structure Structure
N-term 134 C - Structure Structure
N-term 135 G - Structure Structure
N-term 136 F - Structure Structure
N-term 137 D - Structure Structure
N-term 138 E - Structure Structure
TM1 139 Y 1.25x25 AF2 AF2
TM1 140 E 1.26x26 AF2 AF2
TM1 141 S 1.27x27 AF2 AF2
TM1 142 E 1.28x28 AF2 AF2
TM1 143 T 1.29x29 AF2 AF2
TM1 144 G 1.30x30 AF2 AF2
TM1 145 D 1.31x31 AF2 AF2
TM1 146 Q 1.32x32 Structure Structure
TM1 147 D 1.33x33 Structure Structure
TM1 148 Y 1.34x34 Structure Structure
TM1 149 Y 1.35x35 Structure Structure
TM1 150 Y 1.36x36 Structure Structure
TM1 151 L 1.37x37 Structure Structure
TM1 152 S 1.38x38 Structure Structure
TM1 153 V 1.39x39 Structure Structure
TM1 154 K 1.40x40 Structure Structure
TM1 155 A 1.41x41 Structure Structure
TM1 156 L 1.42x42 Structure Structure
TM1 157 Y 1.43x43 Structure Structure
TM1 158 T 1.44x44 Structure Structure
TM1 159 V 1.45x45 Structure Structure
TM1 160 G 1.46x46 Structure Structure
TM1 161 Y 1.47x47 Structure Structure
TM1 162 S 1.48x48 Structure Structure
TM1 163 T 1.49x49 Structure Structure
TM1 164 S 1.50x50 Structure Structure
TM1 165 L 1.51x51 Structure Structure
TM1 166 V 1.52x52 Structure Structure
TM1 167 T 1.53x53 Structure Structure
TM1 168 L 1.54x54 Structure Structure
TM1 169 T 1.55x55 Structure Structure
TM1 170 T 1.56x56 Structure Structure
TM1 171 A 1.57x57 Structure Structure
TM1 172 M 1.58x58 Structure Structure
TM1 173 V 1.59x59 Structure Structure
TM1 174 I 1.60x60 Structure Structure
TM1 175 L 1.61x61 Structure Structure
TM1 176 C 1.62x62 Structure Structure
TM1 177 R 1.63x63 Structure Structure
TM1 178 F 1.64x64 Structure Structure
ICL1 179 R 12.48x48 Structure Structure
ICL1 180 K 12.49x49 Structure Structure
ICL1 181 L 12.50x50 Structure Structure
ICL1 182 H 12.51x51 Structure Structure
TM2 183 C 2.44x44 Structure Structure
TM2 184 T 2.45x45 Structure Structure
TM2 185 R 2.46x46 Structure Structure
TM2 186 N 2.47x47 Structure Structure
TM2 187 F 2.48x48 Structure Structure
TM2 188 I 2.49x49 Structure Structure
TM2 189 H 2.50x50 Structure Structure
TM2 190 M 2.51x51 Structure Structure
TM2 191 N 2.52x52 Structure Structure
TM2 192 L 2.53x53 Structure Structure
TM2 193 F 2.54x54 Structure Structure
TM2 194 V 2.55x55 Structure Structure
TM2 195 S 2.56x56 Structure Structure
TM2 196 F 2.57x57 Structure Structure
TM2 197 M 2.58x58 Structure Structure
TM2 198 L 2.59x59 Structure Structure
TM2 199 R 2.60x60 Structure Structure
TM2 200 A 2.61x61 Structure Structure
TM2 201 I 2.62x62 Structure Structure
TM2 202 S 2.63x63 Structure Structure
TM2 203 V 2.64x64 Structure Structure
TM2 204 F 2.65x65 Structure Structure
TM2 205 I 2.66x66 Structure Structure
TM2 206 K 2.67x67 Structure Structure
TM2 207 D 2.68x68 Structure Structure
TM2 208 W 2.69x69 Structure Structure
TM2 209 I 2.70x70 Structure Structure
TM2 210 L 2.71x71 Structure Structure
ECL1 211 Y - Structure Structure
ECL1 212 A - Structure Structure
ECL1 213 E - Structure Structure
ECL1 214 Q - Structure Structure
ECL1 215 D - Structure Structure
ECL1 216 S - Structure Structure
ECL1 217 N - Structure Structure
ECL1 218 H - Structure Structure
ECL1 219 C - Structure Structure
ECL1 220 F - Structure Structure
ECL1 221 I - Structure Structure
ECL1 222 S - Structure Structure
TM3 223 T 3.26x26 Structure Structure
TM3 224 V 3.27x27 Structure Structure
TM3 225 E 3.28x28 Structure Structure
TM3 226 C 3.29x29 Structure Structure
TM3 227 K 3.30x30 Structure Structure
TM3 228 A 3.31x31 Structure Structure
TM3 229 V 3.32x32 Structure Structure
TM3 230 M 3.33x33 Structure Structure
TM3 231 V 3.34x34 Structure Structure
TM3 232 F 3.35x35 Structure Structure
TM3 233 F 3.36x36 Structure Structure
TM3 234 H 3.37x37 Structure Structure
TM3 235 Y 3.38x38 Structure Structure
TM3 236 C 3.39x39 Structure Structure
TM3 237 V 3.40x40 Structure Structure
TM3 238 V 3.41x41 Structure Structure
TM3 239 S 3.42x42 Structure Structure
TM3 240 N 3.43x43 Structure Structure
TM3 241 Y 3.44x44 Structure Structure
TM3 242 F 3.45x45 Structure Structure
TM3 243 W 3.46x46 Structure Structure
TM3 244 L 3.47x47 Structure Structure
TM3 245 F 3.48x48 Structure Structure
TM3 246 I 3.49x49 Structure Structure
TM3 247 E 3.50x50 Structure Structure
TM3 248 G 3.51x51 Structure Structure
TM3 249 L 3.52x52 Structure Structure
TM3 250 Y 3.53x53 Structure Structure
TM3 251 L 3.54x54 Structure Structure
TM3 252 F 3.55x55 Structure Structure
TM3 253 T 3.56x56 Structure Structure
TM3 254 L 3.57x57 Structure Structure
TM3 255 L 3.58x58 Structure Structure
TM3 256 V 3.59x59 Structure Structure
TM3 257 E 3.60x60 Structure Structure
ICL2 258 T - Structure Structure
ICL2 259 F - Structure Structure
ICL2 260 F - Structure Structure
ICL2 261 P - Structure Structure
ICL2 262 E - Structure Structure
ICL2 263 R - Structure Structure
TM4 264 R 4.40x41 Structure Structure
TM4 265 Y 4.41x42 Structure Structure
TM4 266 F 4.42x43 Structure Structure
TM4 267 Y 4.43x44 Structure Structure
TM4 268 W 4.44x45 Structure Structure
TM4 269 Y 4.45x46 Structure Structure
TM4 270 T 4.46x47 Structure Structure
TM4 271 I 4.47x48 Structure Structure
TM4 272 I 4.48x49 Structure Structure
TM4 273 G 4.49x491 Structure Structure
TM4 274 W 4.50x50 Structure Structure
TM4 275 G 4.51x51 Structure Structure
TM4 276 T 4.52x52 Structure Structure
TM4 277 P 4.53x53 Structure Structure
TM4 278 T 4.54x54 Structure Structure
TM4 279 V 4.55x55 Structure Structure
TM4 280 C 4.56x56 Structure Structure
TM4 281 V 4.57x57 Structure Structure
TM4 282 T 4.58x58 Structure Structure
TM4 283 V 4.59x59 Structure Structure
TM4 284 W 4.60x60 Structure Structure
TM4 285 A 4.61x61 Structure Structure
TM4 286 T 4.62x62 Structure Structure
TM4 287 L 4.63x63 Structure Structure
TM4 288 R 4.64x64 Structure Structure
TM4 289 L 4.65x65 Structure Structure
TM4 290 Y 4.66x66 Structure Structure
TM4 291 F 4.67x67 Structure Structure
TM4 292 D 4.68x68 Structure Structure
ECL2 293 D - Structure Structure
ECL2 294 T - Structure Structure
ECL2 295 G - Structure Structure
ECL2 296 C 45.50x50 Structure Structure
ECL2 297 W 45.51x51 Structure Structure
ECL2 298 D 45.52x52 Structure Structure
ECL2 299 M - Structure Structure
ECL2 300 N - Structure Structure
ECL2 301 D - Structure Structure
TM5 302 S 5.32x33 Structure Structure
TM5 303 T 5.33x34 Structure Structure
TM5 304 A 5.34x35 Structure Structure
TM5 305 L 5.35x36 Structure Structure
TM5 306 W 5.36x37 Structure Structure
TM5 307 W 5.37x38 Structure Structure
TM5 308 V 5.38x381 Structure Structure
TM5 309 I 5.39x39 Structure Structure
TM5 310 K 5.40x40 Structure Structure
TM5 311 G 5.41x41 Structure Structure
TM5 312 P 5.42x42 Structure Structure
TM5 313 V 5.43x43 Structure Structure
TM5 314 V 5.44x44 Structure Structure
TM5 315 G 5.45x45 Structure Structure
TM5 316 S 5.46x46 Structure Structure
TM5 317 I 5.47x47 Structure Structure
TM5 318 M 5.48x48 Structure Structure
TM5 319 V 5.49x49 Structure Structure
TM5 320 N 5.50x50 Structure Structure
TM5 321 F 5.51x51 Structure Structure
TM5 322 V 5.52x52 Structure Structure
TM5 323 L 5.53x53 Structure Structure
TM5 324 F 5.54x54 Structure Structure
TM5 325 I 5.55x55 Structure Structure
TM5 326 G 5.56x56 Structure Structure
TM5 327 I 5.57x57 Structure Structure
TM5 328 I 5.58x58 Structure Structure
TM5 329 V 5.59x59 Structure Structure
TM5 330 I 5.60x60 Structure Structure
TM5 331 L 5.61x61 Structure Structure
TM5 332 V 5.62x62 Structure Structure
TM5 333 Q 5.63x63 Structure Structure
TM5 334 K 5.64x64 Structure Structure
TM5 335 L 5.65x65 Structure Structure
ICL3 336 Q - Structure Structure
ICL3 337 S - Structure Structure
ICL3 338 P - Structure Structure
ICL3 339 D - Structure Structure
ICL3 340 M - Structure Structure
ICL3 341 G - Structure Structure
ICL3 342 G - Structure Structure
TM6 343 N 6.30x30 Structure Structure
TM6 344 E 6.31x31 Structure Structure
TM6 345 S 6.32x32 Structure Structure
TM6 346 S 6.33x33 Structure Structure
TM6 347 I 6.34x34 Structure Structure
TM6 348 Y 6.35x35 Structure Structure
TM6 349 L 6.36x36 Structure Structure
TM6 350 R 6.37x37 Structure Structure
TM6 351 L 6.38x38 Structure Structure
TM6 352 A 6.39x39 Structure Structure
TM6 353 R 6.40x40 Structure Structure
TM6 354 S 6.41x41 Structure Structure
TM6 355 T 6.42x42 Structure Structure
TM6 356 L 6.43x43 Structure Structure
TM6 357 L 6.44x44 Structure Structure
TM6 358 L 6.45x45 Structure Structure
TM6 359 I 6.46x46 Structure Structure
TM6 360 P 6.47x47 Structure Structure
TM6 361 L 6.48x48 Structure Structure
TM6 362 F 6.49x49 Structure Structure
TM6 363 G 6.50x50 Structure Structure
TM6 364 I 6.51x51 Structure Structure
TM6 365 H 6.52x52 Structure Structure
TM6 366 Y 6.53x53 Structure Structure
TM6 367 T 6.54x54 Structure Structure
TM6 368 V 6.55x55 Structure Structure
TM6 369 F 6.56x56 Structure Structure
TM6 370 A 6.57x57 Structure Structure
TM6 371 F 6.58x58 Structure Structure
TM6 372 S 6.59x59 Structure Structure
ECL3 373 P - Structure Structure
ECL3 374 E - Structure Structure
ECL3 375 N - Structure Structure
ECL3 376 V - Structure Structure
ECL3 377 S - Structure Structure
TM7 378 K 7.35x34 Structure Structure
TM7 379 R 7.36x35 Structure Structure
TM7 380 E 7.37x36 Structure Structure
TM7 381 R 7.38x37 Structure Structure
TM7 382 L 7.39x38 Structure Structure
TM7 383 V 7.40x39 Structure Structure
TM7 384 F 7.41x40 Structure Structure
TM7 385 E 7.42x41 Structure Structure
TM7 386 L 7.43x42 Structure Structure
TM7 387 G 7.44x43 Structure Structure
TM7 388 L 7.45x44 Structure Structure
TM7 389 G 7.46x45 Structure Structure
TM7 390 S 7.47x46 Structure Structure
TM7 391 F 7.48x47 Structure Structure
TM7 392 Q 7.49x49 Structure Structure
TM7 393 G 7.50x50 Structure Structure
TM7 394 F 7.51x51 Structure Structure
TM7 395 V 7.52x52 Structure Structure
TM7 396 V 7.53x53 Structure Structure
TM7 397 A 7.54x54 Structure Structure
TM7 398 V 7.55x55 Structure Structure
TM7 399 L 7.56x56 Structure Structure
TM7 400 Y 7.57x57 Structure Structure
TM7 401 C 7.58x58 Structure Structure
TM7 402 F 7.59x59 Structure Structure
TM7 403 L 7.60x60 Structure Structure
H8 404 N 8.47x47 Structure Structure
H8 405 G 8.48x48 Structure Structure
H8 406 E 8.49x49 Structure Structure
H8 407 V 8.50x50 Structure Structure
H8 408 Q 8.51x51 Structure Structure
H8 409 A 8.52x52 Structure Structure
H8 410 E 8.53x53 Structure Structure
H8 411 I 8.54x54 Structure Structure
H8 412 K 8.55x55 Structure Structure
H8 413 R 8.56x56 Structure Structure
H8 414 K 8.57x57 Structure Structure
H8 415 W 8.58x58 Structure Structure
H8 416 R 8.59x59 Structure Structure
H8 417 S 8.60x60 Structure Structure
H8 418 W 8.61x61 Structure Structure
H8 419 K 8.62x62 AF2 AF2
H8 420 V 8.63x63 AF2 AF2
H8 421 N 8.64x64 AF2 AF2
H8 422 R 8.65x65 AF2 AF2
H8 423 Y 8.66x66 AF2 AF2
H8 424 F 8.67x67 AF2 AF2
H8 425 A 8.68x68 AF2 AF2
H8 426 V 8.69x69 AF2 AF2
H8 427 D 8.70x70 AF2 AF2
H8 428 F 8.71x71 AF2 AF2
H8 429 K 8.72x72 AF2 AF2
C-term 430 H - AF2 AF2
C-term 431 R - AF2 AF2
C-term 432 H - AF2 AF2
C-term 433 P - AF2 AF2
C-term 434 S - AF2 AF2
C-term 435 L - AF2 AF2
C-term 436 A - AF2 AF2
C-term 437 S - AF2 AF2
C-term 438 S - AF2 AF2
C-term 439 G - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 331 5x61 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 331 5x61 G.H5 L 394 G.H5.26
Polar TM5 K 334 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 334 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 334 5x64 G.H5 R 385 G.H5.17
Hydrophobic ICL2 F 259 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 259 - G.H5 I 383 G.H5.15
Hydrophobic ICL3 D 339 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 D 339 - G.H4 L 346 G.H4.16
Hydrophobic ICL2 F 259 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 259 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 F 259 - G.S3 F 219 G.S3.03
Hydrophobic TM3 L 251 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 251 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 331 5x61 G.H5 L 388 G.H5.20
Polar TM3 V 256 3x59 G.H5 R 380 G.H5.12
Hydrophobic TM6 R 350 6x37 G.H5 L 394 G.H5.26
Polar ICL2 T 258 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 T 258 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 T 258 - G.H5 Q 384 G.H5.16
Hydrophobic TM7 Y 400 7x57 G.H5 Y 391 G.H5.23
Polar TM2 R 185 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 185 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM3 L 254 3x57 G.H5 Y 391 G.H5.23
Polar ICL3 S 337 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 S 337 - G.H5 R 385 G.H5.17
Hydrophobic ICL3 M 340 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 M 340 - G.h4s6 Y 358 G.h4s6.20
Polar TM6 R 350 6x37 G.H5 E 392 G.H5.24
Hydrophobic TM6 L 358 6x45 G.H5 L 393 G.H5.25
Hydrophobic TM3 L 251 3x54 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 335 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 335 5x65 G.H5 L 394 G.H5.26
Hydrophobic ICL2 F 259 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 259 - G.H5 R 380 G.H5.12
Hydrophobic ICL3 M 340 - G.S6 Y 360 G.S6.02
Polar TM6 R 350 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 R 350 6x37 G.H5 L 393 G.H5.25
Ionic TM5 K 334 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 334 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 334 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 334 5x64 G.H5 D 381 G.H5.13
Polar H8 G 405 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 G 405 8x48 G.H5 E 392 G.H5.24
Polar TM3 L 255 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 255 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 255 3x58 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 M 340 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 M 340 - G.H5 R 385 G.H5.17
Polar ICL2 T 258 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 T 258 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 T 258 - G.H5 R 380 G.H5.12
Hydrophobic TM3 Y 250 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 250 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 331 5x61 G.H5 L 393 G.H5.25
Aromatic ICL2 F 259 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 259 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 259 - G.S1 H 41 G.S1.02
Hydrophobic TM3 L 254 3x57 G.H5 H 387 G.H5.19
Hydrophobic ICL2 T 258 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 T 258 - G.H5 I 383 G.H5.15
Aromatic ICL2 F 259 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 259 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 259 - G.H5 F 376 G.H5.08
Hydrophobic TM6 L 357 6x44 G.H5 L 393 G.H5.25
Aromatic TM2 R 185 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 185 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 185 2x46 G.H5 Y 391 G.H5.23
Hydrophobic H8 N 404 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 404 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM3 L 255 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 255 3x58 G.H5 L 388 G.H5.20
Hydrophobic TM2 H 189 2x50 G.H5 Y 391 G.H5.23
Polar TM6 S 354 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 354 6x41 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 259 - G.H5 C 379 G.H5.11
Polar TM5 K 334 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 334 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 334 5x64 G.H5 Q 384 G.H5.16
Ionic ICL3 D 339 - G.H4 R 342 G.H4.12
Hydrophobic TM5 K 334 5x64 G.H5 L 388 G.H5.20