Refined structure (8GHV) of Gi1 - CB1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 218 from structure (61.6%), 136 from model (38.4%)
Residue sidechains - 191 from structure (54.0%), 163 from model (46.0%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 Structure Structure
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure AF2
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure AF2
G.HN 25 E G.HN.49 Structure AF2
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure AF2
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure AF2
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure AF2
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure AF2
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure Structure
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure AF2
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure AF2
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 AF2 AF2
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure AF2
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure AF2
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure AF2
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure AF2
G.HG 276 E G.HG.06 Structure AF2
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure AF2
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure AF2
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure AF2
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure AF2
G.H4 298 E G.H4.05 Structure AF2
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure AF2
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure AF2
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure AF2
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure AF2
G.H5 350 D G.H5.22 Structure AF2
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 280 from structure (67.0%), 138 from model (33.0%)
Residue sidechains - 251 from structure (60.0%), 167 from model (40.0%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 K - AF2 AF2
N-term 3 S - AF2 AF2
N-term 4 I - AF2 AF2
N-term 5 L - AF2 AF2
N-term 6 D - AF2 AF2
N-term 7 G - AF2 AF2
N-term 8 L - AF2 AF2
N-term 9 A - AF2 AF2
N-term 10 D - AF2 AF2
N-term 11 T - AF2 AF2
N-term 12 T - AF2 AF2
N-term 13 F - AF2 AF2
N-term 14 R - AF2 AF2
N-term 15 T - AF2 AF2
N-term 16 I - AF2 AF2
N-term 17 T - AF2 AF2
N-term 18 T - AF2 AF2
N-term 19 D - AF2 AF2
N-term 20 L - AF2 AF2
N-term 21 L - AF2 AF2
N-term 22 Y - AF2 AF2
N-term 23 V - AF2 AF2
N-term 24 G - AF2 AF2
N-term 25 S - AF2 AF2
N-term 26 N - AF2 AF2
N-term 27 D - AF2 AF2
N-term 28 I - AF2 AF2
N-term 29 Q - AF2 AF2
N-term 30 Y - AF2 AF2
N-term 31 E - AF2 AF2
N-term 32 D - AF2 AF2
N-term 33 I - AF2 AF2
N-term 34 K - AF2 AF2
N-term 35 G - AF2 AF2
N-term 36 D - AF2 AF2
N-term 37 M - AF2 AF2
N-term 38 A - AF2 AF2
N-term 39 S - AF2 AF2
N-term 40 K - AF2 AF2
N-term 41 L - AF2 AF2
N-term 42 G - AF2 AF2
N-term 43 Y - AF2 AF2
N-term 44 F - AF2 AF2
N-term 45 P - AF2 AF2
N-term 46 Q - AF2 AF2
N-term 47 K - AF2 AF2
N-term 48 F - AF2 AF2
N-term 49 P - AF2 AF2
N-term 50 L - AF2 AF2
N-term 51 T - AF2 AF2
N-term 52 S - AF2 AF2
N-term 53 F - AF2 AF2
N-term 54 R - AF2 AF2
N-term 55 G - AF2 AF2
N-term 56 S - AF2 AF2
N-term 57 P - AF2 AF2
N-term 58 F - AF2 AF2
N-term 59 Q - AF2 AF2
N-term 60 E - AF2 AF2
N-term 61 K - AF2 AF2
N-term 62 M - AF2 AF2
N-term 63 T - AF2 AF2
N-term 64 A - AF2 AF2
N-term 65 G - AF2 AF2
N-term 66 D - AF2 AF2
N-term 67 N - AF2 AF2
N-term 68 P - AF2 AF2
N-term 69 Q - AF2 AF2
N-term 70 L - AF2 AF2
N-term 71 V - AF2 AF2
N-term 72 P - AF2 AF2
N-term 73 A - AF2 AF2
N-term 74 D - AF2 AF2
N-term 75 Q - AF2 AF2
N-term 76 V - AF2 AF2
N-term 77 N - AF2 AF2
N-term 78 I - AF2 AF2
N-term 79 T - AF2 AF2
N-term 80 E - AF2 AF2
N-term 81 F - AF2 AF2
N-term 82 Y - AF2 AF2
N-term 83 N - AF2 AF2
N-term 84 K - AF2 AF2
N-term 85 S - AF2 AF2
N-term 86 L - AF2 AF2
N-term 87 S - AF2 AF2
N-term 88 S - AF2 AF2
N-term 89 F - AF2 AF2
N-term 90 K - AF2 AF2
N-term 91 E - AF2 AF2
N-term 92 N - AF2 AF2
N-term 93 E - AF2 AF2
N-term 94 E - AF2 AF2
N-term 95 N - AF2 AF2
N-term 96 I - AF2 AF2
N-term 97 Q - AF2 AF2
N-term 98 C - AF2 AF2
N-term 99 G - AF2 AF2
N-term 100 E - AF2 AF2
N-term 101 N - AF2 AF2
N-term 102 F - AF2 AF2
N-term 103 M - AF2 AF2
N-term 104 D - Structure Structure
N-term 105 I - Structure Structure
N-term 106 E - Structure AF2
N-term 107 C - Structure Structure
N-term 108 F - Structure Structure
N-term 109 M - Structure Structure
N-term 110 V - Structure Structure
N-term 111 L - Structure Structure
TM1 112 N 1.28x28 Structure Structure
TM1 113 P 1.29x29 Structure Structure
TM1 114 S 1.30x30 Structure Structure
TM1 115 Q 1.31x31 Structure AF2
TM1 116 Q 1.32x32 Structure AF2
TM1 117 L 1.33x33 Structure Structure
TM1 118 A 1.34x34 Structure Structure
TM1 119 I 1.35x35 Structure Structure
TM1 120 A 1.36x36 Structure Structure
TM1 121 V 1.37x37 Structure Structure
TM1 122 L 1.38x38 Structure Structure
TM1 123 S 1.39x39 Structure Structure
TM1 124 L 1.40x40 Structure Structure
TM1 125 T 1.41x41 Structure Structure
TM1 126 L 1.42x42 Structure Structure
TM1 127 G 1.43x43 Structure Structure
TM1 128 T 1.44x44 Structure Structure
TM1 129 F 1.45x45 Structure Structure
TM1 130 T 1.46x46 Structure Structure
TM1 131 V 1.47x47 Structure Structure
TM1 132 L 1.48x48 Structure Structure
TM1 133 E 1.49x49 Structure Structure
TM1 134 N 1.50x50 Structure Structure
TM1 135 L 1.51x51 Structure Structure
TM1 136 L 1.52x52 Structure Structure
TM1 137 V 1.53x53 Structure Structure
TM1 138 L 1.54x54 Structure Structure
TM1 139 C 1.55x55 Structure Structure
TM1 140 V 1.56x56 Structure Structure
TM1 141 I 1.57x57 Structure Structure
TM1 142 L 1.58x58 Structure Structure
TM1 143 H 1.59x59 Structure AF2
TM1 144 S 1.60x60 Structure Structure
ICL1 145 R 12.48x48 Structure AF2
ICL1 146 S 12.49x49 Structure Structure
ICL1 147 L 12.50x50 Structure Structure
ICL1 148 R 12.51x51 Structure AF2
ICL1 149 C - Structure Structure
TM2 150 R 2.37x37 Structure AF2
TM2 151 P 2.38x38 Structure Structure
TM2 152 S 2.39x39 Structure Structure
TM2 153 Y 2.40x40 Structure Structure
TM2 154 H 2.41x41 Structure Structure
TM2 155 F 2.42x42 Structure Structure
TM2 156 I 2.43x43 Structure Structure
TM2 157 G 2.44x44 Structure Structure
TM2 158 S 2.45x45 Structure Structure
TM2 159 L 2.46x46 Structure Structure
TM2 160 A 2.47x47 Structure Structure
TM2 161 V 2.48x48 Structure Structure
TM2 162 A 2.49x49 Structure Structure
TM2 163 D 2.50x50 Structure Structure
TM2 164 L 2.51x51 Structure Structure
TM2 165 L 2.52x52 Structure Structure
TM2 166 G 2.53x53 Structure Structure
TM2 167 S 2.54x54 Structure Structure
TM2 168 V 2.55x55 Structure Structure
TM2 169 I 2.56x56 Structure Structure
TM2 170 F 2.57x57 Structure Structure
TM2 171 V 2.58x58 Structure Structure
TM2 172 Y 2.59x59 Structure Structure
TM2 173 S 2.60x60 Structure Structure
TM2 174 F 2.61x61 Structure Structure
TM2 175 I 2.62x62 Structure Structure
TM2 176 D 2.63x63 Structure Structure
TM2 177 F 2.64x64 Structure Structure
TM2 178 H 2.65x65 Structure Structure
TM2 179 V 2.66x66 Structure Structure
ECL1 180 F - Structure AF2
ECL1 181 H - Structure Structure
ECL1 182 R - Structure AF2
ECL1 183 K - Structure AF2
ECL1 184 D - Structure Structure
TM3 185 S 3.21x21 Structure Structure
TM3 186 R 3.22x22 Structure AF2
TM3 187 N 3.23x23 Structure Structure
TM3 188 V 3.24x24 Structure Structure
TM3 189 F 3.25x25 Structure Structure
TM3 190 L 3.26x26 Structure Structure
TM3 191 F 3.27x27 Structure Structure
TM3 192 K 3.28x28 Structure Structure
TM3 193 L 3.29x29 Structure Structure
TM3 194 G 3.30x30 Structure Structure
TM3 195 G 3.31x31 Structure Structure
TM3 196 V 3.32x32 Structure Structure
TM3 197 T 3.33x33 Structure Structure
TM3 198 A 3.34x34 Structure Structure
TM3 199 S 3.35x35 Structure Structure
TM3 200 F 3.36x36 Structure Structure
TM3 201 T 3.37x37 Structure Structure
TM3 202 A 3.38x38 Structure Structure
TM3 203 S 3.39x39 Structure Structure
TM3 204 V 3.40x40 Structure Structure
TM3 205 G 3.41x41 Structure Structure
TM3 206 S 3.42x42 Structure Structure
TM3 207 L 3.43x43 Structure Structure
TM3 208 F 3.44x44 Structure Structure
TM3 209 L 3.45x45 Structure Structure
TM3 210 T 3.46x46 Structure Structure
TM3 211 A 3.47x47 Structure Structure
TM3 212 I 3.48x48 Structure Structure
TM3 213 D 3.49x49 Structure Structure
TM3 214 R 3.50x50 Structure Structure
TM3 215 Y 3.51x51 Structure Structure
TM3 216 I 3.52x52 Structure Structure
TM3 217 S 3.53x53 Structure Structure
TM3 218 I 3.54x54 Structure Structure
TM3 219 H 3.55x55 Structure Structure
TM3 220 R 3.56x56 Structure AF2
ICL2 221 P 34.50x50 Structure Structure
ICL2 222 L 34.51x51 Structure Structure
ICL2 223 A 34.52x52 Structure Structure
ICL2 224 Y 34.53x53 Structure Structure
ICL2 225 K 34.54x54 Structure AF2
ICL2 226 R 34.55x55 Structure AF2
ICL2 227 I 34.56x56 Structure Structure
ICL2 228 V 34.57x57 Structure Structure
TM4 229 T 4.38x38 Structure Structure
TM4 230 R 4.39x39 Structure AF2
TM4 231 P 4.40x40 Structure Structure
TM4 232 K 4.41x41 Structure AF2
TM4 233 A 4.42x42 Structure Structure
TM4 234 V 4.43x43 Structure Structure
TM4 235 V 4.44x44 Structure Structure
TM4 236 A 4.45x45 Structure Structure
TM4 237 F 4.46x46 Structure Structure
TM4 238 C 4.47x47 Structure Structure
TM4 239 L 4.48x48 Structure Structure
TM4 240 M 4.49x49 Structure Structure
TM4 241 W 4.50x50 Structure Structure
TM4 242 T 4.51x51 Structure Structure
TM4 243 I 4.52x52 Structure Structure
TM4 244 A 4.53x53 Structure Structure
TM4 245 I 4.54x54 Structure Structure
TM4 246 V 4.55x55 Structure Structure
TM4 247 I 4.56x56 Structure Structure
TM4 248 A 4.57x57 Structure Structure
TM4 249 V 4.58x58 Structure Structure
TM4 250 L 4.59x59 Structure Structure
TM4 251 P 4.60x60 Structure Structure
TM4 252 L 4.61x61 Structure Structure
TM4 253 L 4.62x62 Structure Structure
TM4 254 G 4.63x63 Structure Structure
ECL2 255 W - Structure AF2
ECL2 256 N - Structure Structure
ECL2 257 C - Structure Structure
ECL2 258 E - Structure AF2
ECL2 259 K - Structure AF2
ECL2 260 L - Structure Structure
ECL2 261 Q - Structure AF2
ECL2 262 S - Structure Structure
ECL2 263 V - Structure Structure
ECL2 264 C - Structure Structure
ECL2 265 S - Structure Structure
ECL2 266 D - Structure Structure
ECL2 267 I - Structure Structure
ECL2 268 F - Structure Structure
ECL2 269 P - Structure Structure
ECL2 270 H - Structure Structure
ECL2 271 I - Structure Structure
TM5 272 D 5.36x36 Structure Structure
TM5 273 E 5.37x37 Structure Structure
TM5 274 T 5.38x38 Structure Structure
TM5 275 Y 5.39x39 Structure Structure
TM5 276 L 5.40x40 Structure Structure
TM5 277 M 5.41x41 Structure Structure
TM5 278 F 5.42x42 Structure Structure
TM5 279 W 5.43x43 Structure Structure
TM5 280 I 5.44x44 Structure Structure
TM5 281 G 5.45x45 Structure Structure
TM5 282 V 5.46x46 Structure Structure
TM5 283 T 5.47x47 Structure Structure
TM5 284 S 5.48x48 Structure Structure
TM5 285 V 5.49x49 Structure Structure
TM5 286 L 5.50x50 Structure Structure
TM5 287 L 5.51x51 Structure Structure
TM5 288 L 5.52x52 Structure Structure
TM5 289 F 5.53x53 Structure Structure
TM5 290 I 5.54x54 Structure Structure
TM5 291 V 5.55x55 Structure Structure
TM5 292 Y 5.56x56 Structure Structure
TM5 293 A 5.57x57 Structure Structure
TM5 294 Y 5.58x58 Structure Structure
TM5 295 M 5.59x59 Structure Structure
TM5 296 Y 5.60x60 Structure Structure
TM5 297 I 5.61x61 Structure Structure
TM5 298 L 5.62x62 Structure Structure
TM5 299 W 5.63x63 Structure Structure
TM5 300 K 5.64x64 Structure Structure
TM5 301 A 5.65x65 Structure Structure
TM5 302 H 5.66x66 Structure Structure
TM5 303 S 5.67x67 Structure Structure
TM5 304 H 5.68x68 Structure Structure
TM5 305 A 5.69x69 Structure Structure
TM5 306 V 5.70x70 Structure Structure
TM5 307 R 5.71x71 AF2 AF2
TM5 308 M 5.72x72 AF2 AF2
TM5 309 I 5.73x73 AF2 AF2
TM5 310 Q 5.74x74 AF2 AF2
TM5 311 R 5.75x75 AF2 AF2
TM5 312 G 5.76x76 AF2 AF2
ICL3 313 T - AF2 AF2
ICL3 314 Q - AF2 AF2
ICL3 315 K - AF2 AF2
ICL3 316 S - AF2 AF2
ICL3 317 I - AF2 AF2
ICL3 318 I - AF2 AF2
ICL3 319 I - AF2 AF2
ICL3 325 G - AF2 AF2
ICL3 326 K - AF2 AF2
ICL3 327 V - AF2 AF2
ICL3 328 Q - AF2 AF2
ICL3 329 V - AF2 AF2
ICL3 330 T - AF2 AF2
ICL3 331 R - AF2 AF2
TM6 332 P 6.24x24 AF2 AF2
TM6 333 D 6.25x25 AF2 AF2
TM6 334 Q 6.26x26 AF2 AF2
TM6 335 A 6.27x27 AF2 AF2
TM6 336 R 6.28x28 Structure AF2
TM6 337 M 6.29x29 Structure Structure
TM6 338 D 6.30x30 Structure Structure
TM6 339 I 6.31x31 Structure Structure
TM6 340 R 6.32x32 Structure Structure
TM6 341 L 6.33x33 Structure Structure
TM6 342 A 6.34x34 Structure Structure
TM6 343 K 6.35x35 Structure AF2
TM6 344 T 6.36x36 Structure Structure
TM6 345 L 6.37x37 Structure Structure
TM6 346 V 6.38x38 Structure Structure
TM6 347 L 6.39x39 Structure Structure
TM6 348 I 6.40x40 Structure Structure
TM6 349 L 6.41x41 Structure Structure
TM6 350 V 6.42x42 Structure Structure
TM6 351 V 6.43x43 Structure Structure
TM6 352 L 6.44x44 Structure Structure
TM6 353 I 6.45x45 Structure Structure
TM6 354 I 6.46x46 Structure Structure
TM6 355 C 6.47x47 Structure Structure
TM6 356 W 6.48x48 Structure Structure
TM6 357 G 6.49x49 Structure Structure
TM6 358 P 6.50x50 Structure Structure
TM6 359 L 6.51x51 Structure Structure
TM6 360 L 6.52x52 Structure Structure
TM6 361 A 6.53x53 Structure Structure
TM6 362 I 6.54x54 Structure Structure
TM6 363 M 6.55x55 Structure Structure
TM6 364 V 6.56x56 Structure Structure
TM6 365 Y 6.57x57 Structure Structure
TM6 366 D 6.58x58 Structure Structure
TM6 367 V 6.59x59 Structure Structure
TM6 368 F 6.60x60 Structure AF2
TM6 369 G 6.61x61 Structure Structure
ECL3 370 K - Structure AF2
ECL3 371 M - Structure Structure
TM7 372 N 7.28x27 Structure Structure
TM7 373 K 7.29x28 Structure AF2
TM7 374 L 7.30x29 Structure Structure
TM7 375 I 7.31x30 Structure Structure
TM7 376 K 7.32x31 Structure Structure
TM7 377 T 7.33x32 Structure Structure
TM7 378 V 7.34x33 Structure Structure
TM7 379 F 7.35x34 Structure Structure
TM7 380 A 7.36x35 Structure Structure
TM7 381 F 7.37x36 Structure Structure
TM7 382 C 7.38x37 Structure Structure
TM7 383 S 7.39x38 Structure Structure
TM7 384 M 7.40x39 Structure Structure
TM7 385 L 7.41x40 Structure Structure
TM7 386 C 7.42x41 Structure Structure
TM7 387 L 7.43x42 Structure Structure
TM7 388 L 7.44x43 Structure Structure
TM7 389 N 7.45x45 Structure Structure
TM7 390 S 7.46x46 Structure Structure
TM7 391 T 7.47x47 Structure Structure
TM7 392 V 7.48x48 Structure Structure
TM7 393 N 7.49x49 Structure Structure
TM7 394 P 7.50x50 Structure Structure
TM7 395 I 7.51x51 Structure Structure
TM7 396 I 7.52x52 Structure Structure
TM7 397 Y 7.53x53 Structure Structure
TM7 398 A 7.54x54 Structure Structure
TM7 399 L 7.55x55 Structure Structure
TM7 400 R 7.56x56 Structure Structure
H8 401 S 8.47x47 Structure Structure
H8 402 K 8.48x48 Structure AF2
H8 403 D 8.49x49 Structure Structure
H8 404 L 8.50x50 Structure Structure
H8 405 R 8.51x51 Structure Structure
H8 406 H 8.52x52 Structure AF2
H8 407 A 8.53x53 Structure Structure
H8 408 F 8.54x54 Structure Structure
H8 409 R 8.55x55 Structure AF2
H8 410 S 8.56x56 Structure Structure
H8 411 M 8.57x57 Structure Structure
H8 412 F 8.58x58 Structure AF2
H8 413 P 8.59x59 AF2 AF2
C-term 414 S - AF2 AF2
C-term 415 C - AF2 AF2
C-term 416 E - AF2 AF2
C-term 417 G - AF2 AF2
C-term 418 T - AF2 AF2
C-term 419 A - AF2 AF2
C-term 420 Q - AF2 AF2
C-term 421 P - AF2 AF2
C-term 422 L - AF2 AF2
C-term 423 D - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Van-der-waals TM7 R 400 7x56 G.H5 F 354 G.H5.26
Ionic ICL2 K 225 34x54 G.H5 D 350 G.H5.22
Polar ICL2 K 225 34x54 G.H5 D 350 G.H5.22
Hydrophobic ICL2 K 225 34x54 G.H5 D 350 G.H5.22
Van-der-waals ICL2 K 225 34x54 G.H5 D 350 G.H5.22
Hydrophobic ICL3 T 313 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 T 313 - G.H5 D 337 G.H5.09
Ionic TM6 R 336 6x28 G.H5 D 341 G.H5.13
Polar TM6 R 336 6x28 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 336 6x28 G.H5 D 341 G.H5.13
Ionic ICL3 K 315 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 K 315 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 K 315 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 L 341 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 341 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 M 308 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 M 308 5x72 G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 221 34x50 G.H5 I 344 G.H5.16
Polar TM2 S 152 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL2 R 226 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 226 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 L 345 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 214 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 214 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 M 337 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 M 337 6x29 G.H5 K 345 G.H5.17
Polar TM3 S 217 3x53 G.H5 N 347 G.H5.19
Polar H8 K 402 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 K 402 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 K 402 8x48 G.H5 F 354 G.H5.26
Ionic TM6 R 336 6x28 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 M 337 6x29 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 221 34x50 G.H5 I 343 G.H5.15
Ionic TM5 R 311 5x75 G.H5 D 337 G.H5.09
Polar TM5 R 311 5x75 G.H5 D 337 G.H5.09
Hydrophobic TM5 R 311 5x75 G.H5 D 337 G.H5.09
Hydrophobic TM6 L 341 6x33 G.H5 L 348 G.H5.20
Polar ICL2 P 221 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 221 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 221 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 222 34x51 G.H5 I 343 G.H5.15
Polar TM6 Q 334 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 Q 334 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 Q 334 6x26 G.h4s6 E 318 G.h4s6.12
Aromatic TM6 R 340 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 340 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 L 222 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM6 R 336 6x28 G.H5 K 345 G.H5.17
Hydrophobic TM3 I 218 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 218 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 Y 224 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 224 34x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 H 304 5x68 G.H5 I 344 G.H5.16
Polar TM3 R 214 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 214 3x50 G.H5 C 351 G.H5.23
Ionic ICL3 R 331 - G.H4 E 308 G.H4.16