Refined structure (8ID9) of Gi1 - FFA4 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 197 from structure (55.6%), 157 from model (44.4%)
Residue sidechains - 151 from structure (42.7%), 203 from model (57.3%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 Structure Structure
G.HN 3 C G.HN.09 Structure AF2
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure AF2
G.HN 26 D G.HN.50 Structure AF2
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure AF2
G.HN 29 K G.HN.53 Structure AF2
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure AF2
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 AF2 AF2
G.s1h1 43 E G.s1h1.04 AF2 AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure AF2
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 AF2 AF2
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure AF2
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure Structure
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure AF2
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure AF2
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure AF2
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure AF2
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure AF2
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure AF2
G.s4h3 232 L G.s4h3.06 Structure AF2
G.s4h3 233 V G.s4h3.07 Structure AF2
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 AF2 AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure AF2
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure AF2
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure AF2
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure AF2
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure AF2
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure AF2
G.s5hg 270 K G.s5hg.01 Structure AF2
G.HG 271 K G.HG.01 Structure AF2
G.HG 272 D G.HG.02 Structure AF2
G.HG 273 L G.HG.03 Structure AF2
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure AF2
G.HG 276 E G.HG.06 Structure AF2
G.HG 277 K G.HG.07 Structure AF2
G.HG 278 I G.HG.08 AF2 AF2
G.HG 279 K G.HG.09 AF2 AF2
G.HG 280 K G.HG.12 AF2 AF2
G.HG 281 S G.HG.13 AF2 AF2
G.HG 282 P G.HG.14 AF2 AF2
G.HG 283 L G.HG.15 AF2 AF2
G.HG 284 T G.HG.16 AF2 AF2
G.HG 285 I G.HG.17 AF2 AF2
G.hgh4 286 C G.hgh4.01 AF2 AF2
G.hgh4 287 Y G.hgh4.02 AF2 AF2
G.hgh4 288 P G.hgh4.03 AF2 AF2
G.hgh4 289 E G.hgh4.04 AF2 AF2
G.hgh4 290 Y G.hgh4.05 AF2 AF2
G.hgh4 291 A G.hgh4.06 AF2 AF2
G.hgh4 292 G G.hgh4.07 AF2 AF2
G.hgh4 293 S G.hgh4.08 AF2 AF2
G.H4 294 N G.H4.01 AF2 AF2
G.H4 295 T G.H4.02 AF2 AF2
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure AF2
G.H4 298 E G.H4.05 Structure AF2
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure AF2
G.H4 306 Q G.H4.14 Structure AF2
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure AF2
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure AF2
G.h4s6 313 R G.h4s6.04 Structure AF2
G.h4s6 314 K G.h4s6.08 Structure AF2
G.h4s6 315 D G.h4s6.09 Structure AF2
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure AF2
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 AF2 AF2
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure AF2
G.H5 331 N G.H5.03 Structure AF2
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure AF2
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure AF2
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure AF2
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 282 from structure (80.8%), 67 from model (19.2%)
Residue sidechains - 237 from structure (67.9%), 112 from model (32.1%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 S - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 E - AF2 AF2
N-term 5 C - AF2 AF2
N-term 6 A - AF2 AF2
N-term 7 R - AF2 AF2
N-term 8 A - AF2 AF2
N-term 9 A - AF2 AF2
N-term 10 G - AF2 AF2
N-term 11 D - AF2 AF2
N-term 12 A - AF2 AF2
N-term 13 P - AF2 AF2
N-term 14 L - AF2 AF2
N-term 15 R - AF2 AF2
N-term 16 S - AF2 AF2
N-term 17 L - AF2 AF2
N-term 18 E - AF2 AF2
N-term 19 Q - AF2 AF2
N-term 20 A - AF2 AF2
N-term 21 N - AF2 AF2
N-term 22 R - AF2 AF2
N-term 23 T - Structure Structure
N-term 24 R - Structure AF2
N-term 25 F - Structure Structure
N-term 26 P - Structure Structure
N-term 27 F - Structure Structure
N-term 28 F - Structure Structure
N-term 29 S - Structure Structure
N-term 30 D - Structure AF2
N-term 31 V - Structure AF2
N-term 32 K - Structure AF2
N-term 33 G - Structure Structure
N-term 34 D - Structure AF2
TM1 35 H 1.27x27 Structure AF2
TM1 36 R 1.28x28 Structure AF2
TM1 37 L 1.29x29 Structure AF2
TM1 38 V 1.30x30 Structure AF2
TM1 39 L 1.31x31 Structure AF2
TM1 40 A 1.32x32 Structure Structure
TM1 41 A 1.33x33 Structure Structure
TM1 42 V 1.34x34 Structure AF2
TM1 43 E 1.35x35 Structure AF2
TM1 44 T 1.36x36 Structure AF2
TM1 45 T 1.37x37 Structure AF2
TM1 46 V 1.38x38 Structure Structure
TM1 47 L 1.39x39 Structure AF2
TM1 48 V 1.40x40 Structure AF2
TM1 49 L 1.41x41 Structure Structure
TM1 50 I 1.42x42 Structure AF2
TM1 51 F 1.43x43 Structure Structure
TM1 52 A 1.44x44 Structure Structure
TM1 53 V 1.45x45 Structure Structure
TM1 54 S 1.46x46 Structure Structure
TM1 55 L 1.47x47 Structure Structure
TM1 56 L 1.48x48 Structure Structure
TM1 57 G 1.49x49 Structure Structure
TM1 58 N 1.50x50 Structure Structure
TM1 59 V 1.51x51 Structure Structure
TM1 60 C 1.52x52 Structure Structure
TM1 61 A 1.53x53 Structure Structure
TM1 62 L 1.54x54 Structure AF2
TM1 63 V 1.55x55 Structure Structure
TM1 64 L 1.56x56 Structure Structure
TM1 65 V 1.57x57 Structure Structure
TM1 66 A 1.58x58 Structure Structure
TM1 67 R 1.59x59 Structure Structure
TM1 68 R 1.60x60 Structure Structure
ICL1 69 R - Structure AF2
ICL1 70 R - Structure Structure
ICL1 71 R - Structure AF2
ICL1 72 G - Structure Structure
ICL1 73 A - Structure Structure
ICL1 74 T - AF2 AF2
TM2 75 A 2.40x40 AF2 AF2
TM2 76 C 2.41x41 AF2 AF2
TM2 77 L 2.42x42 Structure Structure
TM2 78 V 2.43x43 Structure Structure
TM2 79 L 2.44x44 Structure Structure
TM2 80 N 2.45x45 Structure Structure
TM2 81 L 2.46x46 Structure Structure
TM2 82 F 2.47x47 Structure Structure
TM2 83 C 2.48x48 Structure Structure
TM2 84 A 2.49x49 Structure Structure
TM2 85 D 2.50x50 Structure Structure
TM2 86 L 2.51x51 Structure Structure
TM2 87 L 2.52x52 Structure Structure
TM2 88 F 2.53x53 Structure Structure
TM2 89 I 2.54x54 Structure Structure
TM2 90 S 2.55x55 Structure Structure
TM2 91 A 2.56x56 Structure Structure
TM2 92 I 2.57x57 Structure AF2
TM2 93 P 2.58x58 Structure AF2
TM2 94 L 2.59x59 Structure AF2
TM2 95 V 2.60x60 Structure AF2
TM2 96 L 2.61x61 Structure AF2
TM2 97 A 2.62x62 Structure Structure
TM2 98 V 2.63x63 Structure AF2
TM2 99 R 2.64x64 Structure Structure
TM2 100 W 2.65x65 Structure Structure
TM2 101 T 2.66x66 Structure AF2
ECL1 102 E - Structure AF2
ECL1 103 A 23.49x49 Structure Structure
ECL1 104 W 23.50x50 Structure Structure
ECL1 105 L 23.51x51 Structure AF2
ECL1 106 L 23.52x52 Structure Structure
TM3 107 G 3.21x21 Structure Structure
TM3 108 P 3.22x22 Structure Structure
TM3 109 V 3.23x23 Structure Structure
TM3 110 A 3.24x24 Structure Structure
TM3 111 C 3.25x25 Structure Structure
TM3 112 H 3.26x26 Structure Structure
TM3 113 L 3.27x27 Structure AF2
TM3 114 L 3.28x28 Structure Structure
TM3 115 F 3.29x29 Structure Structure
TM3 116 Y 3.30x30 Structure Structure
TM3 117 V 3.31x31 Structure Structure
TM3 118 M 3.32x32 Structure Structure
TM3 119 T 3.33x33 Structure Structure
TM3 120 L 3.34x34 Structure Structure
TM3 121 S 3.35x35 Structure Structure
TM3 122 G 3.36x36 Structure Structure
TM3 123 S 3.37x37 Structure Structure
TM3 124 V 3.38x38 Structure Structure
TM3 125 T 3.39x39 Structure Structure
TM3 126 I 3.40x40 Structure Structure
TM3 127 L 3.41x41 Structure Structure
TM3 128 T 3.42x42 Structure Structure
TM3 129 L 3.43x43 Structure Structure
TM3 130 A 3.44x44 Structure Structure
TM3 131 A 3.45x45 Structure Structure
TM3 132 V 3.46x46 Structure Structure
TM3 133 S 3.47x47 Structure Structure
TM3 134 L 3.48x48 Structure Structure
TM3 135 E 3.49x49 Structure Structure
TM3 136 R 3.50x50 Structure Structure
TM3 137 M 3.51x51 Structure Structure
TM3 138 V 3.52x52 Structure Structure
TM3 139 C 3.53x53 Structure Structure
TM3 140 I 3.54x54 Structure Structure
TM3 141 V 3.55x55 Structure Structure
TM3 142 H 3.56x56 Structure AF2
ICL2 143 L 34.50x50 Structure Structure
ICL2 144 Q 34.51x51 Structure Structure
ICL2 145 R 34.52x52 AF2 AF2
ICL2 146 G 34.53x53 AF2 AF2
ICL2 147 V 34.54x54 AF2 AF2
ICL2 148 R 34.55x55 AF2 AF2
ICL2 149 G 34.56x56 AF2 AF2
ICL2 150 P 34.57x57 AF2 AF2
TM4 151 G 4.38x38 Structure Structure
TM4 152 R 4.39x39 Structure AF2
TM4 153 R 4.40x40 Structure AF2
TM4 154 A 4.41x41 Structure Structure
TM4 155 R 4.42x42 Structure Structure
TM4 156 A 4.43x43 Structure Structure
TM4 157 V 4.44x44 Structure Structure
TM4 158 L 4.45x45 Structure Structure
TM4 159 L 4.46x46 Structure Structure
TM4 160 A 4.47x47 Structure Structure
TM4 161 L 4.48x48 Structure Structure
TM4 162 I 4.49x49 Structure Structure
TM4 163 W 4.50x50 Structure Structure
TM4 164 G 4.51x51 Structure Structure
TM4 165 Y 4.52x52 Structure Structure
TM4 166 S 4.53x53 Structure Structure
TM4 167 A 4.54x54 Structure Structure
TM4 168 V 4.55x55 Structure Structure
TM4 169 A 4.56x56 Structure Structure
TM4 170 A 4.57x57 Structure Structure
TM4 171 L 4.58x59 Structure Structure
TM4 172 P 4.59x60 Structure Structure
TM4 173 L 4.60x61 Structure Structure
TM4 174 C 4.61x62 Structure Structure
TM4 175 V 4.62x63 Structure Structure
TM4 176 F 4.63x64 Structure Structure
TM4 177 F 4.64x65 Structure Structure
ECL2 178 R - Structure AF2
ECL2 179 V - Structure Structure
ECL2 180 V - Structure AF2
ECL2 181 P - Structure Structure
ECL2 182 Q - AF2 AF2
ECL2 183 R - AF2 AF2
ECL2 184 L - AF2 AF2
ECL2 185 P - AF2 AF2
ECL2 186 G - AF2 AF2
ECL2 187 A - AF2 AF2
ECL2 188 D - AF2 AF2
ECL2 189 Q - AF2 AF2
ECL2 190 E - AF2 AF2
ECL2 191 I - Structure AF2
ECL2 192 S - Structure Structure
ECL2 193 I - Structure AF2
ECL2 194 C 45.50x50 Structure Structure
ECL2 195 T 45.51x51 Structure Structure
ECL2 196 L 45.52x52 Structure AF2
ECL2 197 I - Structure Structure
ECL2 198 W - Structure Structure
ECL2 199 P - Structure Structure
TM5 200 T 5.31x32 Structure AF2
TM5 201 I 5.32x33 Structure AF2
TM5 202 P 5.33x34 Structure Structure
TM5 203 G 5.34x35 Structure Structure
TM5 204 E 5.35x36 Structure AF2
TM5 205 I 5.36x37 Structure Structure
TM5 206 S 5.37x38 Structure Structure
TM5 207 W 5.38x39 Structure Structure
TM5 208 D 5.39x40 Structure Structure
TM5 209 V 5.40x41 Structure Structure
TM5 210 S 5.41x42 Structure Structure
TM5 211 F 5.42x43 Structure Structure
TM5 212 V 5.43x44 Structure Structure
TM5 213 T 5.44x45 Structure Structure
TM5 214 L 5.45x46 Structure Structure
TM5 215 N 5.46x461 Structure Structure
TM5 216 F 5.47x47 Structure Structure
TM5 217 L 5.48x48 Structure Structure
TM5 218 V 5.49x49 Structure Structure
TM5 219 P 5.50x50 Structure Structure
TM5 220 G 5.51x51 Structure Structure
TM5 221 L 5.52x52 Structure Structure
TM5 222 V 5.53x53 Structure Structure
TM5 223 I 5.54x54 Structure Structure
TM5 224 V 5.55x55 Structure Structure
TM5 225 I 5.56x56 Structure Structure
TM5 226 S 5.57x57 Structure Structure
TM5 227 Y 5.58x58 Structure Structure
TM5 228 S 5.59x59 Structure Structure
TM5 229 K 5.60x60 Structure Structure
TM5 230 I 5.61x61 Structure Structure
TM5 231 L 5.62x62 Structure Structure
TM5 232 Q 5.63x63 Structure Structure
TM5 233 I 5.64x64 Structure Structure
TM5 234 T 5.65x65 Structure Structure
TM5 235 K 5.66x66 Structure Structure
TM5 236 A 5.67x67 Structure Structure
TM5 237 S 5.68x68 Structure Structure
TM5 238 R 5.69x69 Structure Structure
TM5 239 K 5.70x70 Structure Structure
TM5 240 R 5.71x71 Structure Structure
TM5 241 L 5.72x72 Structure Structure
TM5 242 T 5.73x73 Structure Structure
TM5 243 V 5.74x74 Structure AF2
TM5 244 S 5.75x75 Structure Structure
TM5 245 L 5.76x76 Structure Structure
ICL3 246 A - AF2 AF2
ICL3 247 Y - AF2 AF2
TM6 248 S 6.19x20 AF2 AF2
TM6 249 E 6.20x21 Structure Structure
TM6 250 S 6.21x22 Structure Structure
TM6 251 H 6.22x23 Structure Structure
TM6 252 Q 6.23x24 Structure AF2
TM6 253 I 6.24x25 Structure Structure
TM6 254 R 6.25x26 Structure Structure
TM6 255 V 6.26x27 Structure Structure
TM6 256 S 6.27x28 Structure Structure
TM6 257 Q 6.28x29 Structure Structure
TM6 258 Q 6.29x30 Structure AF2
TM6 259 D 6.30x31 Structure Structure
TM6 260 F 6.31x32 Structure Structure
TM6 261 R 6.32x33 Structure Structure
TM6 262 L 6.33x34 Structure Structure
TM6 263 F 6.34x35 Structure Structure
TM6 264 R 6.35x36 Structure Structure
TM6 265 T 6.36x37 Structure Structure
TM6 266 L 6.37x38 Structure Structure
TM6 267 F 6.38x39 Structure Structure
TM6 268 L 6.39x40 Structure Structure
TM6 269 L 6.40x41 Structure Structure
TM6 270 M 6.41x42 Structure Structure
TM6 271 V 6.42x43 Structure Structure
TM6 272 S 6.43x44 Structure Structure
TM6 273 F 6.44x45 Structure Structure
TM6 274 F 6.45x46 Structure Structure
TM6 275 I 6.46x461 Structure Structure
TM6 276 M 6.47x47 Structure Structure
TM6 277 W 6.48x48 Structure Structure
TM6 278 S 6.49x49 Structure Structure
TM6 279 P 6.50x50 Structure Structure
TM6 280 I 6.51x51 Structure Structure
TM6 281 I 6.52x52 Structure Structure
TM6 282 I 6.53x53 Structure Structure
TM6 283 T 6.54x54 Structure Structure
TM6 284 I 6.55x55 Structure Structure
TM6 285 L 6.56x56 Structure Structure
TM6 286 L 6.57x57 Structure Structure
TM6 287 I 6.58x58 Structure Structure
TM6 288 L 6.59x59 Structure Structure
TM6 289 I 6.60x60 Structure Structure
TM6 290 Q 6.61x61 Structure Structure
TM6 291 N 6.62x62 Structure Structure
TM6 292 F 6.63x63 Structure Structure
TM6 293 K 6.64x64 Structure Structure
TM6 294 Q 6.65x65 AF2 AF2
ECL3 295 D - AF2 AF2
ECL3 296 L - Structure Structure
ECL3 297 V - Structure Structure
ECL3 298 I - Structure Structure
TM7 299 W 7.31x30 Structure AF2
TM7 300 P 7.32x31 Structure Structure
TM7 301 S 7.33x32 Structure Structure
TM7 302 L 7.34x33 Structure Structure
TM7 303 F 7.35x34 Structure Structure
TM7 304 F 7.36x35 Structure Structure
TM7 305 W 7.37x36 Structure Structure
TM7 306 V 7.38x37 Structure Structure
TM7 307 V 7.39x38 Structure Structure
TM7 308 A 7.40x39 Structure Structure
TM7 309 F 7.41x40 Structure Structure
TM7 310 T 7.42x41 Structure Structure
TM7 311 F 7.43x42 Structure Structure
TM7 312 A 7.44x43 Structure Structure
TM7 313 N 7.45x45 Structure Structure
TM7 314 S 7.46x46 Structure Structure
TM7 315 A 7.47x47 Structure Structure
TM7 316 L 7.48x48 Structure Structure
TM7 317 N 7.49x49 Structure Structure
TM7 318 P 7.50x50 Structure Structure
TM7 319 I 7.51x51 Structure Structure
TM7 320 L 7.52x52 Structure Structure
TM7 321 Y 7.53x53 Structure Structure
TM7 322 N 7.54x54 Structure Structure
TM7 323 M 7.55x55 Structure Structure
TM7 324 T 7.56x56 Structure Structure
H8 325 L 8.47x47 Structure Structure
H8 326 C 8.48x48 Structure Structure
H8 327 R 8.49x49 Structure Structure
H8 328 N 8.50x50 AF2 AF2
H8 329 E 8.51x51 AF2 AF2
H8 330 W 8.52x52 AF2 AF2
H8 331 K 8.53x53 AF2 AF2
H8 332 K 8.54x54 AF2 AF2
H8 333 I 8.55x55 AF2 AF2
H8 334 F 8.56x56 AF2 AF2
H8 335 C 8.57x57 AF2 AF2
H8 336 C 8.58x58 AF2 AF2
H8 337 F 8.59x59 AF2 AF2
H8 338 W 8.60x60 AF2 AF2
H8 339 F 8.61x61 AF2 AF2
C-term 340 P - AF2 AF2
C-term 341 E - AF2 AF2
C-term 342 K - AF2 AF2
C-term 343 G - AF2 AF2
C-term 344 A - AF2 AF2
C-term 345 I - AF2 AF2
C-term 346 L - AF2 AF2
C-term 347 T - AF2 AF2
C-term 348 D - AF2 AF2
C-term 349 T - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM5 S 244 5x75 G.H5 D 337 G.H5.09
Polar ICL1 T 74 - G.H5 D 350 G.H5.22
Hydrophobic H8 L 325 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM7 T 324 7x56 G.H5 F 354 G.H5.26
Van-der-waals TM7 T 324 7x56 G.H5 F 354 G.H5.26
Polar TM5 S 237 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 S 237 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL3 A 246 - G.S6 F 323 G.S6.05
Van-der-waals ICL3 A 246 - G.S6 F 323 G.S6.05
Polar ICL3 A 246 - G.H4 Q 304 G.H4.12
Van-der-waals ICL3 A 246 - G.H4 Q 304 G.H4.12
Polar TM6 R 254 6x26 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 L 262 6x34 G.H5 F 354 G.H5.26
Hydrophobic TM6 T 265 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 265 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 245 5x76 G.H5 F 334 G.H5.06
Van-der-waals TM5 L 245 5x76 G.H5 F 334 G.H5.06
Polar TM3 R 136 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 136 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 136 3x50 G.H5 C 351 G.H5.23
Ionic TM5 R 238 5x69 G.H5 D 341 G.H5.13
Van-der-waals ICL2 R 145 34x52 G.hns1 A 31 G.hns1.02
Hydrophobic TM5 I 230 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 230 5x61 G.H5 L 353 G.H5.25
Polar ICL2 R 145 34x52 G.S1 E 33 G.S1.01
Van-der-waals ICL2 R 145 34x52 G.S1 E 33 G.S1.01
Ionic TM5 R 240 5x71 G.H5 D 337 G.H5.09
Polar TM5 R 240 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 R 240 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 R 240 5x71 G.H5 D 337 G.H5.09
Ionic TM6 H 251 6x23 G.H4 E 308 G.H4.16
Polar TM6 H 251 6x23 G.H4 E 308 G.H4.16
Hydrophobic TM6 H 251 6x23 G.H4 E 308 G.H4.16
Hydrophobic C-term T 349 - G.H2 H 213 G.H2.09
Van-der-waals C-term T 349 - G.H2 H 213 G.H2.09
Hydrophobic C-term T 349 - G.H3 W 258 G.H3.17
Van-der-waals C-term T 349 - G.H3 W 258 G.H3.17
Ionic TM5 R 238 5x69 G.h4s6 E 318 G.h4s6.12
Polar TM5 R 238 5x69 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 R 238 5x69 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 R 238 5x69 G.h4s6 E 318 G.h4s6.12
Polar TM6 S 248 6x20 G.H4 C 305 G.H4.13
Hydrophobic TM6 S 248 6x20 G.H4 C 305 G.H4.13
Van-der-waals TM6 S 248 6x20 G.H4 C 305 G.H4.13
Van-der-waals TM5 R 238 5x69 G.H5 K 345 G.H5.17
Hydrophobic TM5 L 241 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 L 241 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM5 L 241 5x72 G.H5 D 337 G.H5.09
Polar ICL3 Y 247 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 Y 247 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 Y 247 - G.h4s6 E 318 G.h4s6.12
Polar TM6 S 248 6x20 G.H4 Q 304 G.H4.12
Hydrophobic TM6 S 248 6x20 G.H4 Q 304 G.H4.12
Van-der-waals TM6 S 248 6x20 G.H4 Q 304 G.H4.12
Polar TM6 S 248 6x20 G.H4 E 308 G.H4.16
Hydrophobic TM6 S 248 6x20 G.H4 E 308 G.H4.16
Van-der-waals TM6 S 248 6x20 G.H4 E 308 G.H4.16
Polar ICL2 Q 144 34x51 G.H5 N 347 G.H5.19
Van-der-waals ICL2 Q 144 34x51 G.H5 N 347 G.H5.19
Hydrophobic TM6 L 262 6x34 G.H5 L 348 G.H5.20
Van-der-waals TM6 L 262 6x34 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 143 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 L 143 34x50 G.H5 I 344 G.H5.16
Ionic C-term D 348 - G.H3 K 257 G.H3.16
Polar C-term D 348 - G.H3 K 257 G.H3.16
Hydrophobic C-term D 348 - G.H3 K 257 G.H3.16
Van-der-waals C-term D 348 - G.H3 K 257 G.H3.16
Hydrophobic TM6 L 266 6x38 G.H5 L 353 G.H5.25
Hydrophobic TM3 C 139 3x53 G.H5 C 351 G.H5.23
Polar C-term D 348 - G.H3 W 258 G.H3.17
Hydrophobic C-term D 348 - G.H3 W 258 G.H3.17
Van-der-waals C-term D 348 - G.H3 W 258 G.H3.17
Polar TM3 C 139 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 C 139 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 C 139 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 Y 227 5x58 G.H5 L 353 G.H5.25
Hydrophobic TM5 S 237 5x68 G.H5 I 344 G.H5.16
Ionic TM6 R 254 6x26 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 R 145 34x52 G.S1 V 34 G.S1.02
Hydrophobic TM3 I 140 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 140 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL3 A 246 - G.S6 H 322 G.S6.04
Polar ICL2 R 148 34x55 G.HN G 27 G.HN.51
Polar TM6 Q 258 6x30 G.H5 K 345 G.H5.17
Van-der-waals TM6 Q 258 6x30 G.H5 K 345 G.H5.17
Hydrophobic TM5 S 244 5x75 G.H5 F 334 G.H5.06
Van-der-waals TM5 S 244 5x75 G.H5 F 334 G.H5.06
Hydrophobic TM3 R 136 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 136 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 241 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 L 241 5x72 G.H5 D 341 G.H5.13
Hydrophobic ICL3 Y 247 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 Y 247 - G.S6 Y 320 G.S6.02
Hydrophobic TM6 R 261 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 261 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM5 I 233 5x64 G.H5 I 344 G.H5.16
Polar ICL3 A 246 - G.S6 T 321 G.S6.03
Hydrophobic ICL3 A 246 - G.S6 T 321 G.S6.03
Van-der-waals ICL3 A 246 - G.S6 T 321 G.S6.03
Hydrophobic ICL2 L 143 34x50 G.H5 T 340 G.H5.12
Polar ICL2 R 145 34x52 G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL2 R 145 34x52 G.h2s4 T 219 G.h2s4.05
Van-der-waals ICL2 R 145 34x52 G.h2s4 T 219 G.h2s4.05
Ionic ICL2 R 148 34x55 G.HN E 28 G.HN.52
Polar ICL2 R 148 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 R 148 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 R 148 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 R 145 34x52 G.H5 I 343 G.H5.15
Van-der-waals ICL2 R 145 34x52 G.H5 I 343 G.H5.15
Polar TM7 T 324 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 T 324 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 T 324 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM5 L 245 5x76 G.S6 Y 320 G.S6.02
Van-der-waals TM5 L 245 5x76 G.S6 Y 320 G.S6.02
Polar ICL2 G 146 34x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 L 262 6x34 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 262 6x34 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 143 34x50 G.H5 I 343 G.H5.15