Refined structure (8JGG) of Gi1 - MRGPRX1

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-11-26

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 216 from structure (61.0%), 138 from model (39.0%)
Residue sidechains - 177 from structure (50.0%), 177 from model (50.0%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 AF2 AF2
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure AF2
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure AF2
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure AF2
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure AF2
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure AF2
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure AF2
G.H1 54 K G.H1.09 Structure AF2
G.H1 55 I G.H1.10 Structure AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure AF2
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure AF2
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure Structure
G.s3h2 204 Q G.s3h2.03 Structure AF2
G.H2 205 R G.H2.01 Structure AF2
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure AF2
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure AF2
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure AF2
G.s4h3 230 Y G.s4h3.04 Structure AF2
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure AF2
G.s4h3 233 V G.s4h3.07 Structure AF2
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 AF2 AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure AF2
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure AF2
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure AF2
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure AF2
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure AF2
G.s5hg 270 K G.s5hg.01 Structure AF2
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure AF2
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure AF2
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure AF2
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure AF2
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure AF2
G.H4 309 D G.H4.17 Structure AF2
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure AF2
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure AF2
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure AF2
G.s6h5 328 D G.s6h5.05 Structure AF2
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure AF2
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure AF2
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure AF2

REFINED GPCR RESIDUES

Residue backbones - 222 from structure (76.8%), 67 from model (23.2%)
Residue sidechains - 197 from structure (68.2%), 92 from model (31.8%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 T - AF2 AF2
N-term 5 I - AF2 AF2
N-term 6 S - AF2 AF2
N-term 7 T - AF2 AF2
N-term 8 L - AF2 AF2
N-term 9 D - AF2 AF2
N-term 10 T - AF2 AF2
N-term 11 E - AF2 AF2
N-term 12 L - AF2 AF2
N-term 13 T - AF2 AF2
N-term 14 P - AF2 AF2
N-term 15 I - AF2 AF2
N-term 16 N - AF2 AF2
N-term 17 G - AF2 AF2
N-term 18 T - AF2 AF2
N-term 19 E - AF2 AF2
N-term 20 E - AF2 AF2
N-term 21 T - AF2 AF2
N-term 22 L - AF2 AF2
N-term 23 C - AF2 AF2
N-term 24 Y - AF2 AF2
N-term 25 K - AF2 AF2
TM1 26 Q 1.31x31 AF2 AF2
TM1 27 T 1.32x32 AF2 AF2
TM1 28 L 1.33x33 AF2 AF2
TM1 29 S 1.34x34 Structure Structure
TM1 30 L 1.35x35 Structure AF2
TM1 31 T 1.36x36 Structure Structure
TM1 32 V 1.37x37 Structure AF2
TM1 33 L 1.38x38 Structure AF2
TM1 34 T 1.39x39 Structure AF2
TM1 35 C 1.40x40 Structure Structure
TM1 36 I 1.41x41 Structure Structure
TM1 37 V 1.42x42 Structure Structure
TM1 38 S 1.43x43 Structure Structure
TM1 39 L 1.44x44 Structure AF2
TM1 40 V 1.45x45 Structure Structure
TM1 41 G 1.46x46 Structure Structure
TM1 42 L 1.47x47 Structure AF2
TM1 43 T 1.48x48 Structure Structure
TM1 44 G 1.49x49 Structure Structure
TM1 45 N 1.50x50 Structure Structure
TM1 46 A 1.51x51 Structure Structure
TM1 47 V 1.52x52 Structure Structure
TM1 48 V 1.53x53 Structure Structure
TM1 49 L 1.54x54 Structure Structure
TM1 50 W 1.55x55 Structure AF2
TM1 51 L 1.56x56 Structure Structure
TM1 52 L 1.57x57 Structure AF2
TM1 53 G 1.58x58 Structure Structure
TM1 54 C 1.59x59 Structure Structure
TM1 55 R 1.60x60 Structure AF2
TM1 56 M 1.61x61 Structure Structure
ICL1 57 R - Structure AF2
ICL1 58 R - Structure Structure
TM2 59 N 2.37x37 Structure Structure
TM2 60 A 2.38x38 Structure Structure
TM2 61 F 2.39x39 Structure Structure
TM2 62 S 2.40x40 Structure Structure
TM2 63 I 2.41x41 Structure Structure
TM2 64 Y 2.42x42 Structure Structure
TM2 65 I 2.43x43 Structure Structure
TM2 66 L 2.44x44 Structure Structure
TM2 67 N 2.45x45 Structure Structure
TM2 68 L 2.46x46 Structure Structure
TM2 69 A 2.47x47 Structure Structure
TM2 70 A 2.48x48 Structure Structure
TM2 71 A 2.49x49 Structure Structure
TM2 72 D 2.50x50 Structure AF2
TM2 73 F 2.51x51 Structure Structure
TM2 74 L 2.52x52 Structure Structure
TM2 75 F 2.53x53 Structure Structure
TM2 76 L 2.54x54 Structure Structure
TM2 77 S 2.55x55 Structure Structure
TM2 78 G 2.56x56 Structure Structure
TM2 79 R 2.57x57 Structure Structure
TM2 80 L 2.58x58 Structure AF2
TM2 81 I 2.59x59 Structure Structure
TM2 82 Y 2.60x60 Structure AF2
TM2 83 S 2.61x61 Structure Structure
TM2 84 L 2.62x62 Structure Structure
TM2 85 L 2.63x63 Structure Structure
TM2 86 S 2.64x64 AF2 AF2
TM2 87 F 2.65x65 AF2 AF2
TM2 88 I 2.66x66 AF2 AF2
ECL1 89 S - AF2 AF2
ECL1 90 I - AF2 AF2
ECL1 91 P - AF2 AF2
ECL1 92 H - AF2 AF2
ECL1 93 T - AF2 AF2
TM3 94 I 3.24x24 AF2 AF2
TM3 95 S 3.25x25 AF2 AF2
TM3 96 K 3.26x26 Structure Structure
TM3 97 I 3.27x27 Structure Structure
TM3 98 L 3.28x28 Structure Structure
TM3 99 Y 3.29x29 Structure Structure
TM3 100 P 3.30x30 Structure Structure
TM3 101 V 3.31x31 Structure Structure
TM3 102 M 3.32x32 Structure Structure
TM3 103 M 3.33x33 Structure Structure
TM3 104 F 3.34x34 Structure Structure
TM3 105 S 3.35x35 Structure Structure
TM3 106 Y 3.36x36 Structure Structure
TM3 107 F 3.37x37 Structure Structure
TM3 108 A 3.38x38 Structure Structure
TM3 109 G 3.39x39 Structure Structure
TM3 110 L 3.40x40 Structure Structure
TM3 111 S 3.41x41 Structure Structure
TM3 112 F 3.42x42 Structure Structure
TM3 113 L 3.43x43 Structure Structure
TM3 114 S 3.44x44 Structure Structure
TM3 115 A 3.45x45 Structure Structure
TM3 116 V 3.46x46 Structure Structure
TM3 117 S 3.47x47 Structure Structure
TM3 118 T 3.48x48 Structure Structure
TM3 119 E 3.49x49 Structure Structure
TM3 120 R 3.50x50 Structure Structure
TM3 121 C 3.51x51 Structure Structure
TM3 122 L 3.52x52 Structure Structure
TM3 123 S 3.53x53 Structure Structure
TM3 124 V 3.54x54 Structure Structure
TM3 125 L 3.55x55 Structure Structure
TM3 126 W 3.56x56 Structure Structure
ICL2 127 P 34.50x50 Structure Structure
ICL2 128 I 34.51x51 Structure Structure
ICL2 129 W 34.52x52 Structure Structure
ICL2 130 Y 34.53x53 Structure Structure
ICL2 131 R 34.54x54 Structure Structure
ICL2 132 C 34.55x55 Structure Structure
ICL2 133 H 34.56x56 Structure Structure
ICL2 134 R 34.57x57 Structure Structure
TM4 135 P 4.38x38 Structure Structure
TM4 136 T 4.39x39 Structure Structure
TM4 137 H 4.40x40 Structure Structure
TM4 138 L 4.41x41 Structure Structure
TM4 139 S 4.42x42 Structure Structure
TM4 140 A 4.43x43 Structure Structure
TM4 141 V 4.44x44 Structure Structure
TM4 142 V 4.45x45 Structure Structure
TM4 143 C 4.46x46 Structure Structure
TM4 144 V 4.47x47 Structure Structure
TM4 145 L 4.48x48 Structure Structure
TM4 146 L 4.49x49 Structure Structure
TM4 147 W 4.50x50 Structure Structure
TM4 148 A 4.51x51 Structure Structure
TM4 149 L 4.52x52 Structure Structure
TM4 150 S 4.53x53 Structure Structure
TM4 151 L 4.54x54 Structure Structure
TM4 152 L 4.55x55 Structure AF2
TM4 153 R 4.56x56 Structure Structure
TM4 154 S 4.57x57 Structure Structure
TM4 155 I 4.58x58 Structure Structure
TM4 156 L 4.59x59 Structure Structure
TM4 157 E 4.60x60 Structure Structure
TM4 158 W 4.61x61 Structure Structure
TM4 159 M 4.62x62 Structure Structure
TM4 160 L 4.63x63 AF2 AF2
TM4 161 C 4.64x64 AF2 AF2
ECL2 162 G - AF2 AF2
ECL2 163 F - AF2 AF2
ECL2 164 L - AF2 AF2
ECL2 165 F - AF2 AF2
ECL2 166 S - AF2 AF2
ECL2 167 G - AF2 AF2
ECL2 168 A - AF2 AF2
TM5 169 D 5.32x32 AF2 AF2
TM5 170 S 5.33x33 AF2 AF2
TM5 171 A 5.34x34 AF2 AF2
TM5 172 W 5.35x35 Structure Structure
TM5 173 C 5.36x36 Structure Structure
TM5 174 Q 5.37x37 Structure Structure
TM5 175 T 5.38x38 Structure Structure
TM5 176 S 5.39x39 Structure Structure
TM5 177 D 5.40x40 Structure Structure
TM5 178 F 5.41x41 Structure Structure
TM5 179 I 5.42x42 Structure Structure
TM5 180 T 5.43x43 Structure Structure
TM5 181 V 5.44x44 Structure Structure
TM5 182 A 5.45x45 Structure Structure
TM5 183 W 5.46x46 Structure Structure
TM5 184 L 5.47x47 Structure Structure
TM5 185 I 5.48x48 Structure Structure
TM5 186 F 5.49x49 Structure Structure
TM5 187 L 5.50x50 Structure Structure
TM5 188 C 5.51x51 Structure Structure
TM5 189 V 5.52x52 Structure Structure
TM5 190 V 5.53x53 Structure Structure
TM5 191 L 5.54x54 Structure Structure
TM5 192 C 5.55x55 Structure Structure
TM5 193 G 5.56x56 Structure Structure
TM5 194 S 5.57x57 Structure Structure
TM5 195 S 5.58x58 Structure Structure
TM5 196 L 5.59x59 Structure Structure
TM5 197 V 5.60x60 Structure Structure
TM5 198 L 5.61x61 Structure Structure
TM5 199 L 5.62x62 Structure Structure
TM5 200 I 5.63x63 Structure Structure
TM5 201 R 5.64x64 Structure Structure
TM5 202 I 5.65x65 Structure Structure
TM5 203 L 5.66x66 Structure Structure
TM5 204 C 5.67x67 Structure Structure
ICL3 205 G - Structure Structure
ICL3 206 S - Structure Structure
ICL3 207 R - Structure Structure
ICL3 208 K - AF2 AF2
ICL3 209 I - AF2 AF2
TM6 210 P 6.29x29 AF2 AF2
TM6 211 L 6.30x30 AF2 AF2
TM6 212 T 6.31x31 Structure Structure
TM6 213 R 6.32x32 Structure Structure
TM6 214 L 6.33x33 Structure AF2
TM6 215 Y 6.34x34 Structure AF2
TM6 216 V 6.35x35 Structure Structure
TM6 217 T 6.36x36 Structure Structure
TM6 218 I 6.37x37 Structure Structure
TM6 219 L 6.38x38 Structure AF2
TM6 220 L 6.39x39 Structure Structure
TM6 221 T 6.40x40 Structure Structure
TM6 222 V 6.41x41 Structure Structure
TM6 223 L 6.42x42 Structure Structure
TM6 224 V 6.43x43 Structure Structure
TM6 225 F 6.44x44 Structure Structure
TM6 226 L 6.45x45 Structure Structure
TM6 227 L 6.46x46 Structure Structure
TM6 228 C 6.47x47 Structure Structure
TM6 229 G 6.48x48 Structure Structure
TM6 230 L 6.49x49 Structure Structure
TM6 231 P 6.50x50 Structure Structure
TM6 232 F 6.51x51 Structure Structure
TM6 233 G 6.52x52 Structure Structure
TM6 234 I 6.53x53 Structure Structure
TM6 235 Q 6.54x54 Structure Structure
TM6 236 F 6.55x55 Structure Structure
TM6 237 F 6.56x56 Structure Structure
TM6 238 L 6.57x57 Structure Structure
TM6 239 F 6.58x58 Structure Structure
TM6 240 L 6.59x59 Structure Structure
TM6 241 W 6.60x60 Structure Structure
TM6 242 I 6.61x61 Structure Structure
TM6 243 H 6.62x62 Structure Structure
ECL3 244 V - Structure AF2
ECL3 245 D - Structure Structure
ECL3 246 R - Structure Structure
ECL3 247 E - Structure AF2
ECL3 248 V - Structure AF2
TM7 249 L 7.30x29 Structure Structure
TM7 250 F 7.31x30 Structure Structure
TM7 251 C 7.32x31 Structure Structure
TM7 252 H 7.33x32 Structure AF2
TM7 253 V 7.34x33 Structure Structure
TM7 254 H 7.35x34 Structure Structure
TM7 255 L 7.36x35 Structure AF2
TM7 256 V 7.37x36 Structure Structure
TM7 257 S 7.38x37 Structure Structure
TM7 258 I 7.39x38 Structure AF2
TM7 259 F 7.40x39 Structure AF2
TM7 260 L 7.41x40 Structure Structure
TM7 261 S 7.42x41 Structure Structure
TM7 262 A 7.43x42 Structure Structure
TM7 263 L 7.44x43 Structure Structure
TM7 264 N 7.45x45 Structure Structure
TM7 265 S 7.46x46 Structure Structure
TM7 266 S 7.47x47 Structure Structure
TM7 267 A 7.48x48 Structure Structure
TM7 268 N 7.49x49 Structure Structure
TM7 269 P 7.50x50 Structure Structure
TM7 270 I 7.51x51 Structure Structure
TM7 271 I 7.52x52 Structure Structure
TM7 272 Y 7.53x53 Structure Structure
TM7 273 F 7.54x54 Structure Structure
TM7 274 F 7.55x55 Structure AF2
TM7 275 V 7.56x56 Structure Structure
TM7 276 G 7.57x57 Structure Structure
TM7 277 S 7.58x58 AF2 AF2
TM7 278 F 7.59x59 AF2 AF2
TM7 279 R 7.60x60 AF2 AF2
C-term 280 Q - AF2 AF2
C-term 281 R - AF2 AF2
C-term 282 Q - AF2 AF2
C-term 283 N - AF2 AF2
C-term 284 R - AF2 AF2
C-term 285 Q - AF2 AF2
C-term 286 N - AF2 AF2
C-term 287 L - AF2 AF2
C-term 288 K - AF2 AF2
C-term 289 L - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 I 128 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 I 128 34x51 G.H5 I 343 G.H5.15
Polar TM3 S 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 123 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic C-term L 287 - G.H3 W 258 G.H3.17
Polar TM3 S 123 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 S 123 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 S 123 3x53 G.H5 C 351 G.H5.23
Polar ICL2 R 131 34x54 G.h2s4 T 219 G.h2s4.05
Polar ICL2 C 132 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 C 132 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 C 132 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 I 128 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM4 T 136 4x39 G.HN E 28 G.HN.52
Van-der-waals TM4 T 136 4x39 G.HN E 28 G.HN.52
Hydrophobic ICL2 C 132 34x55 G.S3 L 194 G.S3.01
Hydrophobic TM6 L 214 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 214 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 214 6x33 G.H5 L 353 G.H5.25
Polar ICL2 R 134 34x57 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 134 34x57 G.hns1 R 32 G.hns1.03
Ionic ICL3 R 207 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 207 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 I 128 34x51 G.H5 F 336 G.H5.08
Aromatic TM6 R 213 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 213 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 213 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM5 L 198 5x61 G.H5 L 353 G.H5.25
Ionic ICL3 R 207 - G.H5 D 341 G.H5.13
Polar ICL3 R 207 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 207 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 207 - G.H5 D 341 G.H5.13
Polar ICL3 R 207 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 R 207 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 207 - G.S6 Y 320 G.S6.02
Hydrophobic TM6 T 217 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 217 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 127 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 127 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 R 131 34x54 G.S1 V 34 G.S1.02
Van-der-waals ICL2 R 131 34x54 G.S1 V 34 G.S1.02
Hydrophobic ICL3 I 209 - G.H5 F 354 G.H5.26
Polar ICL2 R 131 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 L 214 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 L 214 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM2 F 61 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 F 61 2x39 G.H5 C 351 G.H5.23
Polar TM3 R 120 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 120 3x50 G.H5 C 351 G.H5.23
Polar ICL2 R 131 34x54 G.S1 E 33 G.S1.01
Hydrophobic ICL2 R 131 34x54 G.S1 E 33 G.S1.01
Van-der-waals ICL2 R 131 34x54 G.S1 E 33 G.S1.01
Hydrophobic ICL2 P 127 34x50 G.H5 I 343 G.H5.15
Polar TM4 T 136 4x39 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 T 136 4x39 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 I 218 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 R 131 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 R 131 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL2 H 133 34x56 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 H 133 34x56 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 C 132 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 R 120 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 120 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 124 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 P 210 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 P 210 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 127 34x50 G.H5 T 340 G.H5.12