Refined structure (8J6L) of Gi1 - HCA2 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-11-26

3D VIEW

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Structure
GPCR

Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 217 from structure (61.3%), 137 from model (38.7%)
Residue sidechains - 213 from structure (60.2%), 141 from model (39.8%)

REFINED GPCR RESIDUES

Residue backbones - 293 from structure (90.7%), 30 from model (9.3%)
Residue sidechains - 293 from structure (90.7%), 30 from model (9.3%)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
E52G.HNK08E12G.h4s6N19D22G24G.H5GproteinH-P34x50S2x39S4x38S8x47K2x37GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.HNG.h4s6G.H5GPCR segments:TM2ICL2ICL3TM4H8

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x372x392x403x503x533x5434x5034x5134x5434x554x385x655x696x296x306x326x336x378x478x48G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.12G.h4s6.12G.h4s6.09G.h4s6.08G.S3.01G.hns1.03G.HN.52Res. Pos.HCA2 (8J6L_REFINED)- (8J6L_REFINED)---------------------KSRRRVPHLNSLQKIRAISPKSRPHLNRRVSLQKIRAISPDDTIINLRCLLEFKGKDE

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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