GproteinDb

Refined structure (8JXX) of G_i1 - H₄ receptor

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G_i/o

DATE

2024-11-26

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Structure

GPCR

Gα

Gβ

Gγ
Model

AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 219 from structure (61.9%), 135 from model (38.1%)
Residue sidechains - 206 from structure (58.2%), 148 from model (41.8%)

Showing 1 to 354 of 354 entries

Search:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from
	:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from

G.HN	1	M	G.HN.01	AF2	AF2
G.HN	2	G	G.HN.02	AF2	AF2
G.HN	3	C	G.HN.09	Structure	Structure
G.HN	4	T	G.HN.10	Structure	Structure
G.HN	5	L	G.HN.11	Structure	Structure
G.HN	6	S	G.HN.30	Structure	Structure
G.HN	7	A	G.HN.31	Structure	Structure
G.HN	8	E	G.HN.32	Structure	Structure
G.HN	9	D	G.HN.33	Structure	Structure
G.HN	10	K	G.HN.34	Structure	Structure
G.HN	11	A	G.HN.35	Structure	Structure
G.HN	12	A	G.HN.36	Structure	Structure
G.HN	13	V	G.HN.37	Structure	Structure
G.HN	14	E	G.HN.38	Structure	Structure
G.HN	15	R	G.HN.39	Structure	Structure
G.HN	16	S	G.HN.40	Structure	Structure
G.HN	17	K	G.HN.41	Structure	Structure
G.HN	18	M	G.HN.42	Structure	Structure
G.HN	19	I	G.HN.43	Structure	Structure
G.HN	20	D	G.HN.44	Structure	Structure
G.HN	21	R	G.HN.45	Structure	Structure
G.HN	22	N	G.HN.46	Structure	Structure
G.HN	23	L	G.HN.47	Structure	Structure
G.HN	24	R	G.HN.48	Structure	Structure
G.HN	25	E	G.HN.49	Structure	Structure
G.HN	26	D	G.HN.50	Structure	Structure
G.HN	27	G	G.HN.51	Structure	Structure
G.HN	28	E	G.HN.52	Structure	Structure
G.HN	29	K	G.HN.53	Structure	Structure
G.hns1	30	A	G.hns1.01	Structure	Structure
G.hns1	31	A	G.hns1.02	Structure	Structure
G.hns1	32	R	G.hns1.03	Structure	Structure
G.S1	33	E	G.S1.01	Structure	Structure
G.S1	34	V	G.S1.02	Structure	Structure
G.S1	35	K	G.S1.03	Structure	Structure
G.S1	36	L	G.S1.04	Structure	Structure
G.S1	37	L	G.S1.05	Structure	Structure
G.S1	38	L	G.S1.06	Structure	Structure
G.S1	39	L	G.S1.07	Structure	Structure
G.s1h1	40	G	G.s1h1.01	Structure	Structure
G.s1h1	41	A	G.s1h1.02	Structure	Structure
G.s1h1	42	G	G.s1h1.03	Structure	Structure
G.s1h1	43	E	G.s1h1.04	Structure	AF2
G.s1h1	44	S	G.s1h1.05	Structure	Structure
G.s1h1	45	G	G.s1h1.06	Structure	Structure
G.H1	46	K	G.H1.01	Structure	Structure
G.H1	47	S	G.H1.02	Structure	Structure
G.H1	48	T	G.H1.03	Structure	Structure
G.H1	49	I	G.H1.04	Structure	Structure
G.H1	50	V	G.H1.05	Structure	Structure
G.H1	51	K	G.H1.06	Structure	AF2
G.H1	52	Q	G.H1.07	Structure	Structure
G.H1	53	M	G.H1.08	Structure	Structure
G.H1	54	K	G.H1.09	Structure	Structure
G.H1	55	I	G.H1.10	AF2	AF2
G.H1	56	I	G.H1.11	AF2	AF2
G.H1	57	H	G.H1.12	AF2	AF2
G.h1ha	58	E	G.h1ha.01	AF2	AF2
G.h1ha	59	A	G.h1ha.02	AF2	AF2
G.h1ha	60	G	G.h1ha.03	AF2	AF2
G.h1ha	61	Y	G.h1ha.04	AF2	AF2
G.h1ha	62	S	G.h1ha.05	AF2	AF2
H.HA	63	E	H.HA.01	AF2	AF2
H.HA	64	E	H.HA.02	AF2	AF2
H.HA	65	E	H.HA.03	AF2	AF2
H.HA	66	C	H.HA.04	AF2	AF2
H.HA	67	K	H.HA.05	AF2	AF2
H.HA	68	Q	H.HA.06	AF2	AF2
H.HA	69	Y	H.HA.07	AF2	AF2
H.HA	70	K	H.HA.08	AF2	AF2
H.HA	71	A	H.HA.09	AF2	AF2
H.HA	72	V	H.HA.10	AF2	AF2
H.HA	73	V	H.HA.11	AF2	AF2
H.HA	74	Y	H.HA.12	AF2	AF2
H.HA	75	S	H.HA.13	AF2	AF2
H.HA	76	N	H.HA.14	AF2	AF2
H.HA	77	T	H.HA.15	AF2	AF2
H.HA	78	I	H.HA.16	AF2	AF2
H.HA	79	Q	H.HA.17	AF2	AF2
H.HA	80	S	H.HA.18	AF2	AF2
H.HA	81	I	H.HA.19	AF2	AF2
H.HA	82	I	H.HA.20	AF2	AF2
H.HA	83	A	H.HA.21	AF2	AF2
H.HA	84	I	H.HA.22	AF2	AF2
H.HA	85	I	H.HA.23	AF2	AF2
H.HA	86	R	H.HA.24	AF2	AF2
H.HA	87	A	H.HA.25	AF2	AF2
H.HA	88	M	H.HA.26	AF2	AF2
H.HA	89	G	H.HA.27	AF2	AF2
H.HA	90	R	H.HA.28	AF2	AF2
H.HA	91	L	H.HA.29	AF2	AF2
H.hahb	92	K	H.hahb.01	AF2	AF2
H.hahb	93	I	H.hahb.04	AF2	AF2
H.hahb	94	D	H.hahb.05	AF2	AF2
H.hahb	95	F	H.hahb.06	AF2	AF2
H.hahb	96	G	H.hahb.07	AF2	AF2
H.hahb	97	D	H.hahb.08	AF2	AF2
H.hahb	98	S	H.hahb.09	AF2	AF2
H.HB	99	A	H.HB.01	AF2	AF2
H.HB	100	R	H.HB.02	AF2	AF2
H.HB	101	A	H.HB.03	AF2	AF2
H.HB	102	D	H.HB.04	AF2	AF2
H.HB	103	D	H.HB.05	AF2	AF2
H.HB	104	A	H.HB.06	AF2	AF2
H.HB	105	R	H.HB.07	AF2	AF2
H.HB	106	Q	H.HB.08	AF2	AF2
H.HB	107	L	H.HB.09	AF2	AF2
H.HB	108	F	H.HB.10	AF2	AF2
H.HB	109	V	H.HB.11	AF2	AF2
H.HB	110	L	H.HB.12	AF2	AF2
H.HB	111	A	H.HB.13	AF2	AF2
H.HB	112	G	H.HB.14	AF2	AF2
H.hbhc	113	A	H.hbhc.01	AF2	AF2
H.hbhc	114	A	H.hbhc.02	AF2	AF2
H.hbhc	115	E	H.hbhc.03	AF2	AF2
H.hbhc	116	E	H.hbhc.04	AF2	AF2
H.hbhc	117	G	H.hbhc.12	AF2	AF2
H.hbhc	118	F	H.hbhc.13	AF2	AF2
H.hbhc	119	M	H.hbhc.14	AF2	AF2
H.hbhc	120	T	H.hbhc.15	AF2	AF2
H.HC	121	A	H.HC.01	AF2	AF2
H.HC	122	E	H.HC.02	AF2	AF2
H.HC	123	L	H.HC.03	AF2	AF2
H.HC	124	A	H.HC.04	AF2	AF2
H.HC	125	G	H.HC.05	AF2	AF2
H.HC	126	V	H.HC.06	AF2	AF2
H.HC	127	I	H.HC.07	AF2	AF2
H.HC	128	K	H.HC.08	AF2	AF2
H.HC	129	R	H.HC.09	AF2	AF2
H.HC	130	L	H.HC.10	AF2	AF2
H.HC	131	W	H.HC.11	AF2	AF2
H.HC	132	K	H.HC.12	AF2	AF2
H.hchd	133	D	H.hchd.01	AF2	AF2
H.HD	134	S	H.HD.01	AF2	AF2
H.HD	135	G	H.HD.02	AF2	AF2
H.HD	136	V	H.HD.03	AF2	AF2
H.HD	137	Q	H.HD.04	AF2	AF2
H.HD	138	A	H.HD.05	AF2	AF2
H.HD	139	C	H.HD.06	AF2	AF2
H.HD	140	F	H.HD.07	AF2	AF2
H.HD	141	N	H.HD.08	AF2	AF2
H.HD	142	R	H.HD.09	AF2	AF2
H.HD	143	S	H.HD.10	AF2	AF2
H.HD	144	R	H.HD.11	AF2	AF2
H.HD	145	E	H.HD.12	AF2	AF2
H.hdhe	146	Y	H.hdhe.01	AF2	AF2
H.hdhe	147	Q	H.hdhe.02	AF2	AF2
H.hdhe	148	L	H.hdhe.03	AF2	AF2
H.hdhe	149	N	H.hdhe.04	AF2	AF2
H.hdhe	150	D	H.hdhe.05	AF2	AF2
H.HE	151	S	H.HE.01	AF2	AF2
H.HE	152	A	H.HE.02	AF2	AF2
H.HE	153	A	H.HE.03	AF2	AF2
H.HE	154	Y	H.HE.04	AF2	AF2
H.HE	155	Y	H.HE.05	AF2	AF2
H.HE	156	L	H.HE.06	AF2	AF2
H.HE	157	N	H.HE.07	AF2	AF2
H.HE	158	D	H.HE.08	AF2	AF2
H.HE	159	L	H.HE.09	AF2	AF2
H.HE	160	D	H.HE.10	AF2	AF2
H.HE	161	R	H.HE.11	AF2	AF2
H.HE	162	I	H.HE.12	AF2	AF2
H.HE	163	A	H.HE.13	AF2	AF2
H.hehf	164	Q	H.hehf.01	AF2	AF2
H.hehf	165	P	H.hehf.02	AF2	AF2
H.hehf	166	N	H.hehf.03	AF2	AF2
H.hehf	167	Y	H.hehf.04	AF2	AF2
H.hehf	168	I	H.hehf.05	AF2	AF2
H.hehf	169	P	H.hehf.06	AF2	AF2
H.hehf	170	T	H.hehf.07	AF2	AF2
H.HF	171	Q	H.HF.01	AF2	AF2
H.HF	172	Q	H.HF.02	AF2	AF2
H.HF	173	D	H.HF.03	AF2	AF2
H.HF	174	V	H.HF.04	AF2	AF2
H.HF	175	L	H.HF.05	AF2	AF2
H.HF	176	R	H.HF.06	AF2	AF2
G.hfs2	177	T	G.hfs2.01	AF2	AF2
G.hfs2	178	R	G.hfs2.02	AF2	AF2
G.hfs2	179	V	G.hfs2.03	AF2	AF2
G.hfs2	180	K	G.hfs2.04	AF2	AF2
G.hfs2	181	T	G.hfs2.05	AF2	AF2
G.hfs2	182	T	G.hfs2.06	Structure	Structure
G.hfs2	183	G	G.hfs2.07	Structure	Structure
G.S2	184	I	G.S2.01	Structure	Structure
G.S2	185	V	G.S2.02	Structure	Structure
G.S2	186	E	G.S2.03	Structure	Structure
G.S2	187	T	G.S2.04	Structure	Structure
G.S2	188	H	G.S2.05	Structure	Structure
G.S2	189	F	G.S2.06	Structure	Structure
G.S2	190	T	G.S2.07	Structure	Structure
G.S2	191	F	G.S2.08	Structure	Structure
G.s2s3	192	K	G.s2s3.01	Structure	Structure
G.s2s3	193	D	G.s2s3.02	Structure	Structure
G.S3	194	L	G.S3.01	Structure	Structure
G.S3	195	H	G.S3.02	Structure	Structure
G.S3	196	F	G.S3.03	Structure	Structure
G.S3	197	K	G.S3.04	Structure	Structure
G.S3	198	M	G.S3.05	Structure	Structure
G.S3	199	F	G.S3.06	Structure	Structure
G.S3	200	D	G.S3.07	Structure	Structure
G.S3	201	V	G.S3.08	Structure	Structure
G.s3h2	202	G	G.s3h2.01	Structure	Structure
G.s3h2	203	G	G.s3h2.02	Structure	AF2
G.s3h2	204	Q	G.s3h2.03	Structure	Structure
G.H2	205	R	G.H2.01	Structure	AF2
G.H2	206	S	G.H2.02	Structure	Structure
G.H2	207	E	G.H2.03	Structure	AF2
G.H2	208	R	G.H2.04	Structure	Structure
G.H2	209	K	G.H2.05	Structure	Structure
G.H2	210	K	G.H2.06	Structure	Structure
G.H2	211	W	G.H2.07	Structure	Structure
G.H2	212	I	G.H2.08	Structure	Structure
G.H2	213	H	G.H2.09	Structure	Structure
G.H2	214	C	G.H2.10	Structure	Structure
G.h2s4	215	F	G.h2s4.01	Structure	Structure
G.h2s4	216	E	G.h2s4.02	Structure	Structure
G.h2s4	217	G	G.h2s4.03	Structure	Structure
G.h2s4	218	V	G.h2s4.04	Structure	Structure
G.h2s4	219	T	G.h2s4.05	Structure	Structure
G.S4	220	A	G.S4.01	Structure	Structure
G.S4	221	I	G.S4.02	Structure	Structure
G.S4	222	I	G.S4.03	Structure	Structure
G.S4	223	F	G.S4.04	Structure	Structure
G.S4	224	C	G.S4.05	Structure	Structure
G.S4	225	V	G.S4.06	Structure	Structure
G.S4	226	A	G.S4.07	Structure	Structure
G.s4h3	227	L	G.s4h3.01	Structure	Structure
G.s4h3	228	S	G.s4h3.02	Structure	Structure
G.s4h3	229	D	G.s4h3.03	Structure	Structure
G.s4h3	230	Y	G.s4h3.04	Structure	Structure
G.s4h3	231	D	G.s4h3.05	Structure	Structure
G.s4h3	232	L	G.s4h3.06	Structure	Structure
G.s4h3	233	V	G.s4h3.07	Structure	AF2
G.s4h3	234	L	G.s4h3.08	Structure	AF2
G.s4h3	235	A	G.s4h3.09	AF2	AF2
G.s4h3	236	E	G.s4h3.10	AF2	AF2
G.s4h3	237	D	G.s4h3.11	AF2	AF2
G.s4h3	238	E	G.s4h3.12	AF2	AF2
G.s4h3	239	E	G.s4h3.13	AF2	AF2
G.s4h3	240	M	G.s4h3.14	Structure	Structure
G.s4h3	241	N	G.s4h3.15	Structure	Structure
G.H3	242	R	G.H3.01	Structure	Structure
G.H3	243	M	G.H3.02	Structure	Structure
G.H3	244	H	G.H3.03	Structure	Structure
G.H3	245	E	G.H3.04	Structure	Structure
G.H3	246	S	G.H3.05	Structure	Structure
G.H3	247	M	G.H3.06	Structure	Structure
G.H3	248	K	G.H3.07	Structure	AF2
G.H3	249	L	G.H3.08	Structure	Structure
G.H3	250	F	G.H3.09	Structure	Structure
G.H3	251	D	G.H3.10	Structure	Structure
G.H3	252	S	G.H3.11	Structure	Structure
G.H3	253	I	G.H3.12	Structure	Structure
G.H3	254	C	G.H3.13	Structure	Structure
G.H3	255	N	G.H3.14	Structure	Structure
G.H3	256	N	G.H3.15	Structure	Structure
G.H3	257	K	G.H3.16	Structure	Structure
G.H3	258	W	G.H3.17	Structure	Structure
G.H3	259	F	G.H3.18	Structure	Structure
G.h3s5	260	T	G.h3s5.01	Structure	Structure
G.h3s5	261	D	G.h3s5.02	Structure	Structure
G.h3s5	262	T	G.h3s5.03	Structure	Structure
G.S5	263	S	G.S5.01	Structure	Structure
G.S5	264	I	G.S5.02	Structure	Structure
G.S5	265	I	G.S5.03	Structure	Structure
G.S5	266	L	G.S5.04	Structure	Structure
G.S5	267	F	G.S5.05	Structure	Structure
G.S5	268	L	G.S5.06	Structure	Structure
G.S5	269	N	G.S5.07	Structure	Structure
G.s5hg	270	K	G.s5hg.01	Structure	Structure
G.HG	271	K	G.HG.01	Structure	Structure
G.HG	272	D	G.HG.02	Structure	Structure
G.HG	273	L	G.HG.03	Structure	Structure
G.HG	274	F	G.HG.04	Structure	Structure
G.HG	275	E	G.HG.05	Structure	Structure
G.HG	276	E	G.HG.06	Structure	Structure
G.HG	277	K	G.HG.07	Structure	Structure
G.HG	278	I	G.HG.08	Structure	Structure
G.HG	279	K	G.HG.09	Structure	AF2
G.HG	280	K	G.HG.12	Structure	AF2
G.HG	281	S	G.HG.13	Structure	Structure
G.HG	282	P	G.HG.14	Structure	Structure
G.HG	283	L	G.HG.15	Structure	AF2
G.HG	284	T	G.HG.16	Structure	Structure
G.HG	285	I	G.HG.17	Structure	Structure
G.hgh4	286	C	G.hgh4.01	Structure	Structure
G.hgh4	287	Y	G.hgh4.02	Structure	Structure
G.hgh4	288	P	G.hgh4.03	Structure	Structure
G.hgh4	289	E	G.hgh4.04	Structure	Structure
G.hgh4	290	Y	G.hgh4.05	Structure	Structure
G.hgh4	291	A	G.hgh4.06	Structure	Structure
G.hgh4	292	G	G.hgh4.07	Structure	Structure
G.hgh4	293	S	G.hgh4.08	Structure	Structure
G.H4	294	N	G.H4.01	Structure	Structure
G.H4	295	T	G.H4.02	Structure	Structure
G.H4	296	Y	G.H4.03	Structure	Structure
G.H4	297	E	G.H4.04	Structure	Structure
G.H4	298	E	G.H4.05	Structure	Structure
G.H4	299	A	G.H4.06	Structure	Structure
G.H4	300	A	G.H4.07	Structure	Structure
G.H4	301	A	G.H4.08	Structure	Structure
G.H4	302	Y	G.H4.10	Structure	Structure
G.H4	303	I	G.H4.11	Structure	Structure
G.H4	304	Q	G.H4.12	Structure	Structure
G.H4	305	C	G.H4.13	Structure	Structure
G.H4	306	Q	G.H4.14	Structure	Structure
G.H4	307	F	G.H4.15	Structure	Structure
G.H4	308	E	G.H4.16	Structure	Structure
G.H4	309	D	G.H4.17	Structure	Structure
G.h4s6	310	L	G.h4s6.01	Structure	Structure
G.h4s6	311	N	G.h4s6.02	Structure	Structure
G.h4s6	312	K	G.h4s6.03	Structure	AF2
G.h4s6	313	R	G.h4s6.04	Structure	Structure
G.h4s6	314	K	G.h4s6.08	Structure	Structure
G.h4s6	315	D	G.h4s6.09	Structure	Structure
G.h4s6	316	T	G.h4s6.10	Structure	Structure
G.h4s6	317	K	G.h4s6.11	Structure	Structure
G.h4s6	318	E	G.h4s6.12	Structure	Structure
G.S6	319	I	G.S6.01	Structure	Structure
G.S6	320	Y	G.S6.02	Structure	Structure
G.S6	321	T	G.S6.03	Structure	Structure
G.S6	322	H	G.S6.04	Structure	Structure
G.S6	323	F	G.S6.05	Structure	Structure
G.s6h5	324	T	G.s6h5.01	Structure	Structure
G.s6h5	325	C	G.s6h5.02	Structure	Structure
G.s6h5	326	A	G.s6h5.03	Structure	AF2
G.s6h5	327	T	G.s6h5.04	Structure	Structure
G.s6h5	328	D	G.s6h5.05	Structure	Structure
G.H5	329	T	G.H5.01	Structure	Structure
G.H5	330	K	G.H5.02	Structure	Structure
G.H5	331	N	G.H5.03	Structure	Structure
G.H5	332	V	G.H5.04	Structure	Structure
G.H5	333	Q	G.H5.05	Structure	Structure
G.H5	334	F	G.H5.06	Structure	Structure
G.H5	335	V	G.H5.07	Structure	Structure
G.H5	336	F	G.H5.08	Structure	Structure
G.H5	337	D	G.H5.09	Structure	Structure
G.H5	338	A	G.H5.10	Structure	Structure
G.H5	339	V	G.H5.11	Structure	Structure
G.H5	340	T	G.H5.12	Structure	Structure
G.H5	341	D	G.H5.13	Structure	Structure
G.H5	342	V	G.H5.14	Structure	Structure
G.H5	343	I	G.H5.15	Structure	Structure
G.H5	344	I	G.H5.16	Structure	Structure
G.H5	345	K	G.H5.17	Structure	Structure
G.H5	346	N	G.H5.18	Structure	Structure
G.H5	347	N	G.H5.19	Structure	Structure
G.H5	348	L	G.H5.20	Structure	Structure
G.H5	349	K	G.H5.21	Structure	Structure
G.H5	350	D	G.H5.22	Structure	Structure
G.H5	351	C	G.H5.23	Structure	Structure
G.H5	352	G	G.H5.24	Structure	Structure
G.H5	353	L	G.H5.25	Structure	Structure
G.H5	354	F	G.H5.26	AF2	AF2

REFINED GPCR RESIDUES

Residue backbones - 260 from structure (81.2%), 60 from model (18.8%)
Residue sidechains - 252 from structure (78.8%), 68 from model (21.2%)

Showing 1 to 320 of 320 entries

Search:

Segment	Seq.num.	AA	GPCRdb#	Backbone from	Sidechain from

N-term	1	M	-	AF2	AF2
N-term	2	P	-	AF2	AF2
N-term	3	D	-	AF2	AF2
N-term	4	T	-	AF2	AF2
N-term	5	N	-	AF2	AF2
N-term	6	S	-	AF2	AF2
N-term	7	T	-	AF2	AF2
N-term	8	I	-	AF2	AF2
N-term	9	N	-	AF2	AF2
N-term	10	L	-	AF2	AF2
TM1	11	S	1.28x28	AF2	AF2
TM1	12	L	1.29x29	AF2	AF2
TM1	13	S	1.30x30	AF2	AF2
TM1	14	T	1.31x31	AF2	AF2
TM1	15	R	1.32x32	Structure	AF2
TM1	16	V	1.33x33	Structure	Structure
TM1	17	T	1.34x34	Structure	Structure
TM1	18	L	1.35x35	Structure	Structure
TM1	19	A	1.36x36	Structure	Structure
TM1	20	F	1.37x37	Structure	Structure
TM1	21	F	1.38x38	Structure	Structure
TM1	22	M	1.39x39	Structure	Structure
TM1	23	S	1.40x40	Structure	Structure
TM1	24	L	1.41x41	Structure	Structure
TM1	25	V	1.42x42	Structure	Structure
TM1	26	A	1.43x43	Structure	Structure
TM1	27	F	1.44x44	Structure	Structure
TM1	28	A	1.45x45	Structure	Structure
TM1	29	I	1.46x46	Structure	Structure
TM1	30	M	1.47x47	Structure	Structure
TM1	31	L	1.48x48	Structure	Structure
TM1	32	G	1.49x49	Structure	Structure
TM1	33	N	1.50x50	Structure	Structure
TM1	34	A	1.51x51	Structure	Structure
TM1	35	L	1.52x52	Structure	Structure
TM1	36	V	1.53x53	Structure	Structure
TM1	37	I	1.54x54	Structure	Structure
TM1	38	L	1.55x55	Structure	Structure
TM1	39	A	1.56x56	Structure	Structure
TM1	40	F	1.57x57	Structure	Structure
TM1	41	V	1.58x58	Structure	Structure
TM1	42	V	1.59x59	Structure	Structure
TM1	43	D	1.60x60	Structure	Structure
ICL1	44	K	12.48x48	Structure	Structure
ICL1	45	N	12.49x49	Structure	Structure
ICL1	46	L	12.50x50	Structure	Structure
ICL1	47	R	12.51x51	Structure	Structure
TM2	48	H	2.37x37	Structure	Structure
TM2	49	R	2.38x38	Structure	Structure
TM2	50	S	2.39x39	Structure	Structure
TM2	51	S	2.40x40	Structure	Structure
TM2	52	Y	2.41x41	Structure	Structure
TM2	53	F	2.42x42	Structure	Structure
TM2	54	F	2.43x43	Structure	Structure
TM2	55	L	2.44x44	Structure	Structure
TM2	56	N	2.45x45	Structure	Structure
TM2	57	L	2.46x46	Structure	Structure
TM2	58	A	2.47x47	Structure	Structure
TM2	59	I	2.48x48	Structure	Structure
TM2	60	S	2.49x49	Structure	Structure
TM2	61	D	2.50x50	Structure	Structure
TM2	62	F	2.51x51	Structure	Structure
TM2	63	F	2.52x52	Structure	Structure
TM2	64	V	2.53x53	Structure	Structure
TM2	65	G	2.54x54	Structure	Structure
TM2	66	V	2.55x55	Structure	Structure
TM2	67	I	2.56x551	Structure	Structure
TM2	68	S	2.57x56	Structure	Structure
TM2	69	I	2.58x57	Structure	Structure
TM2	70	P	2.59x58	Structure	Structure
TM2	71	L	2.60x59	Structure	Structure
TM2	72	Y	2.61x60	Structure	Structure
TM2	73	I	2.62x61	Structure	Structure
TM2	74	P	2.63x62	Structure	Structure
TM2	75	H	2.64x63	Structure	Structure
TM2	76	T	2.65x64	Structure	Structure
TM2	77	L	2.66x65	Structure	Structure
ECL1	78	F	-	Structure	Structure
ECL1	79	E	23.49x49	Structure	AF2
ECL1	80	W	23.50x50	Structure	Structure
ECL1	81	D	23.51x51	Structure	AF2
ECL1	82	F	23.52x52	Structure	Structure
TM3	83	G	3.21x21	Structure	Structure
TM3	84	K	3.22x22	Structure	AF2
TM3	85	E	3.23x23	Structure	AF2
TM3	86	I	3.24x24	Structure	Structure
TM3	87	C	3.25x25	Structure	Structure
TM3	88	V	3.26x26	Structure	Structure
TM3	89	F	3.27x27	Structure	Structure
TM3	90	W	3.28x28	Structure	Structure
TM3	91	L	3.29x29	Structure	Structure
TM3	92	T	3.30x30	Structure	Structure
TM3	93	T	3.31x31	Structure	Structure
TM3	94	D	3.32x32	Structure	Structure
TM3	95	Y	3.33x33	Structure	Structure
TM3	96	L	3.34x34	Structure	Structure
TM3	97	L	3.35x35	Structure	Structure
TM3	98	C	3.36x36	Structure	Structure
TM3	99	T	3.37x37	Structure	Structure
TM3	100	A	3.38x38	Structure	Structure
TM3	101	S	3.39x39	Structure	Structure
TM3	102	V	3.40x40	Structure	Structure
TM3	103	Y	3.41x41	Structure	Structure
TM3	104	N	3.42x42	Structure	Structure
TM3	105	I	3.43x43	Structure	Structure
TM3	106	V	3.44x44	Structure	Structure
TM3	107	L	3.45x45	Structure	Structure
TM3	108	I	3.46x46	Structure	Structure
TM3	109	S	3.47x47	Structure	Structure
TM3	110	Y	3.48x48	Structure	Structure
TM3	111	D	3.49x49	Structure	Structure
TM3	112	R	3.50x50	Structure	Structure
TM3	113	Y	3.51x51	Structure	Structure
TM3	114	L	3.52x52	Structure	Structure
TM3	115	S	3.53x53	Structure	Structure
TM3	116	V	3.54x54	Structure	Structure
TM3	117	S	3.55x55	Structure	Structure
TM3	118	N	3.56x56	Structure	Structure
ICL2	119	A	34.50x50	Structure	Structure
ICL2	120	V	34.51x51	Structure	Structure
ICL2	121	S	34.52x52	Structure	Structure
ICL2	122	Y	34.53x53	Structure	Structure
ICL2	123	R	34.54x54	Structure	Structure
ICL2	124	T	34.55x55	Structure	Structure
ICL2	125	Q	34.56x56	Structure	Structure
ICL2	126	H	-	Structure	Structure
ICL2	127	T	-	Structure	Structure
TM4	128	G	4.38x38	Structure	Structure
TM4	129	V	4.39x39	Structure	Structure
TM4	130	L	4.40x40	Structure	Structure
TM4	131	K	4.41x41	Structure	Structure
TM4	132	I	4.42x42	Structure	Structure
TM4	133	V	4.43x43	Structure	Structure
TM4	134	T	4.44x44	Structure	Structure
TM4	135	L	4.45x45	Structure	Structure
TM4	136	M	4.46x46	Structure	Structure
TM4	137	V	4.47x47	Structure	Structure
TM4	138	A	4.48x48	Structure	Structure
TM4	139	V	4.49x49	Structure	Structure
TM4	140	W	4.50x50	Structure	Structure
TM4	141	V	4.51x51	Structure	Structure
TM4	142	L	4.52x52	Structure	Structure
TM4	143	A	4.53x53	Structure	Structure
TM4	144	F	4.54x54	Structure	Structure
TM4	145	L	4.55x55	Structure	Structure
TM4	146	V	4.56x56	Structure	Structure
TM4	147	N	4.57x57	Structure	Structure
TM4	148	G	4.58x59	Structure	Structure
TM4	149	P	4.59x60	Structure	Structure
TM4	150	M	4.60x61	Structure	Structure
TM4	151	I	4.61x62	Structure	Structure
TM4	152	L	4.62x63	Structure	Structure
TM4	153	V	4.63x64	Structure	Structure
TM4	154	S	4.64x65	Structure	Structure
TM4	155	E	4.65x66	Structure	Structure
TM4	156	S	4.66x67	Structure	Structure
TM4	157	W	4.67x68	Structure	Structure
TM4	158	K	4.68x69	AF2	AF2
ECL2	159	D	-	AF2	AF2
ECL2	160	E	-	AF2	AF2
ECL2	161	G	-	AF2	AF2
ECL2	162	S	-	AF2	AF2
ECL2	163	E	-	Structure	AF2
ECL2	164	C	45.50x50	Structure	Structure
ECL2	165	E	45.51x51	Structure	Structure
ECL2	166	P	45.52x52	Structure	Structure
ECL2	167	G	-	Structure	Structure
ECL2	168	F	-	Structure	Structure
ECL2	169	F	-	Structure	Structure
ECL2	170	S	-	Structure	Structure
TM5	171	E	5.35x36	Structure	Structure
TM5	172	W	5.36x37	Structure	Structure
TM5	173	Y	5.37x38	Structure	Structure
TM5	174	I	5.38x39	Structure	Structure
TM5	175	L	5.39x40	Structure	Structure
TM5	176	A	5.40x41	Structure	Structure
TM5	177	I	5.41x42	Structure	Structure
TM5	178	T	5.42x43	Structure	Structure
TM5	179	S	5.43x44	Structure	Structure
TM5	180	F	5.44x45	Structure	Structure
TM5	181	L	5.45x46	Structure	Structure
TM5	182	E	5.46x461	Structure	Structure
TM5	183	F	5.47x47	Structure	Structure
TM5	184	V	5.48x48	Structure	Structure
TM5	185	I	5.49x49	Structure	Structure
TM5	186	P	5.50x50	Structure	Structure
TM5	187	V	5.51x51	Structure	Structure
TM5	188	I	5.52x52	Structure	Structure
TM5	189	L	5.53x53	Structure	Structure
TM5	190	V	5.54x54	Structure	Structure
TM5	191	A	5.55x55	Structure	Structure
TM5	192	Y	5.56x56	Structure	Structure
TM5	193	F	5.57x57	Structure	Structure
TM5	194	N	5.58x58	Structure	Structure
TM5	195	M	5.59x59	Structure	Structure
TM5	196	N	5.60x60	Structure	Structure
TM5	197	I	5.61x61	Structure	Structure
TM5	198	Y	5.62x62	Structure	Structure
TM5	199	W	5.63x63	Structure	Structure
TM5	200	S	5.64x64	Structure	Structure
TM5	201	L	5.65x65	Structure	Structure
TM5	202	W	5.66x66	Structure	Structure
TM5	203	K	5.67x67	Structure	Structure
TM5	204	R	5.68x68	AF2	AF2
TM5	205	D	5.69x69	AF2	AF2
TM5	206	H	5.70x70	AF2	AF2
TM5	207	L	5.71x71	AF2	AF2
TM5	208	S	5.72x72	AF2	AF2
TM5	209	R	5.73x73	AF2	AF2
TM5	210	C	5.74x74	AF2	AF2
TM5	211	Q	5.75x75	AF2	AF2
TM5	212	S	5.76x76	AF2	AF2
ICL3	213	H	-	AF2	AF2
ICL3	214	P	-	AF2	AF2
ICL3	215	G	-	AF2	AF2
ICL3	216	L	-	AF2	AF2
ICL3	217	T	-	AF2	AF2
ICL3	218	A	-	AF2	AF2
ICL3	219	V	-	AF2	AF2
ICL3	285	V	-	AF2	AF2
ICL3	286	A	-	AF2	AF2
ICL3	287	L	-	AF2	AF2
ICL3	288	H	-	AF2	AF2
ICL3	289	Q	-	AF2	AF2
ICL3	290	R	-	AF2	AF2
ICL3	291	E	-	AF2	AF2
TM6	292	H	6.24x24	AF2	AF2
TM6	293	V	6.25x25	Structure	Structure
TM6	294	E	6.26x26	Structure	AF2
TM6	295	L	6.27x27	Structure	Structure
TM6	296	L	6.28x28	Structure	Structure
TM6	297	R	6.29x29	Structure	Structure
TM6	298	A	6.30x30	Structure	Structure
TM6	299	R	6.31x31	Structure	Structure
TM6	300	R	6.32x32	Structure	Structure
TM6	301	L	6.33x33	Structure	Structure
TM6	302	A	6.34x34	Structure	Structure
TM6	303	K	6.35x35	Structure	Structure
TM6	304	S	6.36x36	Structure	Structure
TM6	305	L	6.37x37	Structure	Structure
TM6	306	A	6.38x38	Structure	Structure
TM6	307	I	6.39x39	Structure	Structure
TM6	308	L	6.40x40	Structure	Structure
TM6	309	L	6.41x41	Structure	Structure
TM6	310	G	6.42x42	Structure	Structure
TM6	311	V	6.43x43	Structure	Structure
TM6	312	F	6.44x44	Structure	Structure
TM6	313	A	6.45x45	Structure	Structure
TM6	314	V	6.46x46	Structure	Structure
TM6	315	C	6.47x47	Structure	Structure
TM6	316	W	6.48x48	Structure	Structure
TM6	317	A	6.49x49	Structure	Structure
TM6	318	P	6.50x50	Structure	Structure
TM6	319	Y	6.51x51	Structure	Structure
TM6	320	S	6.52x52	Structure	Structure
TM6	321	L	6.53x53	Structure	Structure
TM6	322	F	6.54x54	Structure	Structure
TM6	323	T	6.55x55	Structure	Structure
TM6	324	I	6.56x56	Structure	Structure
TM6	325	V	6.57x57	Structure	Structure
TM6	326	L	6.58x58	Structure	Structure
TM6	327	S	6.59x59	Structure	Structure
TM6	328	F	6.60x60	Structure	Structure
TM6	329	Y	6.61x61	Structure	Structure
ECL3	330	S	-	Structure	Structure
ECL3	331	S	-	Structure	Structure
ECL3	332	A	-	AF2	AF2
ECL3	333	T	-	AF2	AF2
ECL3	334	G	-	AF2	AF2
ECL3	335	P	-	AF2	AF2
ECL3	336	K	-	Structure	Structure
TM7	337	S	7.32x31	Structure	Structure
TM7	338	V	7.33x32	Structure	Structure
TM7	339	W	7.34x33	Structure	Structure
TM7	340	Y	7.35x34	Structure	Structure
TM7	341	R	7.36x35	Structure	AF2
TM7	342	I	7.37x36	Structure	Structure
TM7	343	A	7.38x37	Structure	Structure
TM7	344	F	7.39x38	Structure	Structure
TM7	345	W	7.40x39	Structure	Structure
TM7	346	L	7.41x40	Structure	Structure
TM7	347	Q	7.42x41	Structure	Structure
TM7	348	W	7.43x42	Structure	Structure
TM7	349	F	7.44x43	Structure	Structure
TM7	350	N	7.45x45	Structure	Structure
TM7	351	S	7.46x46	Structure	Structure
TM7	352	F	7.47x47	Structure	Structure
TM7	353	V	7.48x48	Structure	Structure
TM7	354	N	7.49x49	Structure	Structure
TM7	355	P	7.50x50	Structure	Structure
TM7	356	L	7.51x51	Structure	Structure
TM7	357	L	7.52x52	Structure	Structure
TM7	358	Y	7.53x53	Structure	Structure
TM7	359	P	7.54x54	Structure	Structure
TM7	360	L	7.55x55	Structure	Structure
TM7	361	C	7.56x56	Structure	Structure
H8	362	H	8.47x47	Structure	Structure
H8	363	K	8.48x48	Structure	Structure
H8	364	R	8.49x49	Structure	Structure
H8	365	F	8.50x50	Structure	Structure
H8	366	Q	8.51x51	Structure	Structure
H8	367	K	8.52x52	Structure	Structure
H8	368	A	8.53x53	Structure	Structure
H8	369	F	8.54x54	Structure	Structure
H8	370	L	8.55x55	Structure	Structure
H8	371	K	8.56x56	Structure	Structure
H8	372	I	8.57x57	Structure	Structure
H8	373	F	8.58x58	AF2	AF2
H8	374	C	8.59x59	AF2	AF2
H8	375	I	8.60x60	AF2	AF2
C-term	376	K	-	AF2	AF2
C-term	377	K	-	AF2	AF2
C-term	378	Q	-	AF2	AF2
C-term	379	P	-	AF2	AF2
C-term	380	L	-	AF2	AF2
C-term	381	P	-	AF2	AF2
C-term	382	S	-	AF2	AF2
C-term	383	Q	-	AF2	AF2
C-term	384	H	-	AF2	AF2
C-term	385	S	-	AF2	AF2

GPCR - G protein interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Hydrophobic	ICL3	R	290	-	G.h4s6	E	318	G.h4s6.12
Hydrophobic	ICL2	V	120	34x51	G.S3	L	194	G.S3.01
Hydrophobic	C-term	S	385	-	G.H2	I	212	G.H2.08
Hydrophobic	C-term	S	385	-	G.H2	W	211	G.H2.07
Hydrophobic	TM6	L	301	6x33	G.H5	L	353	G.H5.25
Hydrophobic	ICL3	A	218	-	G.H4	C	305	G.H4.13
Hydrophobic	ICL2	A	119	34x50	G.H5	I	343	G.H5.15
Hydrophobic	TM5	R	204	5x68	G.H5	D	341	G.H5.13
Hydrophobic	TM6	S	304	6x36	G.H5	L	353	G.H5.25
Hydrophobic	C-term	H	384	-	G.H2	C	214	G.H2.10
Hydrophobic	TM5	R	204	5x68	G.H5	I	344	G.H5.16
Hydrophobic	TM5	I	197	5x61	G.H5	L	353	G.H5.25
Hydrophobic	ICL2	A	119	34x50	G.H5	I	344	G.H5.16
Hydrophobic	TM3	V	116	3x54	G.H5	L	348	G.H5.20
Hydrophobic	C-term	S	385	-	G.H2	H	213	G.H2.09
Hydrophobic	C-term	S	385	-	G.H2	K	209	G.H2.05
Hydrophobic	TM7	C	361	7x56	G.H5	G	352	G.H5.24
Hydrophobic	TM5	L	201	5x65	G.H5	L	348	G.H5.20
Hydrophobic	TM5	R	204	5x68	G.H5	T	340	G.H5.12
Hydrophobic	C-term	Q	383	-	G.H2	H	213	G.H2.09
Hydrophobic	TM5	L	201	5x65	G.H5	F	354	G.H5.26
Hydrophobic	ICL2	V	120	34x51	G.H5	F	336	G.H5.08
Hydrophobic	TM6	L	301	6x33	G.H5	F	354	G.H5.26
Hydrophobic	H8	K	363	8x48	G.H5	D	350	G.H5.22
Hydrophobic	ICL2	T	124	34x55	G.hns1	R	32	G.hns1.03
Hydrophobic	ICL2	R	123	34x54	G.hns1	R	32	G.hns1.03
Hydrophobic	TM6	L	301	6x33	G.H5	L	348	G.H5.20
Hydrophobic	C-term	H	384	-	G.H2	H	213	G.H2.09
Hydrophobic	ICL2	T	124	34x55	G.S3	L	194	G.S3.01
Hydrophobic	TM6	R	297	6x29	G.H5	F	354	G.H5.26
Hydrophobic	ICL2	R	123	34x54	G.H5	I	343	G.H5.15
Hydrophobic	ICL3	G	215	-	G.H4	A	301	G.H4.08
Hydrophobic	C-term	S	385	-	G.H2	K	210	G.H2.06
Hydrophobic	C-term	Q	383	-	G.H3	K	257	G.H3.16
Hydrophobic	H8	H	362	8x47	G.H5	C	351	G.H5.23
Hydrophobic	C-term	Q	383	-	G.H3	W	258	G.H3.17
Hydrophobic	TM6	L	305	6x37	G.H5	L	353	G.H5.25
Hydrophobic	C-term	P	381	-	G.H3	W	258	G.H3.17
Hydrophobic	TM3	V	116	3x54	G.H5	I	344	G.H5.16
Ionic	ICL3	R	290	-	G.h4s6	E	318	G.h4s6.12
Ionic	TM5	R	204	5x68	G.H5	D	341	G.H5.13
Ionic	C-term	H	384	-	G.h2s4	E	216	G.h2s4.02
Ionic	TM6	R	297	6x29	G.h4s6	E	318	G.h4s6.12
Ionic	ICL3	R	290	-	G.H4	E	308	G.H4.16
Polar	C-term	Q	383	-	G.H2	C	214	G.H2.10
Polar	ICL3	R	290	-	G.h4s6	E	318	G.h4s6.12
Polar	TM3	S	115	3x53	G.H5	N	347	G.H5.19
Polar	C-term	S	385	-	G.H2	I	212	G.H2.08
Polar	C-term	S	385	-	G.H2	W	211	G.H2.07
Polar	ICL3	A	286	-	G.h4s6	K	314	G.h4s6.08
Polar	TM5	R	204	5x68	G.H5	D	341	G.H5.13
Polar	C-term	H	384	-	G.H2	C	214	G.H2.10
Polar	C-term	Q	383	-	G.h2s4	E	216	G.h2s4.02
Polar	C-term	S	385	-	G.H2	H	213	G.H2.09
Polar	TM7	C	361	7x56	G.H5	G	352	G.H5.24
Polar	TM5	R	204	5x68	G.H5	T	340	G.H5.12
Polar	C-term	Q	383	-	G.H2	H	213	G.H2.09
Polar	H8	K	363	8x48	G.H5	D	350	G.H5.22
Polar	ICL3	R	290	-	G.S6	I	319	G.S6.01
Polar	C-term	H	384	-	G.H2	H	213	G.H2.09
Polar	TM6	R	297	6x29	G.h4s6	D	315	G.h4s6.09
Polar	C-term	S	385	-	G.H2	K	210	G.H2.06
Polar	C-term	Q	383	-	G.H3	K	257	G.H3.16
Polar	C-term	Q	383	-	G.H3	W	258	G.H3.17
Polar	ICL3	R	290	-	G.H4	E	308	G.H4.16
Van-der-waals	ICL3	R	290	-	G.h4s6	E	318	G.h4s6.12
Van-der-waals	TM3	S	115	3x53	G.H5	N	347	G.H5.19
Van-der-waals	C-term	S	385	-	G.H2	I	212	G.H2.08
Van-der-waals	C-term	S	385	-	G.H2	W	211	G.H2.07
Van-der-waals	TM6	L	301	6x33	G.H5	L	353	G.H5.25
Van-der-waals	ICL3	A	218	-	G.H4	C	305	G.H4.13
Van-der-waals	TM5	R	204	5x68	G.H5	D	341	G.H5.13
Van-der-waals	C-term	H	384	-	G.H2	C	214	G.H2.10
Van-der-waals	TM5	R	204	5x68	G.H5	I	344	G.H5.16
Van-der-waals	C-term	S	385	-	G.H2	H	213	G.H2.09
Van-der-waals	C-term	S	385	-	G.H2	K	209	G.H2.05
Van-der-waals	TM7	C	361	7x56	G.H5	G	352	G.H5.24
Van-der-waals	TM5	R	204	5x68	G.H5	T	340	G.H5.12
Van-der-waals	C-term	Q	383	-	G.H2	H	213	G.H2.09
Van-der-waals	TM5	L	201	5x65	G.H5	F	354	G.H5.26
Van-der-waals	ICL2	R	123	34x54	G.hns1	R	32	G.hns1.03
Van-der-waals	C-term	H	384	-	G.H2	H	213	G.H2.09
Van-der-waals	TM6	R	297	6x29	G.H5	F	354	G.H5.26
Van-der-waals	C-term	S	385	-	G.H2	K	210	G.H2.06
Van-der-waals	C-term	Q	383	-	G.H3	K	257	G.H3.16
Van-der-waals	C-term	Q	383	-	G.H3	W	258	G.H3.17
Van-der-waals	C-term	P	381	-	G.H3	W	258	G.H3.17
Van-der-waals	ICL3	R	290	-	G.H4	E	308	G.H4.16

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Refined structure (8JXX) of Gi1 - H4 receptor Download Full

GPCR CLASS (FAMILY)

SPECIES

G PROTEIN FAMILY

DATE

3D VIEW

REFINED G PROTEIN RESIDUES

REFINED GPCR RESIDUES

GPCR - G protein interface interactions

Structures

Refined structure (8JXX) of G_i1 - H₄ receptor

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