Refined structure (8JBH) of Gq - NK3 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-11-26

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 203 from structure (56.5%), 156 from model (43.5%)
Residue sidechains - 102 from structure (28.4%), 257 from model (71.6%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 Structure Structure
G.HN 2 T G.HN.02 AF2 AF2
G.HN 3 L G.HN.03 AF2 AF2
G.HN 4 E G.HN.04 AF2 AF2
G.HN 5 S G.HN.05 AF2 AF2
G.HN 6 I G.HN.06 AF2 AF2
G.HN 7 M G.HN.07 AF2 AF2
G.HN 8 A G.HN.08 AF2 AF2
G.HN 9 C G.HN.09 AF2 AF2
G.HN 10 C G.HN.10 AF2 AF2
G.HN 11 L G.HN.11 AF2 AF2
G.HN 12 S G.HN.30 AF2 AF2
G.HN 13 E G.HN.31 Structure AF2
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 A G.HN.33 Structure AF2
G.HN 16 K G.HN.34 Structure Structure
G.HN 17 E G.HN.35 Structure AF2
G.HN 18 A G.HN.36 Structure Structure
G.HN 19 R G.HN.37 Structure AF2
G.HN 20 R G.HN.38 Structure AF2
G.HN 21 I G.HN.39 Structure AF2
G.HN 22 N G.HN.40 Structure AF2
G.HN 23 D G.HN.41 Structure AF2
G.HN 24 E G.HN.42 Structure AF2
G.HN 25 I G.HN.43 Structure Structure
G.HN 26 E G.HN.44 Structure Structure
G.HN 27 R G.HN.45 Structure AF2
G.HN 28 Q G.HN.46 Structure Structure
G.HN 29 L G.HN.47 Structure Structure
G.HN 30 R G.HN.48 Structure AF2
G.HN 31 R G.HN.49 Structure AF2
G.HN 32 D G.HN.50 Structure Structure
G.HN 33 K G.HN.51 Structure Structure
G.HN 34 R G.HN.52 Structure AF2
G.HN 35 D G.HN.53 Structure AF2
G.hns1 36 A G.hns1.01 Structure AF2
G.hns1 37 R G.hns1.02 Structure Structure
G.hns1 38 R G.hns1.03 Structure Structure
G.S1 39 E G.S1.01 Structure AF2
G.S1 40 L G.S1.02 Structure Structure
G.S1 41 K G.S1.03 Structure AF2
G.S1 42 L G.S1.04 Structure Structure
G.S1 43 L G.S1.05 Structure Structure
G.S1 44 L G.S1.06 Structure Structure
G.S1 45 L G.S1.07 Structure Structure
G.s1h1 46 G G.s1h1.01 Structure Structure
G.s1h1 47 T G.s1h1.02 Structure AF2
G.s1h1 48 G G.s1h1.03 Structure AF2
G.s1h1 49 E G.s1h1.04 Structure AF2
G.s1h1 50 S G.s1h1.05 Structure Structure
G.s1h1 51 G G.s1h1.06 Structure Structure
G.H1 52 K G.H1.01 Structure Structure
G.H1 53 S G.H1.02 Structure Structure
G.H1 54 T G.H1.03 Structure Structure
G.H1 55 F G.H1.04 Structure AF2
G.H1 56 I G.H1.05 Structure AF2
G.H1 57 K G.H1.06 Structure AF2
G.H1 58 Q G.H1.07 Structure AF2
G.H1 59 M G.H1.08 AF2 AF2
G.H1 60 R G.H1.09 AF2 AF2
G.H1 61 I G.H1.10 AF2 AF2
G.H1 62 I G.H1.11 AF2 AF2
G.H1 63 H G.H1.12 AF2 AF2
G.h1ha 64 G G.h1ha.01 AF2 AF2
G.h1ha 65 S G.h1ha.02 AF2 AF2
G.h1ha 66 G G.h1ha.03 AF2 AF2
G.h1ha 67 Y G.h1ha.04 AF2 AF2
G.h1ha 68 S G.h1ha.05 AF2 AF2
H.HA 69 D H.HA.01 AF2 AF2
H.HA 70 E H.HA.02 AF2 AF2
H.HA 71 D H.HA.03 AF2 AF2
H.HA 72 K H.HA.04 AF2 AF2
H.HA 73 R H.HA.05 AF2 AF2
H.HA 74 G H.HA.06 AF2 AF2
H.HA 75 F H.HA.07 AF2 AF2
H.HA 76 T H.HA.08 AF2 AF2
H.HA 77 K H.HA.09 AF2 AF2
H.HA 78 L H.HA.10 AF2 AF2
H.HA 79 V H.HA.11 AF2 AF2
H.HA 80 Y H.HA.12 AF2 AF2
H.HA 81 Q H.HA.13 AF2 AF2
H.HA 82 N H.HA.14 AF2 AF2
H.HA 83 I H.HA.15 AF2 AF2
H.HA 84 F H.HA.16 AF2 AF2
H.HA 85 T H.HA.17 AF2 AF2
H.HA 86 A H.HA.18 AF2 AF2
H.HA 87 M H.HA.19 AF2 AF2
H.HA 88 Q H.HA.20 AF2 AF2
H.HA 89 A H.HA.21 AF2 AF2
H.HA 90 M H.HA.22 AF2 AF2
H.HA 91 I H.HA.23 AF2 AF2
H.HA 92 R H.HA.24 AF2 AF2
H.HA 93 A H.HA.25 AF2 AF2
H.HA 94 M H.HA.26 AF2 AF2
H.HA 95 D H.HA.27 AF2 AF2
H.HA 96 T H.HA.28 AF2 AF2
H.HA 97 L H.HA.29 AF2 AF2
H.hahb 98 K H.hahb.01 AF2 AF2
H.hahb 99 I H.hahb.04 AF2 AF2
H.hahb 100 P H.hahb.05 AF2 AF2
H.hahb 101 Y H.hahb.06 AF2 AF2
H.hahb 102 K H.hahb.07 AF2 AF2
H.hahb 103 Y H.hahb.08 AF2 AF2
H.hahb 104 E H.hahb.09 AF2 AF2
H.HB 105 H H.HB.01 AF2 AF2
H.HB 106 N H.HB.02 AF2 AF2
H.HB 107 K H.HB.03 AF2 AF2
H.HB 108 A H.HB.04 AF2 AF2
H.HB 109 H H.HB.05 AF2 AF2
H.HB 110 A H.HB.06 AF2 AF2
H.HB 111 Q H.HB.07 AF2 AF2
H.HB 112 L H.HB.08 AF2 AF2
H.HB 113 V H.HB.09 AF2 AF2
H.HB 114 R H.HB.10 AF2 AF2
H.HB 115 E H.HB.11 AF2 AF2
H.HB 116 V H.HB.12 AF2 AF2
H.HB 117 D H.HB.13 AF2 AF2
H.HB 118 V H.HB.14 AF2 AF2
H.hbhc 119 E H.hbhc.01 AF2 AF2
H.hbhc 120 K H.hbhc.02 AF2 AF2
H.hbhc 121 V H.hbhc.03 AF2 AF2
H.hbhc 122 S H.hbhc.04 AF2 AF2
H.hbhc 123 A H.hbhc.05 AF2 AF2
H.hbhc 124 F H.hbhc.14 AF2 AF2
H.hbhc 125 E H.hbhc.15 AF2 AF2
H.HC 126 N H.HC.01 AF2 AF2
H.HC 127 P H.HC.02 AF2 AF2
H.HC 128 Y H.HC.03 AF2 AF2
H.HC 129 V H.HC.04 AF2 AF2
H.HC 130 D H.HC.05 AF2 AF2
H.HC 131 A H.HC.06 AF2 AF2
H.HC 132 I H.HC.07 AF2 AF2
H.HC 133 K H.HC.08 AF2 AF2
H.HC 134 S H.HC.09 AF2 AF2
H.HC 135 L H.HC.10 AF2 AF2
H.HC 136 W H.HC.11 AF2 AF2
H.HC 137 N H.HC.12 AF2 AF2
H.hchd 138 D H.hchd.01 AF2 AF2
H.HD 139 P H.HD.01 AF2 AF2
H.HD 140 G H.HD.02 AF2 AF2
H.HD 141 I H.HD.03 AF2 AF2
H.HD 142 Q H.HD.04 AF2 AF2
H.HD 143 E H.HD.05 AF2 AF2
H.HD 144 C H.HD.06 AF2 AF2
H.HD 145 Y H.HD.07 AF2 AF2
H.HD 146 D H.HD.08 AF2 AF2
H.HD 147 R H.HD.09 AF2 AF2
H.HD 148 R H.HD.10 AF2 AF2
H.HD 149 R H.HD.11 AF2 AF2
H.HD 150 E H.HD.12 AF2 AF2
H.hdhe 151 Y H.hdhe.01 AF2 AF2
H.hdhe 152 Q H.hdhe.02 AF2 AF2
H.hdhe 153 L H.hdhe.03 AF2 AF2
H.hdhe 154 S H.hdhe.04 AF2 AF2
H.hdhe 155 D H.hdhe.05 AF2 AF2
H.HE 156 S H.HE.01 AF2 AF2
H.HE 157 T H.HE.02 AF2 AF2
H.HE 158 K H.HE.03 AF2 AF2
H.HE 159 Y H.HE.04 AF2 AF2
H.HE 160 Y H.HE.05 AF2 AF2
H.HE 161 L H.HE.06 AF2 AF2
H.HE 162 N H.HE.07 AF2 AF2
H.HE 163 D H.HE.08 AF2 AF2
H.HE 164 L H.HE.09 AF2 AF2
H.HE 165 D H.HE.10 AF2 AF2
H.HE 166 R H.HE.11 AF2 AF2
H.HE 167 V H.HE.12 AF2 AF2
H.HE 168 A H.HE.13 AF2 AF2
H.hehf 169 D H.hehf.01 AF2 AF2
H.hehf 170 P H.hehf.02 AF2 AF2
H.hehf 171 A H.hehf.03 AF2 AF2
H.hehf 172 Y H.hehf.04 AF2 AF2
H.hehf 173 L H.hehf.05 AF2 AF2
H.hehf 174 P H.hehf.06 AF2 AF2
H.hehf 175 T H.hehf.07 AF2 AF2
H.HF 176 Q H.HF.01 AF2 AF2
H.HF 177 Q H.HF.02 AF2 AF2
H.HF 178 D H.HF.03 AF2 AF2
H.HF 179 V H.HF.04 AF2 AF2
H.HF 180 L H.HF.05 AF2 AF2
H.HF 181 R H.HF.06 AF2 AF2
G.hfs2 182 V G.hfs2.01 AF2 AF2
G.hfs2 183 R G.hfs2.02 AF2 AF2
G.hfs2 184 V G.hfs2.03 AF2 AF2
G.hfs2 185 P G.hfs2.04 AF2 AF2
G.hfs2 186 T G.hfs2.05 Structure Structure
G.hfs2 187 T G.hfs2.06 Structure Structure
G.hfs2 188 G G.hfs2.07 Structure Structure
G.S2 189 I G.S2.01 Structure Structure
G.S2 190 I G.S2.02 Structure AF2
G.S2 191 E G.S2.03 Structure Structure
G.S2 192 Y G.S2.04 Structure AF2
G.S2 193 P G.S2.05 Structure AF2
G.S2 194 F G.S2.06 Structure Structure
G.S2 195 D G.S2.07 Structure AF2
G.S2 196 L G.S2.08 Structure AF2
G.s2s3 197 Q G.s2s3.01 Structure AF2
G.s2s3 198 S G.s2s3.02 Structure AF2
G.S3 199 V G.S3.01 Structure Structure
G.S3 200 I G.S3.02 Structure AF2
G.S3 201 F G.S3.03 Structure Structure
G.S3 202 R G.S3.04 Structure AF2
G.S3 203 M G.S3.05 Structure Structure
G.S3 204 V G.S3.06 Structure AF2
G.S3 205 D G.S3.07 Structure Structure
G.S3 206 V G.S3.08 Structure Structure
G.s3h2 207 G G.s3h2.01 Structure Structure
G.s3h2 208 G G.s3h2.02 Structure AF2
G.s3h2 209 Q G.s3h2.03 Structure Structure
G.H2 210 R G.H2.01 Structure Structure
G.H2 211 S G.H2.02 Structure AF2
G.H2 212 E G.H2.03 Structure Structure
G.H2 213 R G.H2.04 Structure Structure
G.H2 214 R G.H2.05 Structure Structure
G.H2 215 K G.H2.06 Structure Structure
G.H2 216 W G.H2.07 Structure Structure
G.H2 217 I G.H2.08 Structure Structure
G.H2 218 H G.H2.09 Structure AF2
G.H2 219 C G.H2.10 Structure Structure
G.h2s4 220 F G.h2s4.01 Structure Structure
G.h2s4 221 E G.h2s4.02 Structure AF2
G.h2s4 222 N G.h2s4.03 Structure AF2
G.h2s4 223 V G.h2s4.04 Structure Structure
G.h2s4 224 T G.h2s4.05 Structure Structure
G.S4 225 S G.S4.01 Structure AF2
G.S4 226 I G.S4.02 Structure Structure
G.S4 227 M G.S4.03 Structure AF2
G.S4 228 F G.S4.04 Structure Structure
G.S4 229 L G.S4.05 Structure AF2
G.S4 230 V G.S4.06 Structure Structure
G.S4 231 A G.S4.07 Structure AF2
G.s4h3 232 L G.s4h3.01 Structure AF2
G.s4h3 233 S G.s4h3.02 Structure Structure
G.s4h3 234 E G.s4h3.03 Structure AF2
G.s4h3 235 Y G.s4h3.04 Structure Structure
G.s4h3 236 D G.s4h3.05 Structure AF2
G.s4h3 237 Q G.s4h3.06 AF2 AF2
G.s4h3 238 V G.s4h3.07 AF2 AF2
G.s4h3 239 L G.s4h3.08 AF2 AF2
G.s4h3 240 V G.s4h3.09 AF2 AF2
G.s4h3 241 E G.s4h3.10 AF2 AF2
G.s4h3 242 S G.s4h3.11 AF2 AF2
G.s4h3 243 D G.s4h3.12 AF2 AF2
G.s4h3 244 N G.s4h3.13 AF2 AF2
G.s4h3 245 E G.s4h3.14 AF2 AF2
G.s4h3 246 N G.s4h3.15 AF2 AF2
G.H3 247 R G.H3.01 Structure Structure
G.H3 248 M G.H3.02 Structure AF2
G.H3 249 E G.H3.03 Structure AF2
G.H3 250 E G.H3.04 Structure AF2
G.H3 251 S G.H3.05 Structure AF2
G.H3 252 K G.H3.06 Structure AF2
G.H3 253 A G.H3.07 Structure AF2
G.H3 254 L G.H3.08 Structure AF2
G.H3 255 F G.H3.09 Structure Structure
G.H3 256 R G.H3.10 Structure AF2
G.H3 257 T G.H3.11 Structure AF2
G.H3 258 I G.H3.12 Structure Structure
G.H3 259 I G.H3.13 Structure AF2
G.H3 260 T G.H3.14 Structure AF2
G.H3 261 Y G.H3.15 Structure AF2
G.H3 262 P G.H3.16 Structure AF2
G.H3 263 W G.H3.17 Structure Structure
G.H3 264 F G.H3.18 Structure AF2
G.h3s5 265 Q G.h3s5.01 Structure AF2
G.h3s5 266 N G.h3s5.02 Structure AF2
G.h3s5 267 S G.h3s5.03 Structure AF2
G.S5 268 S G.S5.01 Structure Structure
G.S5 269 V G.S5.02 Structure Structure
G.S5 270 I G.S5.03 Structure Structure
G.S5 271 L G.S5.04 Structure Structure
G.S5 272 F G.S5.05 Structure Structure
G.S5 273 L G.S5.06 Structure Structure
G.S5 274 N G.S5.07 Structure Structure
G.s5hg 275 K G.s5hg.01 Structure Structure
G.HG 276 K G.HG.01 Structure AF2
G.HG 277 D G.HG.02 Structure Structure
G.HG 278 L G.HG.03 Structure Structure
G.HG 279 L G.HG.04 Structure Structure
G.HG 280 E G.HG.05 Structure AF2
G.HG 281 E G.HG.06 Structure Structure
G.HG 282 K G.HG.07 Structure Structure
G.HG 283 I G.HG.08 Structure AF2
G.HG 284 M G.HG.09 Structure AF2
G.HG 285 Y G.HG.12 Structure AF2
G.HG 286 S G.HG.13 Structure Structure
G.HG 287 H G.HG.14 Structure AF2
G.HG 288 L G.HG.15 Structure AF2
G.HG 289 V G.HG.16 Structure AF2
G.HG 290 D G.HG.17 Structure Structure
G.hgh4 291 Y G.hgh4.01 AF2 AF2
G.hgh4 292 F G.hgh4.02 AF2 AF2
G.hgh4 293 P G.hgh4.03 AF2 AF2
G.hgh4 294 E G.hgh4.04 AF2 AF2
G.hgh4 295 Y G.hgh4.05 AF2 AF2
G.hgh4 296 D G.hgh4.06 AF2 AF2
G.hgh4 297 G G.hgh4.07 AF2 AF2
G.hgh4 298 P G.hgh4.08 AF2 AF2
G.H4 299 Q G.H4.01 Structure AF2
G.H4 300 R G.H4.02 Structure AF2
G.H4 301 D G.H4.03 Structure AF2
G.H4 302 A G.H4.04 Structure AF2
G.H4 303 Q G.H4.05 Structure AF2
G.H4 304 A G.H4.06 Structure AF2
G.H4 305 A G.H4.07 Structure Structure
G.H4 306 R G.H4.08 Structure AF2
G.H4 307 E G.H4.09 Structure AF2
G.H4 308 F G.H4.10 Structure Structure
G.H4 309 I G.H4.11 Structure Structure
G.H4 310 L G.H4.12 Structure AF2
G.H4 311 K G.H4.13 Structure AF2
G.H4 312 M G.H4.14 Structure AF2
G.H4 313 F G.H4.15 Structure Structure
G.H4 314 V G.H4.16 Structure Structure
G.H4 315 D G.H4.17 Structure Structure
G.h4s6 316 L G.h4s6.01 Structure AF2
G.h4s6 317 N G.h4s6.08 Structure AF2
G.h4s6 318 P G.h4s6.09 Structure AF2
G.h4s6 319 D G.h4s6.10 Structure AF2
G.h4s6 320 S G.h4s6.11 Structure AF2
G.h4s6 321 D G.h4s6.12 Structure AF2
G.h4s6 322 K G.h4s6.13 Structure AF2
G.h4s6 323 I G.h4s6.20 Structure Structure
G.S6 324 I G.S6.01 Structure AF2
G.S6 325 Y G.S6.02 Structure Structure
G.S6 326 S G.S6.03 Structure AF2
G.S6 327 H G.S6.04 Structure Structure
G.S6 328 F G.S6.05 Structure Structure
G.s6h5 329 T G.s6h5.01 Structure Structure
G.s6h5 330 C G.s6h5.02 Structure Structure
G.s6h5 331 A G.s6h5.03 Structure Structure
G.s6h5 332 T G.s6h5.04 Structure AF2
G.s6h5 333 D G.s6h5.05 Structure Structure
G.H5 334 T G.H5.01 Structure Structure
G.H5 335 E G.H5.02 Structure Structure
G.H5 336 N G.H5.03 Structure Structure
G.H5 337 I G.H5.04 Structure AF2
G.H5 338 R G.H5.05 Structure Structure
G.H5 339 F G.H5.06 Structure AF2
G.H5 340 V G.H5.07 Structure AF2
G.H5 341 F G.H5.08 Structure Structure
G.H5 342 A G.H5.09 Structure AF2
G.H5 343 A G.H5.10 Structure AF2
G.H5 344 V G.H5.11 Structure AF2
G.H5 345 K G.H5.12 Structure Structure
G.H5 346 D G.H5.13 Structure Structure
G.H5 347 T G.H5.14 Structure AF2
G.H5 348 I G.H5.15 Structure Structure
G.H5 349 L G.H5.16 Structure Structure
G.H5 350 Q G.H5.17 Structure Structure
G.H5 351 L G.H5.18 Structure AF2
G.H5 352 N G.H5.19 Structure Structure
G.H5 353 L G.H5.20 Structure Structure
G.H5 354 K G.H5.21 Structure AF2
G.H5 355 E G.H5.22 Structure Structure
G.H5 356 Y G.H5.23 Structure Structure
G.H5 357 N G.H5.24 Structure Structure
G.H5 358 L G.H5.25 Structure Structure
G.H5 359 V G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 272 from structure (71.4%), 109 from model (28.6%)
Residue sidechains - 254 from structure (66.7%), 127 from model (33.3%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 A - AF2 AF2
N-term 3 T - AF2 AF2
N-term 4 L - AF2 AF2
N-term 5 P - AF2 AF2
N-term 6 A - AF2 AF2
N-term 7 A - AF2 AF2
N-term 8 E - AF2 AF2
N-term 9 T - AF2 AF2
N-term 10 W - AF2 AF2
N-term 11 I - AF2 AF2
N-term 12 D - AF2 AF2
N-term 13 G - AF2 AF2
N-term 14 G - AF2 AF2
N-term 15 G - AF2 AF2
N-term 16 G - AF2 AF2
N-term 17 V - AF2 AF2
N-term 18 G - AF2 AF2
N-term 19 A - AF2 AF2
N-term 20 D - AF2 AF2
N-term 21 A - AF2 AF2
N-term 22 V - AF2 AF2
N-term 23 N - AF2 AF2
N-term 24 L - AF2 AF2
N-term 25 T - AF2 AF2
N-term 26 A - AF2 AF2
N-term 27 S - AF2 AF2
N-term 28 L - AF2 AF2
N-term 29 A - AF2 AF2
N-term 30 A - AF2 AF2
N-term 31 G - AF2 AF2
N-term 32 A - AF2 AF2
N-term 33 A - AF2 AF2
N-term 34 T - AF2 AF2
N-term 35 G - AF2 AF2
N-term 36 A - AF2 AF2
N-term 37 V - AF2 AF2
N-term 38 E - AF2 AF2
N-term 39 T - AF2 AF2
N-term 40 G - AF2 AF2
N-term 41 W - AF2 AF2
N-term 42 L - AF2 AF2
N-term 43 Q - AF2 AF2
N-term 44 L - AF2 AF2
N-term 45 L - AF2 AF2
N-term 46 D - AF2 AF2
N-term 47 Q - AF2 AF2
N-term 48 A - AF2 AF2
N-term 49 G - AF2 AF2
N-term 50 N - AF2 AF2
N-term 51 L - AF2 AF2
N-term 52 S - AF2 AF2
N-term 53 S - AF2 AF2
N-term 54 S - AF2 AF2
N-term 55 P - AF2 AF2
N-term 56 S - AF2 AF2
N-term 57 A - AF2 AF2
N-term 58 L - AF2 AF2
N-term 59 G - AF2 AF2
N-term 60 L - AF2 AF2
N-term 61 P - AF2 AF2
N-term 62 V - AF2 AF2
N-term 63 A - AF2 AF2
N-term 64 S - AF2 AF2
N-term 65 P - AF2 AF2
N-term 66 A - AF2 AF2
N-term 67 P - AF2 AF2
N-term 68 S - AF2 AF2
N-term 69 Q - AF2 AF2
N-term 70 P - AF2 AF2
N-term 71 W - AF2 AF2
N-term 72 A - AF2 AF2
N-term 73 N - AF2 AF2
N-term 74 L - AF2 AF2
N-term 75 T - AF2 AF2
N-term 76 N - AF2 AF2
N-term 77 Q - AF2 AF2
N-term 78 F - AF2 AF2
N-term 79 V - AF2 AF2
N-term 80 Q - AF2 AF2
TM1 81 P 1.28x28 Structure Structure
TM1 82 S 1.29x29 Structure Structure
TM1 83 W 1.30x30 Structure AF2
TM1 84 R 1.31x31 Structure AF2
TM1 85 I 1.32x32 Structure Structure
TM1 86 A 1.33x33 Structure Structure
TM1 87 L 1.34x34 Structure Structure
TM1 88 W 1.35x35 Structure Structure
TM1 89 S 1.36x36 Structure Structure
TM1 90 L 1.37x37 Structure Structure
TM1 91 A 1.38x38 Structure Structure
TM1 92 Y 1.39x39 Structure Structure
TM1 93 G 1.40x40 Structure Structure
TM1 94 V 1.41x41 Structure Structure
TM1 95 V 1.42x42 Structure Structure
TM1 96 V 1.43x43 Structure Structure
TM1 97 A 1.44x44 Structure Structure
TM1 98 V 1.45x45 Structure Structure
TM1 99 A 1.46x46 Structure Structure
TM1 100 V 1.47x47 Structure Structure
TM1 101 L 1.48x48 Structure Structure
TM1 102 G 1.49x49 Structure Structure
TM1 103 N 1.50x50 Structure Structure
TM1 104 L 1.51x51 Structure Structure
TM1 105 I 1.52x52 Structure Structure
TM1 106 V 1.53x53 Structure Structure
TM1 107 I 1.54x54 Structure Structure
TM1 108 W 1.55x55 Structure Structure
TM1 109 I 1.56x56 Structure Structure
TM1 110 I 1.57x57 Structure Structure
TM1 111 L 1.58x58 Structure Structure
TM1 112 A 1.59x59 Structure Structure
TM1 113 H 1.60x60 Structure Structure
ICL1 114 K 12.48x48 Structure Structure
ICL1 115 R 12.49x49 AF2 AF2
ICL1 116 M 12.50x50 Structure Structure
ICL1 117 R 12.51x51 Structure Structure
TM2 118 T 2.37x37 Structure Structure
TM2 119 V 2.38x38 Structure Structure
TM2 120 T 2.39x39 Structure Structure
TM2 121 N 2.40x40 Structure Structure
TM2 122 Y 2.41x41 Structure Structure
TM2 123 F 2.42x42 Structure Structure
TM2 124 L 2.43x43 Structure Structure
TM2 125 V 2.44x44 Structure Structure
TM2 126 N 2.45x45 Structure Structure
TM2 127 L 2.46x46 Structure Structure
TM2 128 A 2.47x47 Structure Structure
TM2 129 F 2.48x48 Structure Structure
TM2 130 S 2.49x49 Structure Structure
TM2 131 D 2.50x50 Structure Structure
TM2 132 A 2.51x51 Structure Structure
TM2 133 S 2.52x52 Structure Structure
TM2 134 M 2.53x53 Structure Structure
TM2 135 A 2.54x54 Structure Structure
TM2 136 A 2.55x55 Structure Structure
TM2 137 F 2.56x56 Structure Structure
TM2 138 N 2.57x57 Structure Structure
TM2 139 T 2.58x58 Structure Structure
TM2 140 L 2.59x59 Structure Structure
TM2 141 V 2.60x60 Structure Structure
TM2 142 N 2.61x61 Structure Structure
TM2 143 F 2.62x62 Structure Structure
TM2 144 I 2.63x63 Structure Structure
TM2 145 Y 2.64x64 Structure Structure
TM2 146 A 2.65x65 Structure Structure
TM2 147 L 2.66x66 Structure AF2
TM2 148 H 2.67x67 Structure Structure
TM2 149 S 2.68x68 Structure Structure
ECL1 150 E 23.49x49 Structure AF2
ECL1 151 W 23.50x50 Structure Structure
ECL1 152 Y 23.51x51 Structure Structure
ECL1 153 F 23.52x52 Structure Structure
TM3 154 G 3.21x21 Structure Structure
TM3 155 A 3.22x22 Structure Structure
TM3 156 N 3.23x23 Structure Structure
TM3 157 Y 3.24x24 Structure Structure
TM3 158 C 3.25x25 Structure Structure
TM3 159 R 3.26x26 Structure AF2
TM3 160 F 3.27x27 Structure Structure
TM3 161 Q 3.28x28 Structure Structure
TM3 162 N 3.29x29 Structure Structure
TM3 163 F 3.30x30 Structure Structure
TM3 164 F 3.31x31 Structure Structure
TM3 165 P 3.32x32 Structure Structure
TM3 166 I 3.33x33 Structure Structure
TM3 167 T 3.34x34 Structure Structure
TM3 168 A 3.35x35 Structure Structure
TM3 169 V 3.36x36 Structure Structure
TM3 170 F 3.37x37 Structure Structure
TM3 171 A 3.38x38 Structure Structure
TM3 172 S 3.39x39 Structure Structure
TM3 173 I 3.40x40 Structure Structure
TM3 174 Y 3.41x41 Structure Structure
TM3 175 S 3.42x42 Structure Structure
TM3 176 M 3.43x43 Structure Structure
TM3 177 T 3.44x44 Structure Structure
TM3 178 A 3.45x45 Structure Structure
TM3 179 I 3.46x46 Structure Structure
TM3 180 A 3.47x47 Structure Structure
TM3 181 V 3.48x48 Structure Structure
TM3 182 D 3.49x49 Structure Structure
TM3 183 R 3.50x50 Structure Structure
TM3 184 Y 3.51x51 Structure Structure
TM3 185 M 3.52x52 Structure Structure
TM3 186 A 3.53x53 Structure Structure
TM3 187 I 3.54x54 Structure Structure
TM3 188 I 3.55x55 Structure Structure
TM3 189 D 3.56x56 Structure Structure
ICL2 190 P - Structure Structure
ICL2 191 L - Structure Structure
ICL2 192 K - Structure Structure
ICL2 193 P - Structure Structure
ICL2 194 R - Structure Structure
ICL2 195 L - Structure Structure
TM4 196 S 4.38x38 Structure Structure
TM4 197 A 4.39x39 Structure Structure
TM4 198 T 4.40x40 Structure Structure
TM4 199 A 4.41x41 Structure Structure
TM4 200 T 4.42x42 Structure Structure
TM4 201 K 4.43x43 Structure Structure
TM4 202 I 4.44x44 Structure Structure
TM4 203 V 4.45x45 Structure Structure
TM4 204 I 4.46x46 Structure Structure
TM4 205 G 4.47x47 Structure Structure
TM4 206 S 4.48x48 Structure Structure
TM4 207 I 4.49x49 Structure Structure
TM4 208 W 4.50x50 Structure Structure
TM4 209 I 4.51x51 Structure Structure
TM4 210 L 4.52x52 Structure Structure
TM4 211 A 4.53x53 Structure Structure
TM4 212 F 4.54x54 Structure Structure
TM4 213 L 4.55x55 Structure Structure
TM4 214 L 4.56x56 Structure Structure
TM4 215 A 4.57x57 Structure Structure
TM4 216 F 4.58x59 Structure Structure
TM4 217 P 4.59x60 Structure Structure
TM4 218 Q 4.60x61 Structure Structure
TM4 219 C 4.61x62 Structure Structure
TM4 220 L 4.62x63 Structure AF2
TM4 221 Y 4.63x64 Structure Structure
TM4 222 S 4.64x65 Structure Structure
ECL2 223 K - Structure Structure
ECL2 224 T - Structure Structure
ECL2 225 K - Structure AF2
ECL2 226 V - Structure AF2
ECL2 227 M - Structure AF2
ECL2 228 P - Structure Structure
ECL2 229 G - AF2 AF2
ECL2 230 R - AF2 AF2
ECL2 231 T - Structure Structure
ECL2 232 L - Structure AF2
ECL2 233 C 45.50x50 Structure Structure
ECL2 234 F 45.51x51 Structure AF2
ECL2 235 V 45.52x52 Structure Structure
ECL2 236 Q - Structure Structure
ECL2 237 W - Structure AF2
ECL2 238 P - Structure Structure
ECL2 239 E - Structure AF2
TM5 240 G 5.31x32 Structure Structure
TM5 241 P 5.32x33 Structure Structure
TM5 242 K 5.33x34 Structure AF2
TM5 243 Q 5.34x35 Structure Structure
TM5 244 H 5.35x36 Structure Structure
TM5 245 F 5.36x37 Structure Structure
TM5 246 T 5.37x38 Structure Structure
TM5 247 Y 5.38x39 Structure Structure
TM5 248 H 5.39x40 Structure Structure
TM5 249 I 5.40x41 Structure Structure
TM5 250 I 5.41x42 Structure Structure
TM5 251 V 5.42x43 Structure Structure
TM5 252 I 5.43x44 Structure Structure
TM5 253 I 5.44x45 Structure Structure
TM5 254 L 5.45x46 Structure Structure
TM5 255 V 5.46x461 Structure Structure
TM5 256 Y 5.47x47 Structure Structure
TM5 257 C 5.48x48 Structure Structure
TM5 258 F 5.49x49 Structure AF2
TM5 259 P 5.50x50 Structure Structure
TM5 260 L 5.51x51 Structure Structure
TM5 261 L 5.52x52 Structure Structure
TM5 262 I 5.53x53 Structure Structure
TM5 263 M 5.54x54 Structure Structure
TM5 264 G 5.55x55 Structure Structure
TM5 265 I 5.56x56 Structure Structure
TM5 266 T 5.57x57 Structure Structure
TM5 267 Y 5.58x58 Structure Structure
TM5 268 T 5.59x59 Structure Structure
TM5 269 I 5.60x60 Structure Structure
TM5 270 V 5.61x61 Structure Structure
TM5 271 G 5.62x62 Structure Structure
TM5 272 I 5.63x63 Structure Structure
TM5 273 T 5.64x64 Structure Structure
TM5 274 L 5.65x65 Structure Structure
TM5 275 W 5.66x66 Structure Structure
TM5 276 G 5.67x67 AF2 AF2
TM5 277 G 5.68x68 AF2 AF2
TM5 278 E 5.69x69 AF2 AF2
TM5 279 I 5.70x70 AF2 AF2
TM5 280 P 5.71x71 AF2 AF2
TM5 281 G 5.72x72 AF2 AF2
TM5 282 D 5.73x73 AF2 AF2
ICL3 283 T - AF2 AF2
ICL3 284 C - AF2 AF2
ICL3 285 D - AF2 AF2
TM6 286 K 6.22x22 AF2 AF2
TM6 287 Y 6.23x23 AF2 AF2
TM6 288 H 6.24x24 AF2 AF2
TM6 289 E 6.25x25 AF2 AF2
TM6 290 Q 6.26x26 Structure Structure
TM6 291 L 6.27x27 Structure Structure
TM6 292 K 6.28x28 Structure Structure
TM6 293 A 6.29x29 Structure Structure
TM6 294 K 6.30x30 Structure Structure
TM6 295 R 6.31x31 Structure Structure
TM6 296 K 6.32x32 Structure Structure
TM6 297 V 6.33x33 Structure Structure
TM6 298 V 6.34x34 Structure Structure
TM6 299 K 6.35x35 Structure Structure
TM6 300 M 6.36x36 Structure Structure
TM6 301 M 6.37x37 Structure Structure
TM6 302 I 6.38x38 Structure Structure
TM6 303 I 6.39x39 Structure Structure
TM6 304 V 6.40x40 Structure Structure
TM6 305 V 6.41x41 Structure Structure
TM6 306 M 6.42x42 Structure Structure
TM6 307 T 6.43x43 Structure Structure
TM6 308 F 6.44x44 Structure Structure
TM6 309 A 6.45x45 Structure Structure
TM6 310 I 6.46x46 Structure Structure
TM6 311 C 6.47x47 Structure Structure
TM6 312 W 6.48x48 Structure Structure
TM6 313 L 6.49x49 Structure Structure
TM6 314 P 6.50x50 Structure Structure
TM6 315 Y 6.51x51 Structure Structure
TM6 316 H 6.52x52 Structure Structure
TM6 317 I 6.53x53 Structure Structure
TM6 318 Y 6.54x54 Structure Structure
TM6 319 F 6.55x55 Structure Structure
TM6 320 I 6.56x56 Structure Structure
TM6 321 L 6.57x57 Structure Structure
TM6 322 T 6.58x58 Structure Structure
TM6 323 A 6.59x59 Structure Structure
TM6 324 I 6.60x60 Structure Structure
TM6 325 Y 6.61x61 Structure Structure
ECL3 326 Q - Structure Structure
ECL3 327 Q - Structure Structure
ECL3 328 L - Structure Structure
ECL3 329 N - Structure Structure
ECL3 330 R - Structure Structure
ECL3 331 W - Structure Structure
TM7 332 K 7.29x28 Structure AF2
TM7 333 Y 7.30x29 Structure Structure
TM7 334 I 7.31x30 Structure Structure
TM7 335 Q 7.32x31 Structure Structure
TM7 336 Q 7.33x32 Structure Structure
TM7 337 V 7.34x33 Structure Structure
TM7 338 Y 7.35x34 Structure Structure
TM7 339 L 7.36x35 Structure Structure
TM7 340 A 7.37x36 Structure Structure
TM7 341 S 7.38x37 Structure Structure
TM7 342 F 7.39x38 Structure Structure
TM7 343 W 7.40x39 Structure Structure
TM7 344 L 7.41x40 Structure Structure
TM7 345 A 7.42x41 Structure Structure
TM7 346 M 7.43x42 Structure Structure
TM7 347 S 7.44x43 Structure Structure
TM7 348 S 7.45x45 Structure Structure
TM7 349 T 7.46x46 Structure Structure
TM7 350 M 7.47x47 Structure Structure
TM7 351 Y 7.48x48 Structure Structure
TM7 352 N 7.49x49 Structure Structure
TM7 353 P 7.50x50 Structure Structure
TM7 354 I 7.51x51 Structure Structure
TM7 355 I 7.52x52 Structure Structure
TM7 356 Y 7.53x53 Structure Structure
TM7 357 C 7.54x54 Structure Structure
TM7 358 C 7.55x55 Structure Structure
TM7 359 L 7.56x56 Structure Structure
H8 360 N 8.47x47 Structure Structure
H8 361 K 8.48x48 Structure AF2
H8 362 R 8.49x49 Structure AF2
H8 363 F 8.50x50 Structure Structure
H8 364 R 8.51x51 Structure Structure
H8 365 A 8.52x52 Structure Structure
H8 366 G 8.53x53 Structure Structure
H8 367 F 8.54x54 Structure Structure
H8 368 K 8.55x55 Structure Structure
H8 369 R 8.56x56 Structure Structure
H8 370 A 8.57x57 AF2 AF2
H8 371 F 8.58x58 AF2 AF2
C-term 372 R - AF2 AF2
C-term 373 W - AF2 AF2
C-term 374 C - AF2 AF2
C-term 375 P - AF2 AF2
C-term 376 F - AF2 AF2
C-term 377 I - AF2 AF2
C-term 378 K - AF2 AF2
C-term 379 V - AF2 AF2
C-term 380 S - AF2 AF2
C-term 381 S - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 190 - G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 190 - G.H5 I 348 G.H5.15
Hydrophobic TM5 P 280 5x71 G.S6 Y 325 G.S6.02
Polar ICL2 R 194 - G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 R 194 - G.hns1 R 37 G.hns1.02
Hydrophobic TM5 P 280 5x71 G.H5 F 339 G.H5.06
Hydrophobic TM6 K 294 6x30 G.H5 L 349 G.H5.16
Hydrophobic TM2 T 120 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM3 I 187 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 187 3x54 G.H5 L 353 G.H5.20
Hydrophobic ICL3 T 283 - G.H4 L 310 G.H4.12
Hydrophobic TM5 D 282 5x73 G.S6 F 328 G.S6.05
Van-der-waals TM5 D 282 5x73 G.S6 F 328 G.S6.05
Hydrophobic ICL2 P 193 - G.hns1 R 38 G.hns1.03
Polar TM6 K 296 6x32 G.H5 V 359 G.H5.26
Polar H8 N 360 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 N 360 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 N 360 8x47 G.H5 N 357 G.H5.24
Hydrophobic ICL2 L 191 - G.H5 I 348 G.H5.15
Ionic TM6 K 286 6x22 G.H4 D 315 G.H4.17
Polar TM6 K 286 6x22 G.H4 D 315 G.H4.17
Van-der-waals TM6 K 286 6x22 G.H4 D 315 G.H4.17
Hydrophobic TM5 D 282 5x73 G.H4 L 310 G.H4.12
Van-der-waals TM5 D 282 5x73 G.H4 L 310 G.H4.12
Hydrophobic H8 F 363 8x50 G.H5 N 357 G.H5.24
Hydrophobic TM3 R 183 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM6 A 293 6x29 G.H5 V 359 G.H5.26
Hydrophobic ICL2 L 191 - G.S1 L 40 G.S1.02
Van-der-waals ICL2 L 191 - G.S1 L 40 G.S1.02
Polar TM5 D 282 5x73 G.S6 S 326 G.S6.03
Polar TM2 N 121 2x40 G.H5 N 357 G.H5.24
Van-der-waals TM2 N 121 2x40 G.H5 N 357 G.H5.24
Polar TM2 T 120 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM2 T 120 2x39 G.H5 E 355 G.H5.22
Van-der-waals TM2 T 120 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM3 R 183 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 183 3x50 G.H5 L 358 G.H5.25
Polar ICL2 P 190 - G.H5 N 352 G.H5.19
Van-der-waals ICL2 P 190 - G.H5 N 352 G.H5.19
Hydrophobic ICL3 T 283 - G.H4 V 314 G.H4.16
Van-der-waals ICL3 T 283 - G.H4 V 314 G.H4.16
Hydrophobic TM6 V 297 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 V 297 6x33 G.H5 L 358 G.H5.25
Polar TM2 T 118 2x37 G.H5 E 355 G.H5.22
Hydrophobic ICL2 L 191 - G.H5 F 341 G.H5.08
Polar TM6 Q 290 6x26 G.H5 Q 350 G.H5.17
Hydrophobic TM6 Q 290 6x26 G.H5 Q 350 G.H5.17
Van-der-waals TM6 Q 290 6x26 G.H5 Q 350 G.H5.17
Polar H8 R 362 8x49 G.H5 K 354 G.H5.21
Hydrophobic TM3 I 187 3x54 G.H5 L 349 G.H5.16
Hydrophobic ICL2 P 190 - G.H5 K 345 G.H5.12
Hydrophobic ICL2 L 191 - G.S3 V 199 G.S3.01
Hydrophobic ICL2 L 191 - G.H5 K 345 G.H5.12
Van-der-waals ICL2 L 191 - G.H5 K 345 G.H5.12
Hydrophobic TM6 K 294 6x30 G.H5 L 353 G.H5.20
Van-der-waals TM6 K 294 6x30 G.H5 L 353 G.H5.20
Hydrophobic TM6 V 297 6x33 G.H5 V 359 G.H5.26
Hydrophobic TM6 Q 290 6x26 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM6 Q 290 6x26 G.h4s6 I 323 G.h4s6.20
Hydrophobic TM5 L 274 5x65 G.H5 L 353 G.H5.20
Polar ICL2 R 194 - G.H5 Y 356 G.H5.23
Hydrophobic ICL2 R 194 - G.H5 Y 356 G.H5.23
Van-der-waals ICL2 R 194 - G.H5 Y 356 G.H5.23
Hydrophobic TM6 K 286 6x22 G.H4 V 314 G.H4.16
Van-der-waals TM6 K 286 6x22 G.H4 V 314 G.H4.16
Polar TM3 D 182 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 182 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 182 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM6 Y 287 6x23 G.h4s6 I 323 G.h4s6.20
Hydrophobic TM7 L 359 7x56 G.H5 L 358 G.H5.25
Hydrophobic TM3 A 186 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 186 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM6 M 300 6x36 G.H5 L 358 G.H5.25
Van-der-waals TM6 M 300 6x36 G.H5 L 358 G.H5.25
Polar TM3 A 186 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 186 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 186 3x53 G.H5 N 352 G.H5.19
Hydrophobic ICL2 P 190 - G.H5 L 349 G.H5.16
Hydrophobic TM7 L 359 7x56 G.H5 V 359 G.H5.26
Van-der-waals TM7 L 359 7x56 G.H5 V 359 G.H5.26
Hydrophobic ICL2 P 193 - G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 P 193 - G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 L 191 - G.H5 V 344 G.H5.11
Hydrophobic TM5 L 274 5x65 G.H5 L 349 G.H5.16