Refined structure (8GGA) of Gs - β2-adrenoceptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-11-27

3D VIEW

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Structure
GPCR

Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 326 from structure (82.7%), 68 from model (17.3%)
Residue sidechains - 228 from structure (57.9%), 166 from model (42.1%)

REFINED GPCR RESIDUES

Residue backbones - 269 from structure (78.9%), 72 from model (21.1%)
Residue sidechains - 183 from structure (53.7%), 158 from model (46.3%)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
R02G.hns1H02G.S1D13G.hgh4D13G.H4Y20G.h4s6C01G.S6R12Q16L25G.H5GproteinQ5x68T3x55Q34x54A6x33R-I3x54E5x76F34x51K6x29GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.hns1G.S1G.hgh4G.H4G.h4s6G.S6G.H5GPCR segments:ICL2TM3ICL3TM5TM6

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null3x503x533x543x5534x5034x5134x545x615x655x685x695x725x766x296x326x336x366x378x47G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.12G.H5.11G.H5.08G.S6.01G.h4s6.20G.h4s6.03G.H4.16G.H4.13G.H4.12G.hgh4.13G.h3s5.01G.S3.01G.S1.02G.hns1.02Res. Pos.β2 (8GGA_REFINED)- (8GGA_REFINED)--------------------RAITPFQVAQLIEKKATLSPFQRAITVAQLIEKKATLSRRIQHFCHVRYLLRLYCEQRDLRTD

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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