GproteinDb

Refined structure (8GCP) of G_i1 - EP₄ receptor

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G_i/o

DATE

2024-07-12

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Structure

GPCR

Gα

Gβ

Gγ
Model

AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 216 from structure (61.0%), 138 from model (39.0%)
Residue sidechains - 161 from structure (45.5%), 193 from model (54.5%)

Showing 1 to 354 of 354 entries

Search:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from
	:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from

G.HN	1	M	G.HN.01	AF2	AF2
G.HN	2	G	G.HN.02	AF2	AF2
G.HN	3	C	G.HN.09	AF2	AF2
G.HN	4	T	G.HN.10	AF2	AF2
G.HN	5	L	G.HN.11	Structure	Structure
G.HN	6	S	G.HN.30	Structure	Structure
G.HN	7	A	G.HN.31	Structure	Structure
G.HN	8	E	G.HN.32	Structure	Structure
G.HN	9	D	G.HN.33	Structure	AF2
G.HN	10	K	G.HN.34	Structure	AF2
G.HN	11	A	G.HN.35	Structure	Structure
G.HN	12	A	G.HN.36	Structure	Structure
G.HN	13	V	G.HN.37	Structure	Structure
G.HN	14	E	G.HN.38	Structure	Structure
G.HN	15	R	G.HN.39	Structure	Structure
G.HN	16	S	G.HN.40	Structure	Structure
G.HN	17	K	G.HN.41	Structure	Structure
G.HN	18	M	G.HN.42	Structure	Structure
G.HN	19	I	G.HN.43	Structure	Structure
G.HN	20	D	G.HN.44	Structure	Structure
G.HN	21	R	G.HN.45	Structure	AF2
G.HN	22	N	G.HN.46	Structure	Structure
G.HN	23	L	G.HN.47	Structure	Structure
G.HN	24	R	G.HN.48	Structure	Structure
G.HN	25	E	G.HN.49	Structure	AF2
G.HN	26	D	G.HN.50	Structure	Structure
G.HN	27	G	G.HN.51	Structure	Structure
G.HN	28	E	G.HN.52	Structure	Structure
G.HN	29	K	G.HN.53	Structure	AF2
G.hns1	30	A	G.hns1.01	Structure	Structure
G.hns1	31	A	G.hns1.02	Structure	Structure
G.hns1	32	R	G.hns1.03	Structure	Structure
G.S1	33	E	G.S1.01	Structure	Structure
G.S1	34	V	G.S1.02	Structure	Structure
G.S1	35	K	G.S1.03	Structure	AF2
G.S1	36	L	G.S1.04	Structure	AF2
G.S1	37	L	G.S1.05	Structure	Structure
G.S1	38	L	G.S1.06	Structure	Structure
G.S1	39	L	G.S1.07	Structure	Structure
G.s1h1	40	G	G.s1h1.01	Structure	Structure
G.s1h1	41	A	G.s1h1.02	Structure	Structure
G.s1h1	42	G	G.s1h1.03	AF2	AF2
G.s1h1	43	E	G.s1h1.04	AF2	AF2
G.s1h1	44	S	G.s1h1.05	AF2	AF2
G.s1h1	45	G	G.s1h1.06	Structure	Structure
G.H1	46	K	G.H1.01	Structure	Structure
G.H1	47	S	G.H1.02	Structure	Structure
G.H1	48	T	G.H1.03	Structure	Structure
G.H1	49	I	G.H1.04	Structure	Structure
G.H1	50	V	G.H1.05	Structure	Structure
G.H1	51	K	G.H1.06	Structure	AF2
G.H1	52	Q	G.H1.07	Structure	Structure
G.H1	53	M	G.H1.08	Structure	Structure
G.H1	54	K	G.H1.09	Structure	AF2
G.H1	55	I	G.H1.10	AF2	AF2
G.H1	56	I	G.H1.11	AF2	AF2
G.H1	57	H	G.H1.12	AF2	AF2
G.h1ha	58	E	G.h1ha.01	AF2	AF2
G.h1ha	59	A	G.h1ha.02	AF2	AF2
G.h1ha	60	G	G.h1ha.03	AF2	AF2
G.h1ha	61	Y	G.h1ha.04	AF2	AF2
G.h1ha	62	S	G.h1ha.05	AF2	AF2
H.HA	63	E	H.HA.01	AF2	AF2
H.HA	64	E	H.HA.02	AF2	AF2
H.HA	65	E	H.HA.03	AF2	AF2
H.HA	66	C	H.HA.04	AF2	AF2
H.HA	67	K	H.HA.05	AF2	AF2
H.HA	68	Q	H.HA.06	AF2	AF2
H.HA	69	Y	H.HA.07	AF2	AF2
H.HA	70	K	H.HA.08	AF2	AF2
H.HA	71	A	H.HA.09	AF2	AF2
H.HA	72	V	H.HA.10	AF2	AF2
H.HA	73	V	H.HA.11	AF2	AF2
H.HA	74	Y	H.HA.12	AF2	AF2
H.HA	75	S	H.HA.13	AF2	AF2
H.HA	76	N	H.HA.14	AF2	AF2
H.HA	77	T	H.HA.15	AF2	AF2
H.HA	78	I	H.HA.16	AF2	AF2
H.HA	79	Q	H.HA.17	AF2	AF2
H.HA	80	S	H.HA.18	AF2	AF2
H.HA	81	I	H.HA.19	AF2	AF2
H.HA	82	I	H.HA.20	AF2	AF2
H.HA	83	A	H.HA.21	AF2	AF2
H.HA	84	I	H.HA.22	AF2	AF2
H.HA	85	I	H.HA.23	AF2	AF2
H.HA	86	R	H.HA.24	AF2	AF2
H.HA	87	A	H.HA.25	AF2	AF2
H.HA	88	M	H.HA.26	AF2	AF2
H.HA	89	G	H.HA.27	AF2	AF2
H.HA	90	R	H.HA.28	AF2	AF2
H.HA	91	L	H.HA.29	AF2	AF2
H.hahb	92	K	H.hahb.01	AF2	AF2
H.hahb	93	I	H.hahb.04	AF2	AF2
H.hahb	94	D	H.hahb.05	AF2	AF2
H.hahb	95	F	H.hahb.06	AF2	AF2
H.hahb	96	G	H.hahb.07	AF2	AF2
H.hahb	97	D	H.hahb.08	AF2	AF2
H.hahb	98	S	H.hahb.09	AF2	AF2
H.HB	99	A	H.HB.01	AF2	AF2
H.HB	100	R	H.HB.02	AF2	AF2
H.HB	101	A	H.HB.03	AF2	AF2
H.HB	102	D	H.HB.04	AF2	AF2
H.HB	103	D	H.HB.05	AF2	AF2
H.HB	104	A	H.HB.06	AF2	AF2
H.HB	105	R	H.HB.07	AF2	AF2
H.HB	106	Q	H.HB.08	AF2	AF2
H.HB	107	L	H.HB.09	AF2	AF2
H.HB	108	F	H.HB.10	AF2	AF2
H.HB	109	V	H.HB.11	AF2	AF2
H.HB	110	L	H.HB.12	AF2	AF2
H.HB	111	A	H.HB.13	AF2	AF2
H.HB	112	G	H.HB.14	AF2	AF2
H.hbhc	113	A	H.hbhc.01	AF2	AF2
H.hbhc	114	A	H.hbhc.02	AF2	AF2
H.hbhc	115	E	H.hbhc.03	AF2	AF2
H.hbhc	116	E	H.hbhc.04	AF2	AF2
H.hbhc	117	G	H.hbhc.12	AF2	AF2
H.hbhc	118	F	H.hbhc.13	AF2	AF2
H.hbhc	119	M	H.hbhc.14	AF2	AF2
H.hbhc	120	T	H.hbhc.15	AF2	AF2
H.HC	121	A	H.HC.01	AF2	AF2
H.HC	122	E	H.HC.02	AF2	AF2
H.HC	123	L	H.HC.03	AF2	AF2
H.HC	124	A	H.HC.04	AF2	AF2
H.HC	125	G	H.HC.05	AF2	AF2
H.HC	126	V	H.HC.06	AF2	AF2
H.HC	127	I	H.HC.07	AF2	AF2
H.HC	128	K	H.HC.08	AF2	AF2
H.HC	129	R	H.HC.09	AF2	AF2
H.HC	130	L	H.HC.10	AF2	AF2
H.HC	131	W	H.HC.11	AF2	AF2
H.HC	132	K	H.HC.12	AF2	AF2
H.hchd	133	D	H.hchd.01	AF2	AF2
H.HD	134	S	H.HD.01	AF2	AF2
H.HD	135	G	H.HD.02	AF2	AF2
H.HD	136	V	H.HD.03	AF2	AF2
H.HD	137	Q	H.HD.04	AF2	AF2
H.HD	138	A	H.HD.05	AF2	AF2
H.HD	139	C	H.HD.06	AF2	AF2
H.HD	140	F	H.HD.07	AF2	AF2
H.HD	141	N	H.HD.08	AF2	AF2
H.HD	142	R	H.HD.09	AF2	AF2
H.HD	143	S	H.HD.10	AF2	AF2
H.HD	144	R	H.HD.11	AF2	AF2
H.HD	145	E	H.HD.12	AF2	AF2
H.hdhe	146	Y	H.hdhe.01	AF2	AF2
H.hdhe	147	Q	H.hdhe.02	AF2	AF2
H.hdhe	148	L	H.hdhe.03	AF2	AF2
H.hdhe	149	N	H.hdhe.04	AF2	AF2
H.hdhe	150	D	H.hdhe.05	AF2	AF2
H.HE	151	S	H.HE.01	AF2	AF2
H.HE	152	A	H.HE.02	AF2	AF2
H.HE	153	A	H.HE.03	AF2	AF2
H.HE	154	Y	H.HE.04	AF2	AF2
H.HE	155	Y	H.HE.05	AF2	AF2
H.HE	156	L	H.HE.06	AF2	AF2
H.HE	157	N	H.HE.07	AF2	AF2
H.HE	158	D	H.HE.08	AF2	AF2
H.HE	159	L	H.HE.09	AF2	AF2
H.HE	160	D	H.HE.10	AF2	AF2
H.HE	161	R	H.HE.11	AF2	AF2
H.HE	162	I	H.HE.12	AF2	AF2
H.HE	163	A	H.HE.13	AF2	AF2
H.hehf	164	Q	H.hehf.01	AF2	AF2
H.hehf	165	P	H.hehf.02	AF2	AF2
H.hehf	166	N	H.hehf.03	AF2	AF2
H.hehf	167	Y	H.hehf.04	AF2	AF2
H.hehf	168	I	H.hehf.05	AF2	AF2
H.hehf	169	P	H.hehf.06	AF2	AF2
H.hehf	170	T	H.hehf.07	AF2	AF2
H.HF	171	Q	H.HF.01	AF2	AF2
H.HF	172	Q	H.HF.02	AF2	AF2
H.HF	173	D	H.HF.03	AF2	AF2
H.HF	174	V	H.HF.04	AF2	AF2
H.HF	175	L	H.HF.05	AF2	AF2
H.HF	176	R	H.HF.06	AF2	AF2
G.hfs2	177	T	G.hfs2.01	AF2	AF2
G.hfs2	178	R	G.hfs2.02	AF2	AF2
G.hfs2	179	V	G.hfs2.03	AF2	AF2
G.hfs2	180	K	G.hfs2.04	AF2	AF2
G.hfs2	181	T	G.hfs2.05	AF2	AF2
G.hfs2	182	T	G.hfs2.06	Structure	Structure
G.hfs2	183	G	G.hfs2.07	Structure	Structure
G.S2	184	I	G.S2.01	Structure	Structure
G.S2	185	V	G.S2.02	Structure	Structure
G.S2	186	E	G.S2.03	Structure	AF2
G.S2	187	T	G.S2.04	Structure	Structure
G.S2	188	H	G.S2.05	Structure	Structure
G.S2	189	F	G.S2.06	Structure	Structure
G.S2	190	T	G.S2.07	Structure	Structure
G.S2	191	F	G.S2.08	Structure	Structure
G.s2s3	192	K	G.s2s3.01	Structure	AF2
G.s2s3	193	D	G.s2s3.02	Structure	AF2
G.S3	194	L	G.S3.01	Structure	Structure
G.S3	195	H	G.S3.02	Structure	Structure
G.S3	196	F	G.S3.03	Structure	Structure
G.S3	197	K	G.S3.04	Structure	Structure
G.S3	198	M	G.S3.05	Structure	Structure
G.S3	199	F	G.S3.06	Structure	Structure
G.S3	200	D	G.S3.07	Structure	AF2
G.S3	201	V	G.S3.08	Structure	Structure
G.s3h2	202	G	G.s3h2.01	Structure	Structure
G.s3h2	203	G	G.s3h2.02	Structure	AF2
G.s3h2	204	Q	G.s3h2.03	Structure	AF2
G.H2	205	R	G.H2.01	Structure	AF2
G.H2	206	S	G.H2.02	Structure	Structure
G.H2	207	E	G.H2.03	Structure	Structure
G.H2	208	R	G.H2.04	Structure	Structure
G.H2	209	K	G.H2.05	Structure	Structure
G.H2	210	K	G.H2.06	Structure	Structure
G.H2	211	W	G.H2.07	Structure	Structure
G.H2	212	I	G.H2.08	Structure	Structure
G.H2	213	H	G.H2.09	Structure	Structure
G.H2	214	C	G.H2.10	Structure	Structure
G.h2s4	215	F	G.h2s4.01	Structure	Structure
G.h2s4	216	E	G.h2s4.02	Structure	Structure
G.h2s4	217	G	G.h2s4.03	Structure	Structure
G.h2s4	218	V	G.h2s4.04	Structure	Structure
G.h2s4	219	T	G.h2s4.05	Structure	Structure
G.S4	220	A	G.S4.01	Structure	Structure
G.S4	221	I	G.S4.02	Structure	Structure
G.S4	222	I	G.S4.03	Structure	Structure
G.S4	223	F	G.S4.04	Structure	Structure
G.S4	224	C	G.S4.05	Structure	Structure
G.S4	225	V	G.S4.06	Structure	Structure
G.S4	226	A	G.S4.07	Structure	Structure
G.s4h3	227	L	G.s4h3.01	Structure	Structure
G.s4h3	228	S	G.s4h3.02	Structure	Structure
G.s4h3	229	D	G.s4h3.03	Structure	AF2
G.s4h3	230	Y	G.s4h3.04	Structure	Structure
G.s4h3	231	D	G.s4h3.05	Structure	AF2
G.s4h3	232	L	G.s4h3.06	Structure	Structure
G.s4h3	233	V	G.s4h3.07	Structure	AF2
G.s4h3	234	L	G.s4h3.08	Structure	AF2
G.s4h3	235	A	G.s4h3.09	Structure	Structure
G.s4h3	236	E	G.s4h3.10	Structure	Structure
G.s4h3	237	D	G.s4h3.11	AF2	AF2
G.s4h3	238	E	G.s4h3.12	AF2	AF2
G.s4h3	239	E	G.s4h3.13	AF2	AF2
G.s4h3	240	M	G.s4h3.14	AF2	AF2
G.s4h3	241	N	G.s4h3.15	Structure	Structure
G.H3	242	R	G.H3.01	Structure	AF2
G.H3	243	M	G.H3.02	Structure	Structure
G.H3	244	H	G.H3.03	Structure	Structure
G.H3	245	E	G.H3.04	Structure	AF2
G.H3	246	S	G.H3.05	Structure	Structure
G.H3	247	M	G.H3.06	Structure	AF2
G.H3	248	K	G.H3.07	Structure	AF2
G.H3	249	L	G.H3.08	Structure	Structure
G.H3	250	F	G.H3.09	Structure	Structure
G.H3	251	D	G.H3.10	Structure	Structure
G.H3	252	S	G.H3.11	Structure	Structure
G.H3	253	I	G.H3.12	Structure	Structure
G.H3	254	C	G.H3.13	Structure	Structure
G.H3	255	N	G.H3.14	Structure	Structure
G.H3	256	N	G.H3.15	Structure	Structure
G.H3	257	K	G.H3.16	Structure	Structure
G.H3	258	W	G.H3.17	Structure	Structure
G.H3	259	F	G.H3.18	Structure	Structure
G.h3s5	260	T	G.h3s5.01	Structure	Structure
G.h3s5	261	D	G.h3s5.02	Structure	Structure
G.h3s5	262	T	G.h3s5.03	Structure	Structure
G.S5	263	S	G.S5.01	Structure	Structure
G.S5	264	I	G.S5.02	Structure	Structure
G.S5	265	I	G.S5.03	Structure	Structure
G.S5	266	L	G.S5.04	Structure	Structure
G.S5	267	F	G.S5.05	Structure	Structure
G.S5	268	L	G.S5.06	Structure	Structure
G.S5	269	N	G.S5.07	Structure	Structure
G.s5hg	270	K	G.s5hg.01	Structure	Structure
G.HG	271	K	G.HG.01	Structure	Structure
G.HG	272	D	G.HG.02	Structure	AF2
G.HG	273	L	G.HG.03	Structure	AF2
G.HG	274	F	G.HG.04	Structure	Structure
G.HG	275	E	G.HG.05	Structure	Structure
G.HG	276	E	G.HG.06	Structure	AF2
G.HG	277	K	G.HG.07	Structure	AF2
G.HG	278	I	G.HG.08	Structure	Structure
G.HG	279	K	G.HG.09	Structure	AF2
G.HG	280	K	G.HG.12	Structure	AF2
G.HG	281	S	G.HG.13	Structure	AF2
G.HG	282	P	G.HG.14	Structure	Structure
G.HG	283	L	G.HG.15	Structure	AF2
G.HG	284	T	G.HG.16	Structure	AF2
G.HG	285	I	G.HG.17	Structure	AF2
G.hgh4	286	C	G.hgh4.01	Structure	Structure
G.hgh4	287	Y	G.hgh4.02	Structure	AF2
G.hgh4	288	P	G.hgh4.03	Structure	AF2
G.hgh4	289	E	G.hgh4.04	Structure	AF2
G.hgh4	290	Y	G.hgh4.05	Structure	AF2
G.hgh4	291	A	G.hgh4.06	Structure	Structure
G.hgh4	292	G	G.hgh4.07	Structure	Structure
G.hgh4	293	S	G.hgh4.08	Structure	AF2
G.H4	294	N	G.H4.01	Structure	AF2
G.H4	295	T	G.H4.02	Structure	Structure
G.H4	296	Y	G.H4.03	Structure	Structure
G.H4	297	E	G.H4.04	Structure	AF2
G.H4	298	E	G.H4.05	Structure	AF2
G.H4	299	A	G.H4.06	Structure	Structure
G.H4	300	A	G.H4.07	Structure	Structure
G.H4	301	A	G.H4.08	Structure	Structure
G.H4	302	Y	G.H4.10	Structure	Structure
G.H4	303	I	G.H4.11	Structure	Structure
G.H4	304	Q	G.H4.12	Structure	Structure
G.H4	305	C	G.H4.13	Structure	Structure
G.H4	306	Q	G.H4.14	Structure	Structure
G.H4	307	F	G.H4.15	Structure	Structure
G.H4	308	E	G.H4.16	Structure	AF2
G.H4	309	D	G.H4.17	Structure	Structure
G.h4s6	310	L	G.h4s6.01	Structure	Structure
G.h4s6	311	N	G.h4s6.02	Structure	Structure
G.h4s6	312	K	G.h4s6.03	Structure	AF2
G.h4s6	313	R	G.h4s6.04	Structure	AF2
G.h4s6	314	K	G.h4s6.08	Structure	AF2
G.h4s6	315	D	G.h4s6.09	Structure	Structure
G.h4s6	316	T	G.h4s6.10	Structure	AF2
G.h4s6	317	K	G.h4s6.11	Structure	Structure
G.h4s6	318	E	G.h4s6.12	Structure	AF2
G.S6	319	I	G.S6.01	Structure	Structure
G.S6	320	Y	G.S6.02	Structure	Structure
G.S6	321	T	G.S6.03	Structure	Structure
G.S6	322	H	G.S6.04	Structure	Structure
G.S6	323	F	G.S6.05	Structure	Structure
G.s6h5	324	T	G.s6h5.01	Structure	AF2
G.s6h5	325	C	G.s6h5.02	Structure	Structure
G.s6h5	326	A	G.s6h5.03	Structure	AF2
G.s6h5	327	T	G.s6h5.04	Structure	Structure
G.s6h5	328	D	G.s6h5.05	Structure	AF2
G.H5	329	T	G.H5.01	Structure	AF2
G.H5	330	K	G.H5.02	Structure	AF2
G.H5	331	N	G.H5.03	Structure	Structure
G.H5	332	V	G.H5.04	Structure	Structure
G.H5	333	Q	G.H5.05	Structure	Structure
G.H5	334	F	G.H5.06	Structure	Structure
G.H5	335	V	G.H5.07	Structure	Structure
G.H5	336	F	G.H5.08	Structure	Structure
G.H5	337	D	G.H5.09	Structure	Structure
G.H5	338	A	G.H5.10	Structure	Structure
G.H5	339	V	G.H5.11	Structure	Structure
G.H5	340	T	G.H5.12	Structure	Structure
G.H5	341	D	G.H5.13	Structure	Structure
G.H5	342	V	G.H5.14	Structure	Structure
G.H5	343	I	G.H5.15	Structure	Structure
G.H5	344	I	G.H5.16	Structure	Structure
G.H5	345	K	G.H5.17	Structure	Structure
G.H5	346	N	G.H5.18	Structure	Structure
G.H5	347	N	G.H5.19	Structure	Structure
G.H5	348	L	G.H5.20	Structure	Structure
G.H5	349	K	G.H5.21	Structure	AF2
G.H5	350	D	G.H5.22	Structure	Structure
G.H5	351	C	G.H5.23	Structure	Structure
G.H5	352	G	G.H5.24	Structure	Structure
G.H5	353	L	G.H5.25	Structure	Structure
G.H5	354	F	G.H5.26	Structure	AF2

REFINED GPCR RESIDUES

Residue backbones - 269 from structure (81.3%), 62 from model (18.7%)
Residue sidechains - 217 from structure (65.6%), 114 from model (34.4%)

Showing 1 to 331 of 331 entries

Search:

Segment	Seq.num.	AA	GPCRdb#	Backbone from	Sidechain from

N-term	1	M	-	AF2	AF2
N-term	2	S	-	AF2	AF2
N-term	3	T	-	AF2	AF2
N-term	4	P	-	AF2	AF2
N-term	5	G	-	AF2	AF2
N-term	6	V	-	AF2	AF2
N-term	7	N	-	AF2	AF2
N-term	8	S	-	AF2	AF2
N-term	9	S	-	AF2	AF2
N-term	10	A	-	AF2	AF2
N-term	11	S	-	AF2	AF2
N-term	12	L	-	AF2	AF2
N-term	13	S	-	AF2	AF2
N-term	14	P	-	AF2	AF2
N-term	15	D	-	AF2	AF2
N-term	16	R	-	AF2	AF2
N-term	17	L	-	AF2	AF2
TM1	18	N	1.33x33	AF2	AF2
TM1	19	S	1.34x34	AF2	AF2
TM1	20	P	1.35x35	AF2	AF2
TM1	21	V	1.36x36	AF2	AF2
TM1	22	T	1.37x37	Structure	AF2
TM1	23	I	1.38x38	Structure	Structure
TM1	24	P	1.39x39	Structure	Structure
TM1	25	A	1.40x40	Structure	Structure
TM1	26	V	1.41x41	Structure	Structure
TM1	27	M	1.42x42	Structure	Structure
TM1	28	F	1.43x43	Structure	AF2
TM1	29	I	1.44x44	Structure	Structure
TM1	30	F	1.45x45	Structure	AF2
TM1	31	G	1.46x46	Structure	Structure
TM1	32	V	1.47x47	Structure	AF2
TM1	33	V	1.48x48	Structure	Structure
TM1	34	G	1.49x49	Structure	Structure
TM1	35	N	1.50x50	Structure	Structure
TM1	36	L	1.51x51	Structure	Structure
TM1	37	V	1.52x52	Structure	Structure
TM1	38	A	1.53x53	Structure	Structure
TM1	39	I	1.54x54	Structure	Structure
TM1	40	V	1.55x55	Structure	Structure
TM1	41	V	1.56x56	Structure	Structure
TM1	42	L	1.57x57	Structure	Structure
TM1	43	C	1.58x58	Structure	Structure
TM1	44	K	1.59x59	Structure	Structure
TM1	45	S	1.60x60	Structure	Structure
ICL1	46	R	-	AF2	AF2
ICL1	47	K	-	AF2	AF2
ICL1	48	E	-	AF2	AF2
ICL1	49	Q	-	Structure	Structure
ICL1	50	K	-	Structure	Structure
ICL1	51	E	-	Structure	Structure
TM2	52	T	2.37x37	Structure	Structure
TM2	53	T	2.38x38	Structure	Structure
TM2	54	F	2.39x39	Structure	Structure
TM2	55	Y	2.40x40	Structure	Structure
TM2	56	T	2.41x41	Structure	Structure
TM2	57	L	2.42x42	Structure	Structure
TM2	58	V	2.43x43	Structure	Structure
TM2	59	C	2.44x44	Structure	Structure
TM2	60	G	2.45x45	Structure	Structure
TM2	61	L	2.46x46	Structure	Structure
TM2	62	A	2.47x47	Structure	Structure
TM2	63	V	2.48x48	Structure	Structure
TM2	64	T	2.49x49	Structure	Structure
TM2	65	D	2.50x50	Structure	AF2
TM2	66	L	2.51x51	Structure	Structure
TM2	67	L	2.52x52	Structure	Structure
TM2	68	G	2.53x53	Structure	Structure
TM2	69	T	2.54x54	Structure	Structure
TM2	70	L	2.55x55	Structure	Structure
TM2	71	L	2.56x56	Structure	Structure
TM2	72	V	2.57x57	Structure	Structure
TM2	73	S	2.58x58	Structure	Structure
TM2	74	P	2.59x59	Structure	Structure
TM2	75	V	2.60x60	Structure	Structure
TM2	76	T	2.61x61	Structure	Structure
TM2	77	I	2.62x62	Structure	Structure
TM2	78	A	2.63x63	Structure	Structure
TM2	79	T	2.64x64	Structure	AF2
TM2	80	Y	2.65x65	Structure	Structure
TM2	81	M	2.66x66	Structure	AF2
TM2	82	K	2.67x67	Structure	AF2
ECL1	83	G	-	Structure	Structure
ECL1	84	Q	23.49x49	Structure	AF2
ECL1	85	W	23.50x50	Structure	Structure
ECL1	86	P	23.51x51	Structure	AF2
ECL1	87	G	23.52x52	Structure	Structure
TM3	88	G	3.21x21	Structure	Structure
TM3	89	Q	3.22x22	Structure	AF2
TM3	90	P	3.23x23	Structure	AF2
TM3	91	L	3.24x24	Structure	Structure
TM3	92	C	3.25x25	Structure	Structure
TM3	93	E	3.26x26	Structure	AF2
TM3	94	Y	3.27x27	Structure	Structure
TM3	95	S	3.28x28	Structure	Structure
TM3	96	T	3.29x29	Structure	Structure
TM3	97	F	3.30x30	Structure	Structure
TM3	98	I	3.31x31	Structure	AF2
TM3	99	L	3.32x32	Structure	Structure
TM3	100	L	3.33x33	Structure	Structure
TM3	101	F	3.34x34	Structure	Structure
TM3	102	F	3.35x35	Structure	Structure
TM3	103	S	3.36x36	Structure	Structure
TM3	104	L	3.37x37	Structure	Structure
TM3	105	S	3.38x38	Structure	Structure
TM3	106	G	3.39x39	Structure	Structure
TM3	107	L	3.40x40	Structure	Structure
TM3	108	S	3.41x41	Structure	Structure
TM3	109	I	3.42x42	Structure	Structure
TM3	110	I	3.43x43	Structure	Structure
TM3	111	C	3.44x44	Structure	Structure
TM3	112	A	3.45x45	Structure	Structure
TM3	113	M	3.46x46	Structure	Structure
TM3	114	S	3.47x47	Structure	Structure
TM3	115	V	3.48x48	Structure	Structure
TM3	116	E	3.49x49	Structure	Structure
TM3	117	R	3.50x50	Structure	Structure
TM3	118	Y	3.51x51	Structure	Structure
TM3	119	L	3.52x52	Structure	Structure
TM3	120	A	3.53x53	Structure	Structure
TM3	121	I	3.54x54	Structure	Structure
TM3	122	N	3.55x55	Structure	Structure
TM3	123	H	3.56x56	Structure	Structure
ICL2	124	A	34.50x50	Structure	Structure
ICL2	125	Y	34.51x51	Structure	Structure
ICL2	126	F	34.52x52	Structure	Structure
ICL2	127	Y	34.53x53	Structure	Structure
ICL2	128	S	34.54x54	Structure	Structure
ICL2	129	H	34.55x55	Structure	Structure
ICL2	130	Y	34.56x56	Structure	Structure
ICL2	131	V	34.57x57	Structure	Structure
TM4	132	D	4.38x38	Structure	AF2
TM4	133	K	4.39x39	Structure	AF2
TM4	134	R	4.40x40	Structure	AF2
TM4	135	L	4.41x41	Structure	Structure
TM4	136	A	4.42x42	Structure	Structure
TM4	137	G	4.43x43	Structure	Structure
TM4	138	L	4.44x44	Structure	Structure
TM4	139	T	4.45x45	Structure	Structure
TM4	140	L	4.46x46	Structure	Structure
TM4	141	F	4.47x47	Structure	Structure
TM4	142	A	4.48x48	Structure	Structure
TM4	143	V	4.49x49	Structure	Structure
TM4	144	Y	4.50x50	Structure	Structure
TM4	145	A	4.51x51	Structure	Structure
TM4	146	S	4.52x52	Structure	Structure
TM4	147	N	4.53x53	Structure	Structure
TM4	148	V	4.54x54	Structure	Structure
TM4	149	L	4.55x55	Structure	AF2
TM4	150	F	4.56x56	Structure	Structure
TM4	151	C	4.57x57	Structure	Structure
TM4	152	A	4.58x58	Structure	Structure
TM4	153	L	4.59x59	Structure	Structure
TM4	154	P	4.60x60	Structure	Structure
TM4	155	N	4.61x61	Structure	AF2
TM4	156	M	4.62x62	Structure	AF2
TM4	157	G	4.63x63	Structure	Structure
ECL2	158	L	-	Structure	AF2
ECL2	159	G	-	Structure	Structure
ECL2	160	S	-	Structure	Structure
ECL2	161	S	-	Structure	Structure
ECL2	162	R	-	Structure	AF2
ECL2	163	L	-	Structure	Structure
ECL2	164	Q	-	Structure	Structure
ECL2	165	Y	-	Structure	AF2
ECL2	166	P	-	Structure	Structure
ECL2	167	D	-	Structure	AF2
ECL2	168	T	-	Structure	Structure
ECL2	169	W	-	Structure	Structure
ECL2	170	C	45.50x50	Structure	Structure
ECL2	171	F	45.51x51	Structure	Structure
ECL2	172	I	45.52x52	Structure	Structure
ECL2	173	D	-	Structure	Structure
ECL2	174	W	-	Structure	Structure
ECL2	175	T	-	Structure	Structure
ECL2	176	T	-	Structure	Structure
ECL2	177	N	-	Structure	Structure
TM5	178	V	5.33x33	Structure	AF2
TM5	179	T	5.34x34	Structure	AF2
TM5	180	A	5.35x35	Structure	Structure
TM5	181	H	5.36x36	Structure	AF2
TM5	182	A	5.37x37	Structure	Structure
TM5	183	A	5.38x38	Structure	Structure
TM5	184	Y	5.39x39	Structure	Structure
TM5	185	S	5.40x40	Structure	Structure
TM5	186	Y	5.41x41	Structure	Structure
TM5	187	M	5.42x42	Structure	AF2
TM5	188	Y	5.43x43	Structure	Structure
TM5	189	A	5.44x44	Structure	Structure
TM5	190	G	5.45x45	Structure	Structure
TM5	191	F	5.46x46	Structure	Structure
TM5	192	S	5.47x47	Structure	Structure
TM5	193	S	5.48x48	Structure	Structure
TM5	194	F	5.49x49	Structure	Structure
TM5	195	L	5.50x50	Structure	AF2
TM5	196	I	5.51x51	Structure	Structure
TM5	197	L	5.52x52	Structure	Structure
TM5	198	A	5.53x53	Structure	Structure
TM5	199	T	5.54x54	Structure	AF2
TM5	200	V	5.55x55	Structure	Structure
TM5	201	L	5.56x56	Structure	Structure
TM5	202	C	5.57x57	Structure	Structure
TM5	203	N	5.58x58	Structure	Structure
TM5	204	V	5.59x59	Structure	Structure
TM5	205	L	5.60x60	Structure	Structure
TM5	206	V	5.61x61	Structure	Structure
TM5	207	C	5.62x62	Structure	Structure
TM5	208	G	5.63x63	Structure	Structure
TM5	209	A	5.64x64	Structure	Structure
TM5	210	L	5.65x65	Structure	Structure
TM5	211	L	5.66x66	Structure	AF2
TM5	212	R	5.67x67	Structure	Structure
TM5	213	M	5.68x68	Structure	Structure
TM5	214	H	5.69x69	Structure	Structure
TM5	215	R	5.70x70	Structure	AF2
TM5	216	Q	5.71x71	Structure	AF2
TM5	217	F	5.72x72	Structure	AF2
TM5	218	M	5.73x73	Structure	Structure
TM5	219	R	5.74x74	Structure	Structure
TM5	220	R	5.75x75	Structure	Structure
TM5	221	T	5.76x76	AF2	AF2
ICL3	222	S	-	AF2	AF2
ICL3	223	L	-	AF2	AF2
ICL3	224	G	-	AF2	AF2
ICL3	225	T	-	AF2	AF2
ICL3	226	E	-	AF2	AF2
ICL3	227	Q	-	AF2	AF2
ICL3	228	H	-	AF2	AF2
ICL3	254	F	-	AF2	AF2
ICL3	255	R	-	AF2	AF2
ICL3	256	R	-	AF2	AF2
ICL3	257	R	-	AF2	AF2
ICL3	258	R	-	AF2	AF2
ICL3	259	S	-	AF2	AF2
ICL3	260	F	-	AF2	AF2
TM6	261	R	6.24x24	AF2	AF2
TM6	262	R	6.25x25	AF2	AF2
TM6	263	I	6.26x26	AF2	AF2
TM6	264	A	6.27x27	AF2	AF2
TM6	265	G	6.28x28	AF2	AF2
TM6	266	A	6.29x29	Structure	Structure
TM6	267	E	6.30x30	Structure	AF2
TM6	268	I	6.31x31	Structure	AF2
TM6	269	Q	6.32x32	Structure	AF2
TM6	270	M	6.33x33	Structure	Structure
TM6	271	V	6.34x34	Structure	Structure
TM6	272	I	6.35x35	Structure	Structure
TM6	273	L	6.36x36	Structure	Structure
TM6	274	L	6.37x37	Structure	AF2
TM6	275	I	6.38x38	Structure	AF2
TM6	276	A	6.39x39	Structure	Structure
TM6	277	T	6.40x40	Structure	Structure
TM6	278	S	6.41x41	Structure	Structure
TM6	279	L	6.42x42	Structure	Structure
TM6	280	V	6.43x43	Structure	Structure
TM6	281	V	6.44x44	Structure	Structure
TM6	282	L	6.45x45	Structure	Structure
TM6	283	I	6.46x46	Structure	AF2
TM6	284	C	6.47x47	Structure	Structure
TM6	285	S	6.48x48	Structure	Structure
TM6	286	I	6.49x49	Structure	Structure
TM6	287	P	6.50x50	Structure	Structure
TM6	288	L	6.51x51	Structure	Structure
TM6	289	V	6.52x52	Structure	Structure
TM6	290	V	6.53x53	Structure	Structure
TM6	291	R	6.54x54	Structure	Structure
TM6	292	V	6.55x55	Structure	Structure
TM6	293	F	6.56x56	Structure	Structure
TM6	294	V	6.57x57	Structure	AF2
TM6	295	N	6.58x58	Structure	Structure
TM6	296	Q	6.59x59	Structure	Structure
TM6	297	L	6.60x60	Structure	Structure
TM6	298	Y	6.61x61	Structure	AF2
ECL3	299	Q	-	Structure	AF2
ECL3	300	P	-	Structure	Structure
ECL3	301	S	-	Structure	Structure
ECL3	302	L	-	Structure	AF2
ECL3	303	E	-	Structure	AF2
ECL3	304	R	-	Structure	AF2
ECL3	305	E	-	Structure	AF2
ECL3	306	V	-	Structure	AF2
ECL3	307	S	-	Structure	Structure
ECL3	308	K	-	Structure	AF2
TM7	309	N	7.33x32	Structure	Structure
TM7	310	P	7.34x33	Structure	Structure
TM7	311	D	7.35x34	Structure	AF2
TM7	312	L	7.36x35	Structure	Structure
TM7	313	Q	7.37x36	Structure	Structure
TM7	314	A	7.38x37	Structure	Structure
TM7	315	I	7.39x38	Structure	Structure
TM7	316	R	7.40x39	Structure	Structure
TM7	317	I	7.41x40	Structure	AF2
TM7	318	A	7.42x41	Structure	Structure
TM7	319	S	7.43x42	Structure	Structure
TM7	320	V	7.44x43	Structure	Structure
TM7	321	N	7.45x45	Structure	Structure
TM7	322	P	7.46x46	Structure	Structure
TM7	323	I	7.47x47	Structure	AF2
TM7	324	L	7.48x48	Structure	Structure
TM7	325	D	7.49x49	Structure	Structure
TM7	326	P	7.50x50	Structure	Structure
TM7	327	W	7.51x51	Structure	Structure
TM7	328	I	7.52x52	Structure	Structure
TM7	329	Y	7.53x53	Structure	Structure
TM7	330	I	7.54x54	Structure	Structure
TM7	331	L	7.55x55	Structure	Structure
TM7	332	L	7.56x56	Structure	Structure
H8	333	R	8.47x47	Structure	Structure
H8	334	K	8.48x48	Structure	Structure
H8	335	T	8.49x49	Structure	Structure
H8	336	V	8.50x50	Structure	Structure
H8	337	L	8.51x51	Structure	Structure
H8	338	S	8.52x52	Structure	Structure
H8	339	K	8.53x53	AF2	AF2
H8	340	A	8.54x54	AF2	AF2
H8	341	I	8.55x55	AF2	AF2
H8	342	E	8.56x56	AF2	AF2
H8	343	K	8.57x57	AF2	AF2
H8	344	I	8.58x58	AF2	AF2
H8	345	K	8.59x59	AF2	AF2
H8	346	C	8.60x60	AF2	AF2
C-term	347	L	-	AF2	AF2
C-term	348	F	-	AF2	AF2
C-term	349	C	-	AF2	AF2
C-term	350	R	-	AF2	AF2
C-term	351	I	-	AF2	AF2
C-term	352	G	-	AF2	AF2
C-term	353	G	-	AF2	AF2
C-term	354	S	-	AF2	AF2
C-term	355	R	-	AF2	AF2
C-term	356	R	-	AF2	AF2

GPCR - G protein interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Hydrophobic	ICL3	G	224	-	G.S6	T	321	G.S6.03
Hydrophobic	ICL3	R	256	-	G.h4s6	E	318	G.h4s6.12
Hydrophobic	ICL3	L	223	-	G.H5	N	346	G.H5.18
Hydrophobic	ICL2	Y	125	34x51	G.h2s4	G	217	G.h2s4.03
Hydrophobic	TM4	D	132	4x38	G.S1	L	38	G.S1.06
Hydrophobic	ICL3	L	223	-	G.S6	T	321	G.S6.03
Hydrophobic	ICL3	S	259	-	G.H5	K	349	G.H5.21
Hydrophobic	ICL3	L	223	-	G.H5	I	343	G.H5.15
Hydrophobic	ICL3	F	260	-	G.H5	D	350	G.H5.22
Hydrophobic	ICL3	S	222	-	G.S6	F	323	G.S6.05
Hydrophobic	ICL2	H	129	34x55	G.h2s4	G	217	G.h2s4.03
Hydrophobic	ICL3	F	260	-	G.H5	L	348	G.H5.20
Hydrophobic	ICL3	S	259	-	G.H5	L	348	G.H5.20
Hydrophobic	ICL3	F	260	-	G.H5	K	349	G.H5.21
Hydrophobic	ICL2	Y	125	34x51	G.h2s4	T	219	G.h2s4.05
Hydrophobic	TM5	T	221	5x76	G.H5	D	350	G.H5.22
Hydrophobic	TM6	I	263	6x26	G.H5	K	349	G.H5.21
Hydrophobic	TM6	I	263	6x26	G.H5	F	354	G.H5.26
Hydrophobic	ICL3	L	223	-	G.H5	L	348	G.H5.20
Hydrophobic	ICL3	R	256	-	G.H5	I	343	G.H5.15
Hydrophobic	ICL3	R	256	-	G.H5	L	348	G.H5.20
Hydrophobic	ICL2	H	129	34x55	G.S1	L	39	G.S1.07
Ionic	ICL3	R	256	-	G.H5	I	343	G.H5.15
Polar	ICL2	V	131	34x57	G.S1	L	38	G.S1.06
Polar	TM5	R	219	5x74	G.s6h5	C	325	G.s6h5.02
Polar	ICL3	G	224	-	G.H5	I	343	G.H5.15
Polar	ICL3	S	222	-	G.H5	V	342	G.H5.14
Polar	ICL2	H	129	34x55	G.S1	L	38	G.S1.06
Polar	ICL3	R	256	-	G.H5	N	347	G.H5.19
Polar	ICL3	S	222	-	G.S6	F	323	G.S6.05
Polar	ICL3	S	259	-	G.H5	L	348	G.H5.20
Polar	ICL3	R	256	-	G.H5	I	343	G.H5.15
Polar	ICL2	H	129	34x55	G.S1	L	39	G.S1.07
Van-der-waals	ICL3	G	224	-	G.S6	T	321	G.S6.03
Van-der-waals	ICL3	R	256	-	G.h4s6	E	318	G.h4s6.12
Van-der-waals	ICL2	V	131	34x57	G.S1	L	38	G.S1.06
Van-der-waals	ICL3	S	222	-	G.H5	V	342	G.H5.14
Van-der-waals	ICL3	T	225	-	G.h4s6	E	318	G.h4s6.12
Van-der-waals	ICL3	R	256	-	G.H5	N	347	G.H5.19
Van-der-waals	ICL3	S	259	-	G.H5	K	349	G.H5.21
Van-der-waals	ICL3	F	260	-	G.H5	D	350	G.H5.22
Van-der-waals	ICL3	S	222	-	G.S6	F	323	G.S6.05
Van-der-waals	ICL3	F	260	-	G.H5	L	348	G.H5.20
Van-der-waals	ICL3	S	259	-	G.H5	L	348	G.H5.20
Van-der-waals	ICL3	F	260	-	G.H5	K	349	G.H5.21
Van-der-waals	TM6	I	263	6x26	G.H5	K	349	G.H5.21
Van-der-waals	ICL3	L	223	-	G.H5	L	348	G.H5.20
Van-der-waals	ICL3	L	223	-	G.H5	N	347	G.H5.19
Van-der-waals	ICL3	R	256	-	G.H5	I	343	G.H5.15
Van-der-waals	ICL3	R	256	-	G.H5	L	348	G.H5.20

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Main reference

Refined structure (8GCP) of Gi1 - EP4 receptor Download Full

GPCR CLASS (FAMILY)

SPECIES

G PROTEIN FAMILY

DATE

3D VIEW

REFINED G PROTEIN RESIDUES

REFINED GPCR RESIDUES

GPCR - G protein interface interactions

Structures

Refined structure (8GCP) of G_i1 - EP₄ receptor

Full