Refined structure (8IU2) of Gi1 - OPN1LW

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-11-26

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 209 from structure (59.0%), 145 from model (41.0%)
Residue sidechains - 180 from structure (50.8%), 174 from model (49.2%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 Structure Structure
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure AF2
G.HN 26 D G.HN.50 Structure AF2
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure AF2
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 AF2 AF2
G.H1 47 S G.H1.02 AF2 AF2
G.H1 48 T G.H1.03 AF2 AF2
G.H1 49 I G.H1.04 AF2 AF2
G.H1 50 V G.H1.05 AF2 AF2
G.H1 51 K G.H1.06 AF2 AF2
G.H1 52 Q G.H1.07 AF2 AF2
G.H1 53 M G.H1.08 AF2 AF2
G.H1 54 K G.H1.09 AF2 AF2
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure AF2
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure AF2
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure AF2
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure AF2
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure AF2
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure AF2
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure AF2
G.s4h3 232 L G.s4h3.06 Structure AF2
G.s4h3 233 V G.s4h3.07 AF2 AF2
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure AF2
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure AF2
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure AF2
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure AF2
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure AF2
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure AF2
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure AF2
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure AF2
G.H4 295 T G.H4.02 Structure AF2
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure AF2
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure AF2
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure AF2
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure AF2
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 298 from structure (85.6%), 50 from model (14.4%)
Residue sidechains - 293 from structure (84.2%), 55 from model (15.8%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 A - AF2 AF2
N-term 3 Q - AF2 AF2
N-term 4 Q - AF2 AF2
N-term 5 W - AF2 AF2
N-term 6 S - AF2 AF2
N-term 7 L - AF2 AF2
N-term 8 Q - AF2 AF2
N-term 9 R - AF2 AF2
N-term 10 L - AF2 AF2
N-term 11 A - AF2 AF2
N-term 12 G - AF2 AF2
N-term 13 R - AF2 AF2
N-term 14 H - AF2 AF2
N-term 15 P - AF2 AF2
N-term 16 Q - AF2 AF2
N-term 17 D - AF2 AF2
N-term 18 S - AF2 AF2
N-term 19 Y - AF2 AF2
N-term 20 E - AF2 AF2
N-term 21 D - AF2 AF2
N-term 22 S - AF2 AF2
N-term 23 T - AF2 AF2
N-term 24 Q - AF2 AF2
N-term 25 S - AF2 AF2
N-term 26 S - AF2 AF2
N-term 27 I - AF2 AF2
N-term 28 F - AF2 AF2
N-term 29 T - AF2 AF2
N-term 30 Y - AF2 AF2
N-term 31 T - AF2 AF2
N-term 32 N - AF2 AF2
N-term 33 S - AF2 AF2
N-term 34 N - AF2 AF2
N-term 35 S - AF2 AF2
N-term 36 T - AF2 AF2
N-term 37 R - AF2 AF2
N-term 38 G - Structure Structure
N-term 39 P - Structure Structure
N-term 40 F - Structure Structure
N-term 41 E - Structure Structure
N-term 42 G - Structure Structure
N-term 43 P - Structure Structure
N-term 44 N - Structure Structure
N-term 45 Y - Structure Structure
N-term 46 H - Structure Structure
N-term 47 I - Structure Structure
N-term 48 A - Structure Structure
TM1 49 P 1.28x28 Structure Structure
TM1 50 R 1.29x29 Structure Structure
TM1 51 W 1.30x30 Structure Structure
TM1 52 V 1.31x31 Structure Structure
TM1 53 Y 1.32x32 Structure Structure
TM1 54 H 1.33x33 Structure Structure
TM1 55 L 1.34x34 Structure Structure
TM1 56 T 1.35x35 Structure Structure
TM1 57 S 1.36x36 Structure Structure
TM1 58 V 1.37x37 Structure Structure
TM1 59 W 1.38x38 Structure Structure
TM1 60 M 1.39x39 Structure AF2
TM1 61 I 1.40x40 Structure Structure
TM1 62 F 1.41x41 Structure Structure
TM1 63 V 1.42x42 Structure Structure
TM1 64 V 1.43x43 Structure Structure
TM1 65 T 1.44x44 Structure Structure
TM1 66 A 1.45x45 Structure Structure
TM1 67 S 1.46x46 Structure Structure
TM1 68 V 1.47x47 Structure Structure
TM1 69 F 1.48x48 Structure Structure
TM1 70 T 1.49x49 Structure Structure
TM1 71 N 1.50x50 Structure Structure
TM1 72 G 1.51x51 Structure Structure
TM1 73 L 1.52x52 Structure Structure
TM1 74 V 1.53x53 Structure Structure
TM1 75 L 1.54x54 Structure Structure
TM1 76 A 1.55x55 Structure Structure
TM1 77 A 1.56x56 Structure Structure
TM1 78 T 1.57x57 Structure Structure
TM1 79 M 1.58x58 Structure Structure
TM1 80 K 1.59x59 Structure Structure
TM1 81 F 1.60x60 Structure Structure
ICL1 82 K 12.48x48 Structure AF2
ICL1 83 K 12.49x49 Structure AF2
ICL1 84 L 12.50x50 Structure Structure
ICL1 85 R 12.51x51 Structure Structure
TM2 86 H 2.37x37 Structure Structure
TM2 87 P 2.38x38 Structure Structure
TM2 88 L 2.39x39 Structure Structure
TM2 89 N 2.40x40 Structure Structure
TM2 90 W 2.41x41 Structure Structure
TM2 91 I 2.42x42 Structure Structure
TM2 92 L 2.43x43 Structure Structure
TM2 93 V 2.44x44 Structure Structure
TM2 94 N 2.45x45 Structure Structure
TM2 95 L 2.46x46 Structure Structure
TM2 96 A 2.47x47 Structure Structure
TM2 97 V 2.48x48 Structure Structure
TM2 98 A 2.49x49 Structure Structure
TM2 99 D 2.50x50 Structure Structure
TM2 100 L 2.51x51 Structure Structure
TM2 101 A 2.52x52 Structure Structure
TM2 102 E 2.53x53 Structure Structure
TM2 103 T 2.54x54 Structure Structure
TM2 104 V 2.55x55 Structure Structure
TM2 105 I 2.56x56 Structure Structure
TM2 106 A 2.57x57 Structure Structure
TM2 107 S 2.58x58 Structure Structure
TM2 108 T 2.59x59 Structure Structure
TM2 109 I 2.60x60 Structure Structure
TM2 110 S 2.61x61 Structure Structure
TM2 111 I 2.62x62 Structure Structure
TM2 112 V 2.63x63 Structure Structure
TM2 113 N 2.64x64 Structure Structure
TM2 114 Q 2.65x65 Structure Structure
TM2 115 V 2.66x66 Structure Structure
TM2 116 S 2.67x67 Structure Structure
TM2 117 G 2.68x68 Structure Structure
ECL1 118 Y 23.49x49 Structure Structure
ECL1 119 F 23.50x50 Structure Structure
ECL1 120 V 23.51x51 Structure Structure
ECL1 121 L 23.52x52 Structure Structure
TM3 122 G 3.21x21 Structure Structure
TM3 123 H 3.22x22 Structure Structure
TM3 124 P 3.23x23 Structure Structure
TM3 125 M 3.24x24 Structure Structure
TM3 126 C 3.25x25 Structure Structure
TM3 127 V 3.26x26 Structure Structure
TM3 128 L 3.27x27 Structure Structure
TM3 129 E 3.28x28 Structure AF2
TM3 130 G 3.29x29 Structure Structure
TM3 131 Y 3.30x30 Structure Structure
TM3 132 T 3.31x31 Structure Structure
TM3 133 V 3.32x32 Structure Structure
TM3 134 S 3.33x33 Structure Structure
TM3 135 L 3.34x34 Structure Structure
TM3 136 C 3.35x35 Structure Structure
TM3 137 G 3.36x36 Structure Structure
TM3 138 I 3.37x37 Structure Structure
TM3 139 T 3.38x38 Structure Structure
TM3 140 G 3.39x39 Structure Structure
TM3 141 L 3.40x40 Structure Structure
TM3 142 W 3.41x41 Structure Structure
TM3 143 S 3.42x42 Structure Structure
TM3 144 L 3.43x43 Structure Structure
TM3 145 A 3.44x44 Structure Structure
TM3 146 I 3.45x45 Structure Structure
TM3 147 I 3.46x46 Structure Structure
TM3 148 S 3.47x47 Structure Structure
TM3 149 W 3.48x48 Structure Structure
TM3 150 E 3.49x49 Structure Structure
TM3 151 R 3.50x50 Structure Structure
TM3 152 W 3.51x51 Structure Structure
TM3 153 M 3.52x52 Structure Structure
TM3 154 V 3.53x53 Structure Structure
TM3 155 V 3.54x54 Structure Structure
TM3 156 C 3.55x55 Structure Structure
TM3 157 K 3.56x56 Structure Structure
ICL2 158 P 34.50x50 Structure Structure
ICL2 159 F 34.51x51 Structure Structure
ICL2 160 G 34.52x52 Structure Structure
ICL2 161 N 34.53x53 Structure Structure
ICL2 162 V 34.54x54 Structure Structure
ICL2 163 R 34.55x55 Structure Structure
ICL2 164 F 34.56x56 Structure Structure
TM4 165 D 4.38x38 Structure Structure
TM4 166 A 4.39x39 Structure Structure
TM4 167 K 4.40x40 Structure Structure
TM4 168 L 4.41x41 Structure Structure
TM4 169 A 4.42x42 Structure Structure
TM4 170 I 4.43x43 Structure Structure
TM4 171 V 4.44x44 Structure Structure
TM4 172 G 4.45x45 Structure Structure
TM4 173 I 4.46x46 Structure Structure
TM4 174 A 4.47x47 Structure Structure
TM4 175 F 4.48x48 Structure Structure
TM4 176 S 4.49x49 Structure Structure
TM4 177 W 4.50x50 Structure Structure
TM4 178 I 4.51x51 Structure Structure
TM4 179 W 4.52x52 Structure Structure
TM4 180 A 4.53x53 Structure Structure
TM4 181 A 4.54x54 Structure Structure
TM4 182 V 4.55x55 Structure Structure
TM4 183 W 4.56x56 Structure Structure
TM4 184 T 4.57x57 Structure Structure
TM4 185 A 4.58x58 Structure Structure
TM4 186 P 4.59x59 Structure Structure
TM4 187 P 4.60x60 Structure Structure
TM4 188 I 4.61x61 Structure Structure
TM4 189 F 4.62x62 Structure Structure
TM4 190 G 4.63x63 Structure Structure
ECL2 191 W - Structure Structure
ECL2 192 S - Structure Structure
ECL2 193 R - Structure AF2
ECL2 194 Y - Structure Structure
ECL2 195 W - Structure Structure
ECL2 196 P - Structure Structure
ECL2 197 H - Structure Structure
ECL2 198 G - Structure Structure
ECL2 199 L - Structure Structure
ECL2 200 K - Structure Structure
ECL2 201 T - Structure Structure
ECL2 202 S - Structure Structure
ECL2 203 C 45.50x50 Structure Structure
ECL2 204 G 45.51x51 Structure Structure
ECL2 205 P 45.52x52 Structure Structure
ECL2 206 D - Structure Structure
ECL2 207 V - Structure Structure
ECL2 208 F - Structure Structure
ECL2 209 S - Structure Structure
ECL2 210 G - Structure Structure
ECL2 211 S - Structure Structure
ECL2 212 S - Structure Structure
ECL2 213 Y - Structure Structure
ECL2 214 P - Structure Structure
TM5 215 G 5.34x35 Structure Structure
TM5 216 V 5.35x36 Structure Structure
TM5 217 Q 5.36x37 Structure Structure
TM5 218 S 5.37x38 Structure Structure
TM5 219 Y 5.38x39 Structure Structure
TM5 220 M 5.39x40 Structure Structure
TM5 221 I 5.40x41 Structure Structure
TM5 222 V 5.41x42 Structure Structure
TM5 223 L 5.42x43 Structure Structure
TM5 224 M 5.43x44 Structure Structure
TM5 225 V 5.44x45 Structure Structure
TM5 226 T 5.45x46 Structure Structure
TM5 227 C 5.46x461 Structure Structure
TM5 228 C 5.47x47 Structure Structure
TM5 229 I 5.48x48 Structure Structure
TM5 230 I 5.49x49 Structure Structure
TM5 231 P 5.50x50 Structure Structure
TM5 232 L 5.51x51 Structure Structure
TM5 233 A 5.52x52 Structure Structure
TM5 234 I 5.53x53 Structure Structure
TM5 235 I 5.54x54 Structure Structure
TM5 236 M 5.55x55 Structure Structure
TM5 237 L 5.56x56 Structure Structure
TM5 238 C 5.57x57 Structure Structure
TM5 239 Y 5.58x58 Structure Structure
TM5 240 L 5.59x59 Structure Structure
TM5 241 Q 5.60x60 Structure Structure
TM5 242 V 5.61x61 Structure Structure
TM5 243 W 5.62x62 Structure Structure
TM5 244 L 5.63x63 Structure Structure
TM5 245 A 5.64x64 Structure Structure
TM5 246 I 5.65x65 Structure Structure
TM5 247 R 5.66x66 Structure Structure
TM5 248 A 5.67x67 Structure Structure
TM5 249 V 5.68x68 Structure Structure
TM5 250 A 5.69x69 Structure Structure
TM5 251 K 5.70x70 Structure Structure
TM5 252 Q 5.71x71 Structure Structure
TM5 253 Q 5.72x72 Structure Structure
ICL3 254 K - Structure Structure
ICL3 255 E - Structure Structure
TM6 256 S 6.23x23 Structure Structure
TM6 257 E 6.24x24 Structure Structure
TM6 258 S 6.25x25 Structure Structure
TM6 259 T 6.26x26 Structure Structure
TM6 260 Q 6.27x27 Structure Structure
TM6 261 K 6.28x28 Structure Structure
TM6 262 A 6.29x29 Structure Structure
TM6 263 E 6.30x30 Structure Structure
TM6 264 K 6.31x31 Structure Structure
TM6 265 E 6.32x32 Structure Structure
TM6 266 V 6.33x33 Structure Structure
TM6 267 T 6.34x34 Structure Structure
TM6 268 R 6.35x35 Structure Structure
TM6 269 M 6.36x36 Structure Structure
TM6 270 V 6.37x37 Structure Structure
TM6 271 V 6.38x38 Structure Structure
TM6 272 V 6.39x39 Structure Structure
TM6 273 M 6.40x40 Structure Structure
TM6 274 I 6.41x41 Structure Structure
TM6 275 F 6.42x42 Structure Structure
TM6 276 A 6.43x43 Structure Structure
TM6 277 Y 6.44x44 Structure Structure
TM6 278 C 6.45x45 Structure Structure
TM6 279 V 6.46x46 Structure Structure
TM6 280 C 6.47x47 Structure Structure
TM6 281 W 6.48x48 Structure Structure
TM6 282 G 6.49x49 Structure Structure
TM6 283 P 6.50x50 Structure Structure
TM6 284 Y 6.51x51 Structure Structure
TM6 285 T 6.52x52 Structure Structure
TM6 286 F 6.53x53 Structure Structure
TM6 287 F 6.54x54 Structure Structure
TM6 288 A 6.55x55 Structure Structure
TM6 289 C 6.56x56 Structure Structure
TM6 290 F 6.57x57 Structure Structure
TM6 291 A 6.58x58 Structure Structure
TM6 292 A 6.59x59 Structure Structure
TM6 293 A 6.60x60 Structure Structure
TM6 294 N 6.61x61 Structure Structure
TM6 295 P 6.62x62 Structure Structure
ECL3 296 G - Structure Structure
ECL3 297 Y - Structure Structure
ECL3 298 A - Structure Structure
ECL3 299 F - Structure Structure
TM7 300 H 7.31x30 Structure Structure
TM7 301 P 7.32x31 Structure Structure
TM7 302 L 7.33x32 Structure Structure
TM7 303 M 7.34x33 Structure Structure
TM7 304 A 7.35x34 Structure Structure
TM7 305 A 7.36x35 Structure Structure
TM7 306 L 7.37x36 Structure Structure
TM7 307 P 7.38x37 Structure Structure
TM7 308 A 7.39x38 Structure Structure
TM7 309 Y 7.40x39 Structure Structure
TM7 310 F 7.41x40 Structure Structure
TM7 311 A 7.42x41 Structure Structure
TM7 312 K 7.43x42 Structure Structure
TM7 313 S 7.44x43 Structure Structure
TM7 314 A 7.45x45 Structure Structure
TM7 315 T 7.46x46 Structure Structure
TM7 316 I 7.47x47 Structure Structure
TM7 317 Y 7.48x48 Structure Structure
TM7 318 N 7.49x49 Structure Structure
TM7 319 P 7.50x50 Structure Structure
TM7 320 V 7.51x51 Structure Structure
TM7 321 I 7.52x52 Structure Structure
TM7 322 Y 7.53x53 Structure Structure
TM7 323 V 7.54x54 Structure Structure
TM7 324 F 7.55x55 Structure Structure
TM7 325 M 7.56x56 Structure Structure
H8 326 N 8.47x47 Structure Structure
H8 327 R 8.48x48 Structure Structure
H8 328 Q 8.49x49 Structure Structure
H8 329 F 8.50x50 Structure Structure
H8 330 R 8.51x51 Structure Structure
H8 331 N 8.52x52 Structure Structure
H8 332 C 8.53x53 Structure Structure
H8 333 I 8.54x54 Structure Structure
H8 334 L 8.55x55 Structure Structure
H8 335 Q 8.56x56 Structure Structure
H8 336 L 8.57x57 AF2 AF2
H8 337 F 8.58x58 AF2 AF2
H8 338 G 8.59x59 AF2 AF2
C-term 339 K - AF2 AF2
C-term 340 K - AF2 AF2
C-term 341 V - AF2 AF2
C-term 342 D - AF2 AF2
C-term 343 D - AF2 AF2
C-term 344 G - AF2 AF2
C-term 345 S - AF2 AF2
C-term 346 E - AF2 AF2
C-term 347 L - AF2 AF2
C-term 348 S - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 V 242 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM6 E 265 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM5 V 249 5x68 G.H5 T 340 G.H5.12
Hydrophobic TM6 A 262 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 262 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM5 I 246 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM6 M 269 6x36 G.H5 L 353 G.H5.25
Polar TM3 R 151 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 151 3x50 G.H5 C 351 G.H5.23
Polar H8 Q 328 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 Q 328 8x49 G.H5 D 350 G.H5.22
Polar TM6 S 256 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 256 6x23 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 S 256 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic H8 N 326 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 326 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 V 154 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 V 154 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 155 3x54 G.H5 C 351 G.H5.23
Polar H8 R 327 8x48 G.H5 F 354 G.H5.26
Aromatic H8 R 327 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 R 327 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 R 327 8x48 G.H5 F 354 G.H5.26
Polar H8 N 326 8x47 G.H5 C 351 G.H5.23
Polar H8 Q 328 8x49 G.H5 K 349 G.H5.21
Polar TM5 Q 253 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM5 Q 253 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 Q 253 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM5 Q 253 5x72 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 Q 253 5x72 G.h4s6 E 318 G.h4s6.12
Polar TM5 Q 253 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM5 Q 253 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 Q 253 5x72 G.S6 Y 320 G.S6.02
Polar TM3 V 154 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 V 154 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 V 155 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 V 266 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM2 L 88 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM5 I 246 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 I 246 5x65 G.H5 L 348 G.H5.20
Hydrophobic H8 N 326 8x47 G.H5 F 354 G.H5.26
Van-der-waals H8 N 326 8x47 G.H5 F 354 G.H5.26
Hydrophobic TM5 V 249 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 V 249 5x68 G.H5 D 341 G.H5.13
Polar ICL2 N 161 34x53 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 N 161 34x53 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 V 249 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 V 249 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 M 273 6x40 G.H5 L 353 G.H5.25
Polar TM6 S 258 6x25 G.H5 K 345 G.H5.17
Van-der-waals TM6 S 258 6x25 G.H5 K 345 G.H5.17
Hydrophobic TM3 V 155 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 V 266 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 R 163 34x55 G.hns1 R 32 G.hns1.03