Refined structure (8IHJ) of Gi1 - HCA3 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-07-12

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 218 from structure (61.6%), 136 from model (38.4%)
Residue sidechains - 200 from structure (56.5%), 154 from model (43.5%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 AF2 AF2
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure AF2
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure AF2
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure AF2
G.HN 18 M G.HN.42 Structure AF2
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure AF2
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure AF2
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure AF2
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 Structure Structure
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure AF2
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure AF2
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure AF2
G.s6h5 328 D G.s6h5.05 Structure AF2
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure AF2
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 283 from structure (88.4%), 37 from model (11.6%)
Residue sidechains - 262 from structure (81.9%), 58 from model (18.1%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 N - AF2 AF2
N-term 3 R - AF2 AF2
N-term 4 H - AF2 AF2
N-term 5 H - AF2 AF2
N-term 6 L - AF2 AF2
N-term 7 Q - AF2 AF2
N-term 8 D - AF2 AF2
N-term 9 H - AF2 AF2
N-term 10 F - AF2 AF2
N-term 11 L - AF2 AF2
N-term 12 E - AF2 AF2
N-term 13 I - AF2 AF2
N-term 14 D - AF2 AF2
N-term 15 K - AF2 AF2
N-term 16 K - AF2 AF2
N-term 17 N - Structure Structure
N-term 18 C - Structure Structure
N-term 19 C - Structure Structure
N-term 20 V - Structure Structure
N-term 21 F - Structure Structure
N-term 22 R - Structure Structure
TM1 23 D 1.28x28 Structure Structure
TM1 24 D 1.29x29 Structure Structure
TM1 25 F 1.30x30 Structure Structure
TM1 26 I 1.31x31 Structure AF2
TM1 27 A 1.32x32 Structure Structure
TM1 28 K 1.33x33 Structure Structure
TM1 29 V 1.34x34 Structure Structure
TM1 30 L 1.35x35 Structure Structure
TM1 31 P 1.36x36 Structure Structure
TM1 32 P 1.37x37 Structure Structure
TM1 33 V 1.38x38 Structure Structure
TM1 34 L 1.39x39 Structure Structure
TM1 35 G 1.40x40 Structure Structure
TM1 36 L 1.41x41 Structure Structure
TM1 37 E 1.42x42 Structure Structure
TM1 38 F 1.43x43 Structure Structure
TM1 39 I 1.44x44 Structure Structure
TM1 40 F 1.45x45 Structure Structure
TM1 41 G 1.46x46 Structure Structure
TM1 42 L 1.47x47 Structure Structure
TM1 43 L 1.48x48 Structure Structure
TM1 44 G 1.49x49 Structure Structure
TM1 45 N 1.50x50 Structure Structure
TM1 46 G 1.51x51 Structure Structure
TM1 47 L 1.52x52 Structure Structure
TM1 48 A 1.53x53 Structure Structure
TM1 49 L 1.54x54 Structure Structure
TM1 50 W 1.55x55 Structure Structure
TM1 51 I 1.56x56 Structure Structure
TM1 52 F 1.57x57 Structure Structure
TM1 53 C 1.58x58 Structure Structure
TM1 54 F 1.59x59 Structure Structure
TM1 55 H 1.60x60 Structure Structure
ICL1 56 L - Structure Structure
ICL1 57 K - Structure Structure
ICL1 58 S - Structure Structure
ICL1 59 W - Structure Structure
TM2 60 K 2.37x37 Structure Structure
TM2 61 S 2.38x38 Structure Structure
TM2 62 S 2.39x39 Structure Structure
TM2 63 R 2.40x40 Structure Structure
TM2 64 I 2.41x41 Structure Structure
TM2 65 F 2.42x42 Structure Structure
TM2 66 L 2.43x43 Structure Structure
TM2 67 F 2.44x44 Structure Structure
TM2 68 N 2.45x45 Structure Structure
TM2 69 L 2.46x46 Structure Structure
TM2 70 A 2.47x47 Structure Structure
TM2 71 V 2.48x48 Structure Structure
TM2 72 A 2.49x49 Structure Structure
TM2 73 D 2.50x50 Structure Structure
TM2 74 F 2.51x51 Structure Structure
TM2 75 L 2.52x52 Structure Structure
TM2 76 L 2.53x53 Structure Structure
TM2 77 I 2.54x54 Structure Structure
TM2 78 I 2.55x55 Structure Structure
TM2 79 C 2.56x56 Structure Structure
TM2 80 L 2.57x57 Structure Structure
TM2 81 P 2.58x58 Structure Structure
TM2 82 F 2.59x59 Structure Structure
TM2 83 V 2.60x60 Structure Structure
TM2 84 M 2.61x61 Structure AF2
TM2 85 D 2.62x62 Structure Structure
TM2 86 Y 2.63x63 Structure Structure
TM2 87 Y 2.64x64 Structure Structure
TM2 88 V 2.65x65 Structure Structure
TM2 89 R 2.66x66 Structure AF2
ECL1 90 R - Structure AF2
ECL1 91 S - Structure Structure
ECL1 92 D 23.49x49 Structure Structure
ECL1 93 W 23.50x50 Structure Structure
ECL1 94 K 23.51x51 Structure AF2
ECL1 95 F 23.52x52 Structure Structure
TM3 96 G 3.21x21 Structure Structure
TM3 97 D 3.22x22 Structure Structure
TM3 98 I 3.23x23 Structure Structure
TM3 99 P 3.24x24 Structure Structure
TM3 100 C 3.25x25 Structure Structure
TM3 101 R 3.26x26 Structure Structure
TM3 102 L 3.27x27 Structure Structure
TM3 103 V 3.28x28 Structure Structure
TM3 104 L 3.29x29 Structure Structure
TM3 105 F 3.30x30 Structure Structure
TM3 106 M 3.31x31 Structure Structure
TM3 107 F 3.32x32 Structure Structure
TM3 108 A 3.33x33 Structure Structure
TM3 109 M 3.34x34 Structure Structure
TM3 110 N 3.35x35 Structure AF2
TM3 111 R 3.36x36 Structure Structure
TM3 112 Q 3.37x37 Structure Structure
TM3 113 G 3.38x38 Structure Structure
TM3 114 S 3.39x39 Structure Structure
TM3 115 I 3.40x40 Structure Structure
TM3 116 I 3.41x41 Structure Structure
TM3 117 F 3.42x42 Structure Structure
TM3 118 L 3.43x43 Structure Structure
TM3 119 T 3.44x44 Structure Structure
TM3 120 V 3.45x45 Structure Structure
TM3 121 V 3.46x46 Structure Structure
TM3 122 A 3.47x47 Structure Structure
TM3 123 V 3.48x48 Structure Structure
TM3 124 D 3.49x49 Structure Structure
TM3 125 R 3.50x50 Structure Structure
TM3 126 Y 3.51x51 Structure Structure
TM3 127 F 3.52x52 Structure Structure
TM3 128 R 3.53x53 Structure Structure
TM3 129 V 3.54x54 Structure Structure
TM3 130 V 3.55x55 Structure Structure
TM3 131 H 3.56x56 Structure Structure
ICL2 132 P 34.50x50 Structure Structure
ICL2 133 H 34.51x51 Structure Structure
ICL2 134 H 34.52x52 Structure Structure
ICL2 135 A 34.53x53 Structure Structure
ICL2 136 L 34.54x54 Structure Structure
ICL2 137 N 34.55x55 Structure Structure
ICL2 138 K 34.56x56 Structure Structure
ICL2 139 I 34.57x57 Structure Structure
TM4 140 S 4.38x38 Structure Structure
TM4 141 N 4.39x39 Structure Structure
TM4 142 W 4.40x40 Structure Structure
TM4 143 T 4.41x41 Structure Structure
TM4 144 A 4.42x42 Structure Structure
TM4 145 A 4.43x43 Structure Structure
TM4 146 I 4.44x44 Structure Structure
TM4 147 I 4.45x45 Structure Structure
TM4 148 S 4.46x46 Structure Structure
TM4 149 C 4.47x47 Structure Structure
TM4 150 L 4.48x48 Structure Structure
TM4 151 L 4.49x49 Structure Structure
TM4 152 W 4.50x50 Structure Structure
TM4 153 G 4.51x51 Structure Structure
TM4 154 I 4.52x52 Structure Structure
TM4 155 T 4.53x53 Structure Structure
TM4 156 V 4.54x54 Structure Structure
TM4 157 G 4.55x55 Structure Structure
TM4 158 L 4.56x56 Structure Structure
TM4 159 T 4.57x57 Structure Structure
TM4 160 V 4.58x58 Structure Structure
TM4 161 H 4.59x59 Structure Structure
TM4 162 L 4.60x60 Structure Structure
TM4 163 L 4.61x61 Structure Structure
TM4 164 K 4.62x62 Structure Structure
TM4 165 K 4.63x63 Structure Structure
TM4 166 K 4.64x64 Structure Structure
ECL2 167 L - Structure Structure
ECL2 168 L - Structure Structure
ECL2 169 I - Structure AF2
ECL2 170 Q - Structure AF2
ECL2 171 N - Structure AF2
ECL2 172 G - Structure Structure
ECL2 173 T - Structure Structure
ECL2 174 A - Structure Structure
ECL2 175 N - Structure Structure
ECL2 176 V - Structure Structure
ECL2 177 C 45.50x50 Structure Structure
ECL2 178 I 45.51x51 Structure Structure
ECL2 179 S 45.52x52 Structure Structure
ECL2 180 F - Structure Structure
ECL2 181 S - Structure Structure
ECL2 182 I - Structure AF2
ECL2 183 C - Structure Structure
ECL2 184 H - Structure AF2
ECL2 185 T - Structure Structure
ECL2 186 F - Structure Structure
TM5 187 R 5.37x38 Structure AF2
TM5 188 W 5.38x39 Structure Structure
TM5 189 H 5.39x40 Structure Structure
TM5 190 E 5.40x41 Structure AF2
TM5 191 A 5.41x42 Structure Structure
TM5 192 M 5.42x43 Structure Structure
TM5 193 F 5.43x44 Structure Structure
TM5 194 L 5.44x45 Structure Structure
TM5 195 L 5.45x46 Structure Structure
TM5 196 E 5.46x461 Structure Structure
TM5 197 F 5.47x47 Structure Structure
TM5 198 F 5.48x48 Structure Structure
TM5 199 L 5.49x49 Structure Structure
TM5 200 P 5.50x50 Structure Structure
TM5 201 L 5.51x51 Structure Structure
TM5 202 G 5.52x52 Structure Structure
TM5 203 I 5.53x53 Structure Structure
TM5 204 I 5.54x54 Structure Structure
TM5 205 L 5.55x55 Structure Structure
TM5 206 F 5.56x56 Structure Structure
TM5 207 C 5.57x57 Structure Structure
TM5 208 S 5.58x58 Structure Structure
TM5 209 A 5.59x59 Structure Structure
TM5 210 R 5.60x60 Structure Structure
TM5 211 I 5.61x61 Structure Structure
TM5 212 I 5.62x62 Structure AF2
TM5 213 W 5.63x63 Structure Structure
TM5 214 S 5.64x64 Structure Structure
TM5 215 L 5.65x65 Structure Structure
TM5 216 R 5.66x66 Structure Structure
TM5 217 Q 5.67x67 Structure Structure
TM5 218 R 5.68x68 Structure Structure
ICL3 219 Q - Structure Structure
ICL3 220 M - Structure Structure
ICL3 221 D - Structure Structure
ICL3 222 R - Structure AF2
ICL3 223 H - Structure AF2
ICL3 224 A - Structure Structure
TM6 225 K 6.29x29 Structure Structure
TM6 226 I 6.30x30 Structure Structure
TM6 227 K 6.31x31 Structure Structure
TM6 228 R 6.32x32 Structure Structure
TM6 229 A 6.33x33 Structure Structure
TM6 230 I 6.34x34 Structure Structure
TM6 231 T 6.35x35 Structure Structure
TM6 232 F 6.36x36 Structure Structure
TM6 233 I 6.37x37 Structure AF2
TM6 234 M 6.38x38 Structure AF2
TM6 235 V 6.39x39 Structure Structure
TM6 236 V 6.40x40 Structure Structure
TM6 237 A 6.41x41 Structure Structure
TM6 238 I 6.42x42 Structure Structure
TM6 239 V 6.43x43 Structure Structure
TM6 240 F 6.44x44 Structure Structure
TM6 241 V 6.45x45 Structure Structure
TM6 242 I 6.46x46 Structure Structure
TM6 243 C 6.47x47 Structure Structure
TM6 244 F 6.48x48 Structure Structure
TM6 245 L 6.49x49 Structure Structure
TM6 246 P 6.50x50 Structure Structure
TM6 247 S 6.51x51 Structure Structure
TM6 248 V 6.52x52 Structure Structure
TM6 249 V 6.53x53 Structure Structure
TM6 250 V 6.54x54 Structure Structure
TM6 251 R 6.55x55 Structure Structure
TM6 252 I 6.56x56 Structure Structure
TM6 253 H 6.57x57 Structure Structure
TM6 254 I 6.58x58 Structure Structure
TM6 255 F 6.59x59 Structure Structure
TM6 256 W 6.60x60 Structure Structure
TM6 257 L 6.61x61 Structure Structure
TM6 258 L 6.62x62 Structure AF2
TM6 259 H 6.63x63 Structure Structure
TM6 260 T 6.64x64 Structure Structure
TM6 261 S 6.65x65 Structure Structure
ECL3 262 G - Structure Structure
ECL3 263 T - Structure Structure
ECL3 264 Q - Structure Structure
ECL3 265 N - Structure Structure
ECL3 266 C - Structure Structure
ECL3 267 E - Structure Structure
TM7 268 V 7.27x26 Structure Structure
TM7 269 Y 7.28x27 Structure Structure
TM7 270 R 7.29x28 Structure AF2
TM7 271 S 7.30x29 Structure Structure
TM7 272 V 7.31x30 Structure Structure
TM7 273 D 7.32x31 Structure Structure
TM7 274 L 7.33x32 Structure Structure
TM7 275 A 7.34x33 Structure Structure
TM7 276 F 7.35x34 Structure Structure
TM7 277 F 7.36x35 Structure Structure
TM7 278 I 7.37x36 Structure Structure
TM7 279 T 7.38x37 Structure AF2
TM7 280 L 7.39x38 Structure Structure
TM7 281 S 7.40x39 Structure Structure
TM7 282 F 7.41x40 Structure Structure
TM7 283 T 7.42x41 Structure Structure
TM7 284 Y 7.43x42 Structure Structure
TM7 285 M 7.44x43 Structure Structure
TM7 286 N 7.45x45 Structure Structure
TM7 287 S 7.46x46 Structure Structure
TM7 288 M 7.47x47 Structure Structure
TM7 289 L 7.48x48 Structure Structure
TM7 290 D 7.49x49 Structure Structure
TM7 291 P 7.50x50 Structure Structure
TM7 292 V 7.51x51 Structure Structure
TM7 293 V 7.52x52 Structure Structure
TM7 294 Y 7.53x53 Structure Structure
TM7 295 Y 7.54x54 Structure Structure
TM7 296 F 7.55x55 Structure Structure
TM7 297 S 7.56x56 Structure Structure
H8 298 S 8.47x47 Structure Structure
H8 299 P 8.48x48 Structure Structure
H8 300 S 8.49x49 AF2 AF2
H8 301 F 8.50x50 AF2 AF2
H8 302 P 8.51x51 AF2 AF2
H8 303 N 8.52x52 AF2 AF2
H8 304 F 8.53x53 AF2 AF2
H8 305 F 8.54x54 AF2 AF2
H8 306 S 8.55x55 AF2 AF2
H8 307 T 8.56x56 AF2 AF2
H8 308 L 8.57x57 AF2 AF2
H8 309 I 8.58x58 AF2 AF2
H8 310 N 8.59x59 AF2 AF2
C-term 311 R - AF2 AF2
C-term 312 C - AF2 AF2
C-term 313 L - AF2 AF2
C-term 314 Q - AF2 AF2
C-term 315 R - AF2 AF2
C-term 316 K - AF2 AF2
C-term 317 I - AF2 AF2
C-term 318 T - AF2 AF2
C-term 319 G - AF2 AF2
C-term 320 E - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 S 62 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 S 62 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL3 M 220 - G.H5 K 345 G.H5.17
Ionic TM3 R 128 3x53 G.H5 D 350 G.H5.22
Hydrophobic ICL2 H 133 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM6 I 226 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 I 226 6x30 G.H5 F 354 G.H5.26
Hydrophobic TM5 R 218 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 218 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 129 3x54 G.H5 I 344 G.H5.16
Polar TM2 R 63 2x40 G.H5 C 351 G.H5.23
Hydrophobic TM2 R 63 2x40 G.H5 C 351 G.H5.23
Van-der-waals TM2 R 63 2x40 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 132 34x50 G.H5 T 340 G.H5.12
Aromatic ICL2 H 133 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 H 133 34x51 G.H5 F 336 G.H5.08
Ionic TM5 R 218 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 218 5x68 G.H5 D 341 G.H5.13
Hydrophobic H8 P 299 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 P 299 8x48 G.H5 F 354 G.H5.26
Polar H8 P 299 8x48 G.H5 G 352 G.H5.24
Hydrophobic H8 P 299 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 P 299 8x48 G.H5 G 352 G.H5.24
Polar ICL3 H 223 - G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL3 H 223 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL3 H 223 - G.h4s6 K 314 G.h4s6.08
Hydrophobic TM3 R 125 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 125 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL3 M 220 - G.H5 D 341 G.H5.13
Hydrophobic TM3 V 129 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 129 3x54 G.H5 L 348 G.H5.20
Polar ICL2 P 132 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM6 I 233 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 233 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 128 3x53 G.H5 C 351 G.H5.23
Polar TM3 R 128 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 128 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 R 128 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 R 218 5x68 G.H5 T 340 G.H5.12
Hydrophobic ICL2 H 133 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 H 133 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 132 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 132 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 215 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM6 I 226 6x30 G.H5 L 348 G.H5.20
Aromatic TM6 K 225 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 225 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 225 6x29 G.H5 F 354 G.H5.26
Polar H8 S 298 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 S 298 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 298 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 P 132 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM2 K 60 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 K 60 2x37 G.H5 D 350 G.H5.22
Hydrophobic H8 P 299 8x48 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 229 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM2 R 63 2x40 G.H5 G 352 G.H5.24
Van-der-waals TM2 R 63 2x40 G.H5 G 352 G.H5.24
Hydrophobic ICL3 M 220 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 M 220 - G.H5 I 344 G.H5.16
Hydrophobic H8 S 300 8x49 G.H5 G 352 G.H5.24
Van-der-waals H8 S 300 8x49 G.H5 G 352 G.H5.24
Polar ICL2 H 133 34x51 G.H5 T 340 G.H5.12
Hydrophobic ICL2 H 133 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 H 133 34x51 G.H5 T 340 G.H5.12