Refined structure (8EFB) of Gi1 - μ receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 227 from structure (64.1%), 127 from model (35.9%)
Residue sidechains - 225 from structure (63.6%), 129 from model (36.4%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 Structure Structure
G.HN 3 C G.HN.09 Structure Structure
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 Structure Structure
G.s4h3 236 E G.s4h3.10 Structure Structure
G.s4h3 237 D G.s4h3.11 Structure Structure
G.s4h3 238 E G.s4h3.12 Structure Structure
G.s4h3 239 E G.s4h3.13 Structure Structure
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 284 from structure (78.0%), 80 from model (22.0%)
Residue sidechains - 283 from structure (77.7%), 81 from model (22.3%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 S - AF2 AF2
N-term 4 S - AF2 AF2
N-term 5 A - AF2 AF2
N-term 6 A - AF2 AF2
N-term 7 P - AF2 AF2
N-term 8 T - AF2 AF2
N-term 9 N - AF2 AF2
N-term 10 A - AF2 AF2
N-term 11 S - AF2 AF2
N-term 12 N - AF2 AF2
N-term 13 C - AF2 AF2
N-term 14 T - AF2 AF2
N-term 15 D - AF2 AF2
N-term 16 A - AF2 AF2
N-term 17 L - AF2 AF2
N-term 18 A - AF2 AF2
N-term 19 Y - AF2 AF2
N-term 20 S - AF2 AF2
N-term 21 S - AF2 AF2
N-term 22 C - AF2 AF2
N-term 23 S - AF2 AF2
N-term 24 P - AF2 AF2
N-term 25 A - AF2 AF2
N-term 26 P - AF2 AF2
N-term 27 S - AF2 AF2
N-term 28 P - AF2 AF2
N-term 29 G - AF2 AF2
N-term 30 S - AF2 AF2
N-term 31 W - AF2 AF2
N-term 32 V - AF2 AF2
N-term 33 N - AF2 AF2
N-term 34 L - AF2 AF2
N-term 35 S - AF2 AF2
N-term 36 H - AF2 AF2
N-term 37 L - AF2 AF2
N-term 38 D - AF2 AF2
N-term 39 G - AF2 AF2
N-term 40 N - AF2 AF2
N-term 41 L - AF2 AF2
N-term 42 S - AF2 AF2
N-term 43 D - AF2 AF2
N-term 44 P - AF2 AF2
N-term 45 C - AF2 AF2
N-term 46 G - AF2 AF2
N-term 47 P - AF2 AF2
N-term 48 N - AF2 AF2
N-term 49 R - AF2 AF2
N-term 50 T - AF2 AF2
N-term 51 D - AF2 AF2
N-term 52 L - AF2 AF2
N-term 53 G - AF2 AF2
N-term 54 G - AF2 AF2
N-term 55 R - AF2 AF2
N-term 56 D - AF2 AF2
N-term 57 S - AF2 AF2
N-term 58 L - AF2 AF2
N-term 59 C - AF2 AF2
N-term 60 P - AF2 AF2
N-term 61 P - AF2 AF2
N-term 62 T - AF2 AF2
N-term 63 G - AF2 AF2
N-term 64 S - AF2 AF2
N-term 65 P - AF2 AF2
N-term 66 S - AF2 AF2
TM1 67 M 1.29x29 AF2 AF2
TM1 68 I 1.30x30 AF2 AF2
TM1 69 T 1.31x31 Structure Structure
TM1 70 A 1.32x32 Structure Structure
TM1 71 I 1.33x33 Structure Structure
TM1 72 T 1.34x34 Structure Structure
TM1 73 I 1.35x35 Structure Structure
TM1 74 M 1.36x36 Structure Structure
TM1 75 A 1.37x37 Structure Structure
TM1 76 L 1.38x38 Structure Structure
TM1 77 Y 1.39x39 Structure Structure
TM1 78 S 1.40x40 Structure Structure
TM1 79 I 1.41x41 Structure Structure
TM1 80 V 1.42x42 Structure Structure
TM1 81 C 1.43x43 Structure Structure
TM1 82 V 1.44x44 Structure Structure
TM1 83 V 1.45x45 Structure Structure
TM1 84 G 1.46x46 Structure Structure
TM1 85 L 1.47x47 Structure Structure
TM1 86 F 1.48x48 Structure Structure
TM1 87 G 1.49x49 Structure Structure
TM1 88 N 1.50x50 Structure Structure
TM1 89 F 1.51x51 Structure Structure
TM1 90 L 1.52x52 Structure Structure
TM1 91 V 1.53x53 Structure Structure
TM1 92 M 1.54x54 Structure Structure
TM1 93 Y 1.55x55 Structure Structure
TM1 94 V 1.56x56 Structure Structure
TM1 95 I 1.57x57 Structure Structure
TM1 96 V 1.58x58 Structure Structure
TM1 97 R 1.59x59 Structure Structure
TM1 98 Y 1.60x60 Structure Structure
ICL1 99 T 12.48x48 Structure Structure
ICL1 100 K 12.49x49 Structure Structure
ICL1 101 M 12.50x50 Structure Structure
ICL1 102 K 12.51x51 Structure Structure
TM2 103 T 2.37x37 Structure Structure
TM2 104 A 2.38x38 Structure Structure
TM2 105 T 2.39x39 Structure Structure
TM2 106 N 2.40x40 Structure Structure
TM2 107 I 2.41x41 Structure Structure
TM2 108 Y 2.42x42 Structure Structure
TM2 109 I 2.43x43 Structure Structure
TM2 110 F 2.44x44 Structure Structure
TM2 111 N 2.45x45 Structure Structure
TM2 112 L 2.46x46 Structure Structure
TM2 113 A 2.47x47 Structure Structure
TM2 114 L 2.48x48 Structure Structure
TM2 115 A 2.49x49 Structure Structure
TM2 116 D 2.50x50 Structure Structure
TM2 117 A 2.51x51 Structure Structure
TM2 118 L 2.52x52 Structure Structure
TM2 119 A 2.53x53 Structure Structure
TM2 120 T 2.54x54 Structure Structure
TM2 121 S 2.55x55 Structure Structure
TM2 122 T 2.56x56 Structure Structure
TM2 123 L 2.57x57 Structure Structure
TM2 124 P 2.58x58 Structure Structure
TM2 125 F 2.59x59 Structure Structure
TM2 126 Q 2.60x60 Structure Structure
TM2 127 S 2.61x61 Structure Structure
TM2 128 V 2.62x62 Structure Structure
TM2 129 N 2.63x63 Structure Structure
TM2 130 Y 2.64x64 Structure Structure
TM2 131 L 2.65x65 Structure Structure
TM2 132 M 2.66x66 Structure Structure
TM2 133 G 2.67x67 Structure Structure
ECL1 134 T 23.49x49 Structure Structure
ECL1 135 W 23.50x50 Structure Structure
ECL1 136 P 23.51x51 Structure Structure
ECL1 137 F 23.52x52 Structure Structure
TM3 138 G 3.21x21 Structure Structure
TM3 139 T 3.22x22 Structure Structure
TM3 140 I 3.23x23 Structure Structure
TM3 141 L 3.24x24 Structure Structure
TM3 142 C 3.25x25 Structure Structure
TM3 143 K 3.26x26 Structure Structure
TM3 144 I 3.27x27 Structure Structure
TM3 145 V 3.28x28 Structure Structure
TM3 146 I 3.29x29 Structure Structure
TM3 147 S 3.30x30 Structure Structure
TM3 148 I 3.31x31 Structure Structure
TM3 149 D 3.32x32 Structure Structure
TM3 150 Y 3.33x33 Structure Structure
TM3 151 Y 3.34x34 Structure Structure
TM3 152 N 3.35x35 Structure Structure
TM3 153 M 3.36x36 Structure Structure
TM3 154 F 3.37x37 Structure Structure
TM3 155 T 3.38x38 Structure Structure
TM3 156 S 3.39x39 Structure Structure
TM3 157 I 3.40x40 Structure Structure
TM3 158 F 3.41x41 Structure AF2
TM3 159 T 3.42x42 Structure Structure
TM3 160 L 3.43x43 Structure Structure
TM3 161 C 3.44x44 Structure Structure
TM3 162 T 3.45x45 Structure Structure
TM3 163 M 3.46x46 Structure Structure
TM3 164 S 3.47x47 Structure Structure
TM3 165 V 3.48x48 Structure Structure
TM3 166 D 3.49x49 Structure Structure
TM3 167 R 3.50x50 Structure Structure
TM3 168 Y 3.51x51 Structure Structure
TM3 169 I 3.52x52 Structure Structure
TM3 170 A 3.53x53 Structure Structure
TM3 171 V 3.54x54 Structure Structure
TM3 172 C 3.55x55 Structure Structure
TM3 173 H 3.56x56 Structure Structure
ICL2 174 P 34.50x50 Structure Structure
ICL2 175 V 34.51x51 Structure Structure
ICL2 176 K 34.52x52 Structure Structure
ICL2 177 A 34.53x53 Structure Structure
ICL2 178 L 34.54x54 Structure Structure
ICL2 179 D 34.55x55 Structure Structure
ICL2 180 F 34.56x56 Structure Structure
ICL2 181 R 34.57x57 Structure Structure
TM4 182 T 4.38x38 Structure Structure
TM4 183 P 4.39x39 Structure Structure
TM4 184 R 4.40x40 Structure Structure
TM4 185 N 4.41x41 Structure Structure
TM4 186 A 4.42x42 Structure Structure
TM4 187 K 4.43x43 Structure Structure
TM4 188 I 4.44x44 Structure Structure
TM4 189 I 4.45x45 Structure Structure
TM4 190 N 4.46x46 Structure Structure
TM4 191 V 4.47x47 Structure Structure
TM4 192 C 4.48x48 Structure Structure
TM4 193 N 4.49x49 Structure Structure
TM4 194 W 4.50x50 Structure Structure
TM4 195 I 4.51x51 Structure Structure
TM4 196 L 4.52x52 Structure Structure
TM4 197 S 4.53x53 Structure Structure
TM4 198 S 4.54x54 Structure Structure
TM4 199 A 4.55x55 Structure Structure
TM4 200 I 4.56x56 Structure Structure
TM4 201 G 4.57x57 Structure Structure
TM4 202 L 4.58x58 Structure Structure
TM4 203 P 4.59x59 Structure Structure
TM4 204 V 4.60x60 Structure Structure
TM4 205 M 4.61x61 Structure Structure
TM4 206 F 4.62x62 Structure Structure
TM4 207 M 4.63x63 Structure Structure
TM4 208 A 4.64x64 Structure Structure
ECL2 209 T - Structure Structure
ECL2 210 T - Structure Structure
ECL2 211 K - Structure Structure
ECL2 212 Y - Structure Structure
ECL2 213 R - Structure Structure
ECL2 214 Q - Structure Structure
ECL2 215 G - Structure Structure
ECL2 216 S - Structure Structure
ECL2 217 I - Structure Structure
ECL2 218 D - Structure Structure
ECL2 219 C 45.50x50 Structure Structure
ECL2 220 T 45.51x51 Structure Structure
ECL2 221 L 45.52x52 Structure Structure
ECL2 222 T - Structure Structure
ECL2 223 F - Structure Structure
ECL2 224 S - Structure Structure
ECL2 225 H - Structure Structure
TM5 226 P 5.30x31 Structure Structure
TM5 227 T 5.31x32 Structure Structure
TM5 228 W 5.32x33 Structure Structure
TM5 229 Y 5.33x34 Structure Structure
TM5 230 W 5.34x35 Structure Structure
TM5 231 E 5.35x36 Structure Structure
TM5 232 N 5.36x37 Structure Structure
TM5 233 L 5.37x38 Structure Structure
TM5 234 L 5.38x39 Structure Structure
TM5 235 K 5.39x40 Structure Structure
TM5 236 I 5.40x41 Structure Structure
TM5 237 C 5.41x42 Structure Structure
TM5 238 V 5.42x43 Structure Structure
TM5 239 F 5.43x44 Structure Structure
TM5 240 I 5.44x45 Structure Structure
TM5 241 F 5.45x46 Structure Structure
TM5 242 A 5.46x461 Structure Structure
TM5 243 F 5.47x47 Structure Structure
TM5 244 I 5.48x48 Structure Structure
TM5 245 M 5.49x49 Structure Structure
TM5 246 P 5.50x50 Structure Structure
TM5 247 V 5.51x51 Structure Structure
TM5 248 L 5.52x52 Structure Structure
TM5 249 I 5.53x53 Structure Structure
TM5 250 I 5.54x54 Structure Structure
TM5 251 T 5.55x55 Structure Structure
TM5 252 V 5.56x56 Structure Structure
TM5 253 C 5.57x57 Structure Structure
TM5 254 Y 5.58x58 Structure Structure
TM5 255 G 5.59x59 Structure Structure
TM5 256 L 5.60x60 Structure Structure
TM5 257 M 5.61x61 Structure Structure
TM5 258 I 5.62x62 Structure Structure
TM5 259 L 5.63x63 Structure Structure
TM5 260 R 5.64x64 Structure Structure
TM5 261 L 5.65x65 Structure Structure
TM5 262 K 5.66x66 Structure Structure
TM5 263 S 5.67x67 Structure Structure
TM5 264 V 5.68x68 Structure Structure
ICL3 265 R - Structure Structure
ICL3 266 M - Structure Structure
ICL3 267 L - Structure Structure
ICL3 268 S - Structure Structure
ICL3 269 G - Structure Structure
TM6 270 S 6.23x23 Structure Structure
TM6 271 K 6.24x24 Structure Structure
TM6 272 E 6.25x25 Structure Structure
TM6 273 K 6.26x26 Structure Structure
TM6 274 D 6.27x27 Structure Structure
TM6 275 R 6.28x28 Structure Structure
TM6 276 N 6.29x29 Structure Structure
TM6 277 L 6.30x30 Structure Structure
TM6 278 R 6.31x31 Structure Structure
TM6 279 R 6.32x32 Structure Structure
TM6 280 I 6.33x33 Structure Structure
TM6 281 T 6.34x34 Structure Structure
TM6 282 R 6.35x35 Structure Structure
TM6 283 M 6.36x36 Structure Structure
TM6 284 V 6.37x37 Structure Structure
TM6 285 L 6.38x38 Structure Structure
TM6 286 V 6.39x39 Structure Structure
TM6 287 V 6.40x40 Structure Structure
TM6 288 V 6.41x41 Structure Structure
TM6 289 A 6.42x42 Structure Structure
TM6 290 V 6.43x43 Structure Structure
TM6 291 F 6.44x44 Structure Structure
TM6 292 I 6.45x45 Structure Structure
TM6 293 V 6.46x46 Structure Structure
TM6 294 C 6.47x47 Structure Structure
TM6 295 W 6.48x48 Structure Structure
TM6 296 T 6.49x49 Structure Structure
TM6 297 P 6.50x50 Structure Structure
TM6 298 I 6.51x51 Structure Structure
TM6 299 H 6.52x52 Structure Structure
TM6 300 I 6.53x53 Structure Structure
TM6 301 Y 6.54x54 Structure Structure
TM6 302 V 6.55x55 Structure Structure
TM6 303 I 6.56x56 Structure Structure
TM6 304 I 6.57x57 Structure Structure
TM6 305 K 6.58x58 Structure Structure
TM6 306 A 6.59x59 Structure Structure
TM6 307 L 6.60x60 Structure Structure
TM6 308 V 6.61x61 Structure Structure
ECL3 309 T - Structure Structure
ECL3 310 I - Structure Structure
ECL3 311 P - Structure Structure
ECL3 312 E - Structure Structure
TM7 313 T 7.28x27 Structure Structure
TM7 314 T 7.29x28 Structure Structure
TM7 315 F 7.30x29 Structure Structure
TM7 316 Q 7.31x30 Structure Structure
TM7 317 T 7.32x31 Structure Structure
TM7 318 V 7.33x32 Structure Structure
TM7 319 S 7.34x33 Structure Structure
TM7 320 W 7.35x34 Structure Structure
TM7 321 H 7.36x35 Structure Structure
TM7 322 F 7.37x36 Structure Structure
TM7 323 C 7.38x37 Structure Structure
TM7 324 I 7.39x38 Structure Structure
TM7 325 A 7.40x39 Structure Structure
TM7 326 L 7.41x40 Structure Structure
TM7 327 G 7.42x41 Structure Structure
TM7 328 Y 7.43x42 Structure Structure
TM7 329 T 7.44x43 Structure Structure
TM7 330 N 7.45x45 Structure Structure
TM7 331 S 7.46x46 Structure Structure
TM7 332 C 7.47x47 Structure Structure
TM7 333 L 7.48x48 Structure Structure
TM7 334 N 7.49x49 Structure Structure
TM7 335 P 7.50x50 Structure Structure
TM7 336 V 7.51x51 Structure Structure
TM7 337 L 7.52x52 Structure Structure
TM7 338 Y 7.53x53 Structure Structure
TM7 339 A 7.54x54 Structure Structure
TM7 340 F 7.55x55 Structure Structure
TM7 341 L 7.56x56 Structure Structure
H8 342 D 8.47x47 Structure Structure
H8 343 E 8.48x48 Structure Structure
H8 344 N 8.49x49 Structure Structure
H8 345 F 8.50x50 Structure Structure
H8 346 K 8.51x51 Structure Structure
H8 347 R 8.52x52 Structure Structure
H8 348 C 8.53x53 Structure Structure
H8 349 F 8.54x54 Structure Structure
H8 350 R 8.55x55 Structure Structure
H8 351 E 8.56x56 Structure Structure
H8 352 F 8.57x57 Structure Structure
H8 353 C 8.58x58 AF2 AF2
H8 354 I 8.59x59 AF2 AF2
C-term 355 P - AF2 AF2
C-term 356 T - AF2 AF2
C-term 357 S - AF2 AF2
C-term 358 S - AF2 AF2
C-term 359 N - AF2 AF2
C-term 360 I - AF2 AF2
C-term 361 E - AF2 AF2
C-term 362 Q - AF2 AF2
C-term 363 Q - AF2 AF2
C-term 364 N - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM6 K 273 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 273 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 273 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 265 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 M 266 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 M 266 - G.H5 K 345 G.H5.17
Hydrophobic TM5 R 260 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 260 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM3 A 170 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 M 257 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 175 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 P 174 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 174 34x50 G.H5 I 344 G.H5.16
Polar TM3 A 170 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 170 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 178 34x54 G.S3 L 194 G.S3.01
Hydrophobic ICL2 L 178 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM6 N 276 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 N 276 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM3 R 167 3x50 G.H5 C 351 G.H5.23
Polar H8 N 344 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 E 343 8x48 G.H5 L 353 G.H5.25
Van-der-waals H8 E 343 8x48 G.H5 L 353 G.H5.25
Hydrophobic ICL3 M 266 - G.h4s6 E 318 G.h4s6.12
Ionic ICL2 D 179 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 D 179 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 V 175 34x51 G.H5 F 336 G.H5.08
Ionic ICL2 R 181 34x57 G.H5 D 350 G.H5.22
Polar ICL2 R 181 34x57 G.H5 D 350 G.H5.22
Hydrophobic ICL2 R 181 34x57 G.H5 D 350 G.H5.22
Van-der-waals ICL2 R 181 34x57 G.H5 D 350 G.H5.22
Polar H8 N 344 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 N 344 8x49 G.H5 K 349 G.H5.21
Hydrophobic TM2 T 103 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 103 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL3 L 267 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 L 267 - G.H5 F 354 G.H5.26
Hydrophobic TM5 L 261 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 261 5x65 G.H5 L 348 G.H5.20
Hydrophobic H8 E 343 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 E 343 8x48 G.H5 F 354 G.H5.26
Polar H8 E 343 8x48 G.H5 G 352 G.H5.24
Hydrophobic H8 E 343 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 E 343 8x48 G.H5 G 352 G.H5.24
Hydrophobic TM6 I 280 6x33 G.H5 L 353 G.H5.25
Polar TM6 S 270 6x23 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 P 174 34x50 G.H5 T 340 G.H5.12
Polar ICL2 R 181 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 181 34x57 G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 181 34x57 G.H5 C 351 G.H5.23
Hydrophobic TM5 V 264 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 171 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL3 M 266 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 M 266 - G.H5 F 354 G.H5.26
Hydrophobic TM6 E 272 6x25 G.h4s6 D 315 G.h4s6.09
Polar TM6 R 279 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 279 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 279 6x32 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 174 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 174 34x50 G.H5 I 343 G.H5.15
Polar ICL2 R 181 34x57 G.H5 N 347 G.H5.19
Van-der-waals ICL2 R 181 34x57 G.H5 N 347 G.H5.19
Hydrophobic ICL2 V 175 34x51 G.s2s3 D 193 G.s2s3.02