Refined structure (8HCX) of Gq - ETB receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 219 from structure (61.0%), 140 from model (39.0%)
Residue sidechains - 39 from structure (10.9%), 320 from model (89.1%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 T G.HN.02 AF2 AF2
G.HN 3 L G.HN.03 AF2 AF2
G.HN 4 E G.HN.04 AF2 AF2
G.HN 5 S G.HN.05 AF2 AF2
G.HN 6 I G.HN.06 AF2 AF2
G.HN 7 M G.HN.07 AF2 AF2
G.HN 8 A G.HN.08 Structure AF2
G.HN 9 C G.HN.09 Structure AF2
G.HN 10 C G.HN.10 Structure AF2
G.HN 11 L G.HN.11 Structure AF2
G.HN 12 S G.HN.30 Structure AF2
G.HN 13 E G.HN.31 Structure AF2
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 A G.HN.33 Structure AF2
G.HN 16 K G.HN.34 Structure AF2
G.HN 17 E G.HN.35 Structure AF2
G.HN 18 A G.HN.36 Structure AF2
G.HN 19 R G.HN.37 Structure AF2
G.HN 20 R G.HN.38 Structure AF2
G.HN 21 I G.HN.39 Structure AF2
G.HN 22 N G.HN.40 Structure Structure
G.HN 23 D G.HN.41 Structure AF2
G.HN 24 E G.HN.42 Structure AF2
G.HN 25 I G.HN.43 Structure AF2
G.HN 26 E G.HN.44 Structure AF2
G.HN 27 R G.HN.45 Structure AF2
G.HN 28 Q G.HN.46 Structure AF2
G.HN 29 L G.HN.47 Structure AF2
G.HN 30 R G.HN.48 Structure AF2
G.HN 31 R G.HN.49 Structure Structure
G.HN 32 D G.HN.50 Structure AF2
G.HN 33 K G.HN.51 Structure AF2
G.HN 34 R G.HN.52 Structure AF2
G.HN 35 D G.HN.53 Structure AF2
G.hns1 36 A G.hns1.01 Structure AF2
G.hns1 37 R G.hns1.02 Structure AF2
G.hns1 38 R G.hns1.03 Structure AF2
G.S1 39 E G.S1.01 Structure AF2
G.S1 40 L G.S1.02 Structure AF2
G.S1 41 K G.S1.03 Structure AF2
G.S1 42 L G.S1.04 Structure AF2
G.S1 43 L G.S1.05 Structure AF2
G.S1 44 L G.S1.06 Structure AF2
G.S1 45 L G.S1.07 Structure AF2
G.s1h1 46 G G.s1h1.01 Structure AF2
G.s1h1 47 T G.s1h1.02 Structure AF2
G.s1h1 48 G G.s1h1.03 Structure AF2
G.s1h1 49 E G.s1h1.04 Structure AF2
G.s1h1 50 S G.s1h1.05 AF2 AF2
G.s1h1 51 G G.s1h1.06 AF2 AF2
G.H1 52 K G.H1.01 AF2 AF2
G.H1 53 S G.H1.02 AF2 AF2
G.H1 54 T G.H1.03 AF2 AF2
G.H1 55 F G.H1.04 AF2 AF2
G.H1 56 I G.H1.05 AF2 AF2
G.H1 57 K G.H1.06 AF2 AF2
G.H1 58 Q G.H1.07 AF2 AF2
G.H1 59 M G.H1.08 AF2 AF2
G.H1 60 R G.H1.09 AF2 AF2
G.H1 61 I G.H1.10 AF2 AF2
G.H1 62 I G.H1.11 AF2 AF2
G.H1 63 H G.H1.12 AF2 AF2
G.h1ha 64 G G.h1ha.01 AF2 AF2
G.h1ha 65 S G.h1ha.02 AF2 AF2
G.h1ha 66 G G.h1ha.03 AF2 AF2
G.h1ha 67 Y G.h1ha.04 AF2 AF2
G.h1ha 68 S G.h1ha.05 AF2 AF2
H.HA 69 D H.HA.01 AF2 AF2
H.HA 70 E H.HA.02 AF2 AF2
H.HA 71 D H.HA.03 AF2 AF2
H.HA 72 K H.HA.04 AF2 AF2
H.HA 73 R H.HA.05 AF2 AF2
H.HA 74 G H.HA.06 AF2 AF2
H.HA 75 F H.HA.07 AF2 AF2
H.HA 76 T H.HA.08 AF2 AF2
H.HA 77 K H.HA.09 AF2 AF2
H.HA 78 L H.HA.10 AF2 AF2
H.HA 79 V H.HA.11 AF2 AF2
H.HA 80 Y H.HA.12 AF2 AF2
H.HA 81 Q H.HA.13 AF2 AF2
H.HA 82 N H.HA.14 AF2 AF2
H.HA 83 I H.HA.15 AF2 AF2
H.HA 84 F H.HA.16 AF2 AF2
H.HA 85 T H.HA.17 AF2 AF2
H.HA 86 A H.HA.18 AF2 AF2
H.HA 87 M H.HA.19 AF2 AF2
H.HA 88 Q H.HA.20 AF2 AF2
H.HA 89 A H.HA.21 AF2 AF2
H.HA 90 M H.HA.22 AF2 AF2
H.HA 91 I H.HA.23 AF2 AF2
H.HA 92 R H.HA.24 AF2 AF2
H.HA 93 A H.HA.25 AF2 AF2
H.HA 94 M H.HA.26 AF2 AF2
H.HA 95 D H.HA.27 AF2 AF2
H.HA 96 T H.HA.28 AF2 AF2
H.HA 97 L H.HA.29 AF2 AF2
H.hahb 98 K H.hahb.01 AF2 AF2
H.hahb 99 I H.hahb.04 AF2 AF2
H.hahb 100 P H.hahb.05 AF2 AF2
H.hahb 101 Y H.hahb.06 AF2 AF2
H.hahb 102 K H.hahb.07 AF2 AF2
H.hahb 103 Y H.hahb.08 AF2 AF2
H.hahb 104 E H.hahb.09 AF2 AF2
H.HB 105 H H.HB.01 AF2 AF2
H.HB 106 N H.HB.02 AF2 AF2
H.HB 107 K H.HB.03 AF2 AF2
H.HB 108 A H.HB.04 AF2 AF2
H.HB 109 H H.HB.05 AF2 AF2
H.HB 110 A H.HB.06 AF2 AF2
H.HB 111 Q H.HB.07 AF2 AF2
H.HB 112 L H.HB.08 AF2 AF2
H.HB 113 V H.HB.09 AF2 AF2
H.HB 114 R H.HB.10 AF2 AF2
H.HB 115 E H.HB.11 AF2 AF2
H.HB 116 V H.HB.12 AF2 AF2
H.HB 117 D H.HB.13 AF2 AF2
H.HB 118 V H.HB.14 AF2 AF2
H.hbhc 119 E H.hbhc.01 AF2 AF2
H.hbhc 120 K H.hbhc.02 AF2 AF2
H.hbhc 121 V H.hbhc.03 AF2 AF2
H.hbhc 122 S H.hbhc.04 AF2 AF2
H.hbhc 123 A H.hbhc.05 AF2 AF2
H.hbhc 124 F H.hbhc.14 AF2 AF2
H.hbhc 125 E H.hbhc.15 AF2 AF2
H.HC 126 N H.HC.01 AF2 AF2
H.HC 127 P H.HC.02 AF2 AF2
H.HC 128 Y H.HC.03 AF2 AF2
H.HC 129 V H.HC.04 AF2 AF2
H.HC 130 D H.HC.05 AF2 AF2
H.HC 131 A H.HC.06 AF2 AF2
H.HC 132 I H.HC.07 AF2 AF2
H.HC 133 K H.HC.08 AF2 AF2
H.HC 134 S H.HC.09 AF2 AF2
H.HC 135 L H.HC.10 AF2 AF2
H.HC 136 W H.HC.11 AF2 AF2
H.HC 137 N H.HC.12 AF2 AF2
H.hchd 138 D H.hchd.01 AF2 AF2
H.HD 139 P H.HD.01 AF2 AF2
H.HD 140 G H.HD.02 AF2 AF2
H.HD 141 I H.HD.03 AF2 AF2
H.HD 142 Q H.HD.04 AF2 AF2
H.HD 143 E H.HD.05 AF2 AF2
H.HD 144 C H.HD.06 AF2 AF2
H.HD 145 Y H.HD.07 AF2 AF2
H.HD 146 D H.HD.08 AF2 AF2
H.HD 147 R H.HD.09 AF2 AF2
H.HD 148 R H.HD.10 AF2 AF2
H.HD 149 R H.HD.11 AF2 AF2
H.HD 150 E H.HD.12 AF2 AF2
H.hdhe 151 Y H.hdhe.01 AF2 AF2
H.hdhe 152 Q H.hdhe.02 AF2 AF2
H.hdhe 153 L H.hdhe.03 AF2 AF2
H.hdhe 154 S H.hdhe.04 AF2 AF2
H.hdhe 155 D H.hdhe.05 AF2 AF2
H.HE 156 S H.HE.01 AF2 AF2
H.HE 157 T H.HE.02 AF2 AF2
H.HE 158 K H.HE.03 AF2 AF2
H.HE 159 Y H.HE.04 AF2 AF2
H.HE 160 Y H.HE.05 AF2 AF2
H.HE 161 L H.HE.06 AF2 AF2
H.HE 162 N H.HE.07 AF2 AF2
H.HE 163 D H.HE.08 AF2 AF2
H.HE 164 L H.HE.09 AF2 AF2
H.HE 165 D H.HE.10 AF2 AF2
H.HE 166 R H.HE.11 AF2 AF2
H.HE 167 V H.HE.12 AF2 AF2
H.HE 168 A H.HE.13 AF2 AF2
H.hehf 169 D H.hehf.01 AF2 AF2
H.hehf 170 P H.hehf.02 AF2 AF2
H.hehf 171 A H.hehf.03 AF2 AF2
H.hehf 172 Y H.hehf.04 AF2 AF2
H.hehf 173 L H.hehf.05 AF2 AF2
H.hehf 174 P H.hehf.06 AF2 AF2
H.hehf 175 T H.hehf.07 AF2 AF2
H.HF 176 Q H.HF.01 AF2 AF2
H.HF 177 Q H.HF.02 AF2 AF2
H.HF 178 D H.HF.03 AF2 AF2
H.HF 179 V H.HF.04 AF2 AF2
H.HF 180 L H.HF.05 Structure Structure
H.HF 181 R H.HF.06 Structure Structure
G.hfs2 182 V G.hfs2.01 Structure AF2
G.hfs2 183 R G.hfs2.02 Structure AF2
G.hfs2 184 V G.hfs2.03 Structure AF2
G.hfs2 185 P G.hfs2.04 Structure AF2
G.hfs2 186 T G.hfs2.05 Structure AF2
G.hfs2 187 T G.hfs2.06 Structure AF2
G.hfs2 188 G G.hfs2.07 Structure AF2
G.S2 189 I G.S2.01 Structure AF2
G.S2 190 I G.S2.02 Structure AF2
G.S2 191 E G.S2.03 Structure AF2
G.S2 192 Y G.S2.04 Structure AF2
G.S2 193 P G.S2.05 Structure AF2
G.S2 194 F G.S2.06 Structure Structure
G.S2 195 D G.S2.07 Structure AF2
G.S2 196 L G.S2.08 Structure AF2
G.s2s3 197 Q G.s2s3.01 Structure AF2
G.s2s3 198 S G.s2s3.02 Structure AF2
G.S3 199 V G.S3.01 Structure Structure
G.S3 200 I G.S3.02 Structure AF2
G.S3 201 F G.S3.03 Structure AF2
G.S3 202 R G.S3.04 Structure AF2
G.S3 203 M G.S3.05 Structure AF2
G.S3 204 V G.S3.06 Structure AF2
G.S3 205 D G.S3.07 Structure AF2
G.S3 206 V G.S3.08 Structure AF2
G.s3h2 207 G G.s3h2.01 Structure AF2
G.s3h2 208 G G.s3h2.02 Structure AF2
G.s3h2 209 Q G.s3h2.03 Structure AF2
G.H2 210 R G.H2.01 Structure AF2
G.H2 211 S G.H2.02 Structure AF2
G.H2 212 E G.H2.03 Structure AF2
G.H2 213 R G.H2.04 Structure AF2
G.H2 214 R G.H2.05 Structure AF2
G.H2 215 K G.H2.06 Structure AF2
G.H2 216 W G.H2.07 Structure AF2
G.H2 217 I G.H2.08 Structure AF2
G.H2 218 H G.H2.09 Structure AF2
G.H2 219 C G.H2.10 Structure AF2
G.h2s4 220 F G.h2s4.01 Structure AF2
G.h2s4 221 E G.h2s4.02 Structure AF2
G.h2s4 222 N G.h2s4.03 Structure AF2
G.h2s4 223 V G.h2s4.04 Structure Structure
G.h2s4 224 T G.h2s4.05 Structure AF2
G.S4 225 S G.S4.01 Structure Structure
G.S4 226 I G.S4.02 Structure AF2
G.S4 227 M G.S4.03 Structure AF2
G.S4 228 F G.S4.04 Structure AF2
G.S4 229 L G.S4.05 Structure AF2
G.S4 230 V G.S4.06 Structure AF2
G.S4 231 A G.S4.07 Structure AF2
G.s4h3 232 L G.s4h3.01 Structure AF2
G.s4h3 233 S G.s4h3.02 Structure AF2
G.s4h3 234 E G.s4h3.03 Structure AF2
G.s4h3 235 Y G.s4h3.04 Structure AF2
G.s4h3 236 D G.s4h3.05 Structure AF2
G.s4h3 237 Q G.s4h3.06 Structure AF2
G.s4h3 238 V G.s4h3.07 Structure AF2
G.s4h3 239 L G.s4h3.08 Structure AF2
G.s4h3 240 V G.s4h3.09 Structure AF2
G.s4h3 241 E G.s4h3.10 Structure AF2
G.s4h3 242 S G.s4h3.11 Structure AF2
G.s4h3 243 D G.s4h3.12 Structure AF2
G.s4h3 244 N G.s4h3.13 Structure Structure
G.s4h3 245 E G.s4h3.14 Structure AF2
G.s4h3 246 N G.s4h3.15 Structure AF2
G.H3 247 R G.H3.01 Structure AF2
G.H3 248 M G.H3.02 Structure AF2
G.H3 249 E G.H3.03 Structure AF2
G.H3 250 E G.H3.04 Structure AF2
G.H3 251 S G.H3.05 Structure Structure
G.H3 252 K G.H3.06 Structure AF2
G.H3 253 A G.H3.07 Structure AF2
G.H3 254 L G.H3.08 Structure Structure
G.H3 255 F G.H3.09 Structure Structure
G.H3 256 R G.H3.10 Structure AF2
G.H3 257 T G.H3.11 Structure AF2
G.H3 258 I G.H3.12 Structure AF2
G.H3 259 I G.H3.13 Structure AF2
G.H3 260 T G.H3.14 Structure AF2
G.H3 261 Y G.H3.15 Structure AF2
G.H3 262 P G.H3.16 Structure AF2
G.H3 263 W G.H3.17 Structure AF2
G.H3 264 F G.H3.18 Structure AF2
G.h3s5 265 Q G.h3s5.01 Structure AF2
G.h3s5 266 N G.h3s5.02 Structure AF2
G.h3s5 267 S G.h3s5.03 Structure AF2
G.S5 268 S G.S5.01 Structure AF2
G.S5 269 V G.S5.02 Structure AF2
G.S5 270 I G.S5.03 Structure AF2
G.S5 271 L G.S5.04 Structure AF2
G.S5 272 F G.S5.05 Structure AF2
G.S5 273 L G.S5.06 Structure AF2
G.S5 274 N G.S5.07 Structure AF2
G.s5hg 275 K G.s5hg.01 Structure AF2
G.HG 276 K G.HG.01 Structure AF2
G.HG 277 D G.HG.02 Structure AF2
G.HG 278 L G.HG.03 Structure AF2
G.HG 279 L G.HG.04 Structure AF2
G.HG 280 E G.HG.05 Structure AF2
G.HG 281 E G.HG.06 Structure AF2
G.HG 282 K G.HG.07 Structure AF2
G.HG 283 I G.HG.08 Structure AF2
G.HG 284 M G.HG.09 Structure AF2
G.HG 285 Y G.HG.12 Structure AF2
G.HG 286 S G.HG.13 Structure AF2
G.HG 287 H G.HG.14 Structure AF2
G.HG 288 L G.HG.15 Structure AF2
G.HG 289 V G.HG.16 Structure AF2
G.HG 290 D G.HG.17 Structure AF2
G.hgh4 291 Y G.hgh4.01 Structure AF2
G.hgh4 292 F G.hgh4.02 Structure AF2
G.hgh4 293 P G.hgh4.03 Structure Structure
G.hgh4 294 E G.hgh4.04 Structure AF2
G.hgh4 295 Y G.hgh4.05 Structure AF2
G.hgh4 296 D G.hgh4.06 Structure Structure
G.hgh4 297 G G.hgh4.07 Structure AF2
G.hgh4 298 P G.hgh4.08 Structure AF2
G.H4 299 Q G.H4.01 Structure AF2
G.H4 300 R G.H4.02 Structure AF2
G.H4 301 D G.H4.03 Structure AF2
G.H4 302 A G.H4.04 Structure Structure
G.H4 303 Q G.H4.05 Structure AF2
G.H4 304 A G.H4.06 Structure AF2
G.H4 305 A G.H4.07 Structure AF2
G.H4 306 R G.H4.08 Structure AF2
G.H4 307 E G.H4.09 Structure AF2
G.H4 308 F G.H4.10 Structure AF2
G.H4 309 I G.H4.11 Structure AF2
G.H4 310 L G.H4.12 Structure AF2
G.H4 311 K G.H4.13 Structure AF2
G.H4 312 M G.H4.14 Structure AF2
G.H4 313 F G.H4.15 Structure AF2
G.H4 314 V G.H4.16 Structure AF2
G.H4 315 D G.H4.17 Structure AF2
G.h4s6 316 L G.h4s6.01 Structure AF2
G.h4s6 317 N G.h4s6.08 Structure AF2
G.h4s6 318 P G.h4s6.09 Structure AF2
G.h4s6 319 D G.h4s6.10 Structure Structure
G.h4s6 320 S G.h4s6.11 Structure AF2
G.h4s6 321 D G.h4s6.12 Structure AF2
G.h4s6 322 K G.h4s6.13 Structure AF2
G.h4s6 323 I G.h4s6.20 Structure Structure
G.S6 324 I G.S6.01 Structure AF2
G.S6 325 Y G.S6.02 Structure Structure
G.S6 326 S G.S6.03 Structure AF2
G.S6 327 H G.S6.04 Structure Structure
G.S6 328 F G.S6.05 Structure Structure
G.s6h5 329 T G.s6h5.01 Structure Structure
G.s6h5 330 C G.s6h5.02 Structure Structure
G.s6h5 331 A G.s6h5.03 AF2 AF2
G.s6h5 332 T G.s6h5.04 AF2 AF2
G.s6h5 333 D G.s6h5.05 Structure Structure
G.H5 334 T G.H5.01 Structure Structure
G.H5 335 E G.H5.02 Structure Structure
G.H5 336 N G.H5.03 Structure Structure
G.H5 337 I G.H5.04 Structure AF2
G.H5 338 R G.H5.05 Structure Structure
G.H5 339 F G.H5.06 Structure AF2
G.H5 340 V G.H5.07 Structure AF2
G.H5 341 F G.H5.08 Structure Structure
G.H5 342 A G.H5.09 Structure AF2
G.H5 343 A G.H5.10 Structure AF2
G.H5 344 V G.H5.11 Structure AF2
G.H5 345 K G.H5.12 Structure AF2
G.H5 346 D G.H5.13 Structure Structure
G.H5 347 T G.H5.14 Structure AF2
G.H5 348 I G.H5.15 Structure Structure
G.H5 349 L G.H5.16 Structure Structure
G.H5 350 Q G.H5.17 Structure Structure
G.H5 351 L G.H5.18 Structure AF2
G.H5 352 N G.H5.19 Structure Structure
G.H5 353 L G.H5.20 Structure Structure
G.H5 354 K G.H5.21 Structure AF2
G.H5 355 E G.H5.22 Structure Structure
G.H5 356 Y G.H5.23 Structure Structure
G.H5 357 N G.H5.24 Structure Structure
G.H5 358 L G.H5.25 Structure Structure
G.H5 359 V G.H5.26 AF2 AF2

REFINED GPCR RESIDUES

Residue backbones - 285 from structure (69.0%), 128 from model (31.0%)
Residue sidechains - 254 from structure (61.5%), 159 from model (38.5%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 Q - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 P - AF2 AF2
N-term 5 P - AF2 AF2
N-term 6 S - AF2 AF2
N-term 7 L - AF2 AF2
N-term 8 C - AF2 AF2
N-term 9 G - AF2 AF2
N-term 10 R - AF2 AF2
N-term 11 A - AF2 AF2
N-term 12 L - AF2 AF2
N-term 13 V - AF2 AF2
N-term 14 A - AF2 AF2
N-term 15 L - AF2 AF2
N-term 16 V - AF2 AF2
N-term 17 L - AF2 AF2
N-term 18 A - AF2 AF2
N-term 19 C - AF2 AF2
N-term 20 G - AF2 AF2
N-term 21 L - AF2 AF2
N-term 22 S - AF2 AF2
N-term 23 R - AF2 AF2
N-term 24 I - AF2 AF2
N-term 25 W - AF2 AF2
N-term 26 G - AF2 AF2
N-term 27 E - AF2 AF2
N-term 28 E - AF2 AF2
N-term 29 R - AF2 AF2
N-term 30 G - AF2 AF2
N-term 31 F - AF2 AF2
N-term 32 P - AF2 AF2
N-term 33 P - AF2 AF2
N-term 34 D - AF2 AF2
N-term 35 R - AF2 AF2
N-term 36 A - AF2 AF2
N-term 37 T - AF2 AF2
N-term 38 P - AF2 AF2
N-term 39 L - AF2 AF2
N-term 40 L - AF2 AF2
N-term 41 Q - AF2 AF2
N-term 42 T - AF2 AF2
N-term 43 A - AF2 AF2
N-term 44 E - AF2 AF2
N-term 45 I - AF2 AF2
N-term 46 M - AF2 AF2
N-term 47 T - AF2 AF2
N-term 48 P - AF2 AF2
N-term 49 P - AF2 AF2
N-term 50 T - AF2 AF2
N-term 51 K - AF2 AF2
N-term 52 T - AF2 AF2
N-term 53 L - AF2 AF2
N-term 54 W - AF2 AF2
N-term 55 P - AF2 AF2
N-term 56 K - AF2 AF2
N-term 57 G - AF2 AF2
N-term 58 S - AF2 AF2
N-term 59 N - AF2 AF2
N-term 60 A - AF2 AF2
N-term 61 S - AF2 AF2
N-term 62 L - AF2 AF2
N-term 63 A - AF2 AF2
N-term 64 R - AF2 AF2
N-term 65 S - AF2 AF2
N-term 66 L - AF2 AF2
N-term 67 A - AF2 AF2
N-term 68 P - AF2 AF2
N-term 69 A - AF2 AF2
N-term 70 E - AF2 AF2
N-term 71 V - AF2 AF2
N-term 72 P - AF2 AF2
N-term 73 K - AF2 AF2
N-term 74 G - AF2 AF2
N-term 75 D - AF2 AF2
N-term 76 R - AF2 AF2
N-term 77 T - AF2 AF2
N-term 78 A - AF2 AF2
N-term 79 G - AF2 AF2
N-term 80 S - AF2 AF2
N-term 81 P - AF2 AF2
N-term 82 P - AF2 AF2
N-term 83 R - AF2 AF2
N-term 84 T - AF2 AF2
N-term 85 I - AF2 AF2
N-term 86 S - AF2 AF2
N-term 87 P - AF2 AF2
N-term 88 P - AF2 AF2
N-term 89 P - AF2 AF2
N-term 90 C - AF2 AF2
TM1 91 Q 1.22x22 AF2 AF2
TM1 92 G 1.23x23 AF2 AF2
TM1 93 P 1.24x24 AF2 AF2
TM1 94 I 1.25x25 AF2 AF2
TM1 95 E 1.26x26 AF2 AF2
TM1 96 I 1.27x27 AF2 AF2
TM1 97 K 1.28x28 Structure AF2
TM1 98 E 1.29x29 Structure AF2
TM1 99 T 1.30x30 Structure Structure
TM1 100 F 1.31x31 Structure Structure
TM1 101 K 1.32x32 Structure AF2
TM1 102 Y 1.33x33 Structure Structure
TM1 103 I 1.34x34 Structure Structure
TM1 104 N 1.35x35 Structure Structure
TM1 105 T 1.36x36 Structure Structure
TM1 106 V 1.37x37 Structure Structure
TM1 107 V 1.38x38 Structure Structure
TM1 108 S 1.39x39 Structure Structure
TM1 109 C 1.40x40 Structure Structure
TM1 110 L 1.41x41 Structure Structure
TM1 111 V 1.42x42 Structure Structure
TM1 112 F 1.43x43 Structure Structure
TM1 113 V 1.44x44 Structure Structure
TM1 114 L 1.45x45 Structure Structure
TM1 115 G 1.46x46 Structure Structure
TM1 116 I 1.47x47 Structure Structure
TM1 117 I 1.48x48 Structure Structure
TM1 118 G 1.49x49 Structure Structure
TM1 119 N 1.50x50 Structure Structure
TM1 120 S 1.51x51 Structure Structure
TM1 121 T 1.52x52 Structure Structure
TM1 122 L 1.53x53 Structure Structure
TM1 123 L 1.54x54 Structure Structure
TM1 124 R 1.55x55 Structure AF2
TM1 125 I 1.56x56 Structure Structure
TM1 126 I 1.57x57 Structure Structure
TM1 127 Y 1.58x58 Structure AF2
TM1 128 K 1.59x59 Structure AF2
TM1 129 N 1.60x60 Structure Structure
ICL1 130 K 12.48x48 Structure AF2
ICL1 131 C 12.49x49 Structure Structure
ICL1 132 M 12.50x50 Structure AF2
ICL1 133 R 12.51x51 Structure AF2
ICL1 134 N 12.52x52 Structure Structure
TM2 135 G 2.38x38 Structure Structure
TM2 136 P 2.39x39 Structure Structure
TM2 137 N 2.40x40 Structure Structure
TM2 138 I 2.41x41 Structure Structure
TM2 139 L 2.42x42 Structure Structure
TM2 140 I 2.43x43 Structure Structure
TM2 141 A 2.44x44 Structure Structure
TM2 142 S 2.45x45 Structure Structure
TM2 143 L 2.46x46 Structure Structure
TM2 144 A 2.47x47 Structure Structure
TM2 145 L 2.48x48 Structure Structure
TM2 146 G 2.49x49 Structure Structure
TM2 147 D 2.50x50 Structure Structure
TM2 148 L 2.51x51 Structure Structure
TM2 149 L 2.52x52 Structure Structure
TM2 150 H 2.53x53 Structure Structure
TM2 151 I 2.54x54 Structure Structure
TM2 152 V 2.55x55 Structure Structure
TM2 153 I 2.56x551 Structure Structure
TM2 154 D 2.57x56 Structure Structure
TM2 155 I 2.58x57 Structure Structure
TM2 156 P 2.59x58 Structure Structure
TM2 157 I 2.60x59 Structure Structure
TM2 158 N 2.61x60 Structure Structure
TM2 159 V 2.62x61 Structure Structure
TM2 160 Y 2.63x62 Structure Structure
TM2 161 K 2.64x63 Structure AF2
TM2 162 L 2.65x64 Structure Structure
TM2 163 L 2.66x65 Structure Structure
TM2 164 A 2.67x66 Structure Structure
ECL1 165 E - Structure AF2
ECL1 166 D 23.49x49 Structure Structure
ECL1 167 W 23.50x50 Structure Structure
ECL1 168 P 23.51x51 Structure Structure
ECL1 169 F 23.52x52 Structure Structure
TM3 170 G 3.21x21 Structure Structure
TM3 171 A 3.22x22 Structure Structure
TM3 172 E 3.23x23 Structure AF2
TM3 173 M 3.24x24 Structure Structure
TM3 174 C 3.25x25 Structure Structure
TM3 175 K 3.26x26 Structure AF2
TM3 176 L 3.27x27 Structure Structure
TM3 177 V 3.28x28 Structure Structure
TM3 178 P 3.29x29 Structure Structure
TM3 179 F 3.30x30 Structure Structure
TM3 180 I 3.31x31 Structure Structure
TM3 181 Q 3.32x32 Structure Structure
TM3 182 K 3.33x33 Structure Structure
TM3 183 A 3.34x34 Structure Structure
TM3 184 S 3.35x35 Structure Structure
TM3 185 V 3.36x36 Structure Structure
TM3 186 G 3.37x37 Structure Structure
TM3 187 I 3.38x38 Structure Structure
TM3 188 T 3.39x39 Structure Structure
TM3 189 V 3.40x40 Structure Structure
TM3 190 L 3.41x41 Structure Structure
TM3 191 S 3.42x42 Structure Structure
TM3 192 L 3.43x43 Structure Structure
TM3 193 C 3.44x44 Structure Structure
TM3 194 A 3.45x45 Structure Structure
TM3 195 L 3.46x46 Structure Structure
TM3 196 S 3.47x47 Structure Structure
TM3 197 I 3.48x48 Structure Structure
TM3 198 D 3.49x49 Structure Structure
TM3 199 R 3.50x50 Structure Structure
TM3 200 Y 3.51x51 Structure Structure
TM3 201 R 3.52x52 Structure AF2
TM3 202 A 3.53x53 Structure Structure
TM3 203 V 3.54x54 Structure Structure
TM3 204 A 3.55x55 Structure Structure
TM3 205 S 3.56x56 Structure Structure
ICL2 206 W 34.50x50 Structure Structure
ICL2 207 S 34.51x51 Structure Structure
ICL2 208 R 34.52x52 Structure Structure
ICL2 209 I 34.53x53 Structure Structure
ICL2 210 K 34.54x54 AF2 AF2
ICL2 211 G 34.55x55 AF2 AF2
ICL2 212 I 34.56x56 AF2 AF2
ICL2 213 G 34.57x57 AF2 AF2
TM4 214 V 4.38x38 Structure Structure
TM4 215 P 4.39x39 Structure Structure
TM4 216 K 4.40x40 Structure AF2
TM4 217 W 4.41x41 Structure AF2
TM4 218 T 4.42x42 Structure Structure
TM4 219 A 4.43x43 Structure Structure
TM4 220 V 4.44x44 Structure Structure
TM4 221 E 4.45x45 Structure Structure
TM4 222 I 4.46x46 Structure Structure
TM4 223 V 4.47x47 Structure Structure
TM4 224 L 4.48x48 Structure Structure
TM4 225 I 4.49x49 Structure Structure
TM4 226 W 4.50x50 Structure Structure
TM4 227 V 4.51x51 Structure Structure
TM4 228 V 4.52x52 Structure Structure
TM4 229 S 4.53x53 Structure Structure
TM4 230 V 4.54x54 Structure Structure
TM4 231 V 4.55x55 Structure Structure
TM4 232 L 4.56x56 Structure Structure
TM4 233 A 4.57x57 Structure Structure
TM4 234 V 4.58x59 Structure Structure
TM4 235 P 4.59x60 Structure Structure
TM4 236 E 4.60x61 Structure Structure
TM4 237 A 4.61x62 Structure Structure
TM4 238 I 4.62x63 Structure Structure
TM4 239 G 4.63x64 Structure Structure
TM4 240 F 4.64x65 Structure Structure
ECL2 241 D - Structure Structure
ECL2 242 I - Structure Structure
ECL2 243 I - Structure Structure
ECL2 244 T - Structure Structure
ECL2 245 M - Structure Structure
ECL2 246 D - Structure Structure
ECL2 247 Y - Structure Structure
ECL2 248 K - Structure Structure
ECL2 249 G - Structure Structure
ECL2 250 S - Structure Structure
ECL2 251 Y - Structure Structure
ECL2 252 L - Structure Structure
ECL2 253 R - Structure AF2
ECL2 254 I - Structure Structure
ECL2 255 C 45.50x50 Structure Structure
ECL2 256 L 45.51x51 Structure Structure
ECL2 257 L 45.52x52 Structure Structure
ECL2 258 H - Structure Structure
ECL2 259 P - Structure Structure
ECL2 260 V - Structure Structure
ECL2 261 Q - Structure Structure
ECL2 262 K - Structure AF2
TM5 263 T 5.28x29 Structure Structure
TM5 264 A 5.29x30 Structure Structure
TM5 265 F 5.30x31 Structure Structure
TM5 266 M 5.31x32 Structure Structure
TM5 267 Q 5.32x33 Structure AF2
TM5 268 F 5.33x34 Structure Structure
TM5 269 Y 5.34x35 Structure Structure
TM5 270 K 5.35x36 Structure Structure
TM5 271 T 5.36x37 Structure Structure
TM5 272 A 5.37x38 Structure Structure
TM5 273 K 5.38x39 Structure Structure
TM5 274 D 5.39x40 Structure Structure
TM5 275 W 5.40x41 Structure Structure
TM5 276 W 5.41x42 Structure Structure
TM5 277 L 5.42x43 Structure Structure
TM5 278 F 5.43x44 Structure Structure
TM5 279 S 5.44x45 Structure Structure
TM5 280 F 5.45x46 Structure Structure
TM5 281 Y 5.46x461 Structure Structure
TM5 282 F 5.47x47 Structure Structure
TM5 283 C 5.48x48 Structure Structure
TM5 284 L 5.49x49 Structure Structure
TM5 285 P 5.50x50 Structure Structure
TM5 286 L 5.51x51 Structure Structure
TM5 287 A 5.52x52 Structure Structure
TM5 288 I 5.53x53 Structure Structure
TM5 289 T 5.54x54 Structure Structure
TM5 290 A 5.55x55 Structure Structure
TM5 291 F 5.56x56 Structure Structure
TM5 292 F 5.57x57 Structure Structure
TM5 293 Y 5.58x58 Structure Structure
TM5 294 T 5.59x59 Structure Structure
TM5 295 L 5.60x60 Structure Structure
TM5 296 M 5.61x61 Structure Structure
TM5 297 T 5.62x62 Structure Structure
TM5 298 C 5.63x63 Structure Structure
TM5 299 E 5.64x64 Structure AF2
TM5 300 M 5.65x65 Structure Structure
TM5 301 L 5.66x66 Structure Structure
TM5 302 R 5.67x67 Structure AF2
TM5 303 K 5.68x68 AF2 AF2
TM5 304 K 5.69x69 AF2 AF2
TM5 305 S 5.70x70 AF2 AF2
TM5 306 G 5.71x71 AF2 AF2
TM5 307 M 5.72x72 AF2 AF2
ICL3 308 Q - AF2 AF2
ICL3 309 I - AF2 AF2
ICL3 310 A - AF2 AF2
ICL3 311 L - AF2 AF2
TM6 312 N 6.24x24 AF2 AF2
TM6 313 D 6.25x25 AF2 AF2
TM6 314 H 6.26x26 AF2 AF2
TM6 315 L 6.27x27 Structure Structure
TM6 316 K 6.28x28 Structure AF2
TM6 317 Q 6.29x29 Structure AF2
TM6 318 R 6.30x30 Structure Structure
TM6 319 R 6.31x31 Structure AF2
TM6 320 E 6.32x32 Structure Structure
TM6 321 V 6.33x33 Structure Structure
TM6 322 A 6.34x34 Structure Structure
TM6 323 K 6.35x35 Structure AF2
TM6 324 T 6.36x36 Structure Structure
TM6 325 V 6.37x37 Structure Structure
TM6 326 F 6.38x38 Structure Structure
TM6 327 C 6.39x39 Structure Structure
TM6 328 L 6.40x40 Structure Structure
TM6 329 V 6.41x41 Structure Structure
TM6 330 L 6.42x42 Structure Structure
TM6 331 V 6.43x43 Structure Structure
TM6 332 F 6.44x44 Structure Structure
TM6 333 A 6.45x45 Structure Structure
TM6 334 L 6.46x46 Structure Structure
TM6 335 C 6.47x47 Structure Structure
TM6 336 W 6.48x48 Structure Structure
TM6 337 L 6.49x49 Structure Structure
TM6 338 P 6.50x50 Structure Structure
TM6 339 L 6.51x51 Structure Structure
TM6 340 H 6.52x52 Structure Structure
TM6 341 L 6.53x53 Structure Structure
TM6 342 S 6.54x54 Structure Structure
TM6 343 R 6.55x55 Structure Structure
TM6 344 I 6.56x56 Structure Structure
TM6 345 L 6.57x57 Structure Structure
TM6 346 K 6.58x58 Structure Structure
TM6 347 L 6.59x59 Structure Structure
TM6 348 T 6.60x60 Structure Structure
TM6 349 L 6.61x61 Structure Structure
TM6 350 Y 6.62x62 Structure Structure
ECL3 351 N - Structure Structure
ECL3 352 Q - Structure Structure
ECL3 353 N - Structure Structure
ECL3 354 D - Structure AF2
ECL3 355 P - Structure Structure
ECL3 356 N - Structure Structure
TM7 357 R 7.24x23 Structure AF2
TM7 358 C 7.25x24 Structure Structure
TM7 359 E 7.26x25 Structure AF2
TM7 360 L 7.27x26 Structure Structure
TM7 361 L 7.28x27 Structure Structure
TM7 362 S 7.29x28 Structure Structure
TM7 363 F 7.30x29 Structure Structure
TM7 364 L 7.31x30 Structure Structure
TM7 365 L 7.32x31 Structure Structure
TM7 366 V 7.33x32 Structure Structure
TM7 367 L 7.34x33 Structure Structure
TM7 368 D 7.35x34 Structure Structure
TM7 369 Y 7.36x35 Structure Structure
TM7 370 I 7.37x36 Structure Structure
TM7 371 G 7.38x37 Structure Structure
TM7 372 I 7.39x38 Structure Structure
TM7 373 N 7.40x39 Structure Structure
TM7 374 M 7.41x40 Structure Structure
TM7 375 A 7.42x41 Structure Structure
TM7 376 S 7.43x42 Structure Structure
TM7 377 L 7.44x43 Structure Structure
TM7 378 N 7.45x45 Structure Structure
TM7 379 S 7.46x46 Structure Structure
TM7 380 C 7.47x47 Structure Structure
TM7 381 I 7.48x48 Structure Structure
TM7 382 N 7.49x49 Structure Structure
TM7 383 P 7.50x50 Structure Structure
TM7 384 I 7.51x51 Structure Structure
TM7 385 A 7.52x52 Structure Structure
TM7 386 L 7.53x53 Structure Structure
TM7 387 Y 7.54x54 Structure Structure
TM7 388 L 7.55x55 Structure Structure
TM7 389 V 7.56x56 Structure Structure
H8 390 S 8.47x47 Structure Structure
H8 391 K 8.48x48 Structure AF2
H8 392 R 8.49x49 Structure AF2
H8 393 F 8.50x50 Structure Structure
H8 394 K 8.51x51 Structure AF2
H8 395 N 8.52x52 Structure Structure
H8 396 C 8.53x53 Structure Structure
H8 397 F 8.54x54 Structure Structure
H8 398 K 8.55x55 AF2 AF2
H8 399 S 8.56x56 AF2 AF2
H8 400 C 8.57x57 AF2 AF2
H8 401 L 8.58x58 AF2 AF2
H8 402 C 8.59x59 AF2 AF2
H8 403 C 8.60x60 AF2 AF2
C-term 404 W - AF2 AF2
C-term 405 C - AF2 AF2
C-term 406 Q - AF2 AF2
C-term 407 S - AF2 AF2
C-term 408 F - AF2 AF2
C-term 409 E - AF2 AF2
C-term 410 E - AF2 AF2
C-term 411 K - AF2 AF2
C-term 412 Q - AF2 AF2
C-term 413 S - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 G 211 34x55 H.hahb Y 101 H.hahb.06
Hydrophobic ICL2 G 211 34x55 H.hahb Y 101 H.hahb.06
Van-der-waals ICL2 G 211 34x55 H.hahb Y 101 H.hahb.06
Polar H8 K 391 8x48 G.h4s6 S 320 G.h4s6.11
Hydrophobic H8 K 391 8x48 G.h4s6 S 320 G.h4s6.11
Van-der-waals H8 K 391 8x48 G.h4s6 S 320 G.h4s6.11
Hydrophobic ICL2 I 209 34x53 H.HB K 107 H.HB.03
Van-der-waals ICL2 I 209 34x53 H.HB K 107 H.HB.03
Hydrophobic ICL2 K 210 34x54 H.HB R 114 H.HB.10
Van-der-waals ICL2 K 210 34x54 H.HB R 114 H.HB.10
Hydrophobic N-term R 29 - G.HN K 16 G.HN.34
Van-der-waals N-term R 29 - G.HN K 16 G.HN.34
Polar ICL2 I 212 34x56 H.hahb E 104 H.hahb.09
Hydrophobic ICL2 I 212 34x56 H.hahb E 104 H.hahb.09
Van-der-waals ICL2 I 212 34x56 H.hahb E 104 H.hahb.09
Polar ICL2 G 213 34x57 H.HB K 107 H.HB.03
Hydrophobic ICL2 G 213 34x57 H.HB K 107 H.HB.03
Van-der-waals ICL2 G 213 34x57 H.HB K 107 H.HB.03
Hydrophobic TM5 M 296 5x61 G.H5 L 358 G.H5.25
Ionic TM6 R 318 6x30 G.H5 D 346 G.H5.13
Polar TM6 R 318 6x30 G.H5 D 346 G.H5.13
Hydrophobic ICL2 I 209 34x53 G.H5 E 355 G.H5.22
Van-der-waals ICL2 I 209 34x53 G.H5 E 355 G.H5.22
Hydrophobic TM5 M 300 5x65 G.H5 L 349 G.H5.16
Hydrophobic TM6 V 321 6x33 H.hahb K 98 H.hahb.01
Van-der-waals TM6 V 321 6x33 H.hahb K 98 H.hahb.01
Hydrophobic ICL1 K 130 12x48 H.hahb Y 103 H.hahb.08
Hydrophobic TM4 P 215 4x39 H.HB K 107 H.HB.03
Hydrophobic ICL2 R 208 34x52 H.HA R 92 H.HA.24
Polar H8 R 392 8x49 H.hahb K 102 H.hahb.07
Hydrophobic H8 R 392 8x49 H.hahb K 102 H.hahb.07
Van-der-waals H8 R 392 8x49 H.hahb K 102 H.hahb.07
Polar TM6 Q 317 6x29 H.hahb K 98 H.hahb.01
Hydrophobic TM6 Q 317 6x29 H.hahb K 98 H.hahb.01
Van-der-waals TM6 Q 317 6x29 H.hahb K 98 H.hahb.01
Polar ICL2 G 213 34x57 H.HB A 108 H.HB.04
Hydrophobic ICL2 G 213 34x57 H.HB A 108 H.HB.04
Van-der-waals ICL2 G 213 34x57 H.HB A 108 H.HB.04
Hydrophobic TM3 R 199 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 199 3x50 G.H5 L 358 G.H5.25
Polar TM6 H 314 6x26 G.H5 Q 350 G.H5.17
Hydrophobic TM6 H 314 6x26 G.H5 Q 350 G.H5.17
Van-der-waals TM6 H 314 6x26 G.H5 Q 350 G.H5.17
Hydrophobic ICL1 R 133 12x51 H.hahb E 104 H.hahb.09
Van-der-waals ICL1 R 133 12x51 H.hahb E 104 H.hahb.09
Ionic TM5 E 299 5x64 G.H5 K 345 G.H5.12
Polar TM5 E 299 5x64 G.H5 K 345 G.H5.12
Polar TM3 A 202 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 A 202 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 202 3x53 G.H5 Y 356 G.H5.23
Polar ICL2 S 207 34x51 H.HB R 114 H.HB.10
Hydrophobic ICL2 S 207 34x51 H.HB R 114 H.HB.10
Van-der-waals ICL2 S 207 34x51 H.HB R 114 H.HB.10
Polar ICL1 R 133 12x51 H.HB H 105 H.HB.01
Polar H8 R 392 8x49 H.hahb Y 101 H.hahb.06
Hydrophobic H8 R 392 8x49 H.hahb Y 101 H.hahb.06
Van-der-waals H8 R 392 8x49 H.hahb Y 101 H.hahb.06
Hydrophobic ICL2 K 210 34x54 H.HB A 110 H.HB.06
Van-der-waals ICL2 K 210 34x54 H.HB A 110 H.HB.06
Polar TM3 D 198 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 198 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 198 3x49 G.H5 Y 356 G.H5.23
Polar ICL2 I 209 34x53 H.hahb Y 101 H.hahb.06
Hydrophobic ICL2 I 209 34x53 H.hahb Y 101 H.hahb.06
Van-der-waals ICL2 I 209 34x53 H.hahb Y 101 H.hahb.06
Hydrophobic N-term F 31 - G.HN C 10 G.HN.10
Van-der-waals N-term F 31 - G.HN C 10 G.HN.10
Polar TM6 R 318 6x30 H.HA T 96 H.HA.28
Hydrophobic TM6 R 318 6x30 H.HA T 96 H.HA.28
Hydrophobic ICL2 S 207 34x51 H.HA D 95 H.HA.27
Van-der-waals ICL2 S 207 34x51 H.HA D 95 H.HA.27
Polar ICL2 R 208 34x52 H.HA I 91 H.HA.23
Hydrophobic ICL2 R 208 34x52 H.HA I 91 H.HA.23
Van-der-waals ICL2 R 208 34x52 H.HA I 91 H.HA.23
Hydrophobic TM5 M 307 5x72 G.H5 F 339 G.H5.06
Van-der-waals TM5 M 307 5x72 G.H5 F 339 G.H5.06
Van-der-waals TM1 N 129 1x60 H.hahb K 102 H.hahb.07
Hydrophobic TM4 V 214 4x38 H.HB A 108 H.HB.04
Van-der-waals TM4 V 214 4x38 H.HB A 108 H.HB.04
Hydrophobic H8 F 393 8x50 G.H5 N 357 G.H5.24
Hydrophobic TM2 G 135 2x38 H.HB K 107 H.HB.03
Van-der-waals TM2 G 135 2x38 H.HB K 107 H.HB.03
Polar ICL2 R 208 34x52 H.HA D 95 H.HA.27
Hydrophobic ICL2 R 208 34x52 H.HA D 95 H.HA.27
Van-der-waals ICL2 R 208 34x52 H.HA D 95 H.HA.27
Hydrophobic TM3 S 205 3x56 G.H5 I 348 G.H5.15
Van-der-waals TM3 S 205 3x56 G.H5 I 348 G.H5.15
Hydrophobic TM6 V 321 6x33 G.H5 L 353 G.H5.20
Polar TM2 G 135 2x38 H.hahb E 104 H.hahb.09
Polar TM6 R 318 6x30 G.H5 Q 350 G.H5.17
Hydrophobic TM6 R 318 6x30 G.H5 Q 350 G.H5.17
Van-der-waals TM6 R 318 6x30 G.H5 Q 350 G.H5.17
Hydrophobic ICL2 R 208 34x52 H.HD I 141 H.HD.03
Van-der-waals ICL2 R 208 34x52 H.HD I 141 H.HD.03
Ionic TM6 H 314 6x26 H.HD E 150 H.HD.12
Polar TM6 H 314 6x26 H.HD E 150 H.HD.12
Hydrophobic TM6 H 314 6x26 H.HD E 150 H.HD.12
Van-der-waals TM6 H 314 6x26 H.HD E 150 H.HD.12
Polar TM7 V 389 7x56 G.H5 V 359 G.H5.26
Hydrophobic TM7 V 389 7x56 G.H5 V 359 G.H5.26
Van-der-waals TM7 V 389 7x56 G.H5 V 359 G.H5.26
Ionic H8 R 392 8x49 H.hahb E 104 H.hahb.09
Polar H8 R 392 8x49 H.hahb E 104 H.hahb.09
Hydrophobic H8 R 392 8x49 H.hahb E 104 H.hahb.09
Van-der-waals H8 R 392 8x49 H.hahb E 104 H.hahb.09
Polar ICL2 W 206 34x50 H.HA R 92 H.HA.24
Hydrophobic ICL2 W 206 34x50 H.HA R 92 H.HA.24
Van-der-waals ICL2 W 206 34x50 H.HA R 92 H.HA.24
Polar TM6 Q 317 6x29 G.H5 Q 350 G.H5.17
Hydrophobic TM6 Q 317 6x29 G.H5 Q 350 G.H5.17
Van-der-waals TM6 Q 317 6x29 G.H5 Q 350 G.H5.17
Polar ICL2 I 212 34x56 H.hahb Y 103 H.hahb.08
Hydrophobic ICL2 I 212 34x56 H.hahb Y 103 H.hahb.08
Van-der-waals ICL2 I 212 34x56 H.hahb Y 103 H.hahb.08
Hydrophobic TM5 M 300 5x65 G.H5 L 353 G.H5.20
Van-der-waals TM5 M 300 5x65 G.H5 L 353 G.H5.20
Hydrophobic TM2 P 136 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 P 136 2x39 G.H5 Y 356 G.H5.23
Hydrophobic H8 R 392 8x49 H.hahb P 100 H.hahb.05
Van-der-waals H8 R 392 8x49 H.hahb P 100 H.hahb.05
Ionic TM6 H 314 6x26 G.H5 D 346 G.H5.13
Polar TM6 H 314 6x26 G.H5 D 346 G.H5.13
Hydrophobic TM6 H 314 6x26 G.H5 D 346 G.H5.13
Van-der-waals TM6 H 314 6x26 G.H5 D 346 G.H5.13
Hydrophobic TM6 V 321 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 V 321 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM5 M 307 5x72 G.S6 H 327 G.S6.04
Polar ICL2 I 212 34x56 H.HB K 107 H.HB.03
Hydrophobic ICL2 I 212 34x56 H.HB K 107 H.HB.03
Van-der-waals ICL2 I 212 34x56 H.HB K 107 H.HB.03
Polar ICL2 G 213 34x57 H.hahb E 104 H.hahb.09
Hydrophobic ICL2 G 213 34x57 H.hahb E 104 H.hahb.09
Van-der-waals ICL2 G 213 34x57 H.hahb E 104 H.hahb.09
Hydrophobic ICL3 I 309 - G.S6 F 328 G.S6.05
Van-der-waals ICL3 I 309 - G.S6 F 328 G.S6.05
Polar ICL2 G 213 34x57 H.HB H 105 H.HB.01
Hydrophobic ICL2 G 213 34x57 H.HB H 105 H.HB.01
Van-der-waals ICL2 G 213 34x57 H.HB H 105 H.HB.01
Hydrophobic ICL2 I 212 34x56 H.HC L 135 H.HC.10
Polar ICL1 C 131 12x49 H.hahb E 104 H.hahb.09
Hydrophobic ICL1 C 131 12x49 H.hahb E 104 H.hahb.09
Van-der-waals ICL1 C 131 12x49 H.hahb E 104 H.hahb.09
Polar ICL2 G 211 34x55 H.HB N 106 H.HB.02
Hydrophobic ICL2 G 211 34x55 H.HB N 106 H.HB.02
Van-der-waals ICL2 G 211 34x55 H.HB N 106 H.HB.02
Hydrophobic TM2 P 136 2x39 H.HB K 107 H.HB.03
Van-der-waals TM2 P 136 2x39 H.HB K 107 H.HB.03
Hydrophobic ICL2 K 210 34x54 H.HB N 106 H.HB.02
Van-der-waals ICL2 K 210 34x54 H.HB N 106 H.HB.02
Hydrophobic ICL1 M 132 12x50 H.hahb E 104 H.hahb.09
Van-der-waals ICL1 M 132 12x50 H.hahb E 104 H.hahb.09
Hydrophobic TM6 V 321 6x33 G.H5 V 359 G.H5.26
Van-der-waals TM6 V 321 6x33 G.H5 V 359 G.H5.26
Hydrophobic ICL3 L 311 - G.H5 D 346 G.H5.13
Hydrophobic ICL2 I 212 34x56 H.hahb Y 101 H.hahb.06
Hydrophobic ICL2 G 211 34x55 H.HB K 107 H.HB.03
Van-der-waals ICL2 G 211 34x55 H.HB K 107 H.HB.03
Hydrophobic ICL2 I 209 34x53 H.HB A 110 H.HB.06
Hydrophobic TM5 K 304 5x69 G.H5 F 341 G.H5.08
Van-der-waals TM5 K 304 5x69 G.H5 F 341 G.H5.08
Hydrophobic H8 K 391 8x48 G.H5 K 354 G.H5.21
Polar ICL2 G 211 34x55 H.hahb E 104 H.hahb.09
Hydrophobic ICL2 G 211 34x55 H.hahb E 104 H.hahb.09
Van-der-waals ICL2 G 211 34x55 H.hahb E 104 H.hahb.09
Polar ICL1 M 132 12x50 H.hahb K 102 H.hahb.07
Hydrophobic ICL1 M 132 12x50 H.hahb K 102 H.hahb.07
Van-der-waals ICL1 M 132 12x50 H.hahb K 102 H.hahb.07
Hydrophobic ICL2 K 210 34x54 H.hahb Y 101 H.hahb.06
Hydrophobic ICL2 I 212 34x56 H.hchd D 138 H.hchd.01
Van-der-waals ICL2 I 212 34x56 H.hchd D 138 H.hchd.01
Aromatic ICL2 W 206 34x50 G.H5 F 341 G.H5.08
Hydrophobic ICL2 W 206 34x50 G.H5 F 341 G.H5.08
Van-der-waals ICL2 W 206 34x50 G.H5 F 341 G.H5.08
Polar ICL2 I 212 34x56 H.HB H 105 H.HB.01
Hydrophobic ICL2 I 212 34x56 H.HB H 105 H.HB.01
Van-der-waals ICL2 I 212 34x56 H.HB H 105 H.HB.01
Polar H8 S 390 8x47 G.H5 V 359 G.H5.26
Hydrophobic H8 S 390 8x47 G.H5 V 359 G.H5.26
Van-der-waals H8 S 390 8x47 G.H5 V 359 G.H5.26
Hydrophobic ICL2 R 208 34x52 H.HB A 110 H.HB.06
Van-der-waals ICL2 R 208 34x52 H.HB A 110 H.HB.06
Hydrophobic ICL3 A 310 - G.S6 H 327 G.S6.04
Van-der-waals ICL3 A 310 - G.S6 H 327 G.S6.04
Hydrophobic ICL2 K 210 34x54 H.HB A 108 H.HB.04
Hydrophobic TM2 N 137 2x40 H.hahb E 104 H.hahb.09
Van-der-waals TM2 N 137 2x40 H.hahb E 104 H.hahb.09
Polar ICL2 I 209 34x53 G.H5 N 352 G.H5.19
Hydrophobic ICL2 I 209 34x53 G.H5 N 352 G.H5.19
Van-der-waals ICL2 I 209 34x53 G.H5 N 352 G.H5.19
Polar ICL2 I 209 34x53 H.HA D 95 H.HA.27
Hydrophobic ICL2 I 209 34x53 H.HA D 95 H.HA.27
Van-der-waals ICL2 I 209 34x53 H.HA D 95 H.HA.27
Hydrophobic ICL2 R 208 34x52 H.HA M 94 H.HA.26
Van-der-waals ICL2 R 208 34x52 H.HA M 94 H.HA.26
Polar H8 K 391 8x48 G.H5 V 359 G.H5.26
Hydrophobic H8 K 391 8x48 G.H5 V 359 G.H5.26
Van-der-waals H8 K 391 8x48 G.H5 V 359 G.H5.26
Hydrophobic ICL2 I 209 34x53 H.HB R 114 H.HB.10
Van-der-waals ICL2 I 209 34x53 H.HB R 114 H.HB.10
Polar ICL2 K 210 34x54 H.HB K 107 H.HB.03
Hydrophobic ICL2 K 210 34x54 H.HB K 107 H.HB.03
Van-der-waals ICL2 K 210 34x54 H.HB K 107 H.HB.03
Hydrophobic ICL2 G 211 34x55 H.HB H 105 H.HB.01
Polar ICL2 K 210 34x54 H.HB Q 111 H.HB.07
Hydrophobic ICL2 K 210 34x54 H.HB Q 111 H.HB.07
Van-der-waals ICL2 K 210 34x54 H.HB Q 111 H.HB.07
Polar ICL2 R 208 34x52 H.hahb Y 101 H.hahb.06
Hydrophobic ICL2 R 208 34x52 H.hahb Y 101 H.hahb.06
Van-der-waals ICL2 R 208 34x52 H.hahb Y 101 H.hahb.06
Polar ICL1 C 131 12x49 H.hahb K 102 H.hahb.07
Hydrophobic ICL1 C 131 12x49 H.hahb K 102 H.hahb.07
Van-der-waals ICL1 C 131 12x49 H.hahb K 102 H.hahb.07
Polar ICL2 R 208 34x52 H.HA M 87 H.HA.19
Hydrophobic ICL2 R 208 34x52 H.HA M 87 H.HA.19
Van-der-waals ICL2 R 208 34x52 H.HA M 87 H.HA.19
Ionic N-term R 29 - G.HN E 13 G.HN.31
Polar N-term R 29 - G.HN E 13 G.HN.31
Hydrophobic N-term R 29 - G.HN E 13 G.HN.31
Van-der-waals N-term R 29 - G.HN E 13 G.HN.31
Polar H8 R 392 8x49 G.H5 N 357 G.H5.24
Hydrophobic H8 R 392 8x49 G.H5 N 357 G.H5.24
Van-der-waals H8 R 392 8x49 G.H5 N 357 G.H5.24
Hydrophobic TM3 V 203 3x54 G.H5 L 353 G.H5.20
Hydrophobic ICL2 I 212 34x56 H.HC S 134 H.HC.09
Van-der-waals ICL2 I 212 34x56 H.HC S 134 H.HC.09
Hydrophobic TM5 M 307 5x72 G.H5 A 343 G.H5.10
Van-der-waals TM5 M 307 5x72 G.H5 A 343 G.H5.10
Polar ICL1 K 130 12x48 H.HB H 105 H.HB.01
Hydrophobic TM6 H 314 6x26 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM6 H 314 6x26 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM2 N 137 2x40 G.H5 N 357 G.H5.24
Hydrophobic TM3 R 199 3x50 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 S 207 34x51 G.H5 I 348 G.H5.15
Polar H8 R 392 8x49 G.H5 E 355 G.H5.22
Polar ICL2 I 212 34x56 H.HB A 108 H.HB.04
Van-der-waals ICL2 I 212 34x56 H.HB A 108 H.HB.04
Hydrophobic ICL3 I 309 - G.hgh4 Y 291 G.hgh4.01
Polar TM6 Q 317 6x29 H.HA L 97 H.HA.29
Hydrophobic TM6 H 314 6x26 H.HA L 97 H.HA.29
Van-der-waals TM6 H 314 6x26 H.HA L 97 H.HA.29
Van-der-waals ICL1 N 134 12x52 G.H5 E 355 G.H5.22
Polar ICL2 R 208 34x52 H.HA M 90 H.HA.22
Hydrophobic ICL2 R 208 34x52 H.HA M 90 H.HA.22
Van-der-waals ICL2 R 208 34x52 H.HA M 90 H.HA.22
Hydrophobic ICL2 W 206 34x50 G.H5 I 348 G.H5.15
Polar ICL1 N 134 12x52 H.hahb E 104 H.hahb.09
Hydrophobic ICL1 N 134 12x52 H.hahb E 104 H.hahb.09
Van-der-waals ICL1 N 134 12x52 H.hahb E 104 H.hahb.09
Polar ICL1 K 130 12x48 H.hahb E 104 H.hahb.09
Polar ICL2 G 211 34x55 H.hahb Y 103 H.hahb.08
Hydrophobic ICL2 G 211 34x55 H.hahb Y 103 H.hahb.08
Van-der-waals ICL2 G 211 34x55 H.hahb Y 103 H.hahb.08
Polar ICL2 R 208 34x52 H.HB R 114 H.HB.10
Hydrophobic ICL2 R 208 34x52 H.HB R 114 H.HB.10
Van-der-waals ICL2 R 208 34x52 H.HB R 114 H.HB.10
Polar TM6 H 314 6x26 G.S6 Y 325 G.S6.02
Aromatic TM6 H 314 6x26 G.S6 Y 325 G.S6.02
Hydrophobic TM6 H 314 6x26 G.S6 Y 325 G.S6.02
Van-der-waals TM6 H 314 6x26 G.S6 Y 325 G.S6.02
Hydrophobic TM5 M 307 5x72 G.H5 A 342 G.H5.09
Van-der-waals TM5 M 307 5x72 G.H5 A 342 G.H5.09
Polar H8 S 390 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 S 390 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 S 390 8x47 G.H5 N 357 G.H5.24
Hydrophobic TM6 Q 317 6x29 G.H5 V 359 G.H5.26
Hydrophobic TM3 A 202 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 202 3x53 G.H5 N 352 G.H5.19
Polar ICL3 A 310 - G.S6 Y 325 G.S6.02
Hydrophobic ICL3 A 310 - G.S6 Y 325 G.S6.02
Van-der-waals ICL3 A 310 - G.S6 Y 325 G.S6.02
Hydrophobic ICL2 R 208 34x52 H.HC L 135 H.HC.10
Van-der-waals ICL2 R 208 34x52 H.HC L 135 H.HC.10
Polar ICL2 I 212 34x56 H.HB N 106 H.HB.02
Hydrophobic ICL2 I 212 34x56 H.HB N 106 H.HB.02
Van-der-waals ICL2 I 212 34x56 H.HB N 106 H.HB.02
Hydrophobic TM3 V 203 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 V 203 3x54 G.H5 L 349 G.H5.16
Hydrophobic ICL1 N 134 12x52 H.HB K 107 H.HB.03
Van-der-waals ICL1 N 134 12x52 H.HB K 107 H.HB.03
Hydrophobic ICL2 G 213 34x57 H.HB N 106 H.HB.02
Van-der-waals ICL2 G 213 34x57 H.HB N 106 H.HB.02
Polar ICL1 C 131 12x49 H.hahb Y 103 H.hahb.08
Hydrophobic ICL1 C 131 12x49 H.hahb Y 103 H.hahb.08
Van-der-waals ICL1 C 131 12x49 H.hahb Y 103 H.hahb.08
Hydrophobic TM7 L 386 7x53 G.H5 N 357 G.H5.24
Van-der-waals TM7 L 386 7x53 G.H5 N 357 G.H5.24
Hydrophobic ICL2 K 210 34x54 H.HB H 109 H.HB.05
Hydrophobic TM7 V 389 7x56 G.H5 L 358 G.H5.25
Van-der-waals TM7 V 389 7x56 G.H5 L 358 G.H5.25
Polar ICL2 W 206 34x50 G.S2 Y 192 G.S2.04
Aromatic ICL2 W 206 34x50 G.S2 Y 192 G.S2.04
Hydrophobic ICL2 W 206 34x50 G.S2 Y 192 G.S2.04
Van-der-waals ICL2 W 206 34x50 G.S2 Y 192 G.S2.04