Refined structure (8WA3) of Gs - GIP receptor

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-11-26

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 232 from structure (58.9%), 162 from model (41.1%)
Residue sidechains - 223 from structure (56.6%), 171 from model (43.4%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 Structure Structure
G.HN 10 E G.HN.27 Structure Structure
G.HN 11 D G.HN.28 Structure Structure
G.HN 12 Q G.HN.29 Structure Structure
G.HN 13 R G.HN.30 Structure Structure
G.HN 14 N G.HN.31 Structure Structure
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure Structure
G.s1h1 50 E G.s1h1.04 Structure Structure
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure AF2
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure Structure
G.H1 58 K G.H1.06 Structure Structure
G.H1 59 Q G.H1.07 Structure Structure
G.H1 60 M G.H1.08 Structure Structure
G.H1 61 R G.H1.09 AF2 AF2
G.H1 62 I G.H1.10 AF2 AF2
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 Structure Structure
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure AF2
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 AF2 AF2
G.s4h3 253 Y G.s4h3.04 AF2 AF2
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 Structure Structure
G.s4h3 263 T G.s4h3.14 Structure Structure
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure AF2
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure AF2
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure AF2
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure AF2
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure AF2
G.h3s5 285 I G.h3s5.03 Structure AF2
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure Structure
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 Structure Structure
G.HG 305 K G.HG.12 Structure Structure
G.HG 306 S G.HG.13 Structure Structure
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure AF2
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 274 from structure (63.6%), 157 from model (36.4%)
Residue sidechains - 265 from structure (61.5%), 166 from model (38.5%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 T - AF2 AF2
N-term 3 T - AF2 AF2
N-term 4 S - AF2 AF2
N-term 5 P - AF2 AF2
N-term 6 I - AF2 AF2
N-term 7 L - AF2 AF2
N-term 8 Q - AF2 AF2
N-term 9 L - AF2 AF2
N-term 10 L - AF2 AF2
N-term 11 L - AF2 AF2
N-term 12 R - AF2 AF2
N-term 13 L - AF2 AF2
N-term 14 S - AF2 AF2
N-term 15 L - AF2 AF2
N-term 16 C - AF2 AF2
N-term 17 G - AF2 AF2
N-term 18 L - AF2 AF2
N-term 19 L - AF2 AF2
N-term 20 L - AF2 AF2
N-term 21 Q - AF2 AF2
N-term 22 R - AF2 AF2
N-term 23 A - AF2 AF2
N-term 24 E - AF2 AF2
N-term 25 T - AF2 AF2
N-term 26 G - AF2 AF2
N-term 27 S - AF2 AF2
N-term 28 K - AF2 AF2
N-term 29 G - AF2 AF2
N-term 30 Q - AF2 AF2
N-term 31 T - AF2 AF2
N-term 32 A - AF2 AF2
N-term 33 G - AF2 AF2
N-term 34 E - AF2 AF2
N-term 35 L - AF2 AF2
N-term 36 Y - AF2 AF2
N-term 37 Q - AF2 AF2
N-term 38 R - AF2 AF2
N-term 39 W - AF2 AF2
N-term 40 E - AF2 AF2
N-term 41 R - AF2 AF2
N-term 42 Y - AF2 AF2
N-term 43 R - AF2 AF2
N-term 44 R - AF2 AF2
N-term 45 E - AF2 AF2
N-term 46 C - AF2 AF2
N-term 47 Q - AF2 AF2
N-term 48 E - AF2 AF2
N-term 49 T - AF2 AF2
N-term 50 L - AF2 AF2
N-term 51 A - AF2 AF2
N-term 52 A - AF2 AF2
N-term 53 A - AF2 AF2
N-term 54 E - AF2 AF2
N-term 55 P - AF2 AF2
N-term 56 P - AF2 AF2
N-term 57 S - AF2 AF2
N-term 58 G - AF2 AF2
N-term 59 L - AF2 AF2
N-term 60 A - AF2 AF2
N-term 61 C - AF2 AF2
N-term 62 N - AF2 AF2
N-term 63 G - AF2 AF2
N-term 64 S - AF2 AF2
N-term 65 F - AF2 AF2
N-term 66 D - AF2 AF2
N-term 67 M - AF2 AF2
N-term 68 Y - AF2 AF2
N-term 69 V - AF2 AF2
N-term 70 C - AF2 AF2
N-term 71 W - AF2 AF2
N-term 72 D - AF2 AF2
N-term 73 Y - AF2 AF2
N-term 74 A - AF2 AF2
N-term 75 A - AF2 AF2
N-term 76 P - AF2 AF2
N-term 77 N - AF2 AF2
N-term 78 A - AF2 AF2
N-term 79 T - AF2 AF2
N-term 80 A - AF2 AF2
N-term 81 R - AF2 AF2
N-term 82 A - AF2 AF2
N-term 83 S - AF2 AF2
N-term 84 C - AF2 AF2
N-term 85 P - AF2 AF2
N-term 86 W - AF2 AF2
N-term 87 Y - AF2 AF2
N-term 88 L - AF2 AF2
N-term 89 P - AF2 AF2
N-term 90 W - AF2 AF2
N-term 91 H - AF2 AF2
N-term 92 H - AF2 AF2
N-term 93 H - AF2 AF2
N-term 94 V - AF2 AF2
N-term 95 A - AF2 AF2
N-term 96 A - AF2 AF2
N-term 97 G - AF2 AF2
N-term 98 F - AF2 AF2
N-term 99 V - AF2 AF2
N-term 100 L - AF2 AF2
N-term 101 R - AF2 AF2
N-term 102 Q - AF2 AF2
N-term 103 C - AF2 AF2
N-term 104 G - AF2 AF2
N-term 105 S - AF2 AF2
N-term 106 D - AF2 AF2
N-term 107 G - AF2 AF2
N-term 108 Q - AF2 AF2
N-term 109 W - AF2 AF2
N-term 110 G - AF2 AF2
N-term 111 L - AF2 AF2
N-term 112 W - AF2 AF2
N-term 113 R - AF2 AF2
N-term 114 D - AF2 AF2
N-term 115 H - AF2 AF2
N-term 116 T - AF2 AF2
N-term 117 Q - AF2 AF2
N-term 118 C - AF2 AF2
N-term 119 E - AF2 AF2
N-term 120 N - AF2 AF2
N-term 121 P - AF2 AF2
N-term 122 E - AF2 AF2
N-term 123 K - AF2 AF2
TM1 124 N 1.26x26 AF2 AF2
TM1 125 E 1.27x27 AF2 AF2
TM1 126 A 1.28x28 AF2 AF2
TM1 127 F 1.29x29 AF2 AF2
TM1 128 L 1.30x30 Structure AF2
TM1 129 D 1.31x31 Structure Structure
TM1 130 Q 1.32x32 Structure Structure
TM1 131 R 1.33x33 Structure Structure
TM1 132 L 1.34x34 Structure Structure
TM1 133 I 1.35x35 Structure Structure
TM1 134 L 1.36x36 Structure Structure
TM1 135 E 1.37x37 Structure Structure
TM1 136 R 1.38x38 Structure AF2
TM1 137 L 1.39x39 Structure Structure
TM1 138 Q 1.40x40 Structure Structure
TM1 139 V 1.41x41 Structure Structure
TM1 140 M 1.42x42 Structure Structure
TM1 141 Y 1.43x43 Structure Structure
TM1 142 T 1.44x44 Structure Structure
TM1 143 V 1.45x45 Structure Structure
TM1 144 G 1.46x46 Structure Structure
TM1 145 Y 1.47x47 Structure Structure
TM1 146 S 1.48x48 Structure Structure
TM1 147 L 1.49x49 Structure Structure
TM1 148 S 1.50x50 Structure Structure
TM1 149 L 1.51x51 Structure Structure
TM1 150 A 1.52x52 Structure Structure
TM1 151 T 1.53x53 Structure Structure
TM1 152 L 1.54x54 Structure Structure
TM1 153 L 1.55x55 Structure Structure
TM1 154 L 1.56x56 Structure Structure
TM1 155 A 1.57x57 Structure Structure
TM1 156 L 1.58x58 Structure Structure
TM1 157 L 1.59x59 Structure Structure
TM1 158 I 1.60x60 Structure Structure
TM1 159 L 1.61x61 Structure Structure
TM1 160 S 1.62x62 Structure Structure
TM1 161 L 1.63x63 Structure Structure
TM1 162 F 1.64x64 Structure Structure
ICL1 163 R 12.48x48 Structure Structure
ICL1 164 R 12.49x49 Structure Structure
ICL1 165 L 12.50x50 Structure Structure
ICL1 166 H 12.51x51 Structure Structure
TM2 167 C 2.44x44 Structure Structure
TM2 168 T 2.45x45 Structure Structure
TM2 169 R 2.46x46 Structure Structure
TM2 170 N 2.47x47 Structure Structure
TM2 171 Y 2.48x48 Structure Structure
TM2 172 I 2.49x49 Structure Structure
TM2 173 H 2.50x50 Structure Structure
TM2 174 I 2.51x51 Structure Structure
TM2 175 N 2.52x52 Structure Structure
TM2 176 L 2.53x53 Structure Structure
TM2 177 F 2.54x54 Structure Structure
TM2 178 T 2.55x55 Structure Structure
TM2 179 S 2.56x56 Structure Structure
TM2 180 F 2.57x57 Structure Structure
TM2 181 M 2.58x58 Structure Structure
TM2 182 L 2.59x59 Structure Structure
TM2 183 R 2.60x60 Structure Structure
TM2 184 A 2.61x61 Structure Structure
TM2 185 A 2.62x62 Structure Structure
TM2 186 A 2.63x63 Structure Structure
TM2 187 I 2.64x64 Structure Structure
TM2 188 L 2.65x65 Structure Structure
TM2 189 S 2.66x66 Structure Structure
TM2 190 R 2.67x67 Structure Structure
TM2 191 D 2.68x68 Structure Structure
TM2 192 R 2.69x69 Structure Structure
TM2 193 L 2.70x70 Structure Structure
TM2 194 L 2.71x71 Structure Structure
ECL1 195 P - Structure Structure
ECL1 196 R - AF2 AF2
ECL1 197 P - AF2 AF2
ECL1 198 G - AF2 AF2
ECL1 199 P - AF2 AF2
ECL1 200 Y - AF2 AF2
ECL1 201 L - AF2 AF2
ECL1 202 G - AF2 AF2
ECL1 203 D - AF2 AF2
ECL1 204 Q - AF2 AF2
ECL1 205 A - AF2 AF2
ECL1 206 L - AF2 AF2
ECL1 207 A - AF2 AF2
ECL1 208 L - AF2 AF2
ECL1 209 W - AF2 AF2
ECL1 210 N - Structure Structure
TM3 211 Q 3.24x24 Structure Structure
TM3 212 A 3.25x25 Structure Structure
TM3 213 L 3.26x26 Structure Structure
TM3 214 A 3.27x27 Structure Structure
TM3 215 A 3.28x28 Structure Structure
TM3 216 C 3.29x29 Structure Structure
TM3 217 R 3.30x30 Structure Structure
TM3 218 T 3.31x31 Structure Structure
TM3 219 A 3.32x32 Structure Structure
TM3 220 Q 3.33x33 Structure Structure
TM3 221 I 3.34x34 Structure Structure
TM3 222 V 3.35x35 Structure Structure
TM3 223 T 3.36x36 Structure Structure
TM3 224 Q 3.37x37 Structure Structure
TM3 225 Y 3.38x38 Structure Structure
TM3 226 C 3.39x39 Structure Structure
TM3 227 V 3.40x40 Structure Structure
TM3 228 G 3.41x41 Structure Structure
TM3 229 A 3.42x42 Structure Structure
TM3 230 N 3.43x43 Structure Structure
TM3 231 Y 3.44x44 Structure Structure
TM3 232 T 3.45x45 Structure Structure
TM3 233 W 3.46x46 Structure Structure
TM3 234 L 3.47x47 Structure Structure
TM3 235 L 3.48x48 Structure Structure
TM3 236 V 3.49x49 Structure Structure
TM3 237 E 3.50x50 Structure Structure
TM3 238 G 3.51x51 Structure Structure
TM3 239 V 3.52x52 Structure Structure
TM3 240 Y 3.53x53 Structure Structure
TM3 241 L 3.54x54 Structure Structure
TM3 242 H 3.55x55 Structure Structure
TM3 243 S 3.56x56 Structure Structure
TM3 244 L 3.57x57 Structure Structure
TM3 245 L 3.58x58 Structure Structure
TM3 246 V 3.59x59 Structure Structure
TM3 247 L 3.60x60 Structure Structure
ICL2 248 V - Structure Structure
ICL2 249 G - Structure Structure
ICL2 250 G - Structure Structure
ICL2 251 S - Structure Structure
ICL2 252 E - Structure Structure
ICL2 253 E - Structure Structure
ICL2 254 G - Structure Structure
TM4 255 H 4.41x42 Structure Structure
TM4 256 F 4.42x43 Structure Structure
TM4 257 R 4.43x44 Structure Structure
TM4 258 Y 4.44x45 Structure Structure
TM4 259 Y 4.45x46 Structure Structure
TM4 260 L 4.46x47 Structure Structure
TM4 261 L 4.47x48 Structure Structure
TM4 262 L 4.48x49 Structure Structure
TM4 263 G 4.49x491 Structure Structure
TM4 264 W 4.50x50 Structure Structure
TM4 265 G 4.51x51 Structure Structure
TM4 266 A 4.52x52 Structure Structure
TM4 267 P 4.53x53 Structure Structure
TM4 268 A 4.54x54 Structure Structure
TM4 269 L 4.55x55 Structure Structure
TM4 270 F 4.56x56 Structure Structure
TM4 271 V 4.57x57 Structure Structure
TM4 272 I 4.58x58 Structure Structure
TM4 273 P 4.59x59 Structure Structure
TM4 274 W 4.60x60 Structure Structure
TM4 275 V 4.61x61 Structure Structure
TM4 276 I 4.62x62 Structure Structure
TM4 277 V 4.63x63 Structure Structure
TM4 278 R 4.64x64 Structure Structure
TM4 279 Y 4.65x65 Structure Structure
TM4 280 L 4.66x66 Structure Structure
TM4 281 Y 4.67x67 Structure Structure
TM4 282 E 4.68x68 Structure Structure
ECL2 283 N - Structure Structure
ECL2 284 T - Structure Structure
ECL2 285 Q - Structure Structure
ECL2 286 C 45.50x50 Structure Structure
ECL2 287 W 45.51x51 Structure Structure
ECL2 288 E 45.52x52 Structure Structure
ECL2 289 R - Structure Structure
ECL2 290 N - Structure Structure
ECL2 291 E - Structure Structure
ECL2 292 V - Structure Structure
TM5 293 K 5.33x34 Structure Structure
TM5 294 A 5.34x35 Structure Structure
TM5 295 I 5.35x36 Structure Structure
TM5 296 W 5.36x37 Structure Structure
TM5 297 W 5.37x38 Structure Structure
TM5 298 I 5.38x381 Structure Structure
TM5 299 I 5.39x39 Structure Structure
TM5 300 R 5.40x40 Structure Structure
TM5 301 T 5.41x41 Structure Structure
TM5 302 P 5.42x42 Structure Structure
TM5 303 I 5.43x43 Structure Structure
TM5 304 L 5.44x44 Structure Structure
TM5 305 M 5.45x45 Structure Structure
TM5 306 T 5.46x46 Structure Structure
TM5 307 I 5.47x47 Structure Structure
TM5 308 L 5.48x48 Structure Structure
TM5 309 I 5.49x49 Structure Structure
TM5 310 N 5.50x50 Structure Structure
TM5 311 F 5.51x51 Structure Structure
TM5 312 L 5.52x52 Structure Structure
TM5 313 I 5.53x53 Structure Structure
TM5 314 F 5.54x54 Structure Structure
TM5 315 I 5.55x55 Structure Structure
TM5 316 R 5.56x56 Structure Structure
TM5 317 I 5.57x57 Structure Structure
TM5 318 L 5.58x58 Structure Structure
TM5 319 G 5.59x59 Structure Structure
TM5 320 I 5.60x60 Structure Structure
TM5 321 L 5.61x61 Structure Structure
TM5 322 L 5.62x62 Structure Structure
TM5 323 S 5.63x63 Structure Structure
TM5 324 K 5.64x64 Structure Structure
TM5 325 L 5.65x65 Structure Structure
TM5 326 R 5.66x66 Structure Structure
TM5 327 T 5.67x67 Structure Structure
TM5 328 R 5.68x68 Structure Structure
ICL3 329 Q - Structure Structure
ICL3 330 M - Structure Structure
TM6 331 R 6.30x30 Structure Structure
TM6 332 C 6.31x31 Structure Structure
TM6 333 R 6.32x32 Structure Structure
TM6 334 D 6.33x33 Structure Structure
TM6 335 Y 6.34x34 Structure Structure
TM6 336 R 6.35x35 Structure Structure
TM6 337 L 6.36x36 Structure Structure
TM6 338 R 6.37x37 Structure Structure
TM6 339 L 6.38x38 Structure Structure
TM6 340 A 6.39x39 Structure Structure
TM6 341 R 6.40x40 Structure Structure
TM6 342 S 6.41x41 Structure Structure
TM6 343 T 6.42x42 Structure Structure
TM6 344 L 6.43x43 Structure Structure
TM6 345 T 6.44x44 Structure AF2
TM6 346 L 6.45x45 Structure Structure
TM6 347 V 6.46x46 Structure Structure
TM6 348 P 6.47x47 Structure Structure
TM6 349 L 6.48x48 Structure Structure
TM6 350 L 6.49x49 Structure Structure
TM6 351 G 6.50x50 Structure Structure
TM6 352 V 6.51x51 Structure Structure
TM6 353 H 6.52x52 Structure Structure
TM6 354 E 6.53x53 Structure Structure
TM6 355 V 6.54x54 Structure Structure
TM6 356 V 6.55x55 Structure Structure
TM6 357 F 6.56x56 Structure AF2
TM6 358 A 6.57x57 Structure Structure
TM6 359 P 6.58x58 Structure Structure
TM6 360 V 6.59x59 Structure Structure
ECL3 361 T - Structure Structure
ECL3 362 E - Structure AF2
ECL3 363 E - Structure AF2
ECL3 364 Q - Structure AF2
ECL3 365 A - Structure Structure
ECL3 366 R - Structure AF2
TM7 367 G 7.32x31 Structure Structure
TM7 368 A 7.33x32 Structure Structure
TM7 369 L 7.34x33 Structure Structure
TM7 370 R 7.35x34 Structure Structure
TM7 371 F 7.36x35 Structure Structure
TM7 372 A 7.37x36 Structure Structure
TM7 373 K 7.38x37 Structure Structure
TM7 374 L 7.39x38 Structure Structure
TM7 375 G 7.40x39 Structure Structure
TM7 376 F 7.41x40 Structure Structure
TM7 377 E 7.42x41 Structure Structure
TM7 378 I 7.43x42 Structure Structure
TM7 379 F 7.44x43 Structure Structure
TM7 380 L 7.45x44 Structure Structure
TM7 381 S 7.46x45 Structure Structure
TM7 382 S 7.47x46 Structure Structure
TM7 383 F 7.48x47 Structure AF2
TM7 384 Q 7.49x49 Structure Structure
TM7 385 G 7.50x50 Structure Structure
TM7 386 F 7.51x51 Structure Structure
TM7 387 L 7.52x52 Structure Structure
TM7 388 V 7.53x53 Structure Structure
TM7 389 S 7.54x54 Structure Structure
TM7 390 V 7.55x55 Structure Structure
TM7 391 L 7.56x56 Structure Structure
TM7 392 Y 7.57x57 Structure Structure
TM7 393 C 7.58x58 Structure Structure
TM7 394 F 7.59x59 Structure Structure
TM7 395 I 7.60x60 Structure Structure
H8 396 N 8.47x47 Structure Structure
H8 397 K 8.48x48 Structure Structure
H8 398 E 8.49x49 Structure Structure
H8 399 V 8.50x50 Structure Structure
H8 400 Q 8.51x51 Structure Structure
H8 401 S 8.52x52 Structure Structure
H8 402 E 8.53x53 Structure Structure
H8 403 I 8.54x54 Structure Structure
H8 404 R 8.55x55 Structure Structure
H8 405 R 8.56x56 Structure Structure
H8 406 G 8.57x57 Structure Structure
H8 407 W 8.58x58 Structure Structure
H8 408 H 8.59x59 Structure Structure
H8 409 H 8.60x60 Structure Structure
H8 410 C 8.61x61 Structure Structure
H8 411 R 8.62x62 Structure Structure
H8 412 L 8.63x63 Structure Structure
H8 413 R 8.64x64 Structure Structure
H8 414 R 8.65x65 Structure Structure
H8 415 S 8.66x66 Structure Structure
H8 416 L 8.67x67 AF2 AF2
H8 417 G 8.68x68 AF2 AF2
H8 418 E 8.69x69 AF2 AF2
H8 419 E 8.70x70 AF2 AF2
H8 420 Q 8.71x71 AF2 AF2
H8 421 R 8.72x72 AF2 AF2
C-term 422 Q - AF2 AF2
C-term 423 L - AF2 AF2
C-term 424 P - AF2 AF2
C-term 425 E - AF2 AF2
C-term 426 R - AF2 AF2
C-term 427 A - AF2 AF2
C-term 428 F - AF2 AF2
C-term 429 R - AF2 AF2
C-term 430 A - AF2 AF2
C-term 431 L - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 241 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 241 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 241 3x54 G.H5 L 393 G.H5.25
Hydrophobic TM5 R 328 5x68 G.H5 R 385 G.H5.17
Polar TM3 L 244 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 244 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 244 3x57 G.H5 H 387 G.H5.19
Polar TM5 R 328 5x68 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 R 328 5x68 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 R 328 5x68 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 G 249 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 V 248 - G.S3 V 217 G.S3.01
Hydrophobic TM7 I 395 7x60 G.H5 E 392 G.H5.24
Van-der-waals TM7 I 395 7x60 G.H5 E 392 G.H5.24
Hydrophobic TM6 R 341 6x40 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 341 6x40 G.H5 E 392 G.H5.24
Polar TM5 K 324 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 324 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 324 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 321 5x61 G.H5 L 388 G.H5.20
Polar TM5 K 324 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 324 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 324 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 L 325 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM6 L 337 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 337 6x36 G.H5 L 393 G.H5.25
Polar H8 N 396 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 N 396 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 V 248 - G.H5 F 376 G.H5.08
Polar TM3 L 245 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 245 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 245 3x58 G.H5 Q 384 G.H5.16
Ionic TM5 K 324 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 324 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 324 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM3 Y 240 3x53 G.H5 Y 391 G.H5.23
Polar TM2 R 169 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 169 2x46 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 V 248 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 V 248 - G.H5 R 380 G.H5.12
Hydrophobic TM5 L 321 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 321 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM6 R 341 6x40 G.H5 L 393 G.H5.25
Polar TM3 L 247 3x60 G.H5 R 380 G.H5.12
Van-der-waals TM3 L 247 3x60 G.H5 R 380 G.H5.12
Hydrophobic TM6 L 337 6x36 G.H5 L 394 G.H5.26
Van-der-waals TM6 L 337 6x36 G.H5 L 394 G.H5.26
Hydrophobic TM5 K 324 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM5 L 321 5x61 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 321 5x61 G.H5 L 394 G.H5.26
Polar ICL2 S 251 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 I 317 5x57 G.H5 L 393 G.H5.25
Hydrophobic TM3 L 245 3x58 G.H5 H 387 G.H5.19
Hydrophobic H8 K 397 8x48 G.H5 E 392 G.H5.24
Aromatic TM2 R 169 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 169 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 169 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 245 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 245 3x58 G.H5 L 388 G.H5.20