GproteinDb

Refined structure (8IU2) of G_i1 - OPN1LW

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G_i/o

DATE

2024-11-26

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Structure

GPCR

Gα

Gβ

Gγ
Model

AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 209 from structure (59.0%), 145 from model (41.0%)
Residue sidechains - 180 from structure (50.8%), 174 from model (49.2%)

Showing 1 to 354 of 354 entries

Search:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from
	:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from

G.HN	1	M	G.HN.01	AF2	AF2
G.HN	2	G	G.HN.02	AF2	AF2
G.HN	3	C	G.HN.09	Structure	Structure
G.HN	4	T	G.HN.10	Structure	Structure
G.HN	5	L	G.HN.11	Structure	Structure
G.HN	6	S	G.HN.30	Structure	Structure
G.HN	7	A	G.HN.31	Structure	Structure
G.HN	8	E	G.HN.32	Structure	Structure
G.HN	9	D	G.HN.33	Structure	Structure
G.HN	10	K	G.HN.34	Structure	Structure
G.HN	11	A	G.HN.35	Structure	Structure
G.HN	12	A	G.HN.36	Structure	Structure
G.HN	13	V	G.HN.37	Structure	Structure
G.HN	14	E	G.HN.38	Structure	Structure
G.HN	15	R	G.HN.39	Structure	Structure
G.HN	16	S	G.HN.40	Structure	Structure
G.HN	17	K	G.HN.41	Structure	Structure
G.HN	18	M	G.HN.42	Structure	Structure
G.HN	19	I	G.HN.43	Structure	Structure
G.HN	20	D	G.HN.44	Structure	Structure
G.HN	21	R	G.HN.45	Structure	Structure
G.HN	22	N	G.HN.46	Structure	Structure
G.HN	23	L	G.HN.47	Structure	Structure
G.HN	24	R	G.HN.48	Structure	Structure
G.HN	25	E	G.HN.49	Structure	AF2
G.HN	26	D	G.HN.50	Structure	AF2
G.HN	27	G	G.HN.51	Structure	Structure
G.HN	28	E	G.HN.52	Structure	Structure
G.HN	29	K	G.HN.53	Structure	Structure
G.hns1	30	A	G.hns1.01	Structure	Structure
G.hns1	31	A	G.hns1.02	Structure	Structure
G.hns1	32	R	G.hns1.03	Structure	Structure
G.S1	33	E	G.S1.01	Structure	AF2
G.S1	34	V	G.S1.02	Structure	Structure
G.S1	35	K	G.S1.03	Structure	Structure
G.S1	36	L	G.S1.04	Structure	Structure
G.S1	37	L	G.S1.05	Structure	Structure
G.S1	38	L	G.S1.06	Structure	Structure
G.S1	39	L	G.S1.07	Structure	Structure
G.s1h1	40	G	G.s1h1.01	Structure	Structure
G.s1h1	41	A	G.s1h1.02	Structure	Structure
G.s1h1	42	G	G.s1h1.03	Structure	Structure
G.s1h1	43	E	G.s1h1.04	Structure	AF2
G.s1h1	44	S	G.s1h1.05	Structure	Structure
G.s1h1	45	G	G.s1h1.06	Structure	Structure
G.H1	46	K	G.H1.01	AF2	AF2
G.H1	47	S	G.H1.02	AF2	AF2
G.H1	48	T	G.H1.03	AF2	AF2
G.H1	49	I	G.H1.04	AF2	AF2
G.H1	50	V	G.H1.05	AF2	AF2
G.H1	51	K	G.H1.06	AF2	AF2
G.H1	52	Q	G.H1.07	AF2	AF2
G.H1	53	M	G.H1.08	AF2	AF2
G.H1	54	K	G.H1.09	AF2	AF2
G.H1	55	I	G.H1.10	AF2	AF2
G.H1	56	I	G.H1.11	AF2	AF2
G.H1	57	H	G.H1.12	AF2	AF2
G.h1ha	58	E	G.h1ha.01	AF2	AF2
G.h1ha	59	A	G.h1ha.02	AF2	AF2
G.h1ha	60	G	G.h1ha.03	AF2	AF2
G.h1ha	61	Y	G.h1ha.04	AF2	AF2
G.h1ha	62	S	G.h1ha.05	AF2	AF2
H.HA	63	E	H.HA.01	AF2	AF2
H.HA	64	E	H.HA.02	AF2	AF2
H.HA	65	E	H.HA.03	AF2	AF2
H.HA	66	C	H.HA.04	AF2	AF2
H.HA	67	K	H.HA.05	AF2	AF2
H.HA	68	Q	H.HA.06	AF2	AF2
H.HA	69	Y	H.HA.07	AF2	AF2
H.HA	70	K	H.HA.08	AF2	AF2
H.HA	71	A	H.HA.09	AF2	AF2
H.HA	72	V	H.HA.10	AF2	AF2
H.HA	73	V	H.HA.11	AF2	AF2
H.HA	74	Y	H.HA.12	AF2	AF2
H.HA	75	S	H.HA.13	AF2	AF2
H.HA	76	N	H.HA.14	AF2	AF2
H.HA	77	T	H.HA.15	AF2	AF2
H.HA	78	I	H.HA.16	AF2	AF2
H.HA	79	Q	H.HA.17	AF2	AF2
H.HA	80	S	H.HA.18	AF2	AF2
H.HA	81	I	H.HA.19	AF2	AF2
H.HA	82	I	H.HA.20	AF2	AF2
H.HA	83	A	H.HA.21	AF2	AF2
H.HA	84	I	H.HA.22	AF2	AF2
H.HA	85	I	H.HA.23	AF2	AF2
H.HA	86	R	H.HA.24	AF2	AF2
H.HA	87	A	H.HA.25	AF2	AF2
H.HA	88	M	H.HA.26	AF2	AF2
H.HA	89	G	H.HA.27	AF2	AF2
H.HA	90	R	H.HA.28	AF2	AF2
H.HA	91	L	H.HA.29	AF2	AF2
H.hahb	92	K	H.hahb.01	AF2	AF2
H.hahb	93	I	H.hahb.04	AF2	AF2
H.hahb	94	D	H.hahb.05	AF2	AF2
H.hahb	95	F	H.hahb.06	AF2	AF2
H.hahb	96	G	H.hahb.07	AF2	AF2
H.hahb	97	D	H.hahb.08	AF2	AF2
H.hahb	98	S	H.hahb.09	AF2	AF2
H.HB	99	A	H.HB.01	AF2	AF2
H.HB	100	R	H.HB.02	AF2	AF2
H.HB	101	A	H.HB.03	AF2	AF2
H.HB	102	D	H.HB.04	AF2	AF2
H.HB	103	D	H.HB.05	AF2	AF2
H.HB	104	A	H.HB.06	AF2	AF2
H.HB	105	R	H.HB.07	AF2	AF2
H.HB	106	Q	H.HB.08	AF2	AF2
H.HB	107	L	H.HB.09	AF2	AF2
H.HB	108	F	H.HB.10	AF2	AF2
H.HB	109	V	H.HB.11	AF2	AF2
H.HB	110	L	H.HB.12	AF2	AF2
H.HB	111	A	H.HB.13	AF2	AF2
H.HB	112	G	H.HB.14	AF2	AF2
H.hbhc	113	A	H.hbhc.01	AF2	AF2
H.hbhc	114	A	H.hbhc.02	AF2	AF2
H.hbhc	115	E	H.hbhc.03	AF2	AF2
H.hbhc	116	E	H.hbhc.04	AF2	AF2
H.hbhc	117	G	H.hbhc.12	AF2	AF2
H.hbhc	118	F	H.hbhc.13	AF2	AF2
H.hbhc	119	M	H.hbhc.14	AF2	AF2
H.hbhc	120	T	H.hbhc.15	AF2	AF2
H.HC	121	A	H.HC.01	AF2	AF2
H.HC	122	E	H.HC.02	AF2	AF2
H.HC	123	L	H.HC.03	AF2	AF2
H.HC	124	A	H.HC.04	AF2	AF2
H.HC	125	G	H.HC.05	AF2	AF2
H.HC	126	V	H.HC.06	AF2	AF2
H.HC	127	I	H.HC.07	AF2	AF2
H.HC	128	K	H.HC.08	AF2	AF2
H.HC	129	R	H.HC.09	AF2	AF2
H.HC	130	L	H.HC.10	AF2	AF2
H.HC	131	W	H.HC.11	AF2	AF2
H.HC	132	K	H.HC.12	AF2	AF2
H.hchd	133	D	H.hchd.01	AF2	AF2
H.HD	134	S	H.HD.01	AF2	AF2
H.HD	135	G	H.HD.02	AF2	AF2
H.HD	136	V	H.HD.03	AF2	AF2
H.HD	137	Q	H.HD.04	AF2	AF2
H.HD	138	A	H.HD.05	AF2	AF2
H.HD	139	C	H.HD.06	AF2	AF2
H.HD	140	F	H.HD.07	AF2	AF2
H.HD	141	N	H.HD.08	AF2	AF2
H.HD	142	R	H.HD.09	AF2	AF2
H.HD	143	S	H.HD.10	AF2	AF2
H.HD	144	R	H.HD.11	AF2	AF2
H.HD	145	E	H.HD.12	AF2	AF2
H.hdhe	146	Y	H.hdhe.01	AF2	AF2
H.hdhe	147	Q	H.hdhe.02	AF2	AF2
H.hdhe	148	L	H.hdhe.03	AF2	AF2
H.hdhe	149	N	H.hdhe.04	AF2	AF2
H.hdhe	150	D	H.hdhe.05	AF2	AF2
H.HE	151	S	H.HE.01	AF2	AF2
H.HE	152	A	H.HE.02	AF2	AF2
H.HE	153	A	H.HE.03	AF2	AF2
H.HE	154	Y	H.HE.04	AF2	AF2
H.HE	155	Y	H.HE.05	AF2	AF2
H.HE	156	L	H.HE.06	AF2	AF2
H.HE	157	N	H.HE.07	AF2	AF2
H.HE	158	D	H.HE.08	AF2	AF2
H.HE	159	L	H.HE.09	AF2	AF2
H.HE	160	D	H.HE.10	AF2	AF2
H.HE	161	R	H.HE.11	AF2	AF2
H.HE	162	I	H.HE.12	AF2	AF2
H.HE	163	A	H.HE.13	AF2	AF2
H.hehf	164	Q	H.hehf.01	AF2	AF2
H.hehf	165	P	H.hehf.02	AF2	AF2
H.hehf	166	N	H.hehf.03	AF2	AF2
H.hehf	167	Y	H.hehf.04	AF2	AF2
H.hehf	168	I	H.hehf.05	AF2	AF2
H.hehf	169	P	H.hehf.06	AF2	AF2
H.hehf	170	T	H.hehf.07	AF2	AF2
H.HF	171	Q	H.HF.01	AF2	AF2
H.HF	172	Q	H.HF.02	AF2	AF2
H.HF	173	D	H.HF.03	AF2	AF2
H.HF	174	V	H.HF.04	AF2	AF2
H.HF	175	L	H.HF.05	AF2	AF2
H.HF	176	R	H.HF.06	AF2	AF2
G.hfs2	177	T	G.hfs2.01	AF2	AF2
G.hfs2	178	R	G.hfs2.02	AF2	AF2
G.hfs2	179	V	G.hfs2.03	AF2	AF2
G.hfs2	180	K	G.hfs2.04	AF2	AF2
G.hfs2	181	T	G.hfs2.05	AF2	AF2
G.hfs2	182	T	G.hfs2.06	Structure	Structure
G.hfs2	183	G	G.hfs2.07	Structure	Structure
G.S2	184	I	G.S2.01	Structure	Structure
G.S2	185	V	G.S2.02	Structure	Structure
G.S2	186	E	G.S2.03	Structure	AF2
G.S2	187	T	G.S2.04	Structure	Structure
G.S2	188	H	G.S2.05	Structure	Structure
G.S2	189	F	G.S2.06	Structure	Structure
G.S2	190	T	G.S2.07	Structure	Structure
G.S2	191	F	G.S2.08	Structure	Structure
G.s2s3	192	K	G.s2s3.01	Structure	Structure
G.s2s3	193	D	G.s2s3.02	Structure	AF2
G.S3	194	L	G.S3.01	Structure	Structure
G.S3	195	H	G.S3.02	Structure	Structure
G.S3	196	F	G.S3.03	Structure	Structure
G.S3	197	K	G.S3.04	Structure	Structure
G.S3	198	M	G.S3.05	Structure	Structure
G.S3	199	F	G.S3.06	Structure	Structure
G.S3	200	D	G.S3.07	Structure	Structure
G.S3	201	V	G.S3.08	Structure	Structure
G.s3h2	202	G	G.s3h2.01	Structure	AF2
G.s3h2	203	G	G.s3h2.02	Structure	AF2
G.s3h2	204	Q	G.s3h2.03	Structure	Structure
G.H2	205	R	G.H2.01	Structure	AF2
G.H2	206	S	G.H2.02	Structure	Structure
G.H2	207	E	G.H2.03	Structure	Structure
G.H2	208	R	G.H2.04	Structure	Structure
G.H2	209	K	G.H2.05	Structure	AF2
G.H2	210	K	G.H2.06	Structure	Structure
G.H2	211	W	G.H2.07	Structure	Structure
G.H2	212	I	G.H2.08	Structure	Structure
G.H2	213	H	G.H2.09	Structure	Structure
G.H2	214	C	G.H2.10	Structure	Structure
G.h2s4	215	F	G.h2s4.01	Structure	Structure
G.h2s4	216	E	G.h2s4.02	Structure	Structure
G.h2s4	217	G	G.h2s4.03	Structure	Structure
G.h2s4	218	V	G.h2s4.04	Structure	Structure
G.h2s4	219	T	G.h2s4.05	Structure	Structure
G.S4	220	A	G.S4.01	Structure	Structure
G.S4	221	I	G.S4.02	Structure	Structure
G.S4	222	I	G.S4.03	Structure	Structure
G.S4	223	F	G.S4.04	Structure	Structure
G.S4	224	C	G.S4.05	Structure	Structure
G.S4	225	V	G.S4.06	Structure	Structure
G.S4	226	A	G.S4.07	Structure	Structure
G.s4h3	227	L	G.s4h3.01	Structure	Structure
G.s4h3	228	S	G.s4h3.02	Structure	Structure
G.s4h3	229	D	G.s4h3.03	Structure	AF2
G.s4h3	230	Y	G.s4h3.04	Structure	Structure
G.s4h3	231	D	G.s4h3.05	Structure	AF2
G.s4h3	232	L	G.s4h3.06	Structure	AF2
G.s4h3	233	V	G.s4h3.07	AF2	AF2
G.s4h3	234	L	G.s4h3.08	AF2	AF2
G.s4h3	235	A	G.s4h3.09	AF2	AF2
G.s4h3	236	E	G.s4h3.10	AF2	AF2
G.s4h3	237	D	G.s4h3.11	AF2	AF2
G.s4h3	238	E	G.s4h3.12	AF2	AF2
G.s4h3	239	E	G.s4h3.13	AF2	AF2
G.s4h3	240	M	G.s4h3.14	Structure	Structure
G.s4h3	241	N	G.s4h3.15	Structure	Structure
G.H3	242	R	G.H3.01	Structure	AF2
G.H3	243	M	G.H3.02	Structure	Structure
G.H3	244	H	G.H3.03	Structure	Structure
G.H3	245	E	G.H3.04	Structure	AF2
G.H3	246	S	G.H3.05	Structure	Structure
G.H3	247	M	G.H3.06	Structure	Structure
G.H3	248	K	G.H3.07	Structure	AF2
G.H3	249	L	G.H3.08	Structure	Structure
G.H3	250	F	G.H3.09	Structure	Structure
G.H3	251	D	G.H3.10	Structure	Structure
G.H3	252	S	G.H3.11	Structure	Structure
G.H3	253	I	G.H3.12	Structure	Structure
G.H3	254	C	G.H3.13	Structure	Structure
G.H3	255	N	G.H3.14	Structure	Structure
G.H3	256	N	G.H3.15	Structure	Structure
G.H3	257	K	G.H3.16	Structure	Structure
G.H3	258	W	G.H3.17	Structure	Structure
G.H3	259	F	G.H3.18	Structure	Structure
G.h3s5	260	T	G.h3s5.01	Structure	Structure
G.h3s5	261	D	G.h3s5.02	Structure	AF2
G.h3s5	262	T	G.h3s5.03	Structure	Structure
G.S5	263	S	G.S5.01	Structure	Structure
G.S5	264	I	G.S5.02	Structure	Structure
G.S5	265	I	G.S5.03	Structure	Structure
G.S5	266	L	G.S5.04	Structure	Structure
G.S5	267	F	G.S5.05	Structure	Structure
G.S5	268	L	G.S5.06	Structure	Structure
G.S5	269	N	G.S5.07	Structure	Structure
G.s5hg	270	K	G.s5hg.01	Structure	Structure
G.HG	271	K	G.HG.01	Structure	Structure
G.HG	272	D	G.HG.02	Structure	AF2
G.HG	273	L	G.HG.03	Structure	Structure
G.HG	274	F	G.HG.04	Structure	Structure
G.HG	275	E	G.HG.05	Structure	Structure
G.HG	276	E	G.HG.06	Structure	Structure
G.HG	277	K	G.HG.07	Structure	AF2
G.HG	278	I	G.HG.08	Structure	Structure
G.HG	279	K	G.HG.09	Structure	AF2
G.HG	280	K	G.HG.12	Structure	AF2
G.HG	281	S	G.HG.13	Structure	Structure
G.HG	282	P	G.HG.14	Structure	Structure
G.HG	283	L	G.HG.15	Structure	Structure
G.HG	284	T	G.HG.16	Structure	Structure
G.HG	285	I	G.HG.17	Structure	Structure
G.hgh4	286	C	G.hgh4.01	Structure	Structure
G.hgh4	287	Y	G.hgh4.02	Structure	Structure
G.hgh4	288	P	G.hgh4.03	Structure	Structure
G.hgh4	289	E	G.hgh4.04	Structure	AF2
G.hgh4	290	Y	G.hgh4.05	Structure	Structure
G.hgh4	291	A	G.hgh4.06	Structure	Structure
G.hgh4	292	G	G.hgh4.07	Structure	Structure
G.hgh4	293	S	G.hgh4.08	Structure	Structure
G.H4	294	N	G.H4.01	Structure	AF2
G.H4	295	T	G.H4.02	Structure	AF2
G.H4	296	Y	G.H4.03	Structure	Structure
G.H4	297	E	G.H4.04	Structure	AF2
G.H4	298	E	G.H4.05	Structure	Structure
G.H4	299	A	G.H4.06	Structure	Structure
G.H4	300	A	G.H4.07	Structure	Structure
G.H4	301	A	G.H4.08	Structure	Structure
G.H4	302	Y	G.H4.10	Structure	Structure
G.H4	303	I	G.H4.11	Structure	Structure
G.H4	304	Q	G.H4.12	Structure	Structure
G.H4	305	C	G.H4.13	Structure	Structure
G.H4	306	Q	G.H4.14	Structure	Structure
G.H4	307	F	G.H4.15	Structure	Structure
G.H4	308	E	G.H4.16	Structure	Structure
G.H4	309	D	G.H4.17	Structure	AF2
G.h4s6	310	L	G.h4s6.01	Structure	Structure
G.h4s6	311	N	G.h4s6.02	Structure	Structure
G.h4s6	312	K	G.h4s6.03	Structure	AF2
G.h4s6	313	R	G.h4s6.04	Structure	Structure
G.h4s6	314	K	G.h4s6.08	Structure	Structure
G.h4s6	315	D	G.h4s6.09	Structure	Structure
G.h4s6	316	T	G.h4s6.10	Structure	Structure
G.h4s6	317	K	G.h4s6.11	Structure	Structure
G.h4s6	318	E	G.h4s6.12	Structure	AF2
G.S6	319	I	G.S6.01	Structure	Structure
G.S6	320	Y	G.S6.02	Structure	Structure
G.S6	321	T	G.S6.03	Structure	Structure
G.S6	322	H	G.S6.04	Structure	Structure
G.S6	323	F	G.S6.05	Structure	Structure
G.s6h5	324	T	G.s6h5.01	Structure	Structure
G.s6h5	325	C	G.s6h5.02	Structure	Structure
G.s6h5	326	A	G.s6h5.03	Structure	AF2
G.s6h5	327	T	G.s6h5.04	Structure	Structure
G.s6h5	328	D	G.s6h5.05	Structure	Structure
G.H5	329	T	G.H5.01	Structure	Structure
G.H5	330	K	G.H5.02	Structure	Structure
G.H5	331	N	G.H5.03	Structure	Structure
G.H5	332	V	G.H5.04	Structure	Structure
G.H5	333	Q	G.H5.05	Structure	Structure
G.H5	334	F	G.H5.06	Structure	Structure
G.H5	335	V	G.H5.07	Structure	Structure
G.H5	336	F	G.H5.08	Structure	Structure
G.H5	337	D	G.H5.09	Structure	Structure
G.H5	338	A	G.H5.10	Structure	Structure
G.H5	339	V	G.H5.11	Structure	Structure
G.H5	340	T	G.H5.12	Structure	Structure
G.H5	341	D	G.H5.13	Structure	Structure
G.H5	342	V	G.H5.14	Structure	Structure
G.H5	343	I	G.H5.15	Structure	Structure
G.H5	344	I	G.H5.16	Structure	Structure
G.H5	345	K	G.H5.17	Structure	Structure
G.H5	346	N	G.H5.18	Structure	Structure
G.H5	347	N	G.H5.19	Structure	Structure
G.H5	348	L	G.H5.20	Structure	Structure
G.H5	349	K	G.H5.21	Structure	Structure
G.H5	350	D	G.H5.22	Structure	Structure
G.H5	351	C	G.H5.23	Structure	Structure
G.H5	352	G	G.H5.24	Structure	Structure
G.H5	353	L	G.H5.25	Structure	Structure
G.H5	354	F	G.H5.26	Structure	Structure

REFINED GPCR RESIDUES

Residue backbones - 298 from structure (85.6%), 50 from model (14.4%)
Residue sidechains - 293 from structure (84.2%), 55 from model (15.8%)

Showing 1 to 348 of 348 entries

Search:

Segment	Seq.num.	AA	GPCRdb#	Backbone from	Sidechain from

N-term	1	M	-	AF2	AF2
N-term	2	A	-	AF2	AF2
N-term	3	Q	-	AF2	AF2
N-term	4	Q	-	AF2	AF2
N-term	5	W	-	AF2	AF2
N-term	6	S	-	AF2	AF2
N-term	7	L	-	AF2	AF2
N-term	8	Q	-	AF2	AF2
N-term	9	R	-	AF2	AF2
N-term	10	L	-	AF2	AF2
N-term	11	A	-	AF2	AF2
N-term	12	G	-	AF2	AF2
N-term	13	R	-	AF2	AF2
N-term	14	H	-	AF2	AF2
N-term	15	P	-	AF2	AF2
N-term	16	Q	-	AF2	AF2
N-term	17	D	-	AF2	AF2
N-term	18	S	-	AF2	AF2
N-term	19	Y	-	AF2	AF2
N-term	20	E	-	AF2	AF2
N-term	21	D	-	AF2	AF2
N-term	22	S	-	AF2	AF2
N-term	23	T	-	AF2	AF2
N-term	24	Q	-	AF2	AF2
N-term	25	S	-	AF2	AF2
N-term	26	S	-	AF2	AF2
N-term	27	I	-	AF2	AF2
N-term	28	F	-	AF2	AF2
N-term	29	T	-	AF2	AF2
N-term	30	Y	-	AF2	AF2
N-term	31	T	-	AF2	AF2
N-term	32	N	-	AF2	AF2
N-term	33	S	-	AF2	AF2
N-term	34	N	-	AF2	AF2
N-term	35	S	-	AF2	AF2
N-term	36	T	-	AF2	AF2
N-term	37	R	-	AF2	AF2
N-term	38	G	-	Structure	Structure
N-term	39	P	-	Structure	Structure
N-term	40	F	-	Structure	Structure
N-term	41	E	-	Structure	Structure
N-term	42	G	-	Structure	Structure
N-term	43	P	-	Structure	Structure
N-term	44	N	-	Structure	Structure
N-term	45	Y	-	Structure	Structure
N-term	46	H	-	Structure	Structure
N-term	47	I	-	Structure	Structure
N-term	48	A	-	Structure	Structure
TM1	49	P	1.28x28	Structure	Structure
TM1	50	R	1.29x29	Structure	Structure
TM1	51	W	1.30x30	Structure	Structure
TM1	52	V	1.31x31	Structure	Structure
TM1	53	Y	1.32x32	Structure	Structure
TM1	54	H	1.33x33	Structure	Structure
TM1	55	L	1.34x34	Structure	Structure
TM1	56	T	1.35x35	Structure	Structure
TM1	57	S	1.36x36	Structure	Structure
TM1	58	V	1.37x37	Structure	Structure
TM1	59	W	1.38x38	Structure	Structure
TM1	60	M	1.39x39	Structure	AF2
TM1	61	I	1.40x40	Structure	Structure
TM1	62	F	1.41x41	Structure	Structure
TM1	63	V	1.42x42	Structure	Structure
TM1	64	V	1.43x43	Structure	Structure
TM1	65	T	1.44x44	Structure	Structure
TM1	66	A	1.45x45	Structure	Structure
TM1	67	S	1.46x46	Structure	Structure
TM1	68	V	1.47x47	Structure	Structure
TM1	69	F	1.48x48	Structure	Structure
TM1	70	T	1.49x49	Structure	Structure
TM1	71	N	1.50x50	Structure	Structure
TM1	72	G	1.51x51	Structure	Structure
TM1	73	L	1.52x52	Structure	Structure
TM1	74	V	1.53x53	Structure	Structure
TM1	75	L	1.54x54	Structure	Structure
TM1	76	A	1.55x55	Structure	Structure
TM1	77	A	1.56x56	Structure	Structure
TM1	78	T	1.57x57	Structure	Structure
TM1	79	M	1.58x58	Structure	Structure
TM1	80	K	1.59x59	Structure	Structure
TM1	81	F	1.60x60	Structure	Structure
ICL1	82	K	12.48x48	Structure	AF2
ICL1	83	K	12.49x49	Structure	AF2
ICL1	84	L	12.50x50	Structure	Structure
ICL1	85	R	12.51x51	Structure	Structure
TM2	86	H	2.37x37	Structure	Structure
TM2	87	P	2.38x38	Structure	Structure
TM2	88	L	2.39x39	Structure	Structure
TM2	89	N	2.40x40	Structure	Structure
TM2	90	W	2.41x41	Structure	Structure
TM2	91	I	2.42x42	Structure	Structure
TM2	92	L	2.43x43	Structure	Structure
TM2	93	V	2.44x44	Structure	Structure
TM2	94	N	2.45x45	Structure	Structure
TM2	95	L	2.46x46	Structure	Structure
TM2	96	A	2.47x47	Structure	Structure
TM2	97	V	2.48x48	Structure	Structure
TM2	98	A	2.49x49	Structure	Structure
TM2	99	D	2.50x50	Structure	Structure
TM2	100	L	2.51x51	Structure	Structure
TM2	101	A	2.52x52	Structure	Structure
TM2	102	E	2.53x53	Structure	Structure
TM2	103	T	2.54x54	Structure	Structure
TM2	104	V	2.55x55	Structure	Structure
TM2	105	I	2.56x56	Structure	Structure
TM2	106	A	2.57x57	Structure	Structure
TM2	107	S	2.58x58	Structure	Structure
TM2	108	T	2.59x59	Structure	Structure
TM2	109	I	2.60x60	Structure	Structure
TM2	110	S	2.61x61	Structure	Structure
TM2	111	I	2.62x62	Structure	Structure
TM2	112	V	2.63x63	Structure	Structure
TM2	113	N	2.64x64	Structure	Structure
TM2	114	Q	2.65x65	Structure	Structure
TM2	115	V	2.66x66	Structure	Structure
TM2	116	S	2.67x67	Structure	Structure
TM2	117	G	2.68x68	Structure	Structure
ECL1	118	Y	23.49x49	Structure	Structure
ECL1	119	F	23.50x50	Structure	Structure
ECL1	120	V	23.51x51	Structure	Structure
ECL1	121	L	23.52x52	Structure	Structure
TM3	122	G	3.21x21	Structure	Structure
TM3	123	H	3.22x22	Structure	Structure
TM3	124	P	3.23x23	Structure	Structure
TM3	125	M	3.24x24	Structure	Structure
TM3	126	C	3.25x25	Structure	Structure
TM3	127	V	3.26x26	Structure	Structure
TM3	128	L	3.27x27	Structure	Structure
TM3	129	E	3.28x28	Structure	AF2
TM3	130	G	3.29x29	Structure	Structure
TM3	131	Y	3.30x30	Structure	Structure
TM3	132	T	3.31x31	Structure	Structure
TM3	133	V	3.32x32	Structure	Structure
TM3	134	S	3.33x33	Structure	Structure
TM3	135	L	3.34x34	Structure	Structure
TM3	136	C	3.35x35	Structure	Structure
TM3	137	G	3.36x36	Structure	Structure
TM3	138	I	3.37x37	Structure	Structure
TM3	139	T	3.38x38	Structure	Structure
TM3	140	G	3.39x39	Structure	Structure
TM3	141	L	3.40x40	Structure	Structure
TM3	142	W	3.41x41	Structure	Structure
TM3	143	S	3.42x42	Structure	Structure
TM3	144	L	3.43x43	Structure	Structure
TM3	145	A	3.44x44	Structure	Structure
TM3	146	I	3.45x45	Structure	Structure
TM3	147	I	3.46x46	Structure	Structure
TM3	148	S	3.47x47	Structure	Structure
TM3	149	W	3.48x48	Structure	Structure
TM3	150	E	3.49x49	Structure	Structure
TM3	151	R	3.50x50	Structure	Structure
TM3	152	W	3.51x51	Structure	Structure
TM3	153	M	3.52x52	Structure	Structure
TM3	154	V	3.53x53	Structure	Structure
TM3	155	V	3.54x54	Structure	Structure
TM3	156	C	3.55x55	Structure	Structure
TM3	157	K	3.56x56	Structure	Structure
ICL2	158	P	34.50x50	Structure	Structure
ICL2	159	F	34.51x51	Structure	Structure
ICL2	160	G	34.52x52	Structure	Structure
ICL2	161	N	34.53x53	Structure	Structure
ICL2	162	V	34.54x54	Structure	Structure
ICL2	163	R	34.55x55	Structure	Structure
ICL2	164	F	34.56x56	Structure	Structure
TM4	165	D	4.38x38	Structure	Structure
TM4	166	A	4.39x39	Structure	Structure
TM4	167	K	4.40x40	Structure	Structure
TM4	168	L	4.41x41	Structure	Structure
TM4	169	A	4.42x42	Structure	Structure
TM4	170	I	4.43x43	Structure	Structure
TM4	171	V	4.44x44	Structure	Structure
TM4	172	G	4.45x45	Structure	Structure
TM4	173	I	4.46x46	Structure	Structure
TM4	174	A	4.47x47	Structure	Structure
TM4	175	F	4.48x48	Structure	Structure
TM4	176	S	4.49x49	Structure	Structure
TM4	177	W	4.50x50	Structure	Structure
TM4	178	I	4.51x51	Structure	Structure
TM4	179	W	4.52x52	Structure	Structure
TM4	180	A	4.53x53	Structure	Structure
TM4	181	A	4.54x54	Structure	Structure
TM4	182	V	4.55x55	Structure	Structure
TM4	183	W	4.56x56	Structure	Structure
TM4	184	T	4.57x57	Structure	Structure
TM4	185	A	4.58x58	Structure	Structure
TM4	186	P	4.59x59	Structure	Structure
TM4	187	P	4.60x60	Structure	Structure
TM4	188	I	4.61x61	Structure	Structure
TM4	189	F	4.62x62	Structure	Structure
TM4	190	G	4.63x63	Structure	Structure
ECL2	191	W	-	Structure	Structure
ECL2	192	S	-	Structure	Structure
ECL2	193	R	-	Structure	AF2
ECL2	194	Y	-	Structure	Structure
ECL2	195	W	-	Structure	Structure
ECL2	196	P	-	Structure	Structure
ECL2	197	H	-	Structure	Structure
ECL2	198	G	-	Structure	Structure
ECL2	199	L	-	Structure	Structure
ECL2	200	K	-	Structure	Structure
ECL2	201	T	-	Structure	Structure
ECL2	202	S	-	Structure	Structure
ECL2	203	C	45.50x50	Structure	Structure
ECL2	204	G	45.51x51	Structure	Structure
ECL2	205	P	45.52x52	Structure	Structure
ECL2	206	D	-	Structure	Structure
ECL2	207	V	-	Structure	Structure
ECL2	208	F	-	Structure	Structure
ECL2	209	S	-	Structure	Structure
ECL2	210	G	-	Structure	Structure
ECL2	211	S	-	Structure	Structure
ECL2	212	S	-	Structure	Structure
ECL2	213	Y	-	Structure	Structure
ECL2	214	P	-	Structure	Structure
TM5	215	G	5.34x35	Structure	Structure
TM5	216	V	5.35x36	Structure	Structure
TM5	217	Q	5.36x37	Structure	Structure
TM5	218	S	5.37x38	Structure	Structure
TM5	219	Y	5.38x39	Structure	Structure
TM5	220	M	5.39x40	Structure	Structure
TM5	221	I	5.40x41	Structure	Structure
TM5	222	V	5.41x42	Structure	Structure
TM5	223	L	5.42x43	Structure	Structure
TM5	224	M	5.43x44	Structure	Structure
TM5	225	V	5.44x45	Structure	Structure
TM5	226	T	5.45x46	Structure	Structure
TM5	227	C	5.46x461	Structure	Structure
TM5	228	C	5.47x47	Structure	Structure
TM5	229	I	5.48x48	Structure	Structure
TM5	230	I	5.49x49	Structure	Structure
TM5	231	P	5.50x50	Structure	Structure
TM5	232	L	5.51x51	Structure	Structure
TM5	233	A	5.52x52	Structure	Structure
TM5	234	I	5.53x53	Structure	Structure
TM5	235	I	5.54x54	Structure	Structure
TM5	236	M	5.55x55	Structure	Structure
TM5	237	L	5.56x56	Structure	Structure
TM5	238	C	5.57x57	Structure	Structure
TM5	239	Y	5.58x58	Structure	Structure
TM5	240	L	5.59x59	Structure	Structure
TM5	241	Q	5.60x60	Structure	Structure
TM5	242	V	5.61x61	Structure	Structure
TM5	243	W	5.62x62	Structure	Structure
TM5	244	L	5.63x63	Structure	Structure
TM5	245	A	5.64x64	Structure	Structure
TM5	246	I	5.65x65	Structure	Structure
TM5	247	R	5.66x66	Structure	Structure
TM5	248	A	5.67x67	Structure	Structure
TM5	249	V	5.68x68	Structure	Structure
TM5	250	A	5.69x69	Structure	Structure
TM5	251	K	5.70x70	Structure	Structure
TM5	252	Q	5.71x71	Structure	Structure
TM5	253	Q	5.72x72	Structure	Structure
ICL3	254	K	-	Structure	Structure
ICL3	255	E	-	Structure	Structure
TM6	256	S	6.23x23	Structure	Structure
TM6	257	E	6.24x24	Structure	Structure
TM6	258	S	6.25x25	Structure	Structure
TM6	259	T	6.26x26	Structure	Structure
TM6	260	Q	6.27x27	Structure	Structure
TM6	261	K	6.28x28	Structure	Structure
TM6	262	A	6.29x29	Structure	Structure
TM6	263	E	6.30x30	Structure	Structure
TM6	264	K	6.31x31	Structure	Structure
TM6	265	E	6.32x32	Structure	Structure
TM6	266	V	6.33x33	Structure	Structure
TM6	267	T	6.34x34	Structure	Structure
TM6	268	R	6.35x35	Structure	Structure
TM6	269	M	6.36x36	Structure	Structure
TM6	270	V	6.37x37	Structure	Structure
TM6	271	V	6.38x38	Structure	Structure
TM6	272	V	6.39x39	Structure	Structure
TM6	273	M	6.40x40	Structure	Structure
TM6	274	I	6.41x41	Structure	Structure
TM6	275	F	6.42x42	Structure	Structure
TM6	276	A	6.43x43	Structure	Structure
TM6	277	Y	6.44x44	Structure	Structure
TM6	278	C	6.45x45	Structure	Structure
TM6	279	V	6.46x46	Structure	Structure
TM6	280	C	6.47x47	Structure	Structure
TM6	281	W	6.48x48	Structure	Structure
TM6	282	G	6.49x49	Structure	Structure
TM6	283	P	6.50x50	Structure	Structure
TM6	284	Y	6.51x51	Structure	Structure
TM6	285	T	6.52x52	Structure	Structure
TM6	286	F	6.53x53	Structure	Structure
TM6	287	F	6.54x54	Structure	Structure
TM6	288	A	6.55x55	Structure	Structure
TM6	289	C	6.56x56	Structure	Structure
TM6	290	F	6.57x57	Structure	Structure
TM6	291	A	6.58x58	Structure	Structure
TM6	292	A	6.59x59	Structure	Structure
TM6	293	A	6.60x60	Structure	Structure
TM6	294	N	6.61x61	Structure	Structure
TM6	295	P	6.62x62	Structure	Structure
ECL3	296	G	-	Structure	Structure
ECL3	297	Y	-	Structure	Structure
ECL3	298	A	-	Structure	Structure
ECL3	299	F	-	Structure	Structure
TM7	300	H	7.31x30	Structure	Structure
TM7	301	P	7.32x31	Structure	Structure
TM7	302	L	7.33x32	Structure	Structure
TM7	303	M	7.34x33	Structure	Structure
TM7	304	A	7.35x34	Structure	Structure
TM7	305	A	7.36x35	Structure	Structure
TM7	306	L	7.37x36	Structure	Structure
TM7	307	P	7.38x37	Structure	Structure
TM7	308	A	7.39x38	Structure	Structure
TM7	309	Y	7.40x39	Structure	Structure
TM7	310	F	7.41x40	Structure	Structure
TM7	311	A	7.42x41	Structure	Structure
TM7	312	K	7.43x42	Structure	Structure
TM7	313	S	7.44x43	Structure	Structure
TM7	314	A	7.45x45	Structure	Structure
TM7	315	T	7.46x46	Structure	Structure
TM7	316	I	7.47x47	Structure	Structure
TM7	317	Y	7.48x48	Structure	Structure
TM7	318	N	7.49x49	Structure	Structure
TM7	319	P	7.50x50	Structure	Structure
TM7	320	V	7.51x51	Structure	Structure
TM7	321	I	7.52x52	Structure	Structure
TM7	322	Y	7.53x53	Structure	Structure
TM7	323	V	7.54x54	Structure	Structure
TM7	324	F	7.55x55	Structure	Structure
TM7	325	M	7.56x56	Structure	Structure
H8	326	N	8.47x47	Structure	Structure
H8	327	R	8.48x48	Structure	Structure
H8	328	Q	8.49x49	Structure	Structure
H8	329	F	8.50x50	Structure	Structure
H8	330	R	8.51x51	Structure	Structure
H8	331	N	8.52x52	Structure	Structure
H8	332	C	8.53x53	Structure	Structure
H8	333	I	8.54x54	Structure	Structure
H8	334	L	8.55x55	Structure	Structure
H8	335	Q	8.56x56	Structure	Structure
H8	336	L	8.57x57	AF2	AF2
H8	337	F	8.58x58	AF2	AF2
H8	338	G	8.59x59	AF2	AF2
C-term	339	K	-	AF2	AF2
C-term	340	K	-	AF2	AF2
C-term	341	V	-	AF2	AF2
C-term	342	D	-	AF2	AF2
C-term	343	D	-	AF2	AF2
C-term	344	G	-	AF2	AF2
C-term	345	S	-	AF2	AF2
C-term	346	E	-	AF2	AF2
C-term	347	L	-	AF2	AF2
C-term	348	S	-	AF2	AF2

GPCR - G protein interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Aromatic	H8	R	327	8x48	G.H5	F	354	G.H5.26
Hydrophobic	TM5	Q	253	5x72	G.H5	D	341	G.H5.13
Hydrophobic	TM3	V	155	3x54	G.H5	N	347	G.H5.19
Hydrophobic	TM6	S	256	6x23	G.h4s6	E	318	G.h4s6.12
Hydrophobic	TM3	R	151	3x50	G.H5	C	351	G.H5.23
Hydrophobic	TM5	V	249	5x68	G.H5	I	344	G.H5.16
Hydrophobic	TM5	V	249	5x68	G.H5	D	341	G.H5.13
Hydrophobic	ICL2	R	163	34x55	G.hns1	R	32	G.hns1.03
Hydrophobic	H8	N	326	8x47	G.H5	F	354	G.H5.26
Hydrophobic	H8	R	327	8x48	G.H5	F	354	G.H5.26
Hydrophobic	TM3	V	155	3x54	G.H5	C	351	G.H5.23
Hydrophobic	H8	N	326	8x47	G.H5	G	352	G.H5.24
Hydrophobic	TM5	V	249	5x68	G.H5	T	340	G.H5.12
Hydrophobic	TM3	V	154	3x53	G.H5	C	351	G.H5.23
Hydrophobic	TM6	E	265	6x32	G.H5	F	354	G.H5.26
Hydrophobic	TM6	V	266	6x33	G.H5	L	353	G.H5.25
Hydrophobic	TM5	V	242	5x61	G.H5	L	353	G.H5.25
Hydrophobic	TM3	V	155	3x54	G.H5	L	348	G.H5.20
Hydrophobic	TM5	I	246	5x65	G.H5	L	348	G.H5.20
Hydrophobic	TM5	Q	253	5x72	G.S6	Y	320	G.S6.02
Hydrophobic	TM5	Q	253	5x72	G.h4s6	E	318	G.h4s6.12
Hydrophobic	TM6	M	269	6x36	G.H5	L	353	G.H5.25
Hydrophobic	TM6	M	273	6x40	G.H5	L	353	G.H5.25
Hydrophobic	TM6	A	262	6x29	G.H5	F	354	G.H5.26
Hydrophobic	TM5	I	246	5x65	G.H5	I	344	G.H5.16
Hydrophobic	TM6	V	266	6x33	G.H5	L	348	G.H5.20
Hydrophobic	TM2	L	88	2x39	G.H5	C	351	G.H5.23
Hydrophobic	TM3	V	154	3x53	G.H5	N	347	G.H5.19
Hydrophobic	ICL2	N	161	34x53	G.hns1	R	32	G.hns1.03
Polar	TM5	Q	253	5x72	G.H5	D	341	G.H5.13
Polar	TM6	S	256	6x23	G.h4s6	E	318	G.h4s6.12
Polar	TM3	R	151	3x50	G.H5	C	351	G.H5.23
Polar	H8	Q	328	8x49	G.H5	D	350	G.H5.22
Polar	H8	R	327	8x48	G.H5	F	354	G.H5.26
Polar	H8	N	326	8x47	G.H5	C	351	G.H5.23
Polar	H8	Q	328	8x49	G.H5	K	349	G.H5.21
Polar	TM5	Q	253	5x72	G.S6	Y	320	G.S6.02
Polar	TM6	S	258	6x25	G.H5	K	345	G.H5.17
Polar	TM3	V	154	3x53	G.H5	N	347	G.H5.19
Polar	ICL2	N	161	34x53	G.hns1	R	32	G.hns1.03
Van-der-waals	TM5	Q	253	5x72	G.H5	D	341	G.H5.13
Van-der-waals	TM6	S	256	6x23	G.h4s6	E	318	G.h4s6.12
Van-der-waals	TM5	V	249	5x68	G.H5	I	344	G.H5.16
Van-der-waals	TM5	V	249	5x68	G.H5	D	341	G.H5.13
Van-der-waals	H8	Q	328	8x49	G.H5	D	350	G.H5.22
Van-der-waals	H8	N	326	8x47	G.H5	F	354	G.H5.26
Van-der-waals	H8	R	327	8x48	G.H5	F	354	G.H5.26
Van-der-waals	H8	N	326	8x47	G.H5	G	352	G.H5.24
Van-der-waals	TM3	V	154	3x53	G.H5	C	351	G.H5.23
Van-der-waals	TM5	I	246	5x65	G.H5	L	348	G.H5.20
Van-der-waals	TM5	Q	253	5x72	G.S6	Y	320	G.S6.02
Van-der-waals	TM5	Q	253	5x72	G.h4s6	E	318	G.h4s6.12
Van-der-waals	TM6	A	262	6x29	G.H5	F	354	G.H5.26
Van-der-waals	TM6	S	258	6x25	G.H5	K	345	G.H5.17

Showing 1 to 54 of 54 entries

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Main reference

Refined structure (8IU2) of Gi1 - OPN1LW Download Full

GPCR CLASS (FAMILY)

SPECIES

G PROTEIN FAMILY

DATE

3D VIEW

REFINED G PROTEIN RESIDUES

REFINED GPCR RESIDUES

GPCR - G protein interface interactions

Structures

Refined structure (8IU2) of G_i1 - OPN1LW

Full