Refined structure (8WSS) of Gi1 - MCH1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-11-26

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 217 from structure (61.3%), 137 from model (38.7%)
Residue sidechains - 212 from structure (59.9%), 142 from model (40.1%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 AF2 AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure AF2
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 279 from structure (68.7%), 127 from model (31.3%)
Residue sidechains - 274 from structure (67.5%), 132 from model (32.5%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 S - AF2 AF2
N-term 3 V - AF2 AF2
N-term 4 G - AF2 AF2
N-term 5 A - AF2 AF2
N-term 6 M - AF2 AF2
N-term 7 K - AF2 AF2
N-term 8 K - AF2 AF2
N-term 9 G - AF2 AF2
N-term 10 V - AF2 AF2
N-term 11 G - AF2 AF2
N-term 12 R - AF2 AF2
N-term 13 A - AF2 AF2
N-term 14 V - AF2 AF2
N-term 15 G - AF2 AF2
N-term 16 L - AF2 AF2
N-term 17 G - AF2 AF2
N-term 18 G - AF2 AF2
N-term 19 G - AF2 AF2
N-term 20 S - AF2 AF2
N-term 21 G - AF2 AF2
N-term 22 C - AF2 AF2
N-term 23 Q - AF2 AF2
N-term 24 A - AF2 AF2
N-term 25 T - AF2 AF2
N-term 26 E - AF2 AF2
N-term 27 E - AF2 AF2
N-term 28 D - AF2 AF2
N-term 29 P - AF2 AF2
N-term 30 L - AF2 AF2
N-term 31 P - AF2 AF2
N-term 32 N - AF2 AF2
N-term 33 C - AF2 AF2
N-term 34 G - AF2 AF2
N-term 35 A - AF2 AF2
N-term 36 C - AF2 AF2
N-term 37 A - AF2 AF2
N-term 38 P - AF2 AF2
N-term 39 G - AF2 AF2
N-term 40 Q - AF2 AF2
N-term 41 G - AF2 AF2
N-term 42 G - AF2 AF2
N-term 43 R - AF2 AF2
N-term 44 R - AF2 AF2
N-term 45 W - AF2 AF2
N-term 46 R - AF2 AF2
N-term 47 L - AF2 AF2
N-term 48 P - AF2 AF2
N-term 49 Q - AF2 AF2
N-term 50 P - AF2 AF2
N-term 51 A - AF2 AF2
N-term 52 W - AF2 AF2
N-term 53 V - AF2 AF2
N-term 54 E - AF2 AF2
N-term 55 G - AF2 AF2
N-term 56 S - AF2 AF2
N-term 57 S - AF2 AF2
N-term 58 A - AF2 AF2
N-term 59 R - AF2 AF2
N-term 60 L - AF2 AF2
N-term 61 W - AF2 AF2
N-term 62 E - AF2 AF2
N-term 63 Q - AF2 AF2
N-term 64 A - AF2 AF2
N-term 65 T - AF2 AF2
N-term 66 G - AF2 AF2
N-term 67 T - AF2 AF2
N-term 68 G - AF2 AF2
N-term 69 W - AF2 AF2
N-term 70 M - AF2 AF2
N-term 71 D - AF2 AF2
N-term 72 L - AF2 AF2
N-term 73 E - AF2 AF2
N-term 74 A - AF2 AF2
N-term 75 S - AF2 AF2
N-term 76 L - AF2 AF2
N-term 77 L - AF2 AF2
N-term 78 P - AF2 AF2
N-term 79 T - AF2 AF2
N-term 80 G - AF2 AF2
N-term 81 P - AF2 AF2
N-term 82 N - AF2 AF2
N-term 83 A - AF2 AF2
N-term 84 S - AF2 AF2
N-term 85 N - AF2 AF2
N-term 86 T - AF2 AF2
N-term 87 S - AF2 AF2
N-term 88 D - AF2 AF2
N-term 89 G - AF2 AF2
N-term 90 P - AF2 AF2
N-term 91 D - AF2 AF2
N-term 92 N - AF2 AF2
N-term 93 L - AF2 AF2
N-term 94 T - AF2 AF2
N-term 95 S - AF2 AF2
N-term 96 A - AF2 AF2
N-term 97 G - AF2 AF2
N-term 98 S - AF2 AF2
N-term 99 P - AF2 AF2
N-term 100 P - AF2 AF2
N-term 101 R - AF2 AF2
N-term 102 T - AF2 AF2
N-term 103 G - AF2 AF2
N-term 104 S - AF2 AF2
N-term 105 I - AF2 AF2
TM1 106 S 1.29x29 AF2 AF2
TM1 107 Y 1.30x30 AF2 AF2
TM1 108 I 1.31x31 AF2 AF2
TM1 109 N 1.32x32 AF2 AF2
TM1 110 I 1.33x33 AF2 AF2
TM1 111 I 1.34x34 Structure Structure
TM1 112 M 1.35x35 Structure Structure
TM1 113 P 1.36x36 Structure Structure
TM1 114 S 1.37x37 Structure Structure
TM1 115 V 1.38x38 Structure Structure
TM1 116 F 1.39x39 Structure Structure
TM1 117 G 1.40x40 Structure Structure
TM1 118 T 1.41x41 Structure Structure
TM1 119 I 1.42x42 Structure Structure
TM1 120 C 1.43x43 Structure Structure
TM1 121 L 1.44x44 Structure Structure
TM1 122 L 1.45x45 Structure Structure
TM1 123 G 1.46x46 Structure Structure
TM1 124 I 1.47x47 Structure Structure
TM1 125 I 1.48x48 Structure Structure
TM1 126 G 1.49x49 Structure Structure
TM1 127 N 1.50x50 Structure Structure
TM1 128 S 1.51x51 Structure Structure
TM1 129 T 1.52x52 Structure Structure
TM1 130 V 1.53x53 Structure Structure
TM1 131 I 1.54x54 Structure Structure
TM1 132 F 1.55x55 Structure Structure
TM1 133 A 1.56x56 Structure Structure
TM1 134 V 1.57x57 Structure Structure
TM1 135 V 1.58x58 Structure Structure
TM1 136 K 1.59x59 Structure Structure
TM1 137 K 1.60x60 Structure Structure
TM1 138 S 1.61x61 Structure Structure
ICL1 139 K - AF2 AF2
ICL1 140 L - AF2 AF2
ICL1 141 H - AF2 AF2
ICL1 142 W - AF2 AF2
ICL1 143 C - Structure Structure
ICL1 144 N - Structure Structure
TM2 145 N 2.37x37 Structure Structure
TM2 146 V 2.38x38 Structure Structure
TM2 147 P 2.39x39 Structure Structure
TM2 148 D 2.40x40 Structure Structure
TM2 149 I 2.41x41 Structure Structure
TM2 150 F 2.42x42 Structure Structure
TM2 151 I 2.43x43 Structure Structure
TM2 152 I 2.44x44 Structure Structure
TM2 153 N 2.45x45 Structure Structure
TM2 154 L 2.46x46 Structure Structure
TM2 155 S 2.47x47 Structure Structure
TM2 156 V 2.48x48 Structure Structure
TM2 157 V 2.49x49 Structure Structure
TM2 158 D 2.50x50 Structure Structure
TM2 159 L 2.51x51 Structure Structure
TM2 160 L 2.52x52 Structure Structure
TM2 161 F 2.53x53 Structure Structure
TM2 162 L 2.54x54 Structure Structure
TM2 163 L 2.55x55 Structure Structure
TM2 164 G 2.56x56 Structure Structure
TM2 165 M 2.57x57 Structure Structure
TM2 166 P 2.58x58 Structure Structure
TM2 167 F 2.59x59 Structure Structure
TM2 168 M 2.60x60 Structure Structure
TM2 169 I 2.61x61 Structure Structure
TM2 170 H 2.62x62 Structure Structure
TM2 171 Q 2.63x63 Structure Structure
TM2 172 L 2.64x64 Structure Structure
TM2 173 M 2.65x65 Structure Structure
TM2 174 G 2.66x66 Structure Structure
ECL1 175 N - Structure Structure
ECL1 176 G - Structure Structure
ECL1 177 V 23.49x49 Structure AF2
ECL1 178 W 23.50x50 Structure Structure
ECL1 179 H 23.51x51 Structure Structure
ECL1 180 F 23.52x52 Structure Structure
TM3 181 G 3.21x21 Structure Structure
TM3 182 E 3.22x22 Structure Structure
TM3 183 T 3.23x23 Structure Structure
TM3 184 M 3.24x24 Structure Structure
TM3 185 C 3.25x25 Structure Structure
TM3 186 T 3.26x26 Structure Structure
TM3 187 L 3.27x27 Structure Structure
TM3 188 I 3.28x28 Structure Structure
TM3 189 T 3.29x29 Structure Structure
TM3 190 A 3.30x30 Structure Structure
TM3 191 M 3.31x31 Structure Structure
TM3 192 D 3.32x32 Structure Structure
TM3 193 A 3.33x33 Structure Structure
TM3 194 N 3.34x34 Structure Structure
TM3 195 S 3.35x35 Structure Structure
TM3 196 Q 3.36x36 Structure Structure
TM3 197 F 3.37x37 Structure Structure
TM3 198 T 3.38x38 Structure Structure
TM3 199 S 3.39x39 Structure Structure
TM3 200 T 3.40x40 Structure Structure
TM3 201 Y 3.41x41 Structure Structure
TM3 202 I 3.42x42 Structure Structure
TM3 203 L 3.43x43 Structure Structure
TM3 204 T 3.44x44 Structure Structure
TM3 205 A 3.45x45 Structure Structure
TM3 206 M 3.46x46 Structure Structure
TM3 207 A 3.47x47 Structure Structure
TM3 208 I 3.48x48 Structure Structure
TM3 209 D 3.49x49 Structure Structure
TM3 210 R 3.50x50 Structure Structure
TM3 211 Y 3.51x51 Structure Structure
TM3 212 L 3.52x52 Structure Structure
TM3 213 A 3.53x53 Structure Structure
TM3 214 T 3.54x54 Structure Structure
TM3 215 V 3.55x55 Structure Structure
TM3 216 H 3.56x56 Structure Structure
ICL2 217 P 34.50x50 Structure Structure
ICL2 218 I 34.51x51 Structure Structure
ICL2 219 S 34.52x52 Structure Structure
ICL2 220 S 34.53x53 Structure Structure
ICL2 221 T 34.54x54 Structure Structure
ICL2 222 K 34.55x55 Structure Structure
ICL2 223 F 34.56x56 Structure Structure
ICL2 224 R 34.57x57 Structure Structure
TM4 225 K 4.38x38 Structure AF2
TM4 226 P 4.39x39 Structure Structure
TM4 227 S 4.40x40 Structure Structure
TM4 228 V 4.41x41 Structure Structure
TM4 229 A 4.42x42 Structure Structure
TM4 230 T 4.43x43 Structure Structure
TM4 231 L 4.44x44 Structure Structure
TM4 232 V 4.45x45 Structure Structure
TM4 233 I 4.46x46 Structure Structure
TM4 234 C 4.47x47 Structure Structure
TM4 235 L 4.48x48 Structure Structure
TM4 236 L 4.49x49 Structure Structure
TM4 237 W 4.50x50 Structure Structure
TM4 238 A 4.51x51 Structure Structure
TM4 239 L 4.52x52 Structure Structure
TM4 240 S 4.53x53 Structure Structure
TM4 241 F 4.54x54 Structure Structure
TM4 242 I 4.55x55 Structure Structure
TM4 243 S 4.56x56 Structure Structure
TM4 244 I 4.57x57 Structure Structure
TM4 245 T 4.58x59 Structure Structure
TM4 246 P 4.59x60 Structure Structure
TM4 247 V 4.60x61 Structure Structure
TM4 248 W 4.61x62 Structure Structure
TM4 249 L 4.62x63 Structure Structure
TM4 250 Y 4.63x64 Structure Structure
TM4 251 A 4.64x65 Structure Structure
ECL2 252 R - Structure Structure
ECL2 253 L - Structure Structure
ECL2 254 I - Structure Structure
ECL2 255 P - Structure Structure
ECL2 256 F - Structure Structure
ECL2 257 P - Structure Structure
ECL2 258 G - Structure Structure
ECL2 259 G - Structure Structure
ECL2 260 A - Structure Structure
ECL2 261 V - Structure Structure
ECL2 262 G - Structure Structure
ECL2 263 C 45.50x50 Structure Structure
ECL2 264 G 45.51x51 Structure Structure
ECL2 265 I 45.52x52 Structure Structure
ECL2 266 R - Structure AF2
ECL2 267 L - Structure AF2
ECL2 268 P - Structure Structure
ECL2 269 N - Structure Structure
TM5 270 P 5.31x32 Structure Structure
TM5 271 D 5.32x33 Structure Structure
TM5 272 T 5.33x34 Structure Structure
TM5 273 D 5.34x35 Structure Structure
TM5 274 L 5.35x36 Structure Structure
TM5 275 Y 5.36x37 Structure Structure
TM5 276 W 5.37x38 Structure Structure
TM5 277 F 5.38x39 Structure Structure
TM5 278 T 5.39x40 Structure Structure
TM5 279 L 5.40x41 Structure Structure
TM5 280 Y 5.41x42 Structure Structure
TM5 281 Q 5.42x43 Structure Structure
TM5 282 F 5.43x44 Structure Structure
TM5 283 F 5.44x45 Structure Structure
TM5 284 L 5.45x46 Structure Structure
TM5 285 A 5.46x461 Structure Structure
TM5 286 F 5.47x47 Structure Structure
TM5 287 A 5.48x48 Structure Structure
TM5 288 L 5.49x49 Structure Structure
TM5 289 P 5.50x50 Structure Structure
TM5 290 F 5.51x51 Structure Structure
TM5 291 V 5.52x52 Structure Structure
TM5 292 V 5.53x53 Structure Structure
TM5 293 I 5.54x54 Structure Structure
TM5 294 T 5.55x55 Structure Structure
TM5 295 A 5.56x56 Structure Structure
TM5 296 A 5.57x57 Structure Structure
TM5 297 Y 5.58x58 Structure Structure
TM5 298 V 5.59x59 Structure Structure
TM5 299 R 5.60x60 Structure Structure
TM5 300 I 5.61x61 Structure Structure
TM5 301 L 5.62x62 Structure Structure
TM5 302 Q 5.63x63 Structure Structure
TM5 303 R 5.64x64 Structure Structure
TM5 304 M 5.65x65 Structure Structure
ICL3 305 T - Structure Structure
ICL3 306 S - Structure Structure
ICL3 307 S - Structure Structure
ICL3 308 V - Structure Structure
ICL3 309 A - Structure Structure
ICL3 310 P - Structure Structure
ICL3 311 A - Structure Structure
ICL3 312 S - Structure Structure
TM6 313 Q 6.23x23 Structure Structure
TM6 314 R 6.24x24 Structure Structure
TM6 315 S 6.25x25 Structure Structure
TM6 316 I 6.26x26 Structure Structure
TM6 317 R 6.27x27 Structure Structure
TM6 318 L 6.28x28 Structure Structure
TM6 319 R 6.29x29 Structure Structure
TM6 320 T 6.30x30 Structure Structure
TM6 321 K 6.31x31 Structure Structure
TM6 322 R 6.32x32 Structure Structure
TM6 323 V 6.33x33 Structure Structure
TM6 324 T 6.34x34 Structure Structure
TM6 325 R 6.35x35 Structure Structure
TM6 326 T 6.36x36 Structure Structure
TM6 327 A 6.37x37 Structure Structure
TM6 328 I 6.38x38 Structure Structure
TM6 329 A 6.39x39 Structure Structure
TM6 330 I 6.40x40 Structure Structure
TM6 331 C 6.41x41 Structure Structure
TM6 332 L 6.42x42 Structure Structure
TM6 333 V 6.43x43 Structure Structure
TM6 334 F 6.44x44 Structure Structure
TM6 335 F 6.45x45 Structure Structure
TM6 336 V 6.46x46 Structure Structure
TM6 337 C 6.47x47 Structure Structure
TM6 338 W 6.48x48 Structure Structure
TM6 339 A 6.49x49 Structure Structure
TM6 340 P 6.50x50 Structure Structure
TM6 341 Y 6.51x51 Structure Structure
TM6 342 Y 6.52x52 Structure Structure
TM6 343 V 6.53x53 Structure Structure
TM6 344 L 6.54x54 Structure Structure
TM6 345 Q 6.55x55 Structure Structure
TM6 346 L 6.56x56 Structure Structure
TM6 347 T 6.57x57 Structure Structure
TM6 348 Q 6.58x58 Structure Structure
TM6 349 L 6.59x59 Structure Structure
TM6 350 S 6.60x60 Structure Structure
TM6 351 I 6.61x61 Structure Structure
ECL3 352 S - Structure Structure
ECL3 353 R - Structure Structure
ECL3 354 P - Structure Structure
ECL3 355 T - Structure Structure
TM7 356 L 7.29x28 Structure Structure
TM7 357 T 7.30x29 Structure Structure
TM7 358 F 7.31x30 Structure Structure
TM7 359 V 7.32x31 Structure Structure
TM7 360 Y 7.33x32 Structure Structure
TM7 361 L 7.34x33 Structure Structure
TM7 362 Y 7.35x34 Structure Structure
TM7 363 N 7.36x35 Structure Structure
TM7 364 A 7.37x36 Structure Structure
TM7 365 A 7.38x37 Structure Structure
TM7 366 I 7.39x38 Structure Structure
TM7 367 S 7.40x39 Structure Structure
TM7 368 L 7.41x40 Structure Structure
TM7 369 G 7.42x41 Structure Structure
TM7 370 Y 7.43x42 Structure Structure
TM7 371 A 7.44x43 Structure Structure
TM7 372 N 7.45x45 Structure Structure
TM7 373 S 7.46x46 Structure Structure
TM7 374 C 7.47x47 Structure Structure
TM7 375 L 7.48x48 Structure Structure
TM7 376 N 7.49x49 Structure Structure
TM7 377 P 7.50x50 Structure Structure
TM7 378 F 7.51x51 Structure Structure
TM7 379 V 7.52x52 Structure Structure
TM7 380 Y 7.53x53 Structure Structure
TM7 381 I 7.54x54 Structure Structure
TM7 382 V 7.55x55 Structure Structure
TM7 383 L 7.56x56 Structure Structure
H8 384 C 8.47x47 Structure Structure
H8 385 E 8.48x48 Structure Structure
H8 386 T 8.49x49 Structure Structure
H8 387 F 8.50x50 Structure Structure
H8 388 R 8.51x51 Structure Structure
H8 389 K 8.52x52 Structure Structure
H8 390 R 8.53x53 Structure AF2
H8 391 L 8.54x54 Structure Structure
H8 392 V 8.55x55 Structure Structure
H8 393 L 8.56x56 Structure Structure
H8 394 S 8.57x57 AF2 AF2
H8 395 V 8.58x58 AF2 AF2
H8 396 K 8.59x59 AF2 AF2
C-term 397 P - AF2 AF2
C-term 398 A - AF2 AF2
C-term 399 A - AF2 AF2
C-term 400 Q - AF2 AF2
C-term 401 G - AF2 AF2
C-term 402 Q - AF2 AF2
C-term 403 L - AF2 AF2
C-term 404 R - AF2 AF2
C-term 405 A - AF2 AF2
C-term 406 V - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic H8 E 385 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 E 385 8x48 G.H5 F 354 G.H5.26
Polar ICL3 S 306 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 S 306 - G.H5 D 337 G.H5.09
Hydrophobic TM4 K 225 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 K 225 4x38 G.hns1 R 32 G.hns1.03
Ionic H8 E 385 8x48 G.H5 K 349 G.H5.21
Polar H8 E 385 8x48 G.H5 K 349 G.H5.21
Polar TM6 S 315 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 R 319 6x29 G.H5 L 348 G.H5.20
Van-der-waals ICL3 T 305 - G.H5 D 341 G.H5.13
Hydrophobic TM6 V 323 6x33 G.H5 L 348 G.H5.20
Polar TM6 S 315 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 S 315 6x25 G.h4s6 D 315 G.h4s6.09
Ionic TM6 R 314 6x24 G.h4s6 D 315 G.h4s6.09
Polar TM6 R 314 6x24 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 L 318 6x28 G.H5 F 354 G.H5.26
Hydrophobic ICL2 I 218 34x51 G.H5 F 336 G.H5.08
Polar N-term Q 49 - G.HN S 6 G.HN.30
Hydrophobic ICL3 P 310 - G.H5 D 341 G.H5.13
Polar TM6 Q 313 6x23 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 Q 313 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic N-term V 53 - G.HN L 5 G.HN.11
Hydrophobic TM6 R 322 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 322 6x32 G.H5 F 354 G.H5.26
Polar ICL2 T 221 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 221 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 221 34x54 G.hns1 R 32 G.hns1.03
Polar H8 C 384 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 C 384 8x47 G.H5 G 352 G.H5.24
Hydrophobic N-term W 52 - G.HN L 5 G.HN.11
Van-der-waals N-term W 52 - G.HN L 5 G.HN.11
Hydrophobic ICL3 P 310 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 P 310 - G.S6 Y 320 G.S6.02
Hydrophobic TM3 R 210 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 210 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL3 A 309 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 P 217 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 217 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 217 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 S 315 6x25 G.h4s6 T 316 G.h4s6.10
Ionic TM6 R 319 6x29 G.H5 D 341 G.H5.13
Polar TM6 R 319 6x29 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 319 6x29 G.H5 D 341 G.H5.13
Hydrophobic TM2 P 147 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 P 147 2x39 G.H5 C 351 G.H5.23
Hydrophobic N-term A 51 - G.HN L 5 G.HN.11
Van-der-waals N-term A 51 - G.HN L 5 G.HN.11
Hydrophobic N-term P 48 - G.HN V 13 G.HN.37
Hydrophobic ICL2 I 218 34x51 G.S3 L 194 G.S3.01
Polar TM6 S 315 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 315 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 S 315 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 S 306 - G.H5 T 340 G.H5.12
Hydrophobic ICL3 S 306 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 S 306 - G.H5 D 341 G.H5.13
Hydrophobic N-term P 48 - G.HN D 9 G.HN.33
Van-der-waals N-term P 48 - G.HN D 9 G.HN.33
Hydrophobic TM6 I 316 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 I 316 6x26 G.h4s6 E 318 G.h4s6.12
Polar N-term Q 49 - G.HN C 3 G.HN.09
Hydrophobic N-term Q 49 - G.HN C 3 G.HN.09
Van-der-waals N-term Q 49 - G.HN C 3 G.HN.09
Hydrophobic N-term C 33 - G.H2 K 209 G.H2.05
Hydrophobic ICL2 I 218 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM6 R 319 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 319 6x29 G.H5 K 345 G.H5.17
Polar TM6 T 326 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 326 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 326 6x36 G.H5 L 353 G.H5.25
Polar N-term W 52 - G.HN C 3 G.HN.09
Ionic TM4 K 225 4x38 G.HN E 28 G.HN.52
Polar TM4 K 225 4x38 G.HN E 28 G.HN.52
Aromatic TM6 R 319 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 319 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 319 6x29 G.H5 F 354 G.H5.26
Polar TM6 S 315 6x25 G.h4s6 K 317 G.h4s6.11
Hydrophobic TM6 S 315 6x25 G.h4s6 K 317 G.h4s6.11
Van-der-waals TM6 S 315 6x25 G.h4s6 K 317 G.h4s6.11
Hydrophobic N-term A 51 - G.HN S 6 G.HN.30
Hydrophobic TM3 T 214 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM3 T 214 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 T 214 3x54 G.H5 L 348 G.H5.20
Polar TM3 R 210 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 210 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 210 3x50 G.H5 C 351 G.H5.23
Polar N-term A 51 - G.HN K 10 G.HN.34
Hydrophobic N-term A 51 - G.HN K 10 G.HN.34
Van-der-waals N-term A 51 - G.HN K 10 G.HN.34
Hydrophobic TM5 I 300 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 M 304 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 V 323 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 323 6x33 G.H5 L 353 G.H5.25
Van-der-waals ICL2 P 217 34x50 G.H5 T 340 G.H5.12
Polar TM3 A 213 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 213 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 213 3x53 G.H5 N 347 G.H5.19