Refined structure (8IKH) of Gi1 - CB1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-11-26

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Structure
GPCR

Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 217 from structure (61.3%), 137 from model (38.7%)
Residue sidechains - 197 from structure (55.6%), 157 from model (44.4%)

REFINED GPCR RESIDUES

Residue backbones - 265 from structure (63.4%), 153 from model (36.6%)
Residue sidechains - 259 from structure (62.0%), 159 from model (38.0%)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
C13G.H4D09D13N19D22G24G.H5GproteinH5x68R-K34x54S8x47R5x75R2x37S3x53P34x50GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.H4G.H5GPCR segments:TM2ICL2TM3ICL3TM5H8

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x372x393x503x533x5434x5034x5134x5334x5434x555x685x725x756x266x296x326x336x378x478x48G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.13G.H5.09G.H5.06G.h4s6.12G.h4s6.08G.H4.13G.S3.01G.hns1.03Res. Pos.CB1 (8IKH_REFINED)- (8IKH_REFINED)---------------------RSRSIPLYKRHMRQMRLLSKRSPLYKRRSIHMRQMRLLSKRDCINILRLLDDKEKFGCF

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.