GproteinDb

Refined structure (8GGF) of G_s - β₂-adrenoceptor

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G_s

DATE

2024-11-27

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Structure

GPCR

Gα

Gβ

Gγ
Model

AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 359 from structure (91.1%), 35 from model (8.9%)
Residue sidechains - 263 from structure (66.8%), 131 from model (33.2%)

Showing 1 to 394 of 394 entries

Search:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from
	:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from

G.HN	1	M	G.HN.01	AF2	AF2
G.HN	2	G	G.HN.02	AF2	AF2
G.HN	3	C	G.HN.09	AF2	AF2
G.HN	4	L	G.HN.10	AF2	AF2
G.HN	5	G	G.HN.11	AF2	AF2
G.HN	6	N	G.HN.22	AF2	AF2
G.HN	7	S	G.HN.23	AF2	AF2
G.HN	8	K	G.HN.24	AF2	AF2
G.HN	9	T	G.HN.26	AF2	AF2
G.HN	10	E	G.HN.27	AF2	AF2
G.HN	11	D	G.HN.28	AF2	AF2
G.HN	12	Q	G.HN.29	Structure	AF2
G.HN	13	R	G.HN.30	Structure	AF2
G.HN	14	N	G.HN.31	Structure	AF2
G.HN	15	E	G.HN.32	Structure	AF2
G.HN	16	E	G.HN.33	Structure	AF2
G.HN	17	K	G.HN.34	Structure	AF2
G.HN	18	A	G.HN.35	Structure	Structure
G.HN	19	Q	G.HN.36	Structure	Structure
G.HN	20	R	G.HN.37	Structure	Structure
G.HN	21	E	G.HN.38	Structure	AF2
G.HN	22	A	G.HN.39	Structure	Structure
G.HN	23	N	G.HN.40	Structure	Structure
G.HN	24	K	G.HN.41	Structure	AF2
G.HN	25	K	G.HN.42	Structure	AF2
G.HN	26	I	G.HN.43	Structure	Structure
G.HN	27	E	G.HN.44	Structure	Structure
G.HN	28	K	G.HN.45	Structure	AF2
G.HN	29	Q	G.HN.46	Structure	AF2
G.HN	30	L	G.HN.47	Structure	Structure
G.HN	31	Q	G.HN.48	Structure	Structure
G.HN	32	K	G.HN.49	Structure	AF2
G.HN	33	D	G.HN.50	Structure	AF2
G.HN	34	K	G.HN.51	Structure	Structure
G.HN	35	Q	G.HN.52	Structure	AF2
G.HN	36	V	G.HN.53	Structure	Structure
G.hns1	37	Y	G.hns1.01	Structure	Structure
G.hns1	38	R	G.hns1.02	Structure	AF2
G.hns1	39	A	G.hns1.03	Structure	Structure
G.S1	40	T	G.S1.01	Structure	Structure
G.S1	41	H	G.S1.02	Structure	Structure
G.S1	42	R	G.S1.03	Structure	Structure
G.S1	43	L	G.S1.04	Structure	Structure
G.S1	44	L	G.S1.05	Structure	Structure
G.S1	45	L	G.S1.06	Structure	Structure
G.S1	46	L	G.S1.07	Structure	Structure
G.s1h1	47	G	G.s1h1.01	Structure	Structure
G.s1h1	48	A	G.s1h1.02	Structure	Structure
G.s1h1	49	G	G.s1h1.03	Structure	Structure
G.s1h1	50	E	G.s1h1.04	Structure	AF2
G.s1h1	51	S	G.s1h1.05	Structure	Structure
G.s1h1	52	G	G.s1h1.06	Structure	Structure
G.H1	53	K	G.H1.01	Structure	Structure
G.H1	54	S	G.H1.02	Structure	Structure
G.H1	55	T	G.H1.03	Structure	Structure
G.H1	56	I	G.H1.04	Structure	Structure
G.H1	57	V	G.H1.05	Structure	Structure
G.H1	58	K	G.H1.06	Structure	Structure
G.H1	59	Q	G.H1.07	Structure	Structure
G.H1	60	M	G.H1.08	Structure	AF2
G.H1	61	R	G.H1.09	Structure	Structure
G.H1	62	I	G.H1.10	Structure	AF2
G.H1	63	L	G.H1.11	Structure	AF2
G.H1	64	H	G.H1.12	Structure	Structure
G.h1ha	65	V	G.h1ha.01	Structure	Structure
G.h1ha	66	N	G.h1ha.02	Structure	AF2
G.h1ha	67	G	G.h1ha.03	Structure	Structure
G.h1ha	68	F	G.h1ha.04	Structure	AF2
G.h1ha	69	N	G.h1ha.05	AF2	AF2
G.h1ha	70	G	G.h1ha.06	AF2	AF2
G.h1ha	71	E	G.h1ha.07	AF2	AF2
G.h1ha	72	G	G.h1ha.08	AF2	AF2
G.h1ha	73	G	G.h1ha.09	AF2	AF2
G.h1ha	74	E	G.h1ha.10	AF2	AF2
G.h1ha	75	E	G.h1ha.11	AF2	AF2
G.h1ha	76	D	G.h1ha.12	AF2	AF2
G.h1ha	77	P	G.h1ha.13	AF2	AF2
G.h1ha	78	Q	G.h1ha.14	AF2	AF2
G.h1ha	79	A	G.h1ha.15	AF2	AF2
G.h1ha	80	A	G.h1ha.16	AF2	AF2
G.h1ha	81	R	G.h1ha.17	AF2	AF2
G.h1ha	82	S	G.h1ha.18	AF2	AF2
G.h1ha	83	N	G.h1ha.19	AF2	AF2
G.h1ha	84	S	G.h1ha.20	AF2	AF2
H.HA	85	D	H.HA.01	AF2	AF2
H.HA	86	G	H.HA.02	AF2	AF2
H.HA	87	E	H.HA.03	AF2	AF2
H.HA	88	K	H.HA.04	Structure	AF2
H.HA	89	A	H.HA.05	Structure	Structure
H.HA	90	T	H.HA.06	Structure	Structure
H.HA	91	K	H.HA.07	Structure	AF2
H.HA	92	V	H.HA.08	Structure	Structure
H.HA	93	Q	H.HA.09	Structure	Structure
H.HA	94	D	H.HA.10	Structure	Structure
H.HA	95	I	H.HA.11	Structure	Structure
H.HA	96	K	H.HA.12	Structure	Structure
H.HA	97	N	H.HA.13	Structure	Structure
H.HA	98	N	H.HA.14	Structure	Structure
H.HA	99	L	H.HA.15	Structure	Structure
H.HA	100	K	H.HA.16	Structure	Structure
H.HA	101	E	H.HA.17	Structure	Structure
H.HA	102	A	H.HA.18	Structure	Structure
H.HA	103	I	H.HA.19	Structure	Structure
H.HA	104	E	H.HA.20	Structure	AF2
H.HA	105	T	H.HA.21	Structure	Structure
H.HA	106	I	H.HA.22	Structure	AF2
H.HA	107	V	H.HA.23	Structure	AF2
H.HA	108	A	H.HA.24	Structure	Structure
H.HA	109	A	H.HA.25	Structure	Structure
H.HA	110	M	H.HA.26	Structure	Structure
H.HA	111	S	H.HA.27	Structure	Structure
H.HA	112	N	H.HA.28	Structure	Structure
H.HA	113	L	H.HA.29	Structure	Structure
H.hahb	114	V	H.hahb.01	Structure	AF2
H.hahb	115	P	H.hahb.02	Structure	Structure
H.hahb	116	P	H.hahb.03	Structure	Structure
H.hahb	117	V	H.hahb.04	Structure	Structure
H.hahb	118	E	H.hahb.05	Structure	Structure
H.hahb	119	L	H.hahb.06	Structure	Structure
H.hahb	120	A	H.hahb.07	AF2	AF2
H.hahb	121	N	H.hahb.08	AF2	AF2
H.hahb	122	P	H.hahb.09	Structure	Structure
H.HB	123	E	H.HB.01	Structure	AF2
H.HB	124	N	H.HB.02	Structure	AF2
H.HB	125	Q	H.HB.03	Structure	Structure
H.HB	126	F	H.HB.04	Structure	AF2
H.HB	127	R	H.HB.05	Structure	Structure
H.HB	128	V	H.HB.06	Structure	Structure
H.HB	129	D	H.HB.07	Structure	Structure
H.HB	130	Y	H.HB.08	Structure	Structure
H.HB	131	I	H.HB.09	Structure	Structure
H.HB	132	L	H.HB.10	Structure	AF2
H.HB	133	S	H.HB.11	Structure	Structure
H.HB	134	V	H.HB.12	Structure	Structure
H.HB	135	M	H.HB.13	Structure	AF2
H.HB	136	N	H.HB.14	Structure	AF2
H.hbhc	137	V	H.hbhc.01	Structure	Structure
H.hbhc	138	P	H.hbhc.02	Structure	Structure
H.hbhc	139	D	H.hbhc.03	Structure	AF2
H.hbhc	140	F	H.hbhc.04	Structure	AF2
H.hbhc	141	D	H.hbhc.13	Structure	AF2
H.hbhc	142	F	H.hbhc.14	Structure	AF2
H.hbhc	143	P	H.hbhc.15	Structure	AF2
H.HC	144	P	H.HC.01	Structure	AF2
H.HC	145	E	H.HC.02	Structure	AF2
H.HC	146	F	H.HC.03	Structure	Structure
H.HC	147	Y	H.HC.04	Structure	Structure
H.HC	148	E	H.HC.05	Structure	Structure
H.HC	149	H	H.HC.06	Structure	Structure
H.HC	150	A	H.HC.07	Structure	Structure
H.HC	151	K	H.HC.08	Structure	Structure
H.HC	152	A	H.HC.09	Structure	Structure
H.HC	153	L	H.HC.10	Structure	Structure
H.HC	154	W	H.HC.11	Structure	Structure
H.HC	155	E	H.HC.12	Structure	AF2
H.hchd	156	D	H.hchd.01	Structure	Structure
H.HD	157	E	H.HD.01	Structure	Structure
H.HD	158	G	H.HD.02	Structure	Structure
H.HD	159	V	H.HD.03	Structure	AF2
H.HD	160	R	H.HD.04	Structure	Structure
H.HD	161	A	H.HD.05	Structure	Structure
H.HD	162	C	H.HD.06	Structure	Structure
H.HD	163	Y	H.HD.07	Structure	Structure
H.HD	164	E	H.HD.08	Structure	AF2
H.HD	165	R	H.HD.09	Structure	Structure
H.HD	166	S	H.HD.10	Structure	Structure
H.HD	167	N	H.HD.11	Structure	Structure
H.HD	168	E	H.HD.12	Structure	Structure
H.hdhe	169	Y	H.hdhe.01	Structure	Structure
H.hdhe	170	Q	H.hdhe.02	Structure	Structure
H.hdhe	171	L	H.hdhe.03	Structure	Structure
H.hdhe	172	I	H.hdhe.04	Structure	Structure
H.hdhe	173	D	H.hdhe.05	Structure	AF2
H.HE	174	C	H.HE.01	Structure	Structure
H.HE	175	A	H.HE.02	Structure	Structure
H.HE	176	Q	H.HE.03	Structure	Structure
H.HE	177	Y	H.HE.04	Structure	Structure
H.HE	178	F	H.HE.05	Structure	Structure
H.HE	179	L	H.HE.06	Structure	AF2
H.HE	180	D	H.HE.07	Structure	Structure
H.HE	181	K	H.HE.08	Structure	Structure
H.HE	182	I	H.HE.09	Structure	Structure
H.HE	183	D	H.HE.10	Structure	Structure
H.HE	184	V	H.HE.11	Structure	Structure
H.HE	185	I	H.HE.12	Structure	Structure
H.HE	186	K	H.HE.13	Structure	AF2
H.hehf	187	Q	H.hehf.01	Structure	Structure
H.hehf	188	A	H.hehf.02	Structure	Structure
H.hehf	189	D	H.hehf.03	Structure	AF2
H.hehf	190	Y	H.hehf.04	Structure	AF2
H.hehf	191	V	H.hehf.05	Structure	Structure
H.hehf	192	P	H.hehf.06	Structure	Structure
H.hehf	193	S	H.hehf.07	Structure	Structure
H.HF	194	D	H.HF.01	Structure	AF2
H.HF	195	Q	H.HF.02	Structure	Structure
H.HF	196	D	H.HF.03	Structure	Structure
H.HF	197	L	H.HF.04	Structure	AF2
H.HF	198	L	H.HF.05	Structure	Structure
H.HF	199	R	H.HF.06	Structure	Structure
G.hfs2	200	C	G.hfs2.01	Structure	AF2
G.hfs2	201	R	G.hfs2.02	Structure	Structure
G.hfs2	202	V	G.hfs2.03	Structure	AF2
G.hfs2	203	L	G.hfs2.04	Structure	AF2
G.hfs2	204	T	G.hfs2.05	Structure	AF2
G.hfs2	205	S	G.hfs2.06	Structure	AF2
G.hfs2	206	G	G.hfs2.07	Structure	Structure
G.S2	207	I	G.S2.01	Structure	Structure
G.S2	208	F	G.S2.02	Structure	Structure
G.S2	209	E	G.S2.03	Structure	AF2
G.S2	210	T	G.S2.04	Structure	Structure
G.S2	211	K	G.S2.05	Structure	Structure
G.S2	212	F	G.S2.06	Structure	Structure
G.S2	213	Q	G.S2.07	Structure	AF2
G.S2	214	V	G.S2.08	Structure	Structure
G.s2s3	215	D	G.s2s3.01	Structure	Structure
G.s2s3	216	K	G.s2s3.02	Structure	AF2
G.S3	217	V	G.S3.01	Structure	AF2
G.S3	218	N	G.S3.02	Structure	AF2
G.S3	219	F	G.S3.03	Structure	Structure
G.S3	220	H	G.S3.04	Structure	Structure
G.S3	221	M	G.S3.05	Structure	Structure
G.S3	222	F	G.S3.06	Structure	Structure
G.S3	223	D	G.S3.07	Structure	Structure
G.S3	224	V	G.S3.08	Structure	Structure
G.s3h2	225	G	G.s3h2.01	Structure	Structure
G.s3h2	226	G	G.s3h2.02	Structure	Structure
G.s3h2	227	Q	G.s3h2.03	Structure	Structure
G.H2	228	R	G.H2.01	Structure	AF2
G.H2	229	D	G.H2.02	Structure	AF2
G.H2	230	E	G.H2.03	Structure	AF2
G.H2	231	R	G.H2.04	Structure	Structure
G.H2	232	R	G.H2.05	Structure	Structure
G.H2	233	K	G.H2.06	Structure	Structure
G.H2	234	W	G.H2.07	Structure	Structure
G.H2	235	I	G.H2.08	Structure	Structure
G.H2	236	Q	G.H2.09	Structure	AF2
G.H2	237	C	G.H2.10	Structure	Structure
G.h2s4	238	F	G.h2s4.01	Structure	Structure
G.h2s4	239	N	G.h2s4.02	Structure	Structure
G.h2s4	240	D	G.h2s4.03	Structure	AF2
G.h2s4	241	V	G.h2s4.04	Structure	Structure
G.h2s4	242	T	G.h2s4.05	Structure	Structure
G.S4	243	A	G.S4.01	Structure	Structure
G.S4	244	I	G.S4.02	Structure	Structure
G.S4	245	I	G.S4.03	Structure	Structure
G.S4	246	F	G.S4.04	Structure	Structure
G.S4	247	V	G.S4.05	Structure	Structure
G.S4	248	V	G.S4.06	Structure	Structure
G.S4	249	A	G.S4.07	Structure	Structure
G.s4h3	250	S	G.s4h3.01	Structure	Structure
G.s4h3	251	S	G.s4h3.02	Structure	Structure
G.s4h3	252	S	G.s4h3.03	Structure	Structure
G.s4h3	253	Y	G.s4h3.04	Structure	Structure
G.s4h3	254	N	G.s4h3.05	Structure	Structure
G.s4h3	255	M	G.s4h3.06	Structure	Structure
G.s4h3	256	V	G.s4h3.07	Structure	Structure
G.s4h3	257	I	G.s4h3.08	Structure	Structure
G.s4h3	258	R	G.s4h3.09	Structure	Structure
G.s4h3	259	E	G.s4h3.10	Structure	Structure
G.s4h3	260	D	G.s4h3.11	Structure	Structure
G.s4h3	261	N	G.s4h3.12	Structure	AF2
G.s4h3	262	Q	G.s4h3.13	Structure	AF2
G.s4h3	263	T	G.s4h3.14	Structure	AF2
G.s4h3	264	N	G.s4h3.15	Structure	Structure
G.H3	265	R	G.H3.01	Structure	Structure
G.H3	266	L	G.H3.02	Structure	Structure
G.H3	267	Q	G.H3.03	Structure	Structure
G.H3	268	E	G.H3.04	Structure	AF2
G.H3	269	A	G.H3.05	Structure	Structure
G.H3	270	L	G.H3.06	Structure	Structure
G.H3	271	N	G.H3.07	Structure	Structure
G.H3	272	L	G.H3.08	Structure	Structure
G.H3	273	F	G.H3.09	Structure	Structure
G.H3	274	K	G.H3.10	Structure	Structure
G.H3	275	S	G.H3.11	Structure	Structure
G.H3	276	I	G.H3.12	Structure	Structure
G.H3	277	W	G.H3.13	Structure	Structure
G.H3	278	N	G.H3.14	Structure	Structure
G.H3	279	N	G.H3.15	Structure	Structure
G.H3	280	R	G.H3.16	Structure	AF2
G.H3	281	W	G.H3.17	Structure	Structure
G.H3	282	L	G.H3.18	Structure	Structure
G.h3s5	283	R	G.h3s5.01	Structure	AF2
G.h3s5	284	T	G.h3s5.02	Structure	Structure
G.h3s5	285	I	G.h3s5.03	Structure	Structure
G.S5	286	S	G.S5.01	Structure	Structure
G.S5	287	V	G.S5.02	Structure	Structure
G.S5	288	I	G.S5.03	Structure	Structure
G.S5	289	L	G.S5.04	Structure	Structure
G.S5	290	F	G.S5.05	Structure	Structure
G.S5	291	L	G.S5.06	Structure	Structure
G.S5	292	N	G.S5.07	Structure	Structure
G.s5hg	293	K	G.s5hg.01	Structure	Structure
G.HG	294	Q	G.HG.01	Structure	Structure
G.HG	295	D	G.HG.02	Structure	Structure
G.HG	296	L	G.HG.03	Structure	Structure
G.HG	297	L	G.HG.04	Structure	Structure
G.HG	298	A	G.HG.05	Structure	Structure
G.HG	299	E	G.HG.06	Structure	Structure
G.HG	300	K	G.HG.07	Structure	Structure
G.HG	301	V	G.HG.08	Structure	Structure
G.HG	302	L	G.HG.09	Structure	Structure
G.HG	303	A	G.HG.10	Structure	Structure
G.HG	304	G	G.HG.11	Structure	Structure
G.HG	305	K	G.HG.12	Structure	AF2
G.HG	306	S	G.HG.13	Structure	Structure
G.HG	307	K	G.HG.14	Structure	AF2
G.HG	308	I	G.HG.15	Structure	Structure
G.HG	309	E	G.HG.16	Structure	AF2
G.HG	310	D	G.HG.17	Structure	AF2
G.hgh4	311	Y	G.hgh4.01	Structure	Structure
G.hgh4	312	F	G.hgh4.02	Structure	Structure
G.hgh4	313	P	G.hgh4.03	Structure	Structure
G.hgh4	314	E	G.hgh4.04	Structure	AF2
G.hgh4	315	F	G.hgh4.05	Structure	Structure
G.hgh4	316	A	G.hgh4.06	Structure	Structure
G.hgh4	317	R	G.hgh4.07	Structure	AF2
G.hgh4	318	Y	G.hgh4.08	Structure	Structure
G.hgh4	319	T	G.hgh4.09	Structure	AF2
G.hgh4	320	T	G.hgh4.10	Structure	Structure
G.hgh4	321	P	G.hgh4.11	Structure	Structure
G.hgh4	322	E	G.hgh4.12	Structure	AF2
G.hgh4	323	D	G.hgh4.13	Structure	AF2
G.hgh4	324	A	G.hgh4.14	Structure	Structure
G.hgh4	325	T	G.hgh4.15	Structure	Structure
G.hgh4	326	P	G.hgh4.16	Structure	Structure
G.hgh4	327	E	G.hgh4.17	Structure	Structure
G.hgh4	328	P	G.hgh4.18	Structure	Structure
G.hgh4	329	G	G.hgh4.19	Structure	Structure
G.hgh4	330	E	G.hgh4.20	Structure	AF2
G.hgh4	331	D	G.hgh4.21	Structure	Structure
G.H4	332	P	G.H4.01	Structure	Structure
G.H4	333	R	G.H4.02	Structure	Structure
G.H4	334	V	G.H4.03	Structure	Structure
G.H4	335	T	G.H4.04	Structure	Structure
G.H4	336	R	G.H4.05	Structure	Structure
G.H4	337	A	G.H4.06	Structure	Structure
G.H4	338	K	G.H4.07	Structure	Structure
G.H4	339	Y	G.H4.08	Structure	Structure
G.H4	340	F	G.H4.10	Structure	Structure
G.H4	341	I	G.H4.11	Structure	Structure
G.H4	342	R	G.H4.12	Structure	Structure
G.H4	343	D	G.H4.13	Structure	AF2
G.H4	344	E	G.H4.14	Structure	AF2
G.H4	345	F	G.H4.15	Structure	Structure
G.H4	346	L	G.H4.16	Structure	Structure
G.H4	347	R	G.H4.17	Structure	Structure
G.h4s6	348	I	G.h4s6.01	Structure	Structure
G.h4s6	349	S	G.h4s6.02	Structure	Structure
G.h4s6	350	T	G.h4s6.03	Structure	Structure
G.h4s6	351	A	G.h4s6.04	Structure	Structure
G.h4s6	352	S	G.h4s6.08	Structure	Structure
G.h4s6	353	G	G.h4s6.09	AF2	AF2
G.h4s6	354	D	G.h4s6.10	AF2	AF2
G.h4s6	355	G	G.h4s6.11	AF2	AF2
G.h4s6	356	R	G.h4s6.12	Structure	Structure
G.h4s6	357	H	G.h4s6.13	Structure	Structure
G.h4s6	358	Y	G.h4s6.20	Structure	Structure
G.S6	359	C	G.S6.01	Structure	Structure
G.S6	360	Y	G.S6.02	Structure	Structure
G.S6	361	P	G.S6.03	Structure	Structure
G.S6	362	H	G.S6.04	Structure	Structure
G.S6	363	F	G.S6.05	Structure	Structure
G.s6h5	364	T	G.s6h5.01	Structure	Structure
G.s6h5	365	C	G.s6h5.02	Structure	Structure
G.s6h5	366	A	G.s6h5.03	Structure	Structure
G.s6h5	367	V	G.s6h5.04	Structure	Structure
G.s6h5	368	D	G.s6h5.05	Structure	AF2
G.H5	369	T	G.H5.01	Structure	Structure
G.H5	370	E	G.H5.02	Structure	AF2
G.H5	371	N	G.H5.03	Structure	Structure
G.H5	372	I	G.H5.04	Structure	Structure
G.H5	373	R	G.H5.05	Structure	Structure
G.H5	374	R	G.H5.06	Structure	Structure
G.H5	375	V	G.H5.07	Structure	Structure
G.H5	376	F	G.H5.08	Structure	AF2
G.H5	377	N	G.H5.09	Structure	Structure
G.H5	378	D	G.H5.10	Structure	AF2
G.H5	379	C	G.H5.11	Structure	Structure
G.H5	380	R	G.H5.12	Structure	AF2
G.H5	381	D	G.H5.13	Structure	AF2
G.H5	382	I	G.H5.14	Structure	Structure
G.H5	383	I	G.H5.15	Structure	Structure
G.H5	384	Q	G.H5.16	Structure	AF2
G.H5	385	R	G.H5.17	Structure	Structure
G.H5	386	M	G.H5.18	Structure	Structure
G.H5	387	H	G.H5.19	Structure	Structure
G.H5	388	L	G.H5.20	Structure	AF2
G.H5	389	R	G.H5.21	Structure	AF2
G.H5	390	Q	G.H5.22	Structure	AF2
G.H5	391	Y	G.H5.23	Structure	AF2
G.H5	392	E	G.H5.24	Structure	AF2
G.H5	393	L	G.H5.25	Structure	AF2
G.H5	394	L	G.H5.26	Structure	Structure

REFINED GPCR RESIDUES

Residue backbones - 202 from structure (59.2%), 139 from model (40.8%)
Residue sidechains - 90 from structure (26.4%), 251 from model (73.6%)

Showing 1 to 341 of 341 entries

Search:

Segment	Seq.num.	AA	GPCRdb#	Backbone from	Sidechain from

N-term	1	M	-	AF2	AF2
N-term	2	G	-	AF2	AF2
N-term	3	Q	-	AF2	AF2
N-term	4	P	-	AF2	AF2
N-term	5	G	-	AF2	AF2
N-term	6	N	-	AF2	AF2
N-term	7	G	-	AF2	AF2
N-term	8	S	-	AF2	AF2
N-term	9	A	-	AF2	AF2
N-term	10	F	-	AF2	AF2
N-term	11	L	-	AF2	AF2
N-term	12	L	-	AF2	AF2
N-term	13	A	-	AF2	AF2
N-term	14	P	-	AF2	AF2
N-term	15	N	-	AF2	AF2
N-term	16	G	-	AF2	AF2
N-term	17	S	-	AF2	AF2
N-term	18	H	-	AF2	AF2
N-term	19	A	-	AF2	AF2
N-term	20	P	-	AF2	AF2
N-term	21	D	-	AF2	AF2
N-term	22	H	-	AF2	AF2
N-term	23	D	-	AF2	AF2
N-term	24	V	-	AF2	AF2
N-term	25	T	-	AF2	AF2
TM1	26	Q	1.25x25	AF2	AF2
TM1	27	E	1.26x26	AF2	AF2
TM1	28	R	1.27x27	AF2	AF2
TM1	29	D	1.28x28	AF2	AF2
TM1	30	E	1.29x29	AF2	AF2
TM1	31	V	1.30x30	AF2	AF2
TM1	32	W	1.31x31	AF2	AF2
TM1	33	V	1.32x32	AF2	AF2
TM1	34	V	1.33x33	AF2	AF2
TM1	35	G	1.34x34	Structure	Structure
TM1	36	M	1.35x35	Structure	AF2
TM1	37	G	1.36x36	Structure	Structure
TM1	38	I	1.37x37	Structure	AF2
TM1	39	V	1.38x38	Structure	AF2
TM1	40	M	1.39x39	Structure	AF2
TM1	41	S	1.40x40	Structure	Structure
TM1	42	L	1.41x41	Structure	AF2
TM1	43	I	1.42x42	Structure	AF2
TM1	44	V	1.43x43	Structure	Structure
TM1	45	L	1.44x44	Structure	AF2
TM1	46	A	1.45x45	Structure	Structure
TM1	47	I	1.46x46	Structure	AF2
TM1	48	V	1.47x47	Structure	AF2
TM1	49	F	1.48x48	Structure	AF2
TM1	50	G	1.49x49	Structure	Structure
TM1	51	N	1.50x50	Structure	AF2
TM1	52	V	1.51x51	Structure	AF2
TM1	53	L	1.52x52	Structure	AF2
TM1	54	V	1.53x53	Structure	AF2
TM1	55	I	1.54x54	Structure	AF2
TM1	56	T	1.55x55	AF2	AF2
TM1	57	A	1.56x56	AF2	AF2
TM1	58	I	1.57x57	AF2	AF2
TM1	59	A	1.58x58	AF2	AF2
TM1	60	K	1.59x59	AF2	AF2
TM1	61	F	1.60x60	AF2	AF2
ICL1	62	E	12.48x48	AF2	AF2
ICL1	63	R	12.49x49	AF2	AF2
ICL1	64	L	12.50x50	AF2	AF2
ICL1	65	Q	12.51x51	Structure	Structure
TM2	66	T	2.37x37	Structure	AF2
TM2	67	V	2.38x38	Structure	AF2
TM2	68	T	2.39x39	Structure	AF2
TM2	69	N	2.40x40	Structure	AF2
TM2	70	Y	2.41x41	Structure	AF2
TM2	71	F	2.42x42	Structure	Structure
TM2	72	I	2.43x43	Structure	AF2
TM2	73	T	2.44x44	Structure	AF2
TM2	74	S	2.45x45	Structure	Structure
TM2	75	L	2.46x46	Structure	AF2
TM2	76	A	2.47x47	Structure	Structure
TM2	77	C	2.48x48	Structure	Structure
TM2	78	A	2.49x49	Structure	Structure
TM2	79	D	2.50x50	AF2	AF2
TM2	80	L	2.51x51	AF2	AF2
TM2	81	V	2.52x52	AF2	AF2
TM2	82	M	2.53x53	AF2	AF2
TM2	83	G	2.54x54	AF2	AF2
TM2	84	L	2.55x55	AF2	AF2
TM2	85	A	2.56x551	AF2	AF2
TM2	86	V	2.57x56	AF2	AF2
TM2	87	V	2.58x57	Structure	AF2
TM2	88	P	2.59x58	Structure	Structure
TM2	89	F	2.60x59	Structure	AF2
TM2	90	G	2.61x60	Structure	Structure
TM2	91	A	2.62x61	Structure	Structure
TM2	92	A	2.63x62	Structure	Structure
TM2	93	H	2.64x63	Structure	Structure
TM2	94	I	2.65x64	Structure	Structure
TM2	95	L	2.66x65	AF2	AF2
TM2	96	M	2.67x66	AF2	AF2
TM2	97	K	2.68x67	AF2	AF2
ECL1	98	M	23.49x49	AF2	AF2
ECL1	99	W	23.50x50	Structure	Structure
ECL1	100	T	23.51x51	Structure	Structure
ECL1	101	F	23.52x52	Structure	Structure
TM3	102	G	3.21x21	Structure	Structure
TM3	103	N	3.22x22	Structure	AF2
TM3	104	F	3.23x23	Structure	AF2
TM3	105	W	3.24x24	Structure	AF2
TM3	106	C	3.25x25	Structure	Structure
TM3	107	E	3.26x26	Structure	AF2
TM3	108	F	3.27x27	Structure	AF2
TM3	109	W	3.28x28	Structure	AF2
TM3	110	T	3.29x29	Structure	AF2
TM3	111	S	3.30x30	Structure	Structure
TM3	112	I	3.31x31	Structure	AF2
TM3	113	D	3.32x32	Structure	AF2
TM3	114	V	3.33x33	Structure	AF2
TM3	115	L	3.34x34	Structure	AF2
TM3	116	C	3.35x35	Structure	Structure
TM3	117	V	3.36x36	Structure	AF2
TM3	118	T	3.37x37	Structure	Structure
TM3	119	A	3.38x38	Structure	Structure
TM3	120	S	3.39x39	Structure	Structure
TM3	121	I	3.40x40	Structure	AF2
TM3	122	E	3.41x41	Structure	AF2
TM3	123	T	3.42x42	Structure	AF2
TM3	124	L	3.43x43	Structure	Structure
TM3	125	C	3.44x44	Structure	Structure
TM3	126	V	3.45x45	Structure	AF2
TM3	127	I	3.46x46	Structure	Structure
TM3	128	A	3.47x47	Structure	Structure
TM3	129	V	3.48x48	Structure	AF2
TM3	130	D	3.49x49	Structure	AF2
TM3	131	R	3.50x50	Structure	AF2
TM3	132	Y	3.51x51	Structure	AF2
TM3	133	F	3.52x52	Structure	Structure
TM3	134	A	3.53x53	Structure	Structure
TM3	135	I	3.54x54	Structure	AF2
TM3	136	T	3.55x55	Structure	AF2
TM3	137	S	3.56x56	Structure	Structure
ICL2	138	P	34.50x50	Structure	Structure
ICL2	139	F	34.51x51	Structure	Structure
ICL2	140	K	34.52x52	Structure	Structure
ICL2	141	Y	34.53x53	Structure	Structure
ICL2	142	Q	34.54x54	AF2	AF2
ICL2	143	S	34.55x55	AF2	AF2
ICL2	144	L	34.56x56	AF2	AF2
ICL2	145	L	34.57x57	AF2	AF2
TM4	146	T	4.38x38	AF2	AF2
TM4	147	K	4.39x39	AF2	AF2
TM4	148	N	4.40x40	AF2	AF2
TM4	149	K	4.41x41	AF2	AF2
TM4	150	A	4.42x42	AF2	AF2
TM4	151	R	4.43x43	AF2	AF2
TM4	152	V	4.44x44	AF2	AF2
TM4	153	I	4.45x45	AF2	AF2
TM4	154	I	4.46x46	AF2	AF2
TM4	155	L	4.47x47	AF2	AF2
TM4	156	M	4.48x48	Structure	AF2
TM4	157	V	4.49x49	Structure	AF2
TM4	158	W	4.50x50	Structure	Structure
TM4	159	I	4.51x51	Structure	AF2
TM4	160	V	4.52x52	Structure	AF2
TM4	161	S	4.53x53	Structure	Structure
TM4	162	G	4.54x54	Structure	Structure
TM4	163	L	4.55x55	Structure	AF2
TM4	164	T	4.56x56	Structure	AF2
TM4	165	S	4.57x57	Structure	Structure
TM4	166	F	4.58x58	Structure	AF2
TM4	167	L	4.59x59	Structure	AF2
TM4	168	P	4.60x60	Structure	Structure
TM4	169	I	4.61x61	Structure	AF2
TM4	170	Q	4.62x62	Structure	AF2
TM4	171	M	4.63x63	Structure	AF2
TM4	172	H	4.64x64	Structure	Structure
ECL2	173	W	-	Structure	Structure
ECL2	174	Y	-	Structure	Structure
ECL2	175	R	-	Structure	Structure
ECL2	176	A	-	AF2	AF2
ECL2	177	T	-	AF2	AF2
ECL2	178	H	-	Structure	AF2
ECL2	179	Q	-	Structure	AF2
ECL2	180	E	-	Structure	AF2
ECL2	181	A	-	Structure	Structure
ECL2	182	I	-	Structure	Structure
ECL2	183	N	-	Structure	AF2
ECL2	184	C	-	Structure	Structure
ECL2	185	Y	-	Structure	Structure
ECL2	186	A	-	Structure	Structure
ECL2	187	N	-	Structure	AF2
ECL2	188	E	-	Structure	AF2
ECL2	189	T	-	AF2	AF2
ECL2	190	C	-	AF2	AF2
ECL2	191	C	45.50x50	Structure	Structure
ECL2	192	D	45.51x51	Structure	AF2
ECL2	193	F	45.52x52	Structure	Structure
ECL2	194	F	-	Structure	Structure
ECL2	195	T	-	Structure	Structure
TM5	196	N	5.35x36	AF2	AF2
TM5	197	Q	5.36x37	AF2	AF2
TM5	198	A	5.37x38	AF2	AF2
TM5	199	Y	5.38x39	AF2	AF2
TM5	200	A	5.39x40	Structure	Structure
TM5	201	I	5.40x41	Structure	AF2
TM5	202	A	5.41x42	Structure	Structure
TM5	203	S	5.42x43	Structure	Structure
TM5	204	S	5.43x44	Structure	Structure
TM5	205	I	5.44x45	Structure	AF2
TM5	206	V	5.45x46	Structure	AF2
TM5	207	S	5.46x461	Structure	Structure
TM5	208	F	5.47x47	Structure	AF2
TM5	209	Y	5.48x48	Structure	AF2
TM5	210	V	5.49x49	Structure	AF2
TM5	211	P	5.50x50	Structure	Structure
TM5	212	L	5.51x51	Structure	AF2
TM5	213	V	5.52x52	Structure	AF2
TM5	214	I	5.53x53	Structure	AF2
TM5	215	M	5.54x54	Structure	Structure
TM5	216	V	5.55x55	Structure	Structure
TM5	217	F	5.56x56	Structure	AF2
TM5	218	V	5.57x57	Structure	Structure
TM5	219	Y	5.58x58	Structure	Structure
TM5	220	S	5.59x59	Structure	Structure
TM5	221	R	5.60x60	Structure	AF2
TM5	222	V	5.61x61	Structure	AF2
TM5	223	F	5.62x62	Structure	Structure
TM5	224	Q	5.63x63	Structure	AF2
TM5	225	E	5.64x64	Structure	AF2
TM5	226	A	5.65x65	Structure	Structure
TM5	227	K	5.66x66	Structure	AF2
TM5	228	R	5.67x67	Structure	AF2
TM5	229	Q	5.68x68	Structure	Structure
TM5	230	L	5.69x69	AF2	AF2
TM5	231	Q	5.70x70	AF2	AF2
TM5	232	K	5.71x71	AF2	AF2
TM5	233	I	5.72x72	AF2	AF2
TM5	234	D	5.73x73	AF2	AF2
TM5	235	K	5.74x74	AF2	AF2
TM5	236	S	5.75x75	AF2	AF2
TM5	237	E	5.76x76	AF2	AF2
ICL3	238	G	-	AF2	AF2
ICL3	239	R	-	AF2	AF2
ICL3	240	F	-	AF2	AF2
ICL3	241	H	-	AF2	AF2
ICL3	242	V	-	AF2	AF2
ICL3	243	Q	-	AF2	AF2
ICL3	244	N	-	AF2	AF2
ICL3	255	G	-	AF2	AF2
ICL3	256	H	-	AF2	AF2
ICL3	257	G	-	AF2	AF2
ICL3	258	L	-	AF2	AF2
ICL3	259	R	-	AF2	AF2
ICL3	260	R	-	AF2	AF2
ICL3	261	S	-	AF2	AF2
TM6	262	S	6.24x24	AF2	AF2
TM6	263	K	6.25x25	AF2	AF2
TM6	264	F	6.26x26	AF2	AF2
TM6	265	C	6.27x27	AF2	AF2
TM6	266	L	6.28x28	AF2	AF2
TM6	267	K	6.29x29	AF2	AF2
TM6	268	E	6.30x30	AF2	AF2
TM6	269	H	6.31x31	Structure	AF2
TM6	270	K	6.32x32	Structure	Structure
TM6	271	A	6.33x33	Structure	Structure
TM6	272	L	6.34x34	Structure	AF2
TM6	273	K	6.35x35	Structure	AF2
TM6	274	T	6.36x36	Structure	Structure
TM6	275	L	6.37x37	Structure	AF2
TM6	276	G	6.38x38	Structure	Structure
TM6	277	I	6.39x39	Structure	AF2
TM6	278	I	6.40x40	Structure	AF2
TM6	279	M	6.41x41	Structure	Structure
TM6	280	G	6.42x42	Structure	Structure
TM6	281	T	6.43x43	Structure	AF2
TM6	282	F	6.44x44	Structure	AF2
TM6	283	T	6.45x45	Structure	AF2
TM6	284	L	6.46x46	Structure	AF2
TM6	285	C	6.47x47	Structure	Structure
TM6	286	W	6.48x48	Structure	Structure
TM6	287	L	6.49x49	Structure	AF2
TM6	288	P	6.50x50	Structure	Structure
TM6	289	F	6.51x51	Structure	Structure
TM6	290	F	6.52x52	Structure	AF2
TM6	291	I	6.53x53	Structure	AF2
TM6	292	V	6.54x54	Structure	AF2
TM6	293	N	6.55x55	Structure	AF2
TM6	294	I	6.56x56	Structure	AF2
TM6	295	V	6.57x57	Structure	AF2
TM6	296	H	6.58x58	Structure	Structure
TM6	297	V	6.59x59	AF2	AF2
TM6	298	I	6.60x60	AF2	AF2
TM6	299	Q	6.61x61	AF2	AF2
ECL3	300	D	-	AF2	AF2
ECL3	301	N	-	Structure	Structure
ECL3	302	L	-	Structure	Structure
ECL3	303	I	-	Structure	Structure
TM7	304	R	7.31x30	Structure	AF2
TM7	305	K	7.32x31	Structure	AF2
TM7	306	E	7.33x32	Structure	AF2
TM7	307	V	7.34x33	Structure	AF2
TM7	308	Y	7.35x34	Structure	Structure
TM7	309	I	7.36x35	Structure	AF2
TM7	310	L	7.37x36	Structure	AF2
TM7	311	L	7.38x37	Structure	AF2
TM7	312	N	7.39x38	Structure	AF2
TM7	313	W	7.40x39	Structure	AF2
TM7	314	I	7.41x40	Structure	AF2
TM7	315	G	7.42x41	Structure	Structure
TM7	316	Y	7.43x42	Structure	AF2
TM7	317	V	7.44x43	Structure	AF2
TM7	318	N	7.45x45	Structure	Structure
TM7	319	S	7.46x46	Structure	Structure
TM7	320	G	7.47x47	Structure	Structure
TM7	321	F	7.48x48	Structure	AF2
TM7	322	N	7.49x49	Structure	AF2
TM7	323	P	7.50x50	AF2	AF2
TM7	324	L	7.51x51	AF2	AF2
TM7	325	I	7.52x52	AF2	AF2
TM7	326	Y	7.53x53	AF2	AF2
TM7	327	C	7.54x54	AF2	AF2
TM7	328	R	7.55x55	AF2	AF2
H8	329	S	8.47x47	AF2	AF2
H8	330	P	8.48x48	AF2	AF2
H8	331	D	8.49x49	AF2	AF2
H8	332	F	8.50x50	AF2	AF2
H8	333	R	8.51x51	AF2	AF2
H8	334	I	8.52x52	AF2	AF2
H8	335	A	8.53x53	AF2	AF2
H8	336	F	8.54x54	AF2	AF2
H8	337	Q	8.55x55	AF2	AF2
H8	338	E	8.56x56	AF2	AF2
H8	339	L	8.57x57	AF2	AF2
H8	340	L	8.58x58	AF2	AF2
H8	341	C	8.59x59	AF2	AF2
C-term	342	L	-	AF2	AF2
C-term	343	R	-	AF2	AF2
C-term	344	R	-	AF2	AF2
C-term	345	S	-	AF2	AF2
C-term	346	S	-	AF2	AF2
C-term	347	L	-	AF2	AF2
C-term	348	K	-	AF2	AF2
C-term	349	A	-	AF2	AF2
C-term	350	Y	-	AF2	AF2
C-term	351	G	-	AF2	AF2

GPCR - G protein interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Aromatic	ICL2	F	139	34x51	G.H5	R	380	G.H5.12
Hydrophobic	TM3	T	136	3x55	G.H5	R	389	G.H5.21
Hydrophobic	ICL3	R	239	-	G.hgh4	D	323	G.hgh4.13
Hydrophobic	TM3	S	137	3x56	G.H5	R	389	G.H5.21
Hydrophobic	TM6	T	274	6x36	G.H5	L	394	G.H5.26
Hydrophobic	TM3	I	135	3x54	G.H5	E	392	G.H5.24
Hydrophobic	TM5	Q	229	5x68	G.H5	I	382	G.H5.14
Hydrophobic	TM5	V	222	5x61	G.H5	Q	390	G.H5.22
Hydrophobic	TM3	I	135	3x54	G.H5	Q	390	G.H5.22
Hydrophobic	TM6	K	270	6x32	G.H5	L	394	G.H5.26
Hydrophobic	ICL3	R	239	-	G.hgh4	P	321	G.hgh4.11
Hydrophobic	TM5	Q	229	5x68	G.H5	H	387	G.H5.19
Hydrophobic	TM6	A	271	6x33	G.H5	L	394	G.H5.26
Hydrophobic	ICL2	F	139	34x51	G.s2s3	K	216	G.s2s3.02
Hydrophobic	TM3	I	135	3x54	G.H5	R	389	G.H5.21
Hydrophobic	ICL2	F	139	34x51	G.H5	R	385	G.H5.17
Hydrophobic	TM5	Q	229	5x68	G.H5	M	386	G.H5.18
Hydrophobic	ICL2	P	138	34x50	G.H5	R	389	G.H5.21
Hydrophobic	ICL2	F	139	34x51	G.H5	R	380	G.H5.12
Hydrophobic	TM3	A	134	3x53	G.H5	R	389	G.H5.21
Ionic	ICL3	R	239	-	G.hgh4	D	323	G.hgh4.13
Polar	TM3	T	136	3x55	G.H5	R	389	G.H5.21
Polar	ICL3	R	239	-	G.hgh4	D	323	G.hgh4.13
Polar	TM3	S	137	3x56	G.H5	R	389	G.H5.21
Polar	TM6	T	274	6x36	G.H5	L	394	G.H5.26
Polar	TM6	A	271	6x33	G.H5	L	394	G.H5.26
Polar	TM3	I	135	3x54	G.H5	R	389	G.H5.21
Polar	TM6	T	274	6x36	G.H5	L	393	G.H5.25
Polar	TM5	Q	229	5x68	G.H5	M	386	G.H5.18
Polar	TM3	A	134	3x53	G.H5	R	389	G.H5.21
Van-der-waals	TM3	T	136	3x55	G.H5	R	389	G.H5.21
Van-der-waals	ICL3	R	239	-	G.hgh4	D	323	G.hgh4.13
Van-der-waals	TM3	S	137	3x56	G.H5	R	389	G.H5.21
Van-der-waals	TM6	T	274	6x36	G.H5	L	394	G.H5.26
Van-der-waals	TM3	I	135	3x54	G.H5	E	392	G.H5.24
Van-der-waals	TM5	Q	229	5x68	G.H5	I	382	G.H5.14
Van-der-waals	TM6	K	270	6x32	G.H5	L	394	G.H5.26
Van-der-waals	TM5	Q	229	5x68	G.H5	H	387	G.H5.19
Van-der-waals	TM3	R	131	3x50	G.H5	E	392	G.H5.24
Van-der-waals	TM6	A	271	6x33	G.H5	L	394	G.H5.26
Van-der-waals	ICL2	F	139	34x51	G.s2s3	K	216	G.s2s3.02
Van-der-waals	TM3	I	135	3x54	G.H5	R	389	G.H5.21
Van-der-waals	ICL2	F	139	34x51	G.H5	R	385	G.H5.17
Van-der-waals	TM5	Q	229	5x68	G.H5	M	386	G.H5.18
Van-der-waals	ICL2	P	138	34x50	G.H5	R	389	G.H5.21
Van-der-waals	ICL2	F	139	34x51	G.H5	R	380	G.H5.12
Van-der-waals	TM3	A	134	3x53	G.H5	R	389	G.H5.21

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Refined structure (8GGF) of Gs - β2-adrenoceptor Download Full

GPCR CLASS (FAMILY)

SPECIES

G PROTEIN FAMILY

DATE

3D VIEW

REFINED G PROTEIN RESIDUES

REFINED GPCR RESIDUES

GPCR - G protein interface interactions

Structures

Refined structure (8GGF) of G_s - β₂-adrenoceptor

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