Refined structure (8GCP) of Gi1 - EP4 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-07-12

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 216 from structure (61.0%), 138 from model (39.0%)
Residue sidechains - 161 from structure (45.5%), 193 from model (54.5%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure AF2
G.HN 10 K G.HN.34 Structure AF2
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure AF2
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure AF2
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure AF2
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure AF2
G.S1 36 L G.S1.04 Structure AF2
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 AF2 AF2
G.s1h1 43 E G.s1h1.04 AF2 AF2
G.s1h1 44 S G.s1h1.05 AF2 AF2
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure AF2
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure AF2
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure AF2
G.s2s3 193 D G.s2s3.02 Structure AF2
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure AF2
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure AF2
G.H2 205 R G.H2.01 Structure AF2
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure AF2
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure AF2
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure AF2
G.s4h3 234 L G.s4h3.08 Structure AF2
G.s4h3 235 A G.s4h3.09 Structure Structure
G.s4h3 236 E G.s4h3.10 Structure Structure
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 AF2 AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure AF2
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure AF2
G.H3 248 K G.H3.07 Structure AF2
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure AF2
G.HG 273 L G.HG.03 Structure AF2
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure AF2
G.HG 277 K G.HG.07 Structure AF2
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure AF2
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure AF2
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure AF2
G.HG 284 T G.HG.16 Structure AF2
G.HG 285 I G.HG.17 Structure AF2
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure AF2
G.hgh4 288 P G.hgh4.03 Structure AF2
G.hgh4 289 E G.hgh4.04 Structure AF2
G.hgh4 290 Y G.hgh4.05 Structure AF2
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure AF2
G.H4 294 N G.H4.01 Structure AF2
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure AF2
G.H4 298 E G.H4.05 Structure AF2
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure AF2
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure AF2
G.h4s6 313 R G.h4s6.04 Structure AF2
G.h4s6 314 K G.h4s6.08 Structure AF2
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure AF2
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure AF2
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure AF2
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure AF2
G.H5 329 T G.H5.01 Structure AF2
G.H5 330 K G.H5.02 Structure AF2
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure AF2
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure AF2

REFINED GPCR RESIDUES

Residue backbones - 269 from structure (81.3%), 62 from model (18.7%)
Residue sidechains - 217 from structure (65.6%), 114 from model (34.4%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 S - AF2 AF2
N-term 3 T - AF2 AF2
N-term 4 P - AF2 AF2
N-term 5 G - AF2 AF2
N-term 6 V - AF2 AF2
N-term 7 N - AF2 AF2
N-term 8 S - AF2 AF2
N-term 9 S - AF2 AF2
N-term 10 A - AF2 AF2
N-term 11 S - AF2 AF2
N-term 12 L - AF2 AF2
N-term 13 S - AF2 AF2
N-term 14 P - AF2 AF2
N-term 15 D - AF2 AF2
N-term 16 R - AF2 AF2
N-term 17 L - AF2 AF2
TM1 18 N 1.33x33 AF2 AF2
TM1 19 S 1.34x34 AF2 AF2
TM1 20 P 1.35x35 AF2 AF2
TM1 21 V 1.36x36 AF2 AF2
TM1 22 T 1.37x37 Structure AF2
TM1 23 I 1.38x38 Structure Structure
TM1 24 P 1.39x39 Structure Structure
TM1 25 A 1.40x40 Structure Structure
TM1 26 V 1.41x41 Structure Structure
TM1 27 M 1.42x42 Structure Structure
TM1 28 F 1.43x43 Structure AF2
TM1 29 I 1.44x44 Structure Structure
TM1 30 F 1.45x45 Structure AF2
TM1 31 G 1.46x46 Structure Structure
TM1 32 V 1.47x47 Structure AF2
TM1 33 V 1.48x48 Structure Structure
TM1 34 G 1.49x49 Structure Structure
TM1 35 N 1.50x50 Structure Structure
TM1 36 L 1.51x51 Structure Structure
TM1 37 V 1.52x52 Structure Structure
TM1 38 A 1.53x53 Structure Structure
TM1 39 I 1.54x54 Structure Structure
TM1 40 V 1.55x55 Structure Structure
TM1 41 V 1.56x56 Structure Structure
TM1 42 L 1.57x57 Structure Structure
TM1 43 C 1.58x58 Structure Structure
TM1 44 K 1.59x59 Structure Structure
TM1 45 S 1.60x60 Structure Structure
ICL1 46 R - AF2 AF2
ICL1 47 K - AF2 AF2
ICL1 48 E - AF2 AF2
ICL1 49 Q - Structure Structure
ICL1 50 K - Structure Structure
ICL1 51 E - Structure Structure
TM2 52 T 2.37x37 Structure Structure
TM2 53 T 2.38x38 Structure Structure
TM2 54 F 2.39x39 Structure Structure
TM2 55 Y 2.40x40 Structure Structure
TM2 56 T 2.41x41 Structure Structure
TM2 57 L 2.42x42 Structure Structure
TM2 58 V 2.43x43 Structure Structure
TM2 59 C 2.44x44 Structure Structure
TM2 60 G 2.45x45 Structure Structure
TM2 61 L 2.46x46 Structure Structure
TM2 62 A 2.47x47 Structure Structure
TM2 63 V 2.48x48 Structure Structure
TM2 64 T 2.49x49 Structure Structure
TM2 65 D 2.50x50 Structure AF2
TM2 66 L 2.51x51 Structure Structure
TM2 67 L 2.52x52 Structure Structure
TM2 68 G 2.53x53 Structure Structure
TM2 69 T 2.54x54 Structure Structure
TM2 70 L 2.55x55 Structure Structure
TM2 71 L 2.56x56 Structure Structure
TM2 72 V 2.57x57 Structure Structure
TM2 73 S 2.58x58 Structure Structure
TM2 74 P 2.59x59 Structure Structure
TM2 75 V 2.60x60 Structure Structure
TM2 76 T 2.61x61 Structure Structure
TM2 77 I 2.62x62 Structure Structure
TM2 78 A 2.63x63 Structure Structure
TM2 79 T 2.64x64 Structure AF2
TM2 80 Y 2.65x65 Structure Structure
TM2 81 M 2.66x66 Structure AF2
TM2 82 K 2.67x67 Structure AF2
ECL1 83 G - Structure Structure
ECL1 84 Q 23.49x49 Structure AF2
ECL1 85 W 23.50x50 Structure Structure
ECL1 86 P 23.51x51 Structure AF2
ECL1 87 G 23.52x52 Structure Structure
TM3 88 G 3.21x21 Structure Structure
TM3 89 Q 3.22x22 Structure AF2
TM3 90 P 3.23x23 Structure AF2
TM3 91 L 3.24x24 Structure Structure
TM3 92 C 3.25x25 Structure Structure
TM3 93 E 3.26x26 Structure AF2
TM3 94 Y 3.27x27 Structure Structure
TM3 95 S 3.28x28 Structure Structure
TM3 96 T 3.29x29 Structure Structure
TM3 97 F 3.30x30 Structure Structure
TM3 98 I 3.31x31 Structure AF2
TM3 99 L 3.32x32 Structure Structure
TM3 100 L 3.33x33 Structure Structure
TM3 101 F 3.34x34 Structure Structure
TM3 102 F 3.35x35 Structure Structure
TM3 103 S 3.36x36 Structure Structure
TM3 104 L 3.37x37 Structure Structure
TM3 105 S 3.38x38 Structure Structure
TM3 106 G 3.39x39 Structure Structure
TM3 107 L 3.40x40 Structure Structure
TM3 108 S 3.41x41 Structure Structure
TM3 109 I 3.42x42 Structure Structure
TM3 110 I 3.43x43 Structure Structure
TM3 111 C 3.44x44 Structure Structure
TM3 112 A 3.45x45 Structure Structure
TM3 113 M 3.46x46 Structure Structure
TM3 114 S 3.47x47 Structure Structure
TM3 115 V 3.48x48 Structure Structure
TM3 116 E 3.49x49 Structure Structure
TM3 117 R 3.50x50 Structure Structure
TM3 118 Y 3.51x51 Structure Structure
TM3 119 L 3.52x52 Structure Structure
TM3 120 A 3.53x53 Structure Structure
TM3 121 I 3.54x54 Structure Structure
TM3 122 N 3.55x55 Structure Structure
TM3 123 H 3.56x56 Structure Structure
ICL2 124 A 34.50x50 Structure Structure
ICL2 125 Y 34.51x51 Structure Structure
ICL2 126 F 34.52x52 Structure Structure
ICL2 127 Y 34.53x53 Structure Structure
ICL2 128 S 34.54x54 Structure Structure
ICL2 129 H 34.55x55 Structure Structure
ICL2 130 Y 34.56x56 Structure Structure
ICL2 131 V 34.57x57 Structure Structure
TM4 132 D 4.38x38 Structure AF2
TM4 133 K 4.39x39 Structure AF2
TM4 134 R 4.40x40 Structure AF2
TM4 135 L 4.41x41 Structure Structure
TM4 136 A 4.42x42 Structure Structure
TM4 137 G 4.43x43 Structure Structure
TM4 138 L 4.44x44 Structure Structure
TM4 139 T 4.45x45 Structure Structure
TM4 140 L 4.46x46 Structure Structure
TM4 141 F 4.47x47 Structure Structure
TM4 142 A 4.48x48 Structure Structure
TM4 143 V 4.49x49 Structure Structure
TM4 144 Y 4.50x50 Structure Structure
TM4 145 A 4.51x51 Structure Structure
TM4 146 S 4.52x52 Structure Structure
TM4 147 N 4.53x53 Structure Structure
TM4 148 V 4.54x54 Structure Structure
TM4 149 L 4.55x55 Structure AF2
TM4 150 F 4.56x56 Structure Structure
TM4 151 C 4.57x57 Structure Structure
TM4 152 A 4.58x58 Structure Structure
TM4 153 L 4.59x59 Structure Structure
TM4 154 P 4.60x60 Structure Structure
TM4 155 N 4.61x61 Structure AF2
TM4 156 M 4.62x62 Structure AF2
TM4 157 G 4.63x63 Structure Structure
ECL2 158 L - Structure AF2
ECL2 159 G - Structure Structure
ECL2 160 S - Structure Structure
ECL2 161 S - Structure Structure
ECL2 162 R - Structure AF2
ECL2 163 L - Structure Structure
ECL2 164 Q - Structure Structure
ECL2 165 Y - Structure AF2
ECL2 166 P - Structure Structure
ECL2 167 D - Structure AF2
ECL2 168 T - Structure Structure
ECL2 169 W - Structure Structure
ECL2 170 C 45.50x50 Structure Structure
ECL2 171 F 45.51x51 Structure Structure
ECL2 172 I 45.52x52 Structure Structure
ECL2 173 D - Structure Structure
ECL2 174 W - Structure Structure
ECL2 175 T - Structure Structure
ECL2 176 T - Structure Structure
ECL2 177 N - Structure Structure
TM5 178 V 5.33x33 Structure AF2
TM5 179 T 5.34x34 Structure AF2
TM5 180 A 5.35x35 Structure Structure
TM5 181 H 5.36x36 Structure AF2
TM5 182 A 5.37x37 Structure Structure
TM5 183 A 5.38x38 Structure Structure
TM5 184 Y 5.39x39 Structure Structure
TM5 185 S 5.40x40 Structure Structure
TM5 186 Y 5.41x41 Structure Structure
TM5 187 M 5.42x42 Structure AF2
TM5 188 Y 5.43x43 Structure Structure
TM5 189 A 5.44x44 Structure Structure
TM5 190 G 5.45x45 Structure Structure
TM5 191 F 5.46x46 Structure Structure
TM5 192 S 5.47x47 Structure Structure
TM5 193 S 5.48x48 Structure Structure
TM5 194 F 5.49x49 Structure Structure
TM5 195 L 5.50x50 Structure AF2
TM5 196 I 5.51x51 Structure Structure
TM5 197 L 5.52x52 Structure Structure
TM5 198 A 5.53x53 Structure Structure
TM5 199 T 5.54x54 Structure AF2
TM5 200 V 5.55x55 Structure Structure
TM5 201 L 5.56x56 Structure Structure
TM5 202 C 5.57x57 Structure Structure
TM5 203 N 5.58x58 Structure Structure
TM5 204 V 5.59x59 Structure Structure
TM5 205 L 5.60x60 Structure Structure
TM5 206 V 5.61x61 Structure Structure
TM5 207 C 5.62x62 Structure Structure
TM5 208 G 5.63x63 Structure Structure
TM5 209 A 5.64x64 Structure Structure
TM5 210 L 5.65x65 Structure Structure
TM5 211 L 5.66x66 Structure AF2
TM5 212 R 5.67x67 Structure Structure
TM5 213 M 5.68x68 Structure Structure
TM5 214 H 5.69x69 Structure Structure
TM5 215 R 5.70x70 Structure AF2
TM5 216 Q 5.71x71 Structure AF2
TM5 217 F 5.72x72 Structure AF2
TM5 218 M 5.73x73 Structure Structure
TM5 219 R 5.74x74 Structure Structure
TM5 220 R 5.75x75 Structure Structure
TM5 221 T 5.76x76 AF2 AF2
ICL3 222 S - AF2 AF2
ICL3 223 L - AF2 AF2
ICL3 224 G - AF2 AF2
ICL3 225 T - AF2 AF2
ICL3 226 E - AF2 AF2
ICL3 227 Q - AF2 AF2
ICL3 228 H - AF2 AF2
ICL3 254 F - AF2 AF2
ICL3 255 R - AF2 AF2
ICL3 256 R - AF2 AF2
ICL3 257 R - AF2 AF2
ICL3 258 R - AF2 AF2
ICL3 259 S - AF2 AF2
ICL3 260 F - AF2 AF2
TM6 261 R 6.24x24 AF2 AF2
TM6 262 R 6.25x25 AF2 AF2
TM6 263 I 6.26x26 AF2 AF2
TM6 264 A 6.27x27 AF2 AF2
TM6 265 G 6.28x28 AF2 AF2
TM6 266 A 6.29x29 Structure Structure
TM6 267 E 6.30x30 Structure AF2
TM6 268 I 6.31x31 Structure AF2
TM6 269 Q 6.32x32 Structure AF2
TM6 270 M 6.33x33 Structure Structure
TM6 271 V 6.34x34 Structure Structure
TM6 272 I 6.35x35 Structure Structure
TM6 273 L 6.36x36 Structure Structure
TM6 274 L 6.37x37 Structure AF2
TM6 275 I 6.38x38 Structure AF2
TM6 276 A 6.39x39 Structure Structure
TM6 277 T 6.40x40 Structure Structure
TM6 278 S 6.41x41 Structure Structure
TM6 279 L 6.42x42 Structure Structure
TM6 280 V 6.43x43 Structure Structure
TM6 281 V 6.44x44 Structure Structure
TM6 282 L 6.45x45 Structure Structure
TM6 283 I 6.46x46 Structure AF2
TM6 284 C 6.47x47 Structure Structure
TM6 285 S 6.48x48 Structure Structure
TM6 286 I 6.49x49 Structure Structure
TM6 287 P 6.50x50 Structure Structure
TM6 288 L 6.51x51 Structure Structure
TM6 289 V 6.52x52 Structure Structure
TM6 290 V 6.53x53 Structure Structure
TM6 291 R 6.54x54 Structure Structure
TM6 292 V 6.55x55 Structure Structure
TM6 293 F 6.56x56 Structure Structure
TM6 294 V 6.57x57 Structure AF2
TM6 295 N 6.58x58 Structure Structure
TM6 296 Q 6.59x59 Structure Structure
TM6 297 L 6.60x60 Structure Structure
TM6 298 Y 6.61x61 Structure AF2
ECL3 299 Q - Structure AF2
ECL3 300 P - Structure Structure
ECL3 301 S - Structure Structure
ECL3 302 L - Structure AF2
ECL3 303 E - Structure AF2
ECL3 304 R - Structure AF2
ECL3 305 E - Structure AF2
ECL3 306 V - Structure AF2
ECL3 307 S - Structure Structure
ECL3 308 K - Structure AF2
TM7 309 N 7.33x32 Structure Structure
TM7 310 P 7.34x33 Structure Structure
TM7 311 D 7.35x34 Structure AF2
TM7 312 L 7.36x35 Structure Structure
TM7 313 Q 7.37x36 Structure Structure
TM7 314 A 7.38x37 Structure Structure
TM7 315 I 7.39x38 Structure Structure
TM7 316 R 7.40x39 Structure Structure
TM7 317 I 7.41x40 Structure AF2
TM7 318 A 7.42x41 Structure Structure
TM7 319 S 7.43x42 Structure Structure
TM7 320 V 7.44x43 Structure Structure
TM7 321 N 7.45x45 Structure Structure
TM7 322 P 7.46x46 Structure Structure
TM7 323 I 7.47x47 Structure AF2
TM7 324 L 7.48x48 Structure Structure
TM7 325 D 7.49x49 Structure Structure
TM7 326 P 7.50x50 Structure Structure
TM7 327 W 7.51x51 Structure Structure
TM7 328 I 7.52x52 Structure Structure
TM7 329 Y 7.53x53 Structure Structure
TM7 330 I 7.54x54 Structure Structure
TM7 331 L 7.55x55 Structure Structure
TM7 332 L 7.56x56 Structure Structure
H8 333 R 8.47x47 Structure Structure
H8 334 K 8.48x48 Structure Structure
H8 335 T 8.49x49 Structure Structure
H8 336 V 8.50x50 Structure Structure
H8 337 L 8.51x51 Structure Structure
H8 338 S 8.52x52 Structure Structure
H8 339 K 8.53x53 AF2 AF2
H8 340 A 8.54x54 AF2 AF2
H8 341 I 8.55x55 AF2 AF2
H8 342 E 8.56x56 AF2 AF2
H8 343 K 8.57x57 AF2 AF2
H8 344 I 8.58x58 AF2 AF2
H8 345 K 8.59x59 AF2 AF2
H8 346 C 8.60x60 AF2 AF2
C-term 347 L - AF2 AF2
C-term 348 F - AF2 AF2
C-term 349 C - AF2 AF2
C-term 350 R - AF2 AF2
C-term 351 I - AF2 AF2
C-term 352 G - AF2 AF2
C-term 353 G - AF2 AF2
C-term 354 S - AF2 AF2
C-term 355 R - AF2 AF2
C-term 356 R - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 F 260 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 F 260 - G.H5 L 348 G.H5.20
Hydrophobic ICL2 H 129 34x55 G.h2s4 G 217 G.h2s4.03
Hydrophobic ICL3 L 223 - G.H5 N 346 G.H5.18
Van-der-waals ICL3 L 223 - G.H5 N 347 G.H5.19
Ionic ICL3 R 256 - G.H5 I 343 G.H5.15
Polar ICL3 R 256 - G.H5 I 343 G.H5.15
Hydrophobic ICL3 R 256 - G.H5 I 343 G.H5.15
Van-der-waals ICL3 R 256 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 Y 125 34x51 G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL3 L 223 - G.S6 T 321 G.S6.03
Hydrophobic ICL3 F 260 - G.H5 D 350 G.H5.22
Van-der-waals ICL3 F 260 - G.H5 D 350 G.H5.22
Hydrophobic ICL3 R 256 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 256 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 I 263 6x26 G.H5 K 349 G.H5.21
Van-der-waals TM6 I 263 6x26 G.H5 K 349 G.H5.21
Van-der-waals ICL3 T 225 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 256 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 R 256 - G.H5 L 348 G.H5.20
Hydrophobic ICL3 G 224 - G.S6 T 321 G.S6.03
Van-der-waals ICL3 G 224 - G.S6 T 321 G.S6.03
Hydrophobic TM6 I 263 6x26 G.H5 F 354 G.H5.26
Hydrophobic ICL2 Y 125 34x51 G.h2s4 G 217 G.h2s4.03
Polar ICL3 R 256 - G.H5 N 347 G.H5.19
Van-der-waals ICL3 R 256 - G.H5 N 347 G.H5.19
Polar ICL3 S 222 - G.S6 F 323 G.S6.05
Hydrophobic ICL3 S 222 - G.S6 F 323 G.S6.05
Van-der-waals ICL3 S 222 - G.S6 F 323 G.S6.05
Hydrophobic ICL3 L 223 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 L 223 - G.H5 L 348 G.H5.20
Hydrophobic TM4 D 132 4x38 G.S1 L 38 G.S1.06
Hydrophobic ICL3 L 223 - G.H5 I 343 G.H5.15
Polar ICL2 H 129 34x55 G.S1 L 39 G.S1.07
Hydrophobic ICL2 H 129 34x55 G.S1 L 39 G.S1.07
Hydrophobic ICL3 F 260 - G.H5 K 349 G.H5.21
Van-der-waals ICL3 F 260 - G.H5 K 349 G.H5.21
Polar ICL2 H 129 34x55 G.S1 L 38 G.S1.06
Polar TM5 R 219 5x74 G.s6h5 C 325 G.s6h5.02
Polar ICL3 G 224 - G.H5 I 343 G.H5.15
Polar ICL3 S 259 - G.H5 L 348 G.H5.20
Hydrophobic ICL3 S 259 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 S 259 - G.H5 L 348 G.H5.20
Hydrophobic ICL3 S 259 - G.H5 K 349 G.H5.21
Van-der-waals ICL3 S 259 - G.H5 K 349 G.H5.21
Polar ICL2 V 131 34x57 G.S1 L 38 G.S1.06
Van-der-waals ICL2 V 131 34x57 G.S1 L 38 G.S1.06
Polar ICL3 S 222 - G.H5 V 342 G.H5.14
Van-der-waals ICL3 S 222 - G.H5 V 342 G.H5.14
Hydrophobic TM5 T 221 5x76 G.H5 D 350 G.H5.22