Refined structure (8XJN) of Gq - TP receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-11-27

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 199 from structure (55.4%), 160 from model (44.6%)
Residue sidechains - 103 from structure (28.7%), 256 from model (71.3%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 T G.HN.02 AF2 AF2
G.HN 3 L G.HN.03 AF2 AF2
G.HN 4 E G.HN.04 AF2 AF2
G.HN 5 S G.HN.05 AF2 AF2
G.HN 6 I G.HN.06 AF2 AF2
G.HN 7 M G.HN.07 AF2 AF2
G.HN 8 A G.HN.08 AF2 AF2
G.HN 9 C G.HN.09 AF2 AF2
G.HN 10 C G.HN.10 AF2 AF2
G.HN 11 L G.HN.11 Structure Structure
G.HN 12 S G.HN.30 Structure Structure
G.HN 13 E G.HN.31 Structure AF2
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 A G.HN.33 Structure AF2
G.HN 16 K G.HN.34 Structure Structure
G.HN 17 E G.HN.35 Structure AF2
G.HN 18 A G.HN.36 Structure Structure
G.HN 19 R G.HN.37 Structure AF2
G.HN 20 R G.HN.38 Structure AF2
G.HN 21 I G.HN.39 Structure AF2
G.HN 22 N G.HN.40 Structure AF2
G.HN 23 D G.HN.41 Structure AF2
G.HN 24 E G.HN.42 Structure AF2
G.HN 25 I G.HN.43 Structure Structure
G.HN 26 E G.HN.44 Structure Structure
G.HN 27 R G.HN.45 Structure AF2
G.HN 28 Q G.HN.46 Structure Structure
G.HN 29 L G.HN.47 Structure Structure
G.HN 30 R G.HN.48 Structure AF2
G.HN 31 R G.HN.49 Structure AF2
G.HN 32 D G.HN.50 Structure Structure
G.HN 33 K G.HN.51 Structure Structure
G.HN 34 R G.HN.52 Structure AF2
G.HN 35 D G.HN.53 Structure AF2
G.hns1 36 A G.hns1.01 Structure AF2
G.hns1 37 R G.hns1.02 Structure Structure
G.hns1 38 R G.hns1.03 Structure AF2
G.S1 39 E G.S1.01 Structure AF2
G.S1 40 L G.S1.02 Structure Structure
G.S1 41 K G.S1.03 Structure AF2
G.S1 42 L G.S1.04 Structure Structure
G.S1 43 L G.S1.05 Structure Structure
G.S1 44 L G.S1.06 Structure Structure
G.S1 45 L G.S1.07 Structure Structure
G.s1h1 46 G G.s1h1.01 Structure Structure
G.s1h1 47 T G.s1h1.02 Structure AF2
G.s1h1 48 G G.s1h1.03 Structure AF2
G.s1h1 49 E G.s1h1.04 Structure AF2
G.s1h1 50 S G.s1h1.05 Structure Structure
G.s1h1 51 G G.s1h1.06 Structure Structure
G.H1 52 K G.H1.01 Structure Structure
G.H1 53 S G.H1.02 Structure Structure
G.H1 54 T G.H1.03 Structure Structure
G.H1 55 F G.H1.04 Structure AF2
G.H1 56 I G.H1.05 Structure AF2
G.H1 57 K G.H1.06 Structure Structure
G.H1 58 Q G.H1.07 Structure Structure
G.H1 59 M G.H1.08 Structure Structure
G.H1 60 R G.H1.09 Structure Structure
G.H1 61 I G.H1.10 AF2 AF2
G.H1 62 I G.H1.11 AF2 AF2
G.H1 63 H G.H1.12 AF2 AF2
G.h1ha 64 G G.h1ha.01 AF2 AF2
G.h1ha 65 S G.h1ha.02 AF2 AF2
G.h1ha 66 G G.h1ha.03 AF2 AF2
G.h1ha 67 Y G.h1ha.04 AF2 AF2
G.h1ha 68 S G.h1ha.05 AF2 AF2
H.HA 69 D H.HA.01 AF2 AF2
H.HA 70 E H.HA.02 AF2 AF2
H.HA 71 D H.HA.03 AF2 AF2
H.HA 72 K H.HA.04 AF2 AF2
H.HA 73 R H.HA.05 AF2 AF2
H.HA 74 G H.HA.06 AF2 AF2
H.HA 75 F H.HA.07 AF2 AF2
H.HA 76 T H.HA.08 AF2 AF2
H.HA 77 K H.HA.09 AF2 AF2
H.HA 78 L H.HA.10 AF2 AF2
H.HA 79 V H.HA.11 AF2 AF2
H.HA 80 Y H.HA.12 AF2 AF2
H.HA 81 Q H.HA.13 AF2 AF2
H.HA 82 N H.HA.14 AF2 AF2
H.HA 83 I H.HA.15 AF2 AF2
H.HA 84 F H.HA.16 AF2 AF2
H.HA 85 T H.HA.17 AF2 AF2
H.HA 86 A H.HA.18 AF2 AF2
H.HA 87 M H.HA.19 AF2 AF2
H.HA 88 Q H.HA.20 AF2 AF2
H.HA 89 A H.HA.21 AF2 AF2
H.HA 90 M H.HA.22 AF2 AF2
H.HA 91 I H.HA.23 AF2 AF2
H.HA 92 R H.HA.24 AF2 AF2
H.HA 93 A H.HA.25 AF2 AF2
H.HA 94 M H.HA.26 AF2 AF2
H.HA 95 D H.HA.27 AF2 AF2
H.HA 96 T H.HA.28 AF2 AF2
H.HA 97 L H.HA.29 AF2 AF2
H.hahb 98 K H.hahb.01 AF2 AF2
H.hahb 99 I H.hahb.04 AF2 AF2
H.hahb 100 P H.hahb.05 AF2 AF2
H.hahb 101 Y H.hahb.06 AF2 AF2
H.hahb 102 K H.hahb.07 AF2 AF2
H.hahb 103 Y H.hahb.08 AF2 AF2
H.hahb 104 E H.hahb.09 AF2 AF2
H.HB 105 H H.HB.01 AF2 AF2
H.HB 106 N H.HB.02 AF2 AF2
H.HB 107 K H.HB.03 AF2 AF2
H.HB 108 A H.HB.04 AF2 AF2
H.HB 109 H H.HB.05 AF2 AF2
H.HB 110 A H.HB.06 AF2 AF2
H.HB 111 Q H.HB.07 AF2 AF2
H.HB 112 L H.HB.08 AF2 AF2
H.HB 113 V H.HB.09 AF2 AF2
H.HB 114 R H.HB.10 AF2 AF2
H.HB 115 E H.HB.11 AF2 AF2
H.HB 116 V H.HB.12 AF2 AF2
H.HB 117 D H.HB.13 AF2 AF2
H.HB 118 V H.HB.14 AF2 AF2
H.hbhc 119 E H.hbhc.01 AF2 AF2
H.hbhc 120 K H.hbhc.02 AF2 AF2
H.hbhc 121 V H.hbhc.03 AF2 AF2
H.hbhc 122 S H.hbhc.04 AF2 AF2
H.hbhc 123 A H.hbhc.05 AF2 AF2
H.hbhc 124 F H.hbhc.14 AF2 AF2
H.hbhc 125 E H.hbhc.15 AF2 AF2
H.HC 126 N H.HC.01 AF2 AF2
H.HC 127 P H.HC.02 AF2 AF2
H.HC 128 Y H.HC.03 AF2 AF2
H.HC 129 V H.HC.04 AF2 AF2
H.HC 130 D H.HC.05 AF2 AF2
H.HC 131 A H.HC.06 AF2 AF2
H.HC 132 I H.HC.07 AF2 AF2
H.HC 133 K H.HC.08 AF2 AF2
H.HC 134 S H.HC.09 AF2 AF2
H.HC 135 L H.HC.10 AF2 AF2
H.HC 136 W H.HC.11 AF2 AF2
H.HC 137 N H.HC.12 AF2 AF2
H.hchd 138 D H.hchd.01 AF2 AF2
H.HD 139 P H.HD.01 AF2 AF2
H.HD 140 G H.HD.02 AF2 AF2
H.HD 141 I H.HD.03 AF2 AF2
H.HD 142 Q H.HD.04 AF2 AF2
H.HD 143 E H.HD.05 AF2 AF2
H.HD 144 C H.HD.06 AF2 AF2
H.HD 145 Y H.HD.07 AF2 AF2
H.HD 146 D H.HD.08 AF2 AF2
H.HD 147 R H.HD.09 AF2 AF2
H.HD 148 R H.HD.10 AF2 AF2
H.HD 149 R H.HD.11 AF2 AF2
H.HD 150 E H.HD.12 AF2 AF2
H.hdhe 151 Y H.hdhe.01 AF2 AF2
H.hdhe 152 Q H.hdhe.02 AF2 AF2
H.hdhe 153 L H.hdhe.03 AF2 AF2
H.hdhe 154 S H.hdhe.04 AF2 AF2
H.hdhe 155 D H.hdhe.05 AF2 AF2
H.HE 156 S H.HE.01 AF2 AF2
H.HE 157 T H.HE.02 AF2 AF2
H.HE 158 K H.HE.03 AF2 AF2
H.HE 159 Y H.HE.04 AF2 AF2
H.HE 160 Y H.HE.05 AF2 AF2
H.HE 161 L H.HE.06 AF2 AF2
H.HE 162 N H.HE.07 AF2 AF2
H.HE 163 D H.HE.08 AF2 AF2
H.HE 164 L H.HE.09 AF2 AF2
H.HE 165 D H.HE.10 AF2 AF2
H.HE 166 R H.HE.11 AF2 AF2
H.HE 167 V H.HE.12 AF2 AF2
H.HE 168 A H.HE.13 AF2 AF2
H.hehf 169 D H.hehf.01 AF2 AF2
H.hehf 170 P H.hehf.02 AF2 AF2
H.hehf 171 A H.hehf.03 AF2 AF2
H.hehf 172 Y H.hehf.04 AF2 AF2
H.hehf 173 L H.hehf.05 AF2 AF2
H.hehf 174 P H.hehf.06 AF2 AF2
H.hehf 175 T H.hehf.07 AF2 AF2
H.HF 176 Q H.HF.01 AF2 AF2
H.HF 177 Q H.HF.02 AF2 AF2
H.HF 178 D H.HF.03 AF2 AF2
H.HF 179 V H.HF.04 AF2 AF2
H.HF 180 L H.HF.05 AF2 AF2
H.HF 181 R H.HF.06 AF2 AF2
G.hfs2 182 V G.hfs2.01 AF2 AF2
G.hfs2 183 R G.hfs2.02 AF2 AF2
G.hfs2 184 V G.hfs2.03 AF2 AF2
G.hfs2 185 P G.hfs2.04 AF2 AF2
G.hfs2 186 T G.hfs2.05 AF2 AF2
G.hfs2 187 T G.hfs2.06 AF2 AF2
G.hfs2 188 G G.hfs2.07 Structure Structure
G.S2 189 I G.S2.01 Structure Structure
G.S2 190 I G.S2.02 Structure AF2
G.S2 191 E G.S2.03 Structure Structure
G.S2 192 Y G.S2.04 Structure AF2
G.S2 193 P G.S2.05 Structure AF2
G.S2 194 F G.S2.06 Structure Structure
G.S2 195 D G.S2.07 Structure AF2
G.S2 196 L G.S2.08 Structure AF2
G.s2s3 197 Q G.s2s3.01 Structure AF2
G.s2s3 198 S G.s2s3.02 Structure AF2
G.S3 199 V G.S3.01 Structure Structure
G.S3 200 I G.S3.02 Structure AF2
G.S3 201 F G.S3.03 Structure Structure
G.S3 202 R G.S3.04 Structure AF2
G.S3 203 M G.S3.05 Structure Structure
G.S3 204 V G.S3.06 Structure AF2
G.S3 205 D G.S3.07 Structure Structure
G.S3 206 V G.S3.08 Structure Structure
G.s3h2 207 G G.s3h2.01 Structure Structure
G.s3h2 208 G G.s3h2.02 AF2 AF2
G.s3h2 209 Q G.s3h2.03 AF2 AF2
G.H2 210 R G.H2.01 AF2 AF2
G.H2 211 S G.H2.02 AF2 AF2
G.H2 212 E G.H2.03 AF2 AF2
G.H2 213 R G.H2.04 Structure Structure
G.H2 214 R G.H2.05 Structure Structure
G.H2 215 K G.H2.06 Structure Structure
G.H2 216 W G.H2.07 Structure Structure
G.H2 217 I G.H2.08 Structure Structure
G.H2 218 H G.H2.09 Structure AF2
G.H2 219 C G.H2.10 Structure Structure
G.h2s4 220 F G.h2s4.01 Structure Structure
G.h2s4 221 E G.h2s4.02 Structure AF2
G.h2s4 222 N G.h2s4.03 Structure AF2
G.h2s4 223 V G.h2s4.04 Structure Structure
G.h2s4 224 T G.h2s4.05 Structure Structure
G.S4 225 S G.S4.01 Structure AF2
G.S4 226 I G.S4.02 Structure Structure
G.S4 227 M G.S4.03 Structure AF2
G.S4 228 F G.S4.04 Structure Structure
G.S4 229 L G.S4.05 Structure AF2
G.S4 230 V G.S4.06 Structure Structure
G.S4 231 A G.S4.07 Structure AF2
G.s4h3 232 L G.s4h3.01 Structure AF2
G.s4h3 233 S G.s4h3.02 Structure Structure
G.s4h3 234 E G.s4h3.03 Structure AF2
G.s4h3 235 Y G.s4h3.04 Structure Structure
G.s4h3 236 D G.s4h3.05 Structure AF2
G.s4h3 237 Q G.s4h3.06 AF2 AF2
G.s4h3 238 V G.s4h3.07 AF2 AF2
G.s4h3 239 L G.s4h3.08 AF2 AF2
G.s4h3 240 V G.s4h3.09 AF2 AF2
G.s4h3 241 E G.s4h3.10 AF2 AF2
G.s4h3 242 S G.s4h3.11 AF2 AF2
G.s4h3 243 D G.s4h3.12 AF2 AF2
G.s4h3 244 N G.s4h3.13 AF2 AF2
G.s4h3 245 E G.s4h3.14 AF2 AF2
G.s4h3 246 N G.s4h3.15 AF2 AF2
G.H3 247 R G.H3.01 Structure Structure
G.H3 248 M G.H3.02 Structure AF2
G.H3 249 E G.H3.03 Structure AF2
G.H3 250 E G.H3.04 Structure Structure
G.H3 251 S G.H3.05 Structure AF2
G.H3 252 K G.H3.06 Structure AF2
G.H3 253 A G.H3.07 Structure AF2
G.H3 254 L G.H3.08 Structure AF2
G.H3 255 F G.H3.09 Structure Structure
G.H3 256 R G.H3.10 Structure AF2
G.H3 257 T G.H3.11 Structure AF2
G.H3 258 I G.H3.12 Structure Structure
G.H3 259 I G.H3.13 Structure AF2
G.H3 260 T G.H3.14 Structure AF2
G.H3 261 Y G.H3.15 Structure AF2
G.H3 262 P G.H3.16 Structure AF2
G.H3 263 W G.H3.17 Structure Structure
G.H3 264 F G.H3.18 Structure AF2
G.h3s5 265 Q G.h3s5.01 Structure AF2
G.h3s5 266 N G.h3s5.02 Structure AF2
G.h3s5 267 S G.h3s5.03 Structure AF2
G.S5 268 S G.S5.01 Structure Structure
G.S5 269 V G.S5.02 Structure Structure
G.S5 270 I G.S5.03 Structure Structure
G.S5 271 L G.S5.04 Structure Structure
G.S5 272 F G.S5.05 Structure Structure
G.S5 273 L G.S5.06 Structure Structure
G.S5 274 N G.S5.07 Structure Structure
G.s5hg 275 K G.s5hg.01 Structure Structure
G.HG 276 K G.HG.01 Structure AF2
G.HG 277 D G.HG.02 Structure Structure
G.HG 278 L G.HG.03 Structure Structure
G.HG 279 L G.HG.04 Structure Structure
G.HG 280 E G.HG.05 Structure AF2
G.HG 281 E G.HG.06 Structure Structure
G.HG 282 K G.HG.07 Structure Structure
G.HG 283 I G.HG.08 Structure AF2
G.HG 284 M G.HG.09 Structure AF2
G.HG 285 Y G.HG.12 Structure AF2
G.HG 286 S G.HG.13 Structure Structure
G.HG 287 H G.HG.14 Structure AF2
G.HG 288 L G.HG.15 Structure AF2
G.HG 289 V G.HG.16 Structure AF2
G.HG 290 D G.HG.17 Structure Structure
G.hgh4 291 Y G.hgh4.01 AF2 AF2
G.hgh4 292 F G.hgh4.02 AF2 AF2
G.hgh4 293 P G.hgh4.03 AF2 AF2
G.hgh4 294 E G.hgh4.04 AF2 AF2
G.hgh4 295 Y G.hgh4.05 AF2 AF2
G.hgh4 296 D G.hgh4.06 AF2 AF2
G.hgh4 297 G G.hgh4.07 AF2 AF2
G.hgh4 298 P G.hgh4.08 AF2 AF2
G.H4 299 Q G.H4.01 Structure AF2
G.H4 300 R G.H4.02 Structure AF2
G.H4 301 D G.H4.03 Structure AF2
G.H4 302 A G.H4.04 Structure AF2
G.H4 303 Q G.H4.05 Structure AF2
G.H4 304 A G.H4.06 Structure AF2
G.H4 305 A G.H4.07 Structure Structure
G.H4 306 R G.H4.08 Structure AF2
G.H4 307 E G.H4.09 Structure AF2
G.H4 308 F G.H4.10 Structure Structure
G.H4 309 I G.H4.11 Structure Structure
G.H4 310 L G.H4.12 Structure AF2
G.H4 311 K G.H4.13 Structure Structure
G.H4 312 M G.H4.14 Structure AF2
G.H4 313 F G.H4.15 Structure Structure
G.H4 314 V G.H4.16 Structure Structure
G.H4 315 D G.H4.17 Structure Structure
G.h4s6 316 L G.h4s6.01 Structure AF2
G.h4s6 317 N G.h4s6.08 Structure AF2
G.h4s6 318 P G.h4s6.09 Structure AF2
G.h4s6 319 D G.h4s6.10 Structure Structure
G.h4s6 320 S G.h4s6.11 Structure AF2
G.h4s6 321 D G.h4s6.12 Structure AF2
G.h4s6 322 K G.h4s6.13 Structure AF2
G.h4s6 323 I G.h4s6.20 Structure Structure
G.S6 324 I G.S6.01 Structure AF2
G.S6 325 Y G.S6.02 Structure Structure
G.S6 326 S G.S6.03 Structure AF2
G.S6 327 H G.S6.04 Structure Structure
G.S6 328 F G.S6.05 Structure Structure
G.s6h5 329 T G.s6h5.01 Structure Structure
G.s6h5 330 C G.s6h5.02 Structure Structure
G.s6h5 331 A G.s6h5.03 Structure AF2
G.s6h5 332 T G.s6h5.04 Structure AF2
G.s6h5 333 D G.s6h5.05 Structure Structure
G.H5 334 T G.H5.01 Structure Structure
G.H5 335 E G.H5.02 Structure Structure
G.H5 336 N G.H5.03 Structure Structure
G.H5 337 I G.H5.04 Structure AF2
G.H5 338 R G.H5.05 Structure Structure
G.H5 339 F G.H5.06 Structure AF2
G.H5 340 V G.H5.07 Structure AF2
G.H5 341 F G.H5.08 Structure Structure
G.H5 342 A G.H5.09 Structure AF2
G.H5 343 A G.H5.10 Structure AF2
G.H5 344 V G.H5.11 Structure AF2
G.H5 345 K G.H5.12 Structure Structure
G.H5 346 D G.H5.13 Structure Structure
G.H5 347 T G.H5.14 Structure AF2
G.H5 348 I G.H5.15 Structure Structure
G.H5 349 L G.H5.16 Structure Structure
G.H5 350 Q G.H5.17 Structure Structure
G.H5 351 L G.H5.18 Structure AF2
G.H5 352 N G.H5.19 Structure Structure
G.H5 353 L G.H5.20 Structure Structure
G.H5 354 K G.H5.21 Structure AF2
G.H5 355 E G.H5.22 Structure Structure
G.H5 356 Y G.H5.23 Structure Structure
G.H5 357 N G.H5.24 Structure Structure
G.H5 358 L G.H5.25 Structure Structure
G.H5 359 V G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 310 from structure (90.9%), 31 from model (9.1%)
Residue sidechains - 281 from structure (82.4%), 60 from model (17.6%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 W - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 N - AF2 AF2
N-term 5 G - AF2 AF2
N-term 6 S - AF2 AF2
N-term 7 S - AF2 AF2
N-term 8 L - AF2 AF2
N-term 9 G - AF2 AF2
N-term 10 P - AF2 AF2
N-term 11 C - Structure Structure
N-term 12 F - Structure AF2
N-term 13 R - Structure AF2
N-term 14 P - Structure Structure
N-term 15 T - Structure AF2
N-term 16 N - Structure AF2
N-term 17 I - Structure AF2
N-term 18 T - Structure AF2
N-term 19 L - Structure AF2
N-term 20 E - Structure AF2
N-term 21 E - Structure AF2
N-term 22 R - Structure AF2
N-term 23 R - Structure AF2
N-term 24 L - Structure AF2
N-term 25 I - Structure AF2
N-term 26 A - Structure Structure
TM1 27 S 1.35x35 Structure Structure
TM1 28 P 1.36x36 Structure Structure
TM1 29 W 1.37x37 Structure Structure
TM1 30 F 1.38x38 Structure Structure
TM1 31 A 1.39x39 Structure Structure
TM1 32 A 1.40x40 Structure Structure
TM1 33 S 1.41x41 Structure Structure
TM1 34 F 1.42x42 Structure Structure
TM1 35 C 1.43x43 Structure Structure
TM1 36 V 1.44x44 Structure Structure
TM1 37 V 1.45x45 Structure Structure
TM1 38 G 1.46x46 Structure Structure
TM1 39 L 1.47x47 Structure Structure
TM1 40 A 1.48x48 Structure Structure
TM1 41 S 1.49x49 Structure Structure
TM1 42 N 1.50x50 Structure Structure
TM1 43 L 1.51x51 Structure Structure
TM1 44 L 1.52x52 Structure Structure
TM1 45 A 1.53x53 Structure Structure
TM1 46 L 1.54x54 Structure Structure
TM1 47 S 1.55x55 Structure Structure
TM1 48 V 1.56x56 Structure Structure
TM1 49 L 1.57x57 Structure Structure
TM1 50 A 1.58x58 Structure Structure
TM1 51 G 1.59x59 Structure Structure
TM1 52 A 1.60x60 Structure Structure
TM1 53 R 1.61x61 Structure Structure
TM1 54 Q 1.62x62 Structure AF2
ICL1 55 G - Structure Structure
ICL1 56 G - Structure Structure
ICL1 57 S - Structure Structure
ICL1 58 H - Structure Structure
ICL1 59 T - Structure Structure
ICL1 60 R - Structure Structure
TM2 61 S 2.37x37 Structure Structure
TM2 62 S 2.38x38 Structure Structure
TM2 63 F 2.39x39 Structure Structure
TM2 64 L 2.40x40 Structure Structure
TM2 65 T 2.41x41 Structure Structure
TM2 66 F 2.42x42 Structure Structure
TM2 67 L 2.43x43 Structure Structure
TM2 68 C 2.44x44 Structure Structure
TM2 69 G 2.45x45 Structure Structure
TM2 70 L 2.46x46 Structure Structure
TM2 71 V 2.47x47 Structure Structure
TM2 72 L 2.48x48 Structure Structure
TM2 73 T 2.49x49 Structure Structure
TM2 74 D 2.50x50 Structure Structure
TM2 75 F 2.51x51 Structure Structure
TM2 76 L 2.52x52 Structure Structure
TM2 77 G 2.53x53 Structure Structure
TM2 78 L 2.54x54 Structure Structure
TM2 79 L 2.55x55 Structure Structure
TM2 80 V 2.56x56 Structure Structure
TM2 81 T 2.57x57 Structure Structure
TM2 82 G 2.58x58 Structure Structure
TM2 83 T 2.59x59 Structure Structure
TM2 84 I 2.60x60 Structure Structure
TM2 85 V 2.61x61 Structure Structure
TM2 86 V 2.62x62 Structure Structure
TM2 87 S 2.63x63 Structure Structure
TM2 88 Q 2.64x64 Structure Structure
TM2 89 H 2.65x65 Structure Structure
TM2 90 A 2.66x66 Structure Structure
TM2 91 A 2.67x67 Structure Structure
ECL1 92 L - Structure AF2
ECL1 93 F - Structure AF2
ECL1 94 E 23.49x49 Structure AF2
ECL1 95 W 23.50x50 Structure Structure
ECL1 96 H 23.51x501 Structure AF2
ECL1 97 A 23.52x51 Structure Structure
ECL1 98 V 23.53x52 Structure AF2
ECL1 99 D - Structure AF2
ECL1 100 P - Structure Structure
ECL1 101 G - Structure Structure
TM3 102 C 3.22x22 Structure Structure
TM3 103 R 3.23x23 Structure Structure
TM3 104 L 3.24x24 Structure Structure
TM3 105 C 3.25x25 Structure Structure
TM3 106 R 3.26x26 Structure Structure
TM3 107 F 3.27x27 Structure Structure
TM3 108 M 3.28x28 Structure Structure
TM3 109 G 3.29x29 Structure Structure
TM3 110 V 3.30x30 Structure Structure
TM3 111 V 3.31x31 Structure Structure
TM3 112 M 3.32x32 Structure Structure
TM3 113 I 3.33x33 Structure Structure
TM3 114 F 3.34x34 Structure Structure
TM3 115 F 3.35x35 Structure Structure
TM3 116 G 3.36x36 Structure Structure
TM3 117 L 3.37x37 Structure Structure
TM3 118 S 3.38x38 Structure Structure
TM3 119 P 3.39x39 Structure Structure
TM3 120 L 3.40x40 Structure Structure
TM3 121 L 3.41x41 Structure Structure
TM3 122 L 3.42x42 Structure Structure
TM3 123 G 3.43x43 Structure Structure
TM3 124 A 3.44x44 Structure Structure
TM3 125 A 3.45x45 Structure Structure
TM3 126 M 3.46x46 Structure Structure
TM3 127 A 3.47x47 Structure Structure
TM3 128 S 3.48x48 Structure Structure
TM3 129 E 3.49x49 Structure Structure
TM3 130 R 3.50x50 Structure Structure
TM3 131 Y 3.51x51 Structure Structure
TM3 132 L 3.52x52 Structure Structure
TM3 133 G 3.53x53 Structure Structure
TM3 134 I 3.54x54 Structure Structure
TM3 135 T 3.55x55 Structure Structure
TM3 136 R 3.56x56 Structure Structure
ICL2 137 P 34.50x50 Structure Structure
ICL2 138 F 34.51x51 Structure Structure
ICL2 139 S 34.52x52 Structure Structure
ICL2 140 R 34.53x53 Structure Structure
ICL2 141 P 34.54x54 Structure Structure
ICL2 142 A 34.55x55 Structure Structure
ICL2 143 V 34.56x56 Structure Structure
ICL2 144 A 34.57x57 Structure Structure
TM4 145 S 4.38x38 Structure Structure
TM4 146 Q 4.39x39 Structure Structure
TM4 147 R 4.40x40 Structure AF2
TM4 148 R 4.41x41 Structure AF2
TM4 149 A 4.42x42 Structure Structure
TM4 150 W 4.43x43 Structure Structure
TM4 151 A 4.44x44 Structure Structure
TM4 152 T 4.45x45 Structure Structure
TM4 153 V 4.46x46 Structure Structure
TM4 154 G 4.47x47 Structure Structure
TM4 155 L 4.48x48 Structure Structure
TM4 156 V 4.49x49 Structure Structure
TM4 157 W 4.50x50 Structure Structure
TM4 158 A 4.51x51 Structure Structure
TM4 159 A 4.52x52 Structure Structure
TM4 160 A 4.53x53 Structure Structure
TM4 161 L 4.54x54 Structure Structure
TM4 162 A 4.55x55 Structure Structure
TM4 163 L 4.56x56 Structure Structure
TM4 164 G 4.57x57 Structure Structure
TM4 165 L 4.58x58 Structure Structure
TM4 166 L 4.59x59 Structure Structure
TM4 167 P 4.60x60 Structure Structure
TM4 168 L 4.61x61 Structure Structure
TM4 169 L 4.62x62 Structure Structure
TM4 170 G 4.63x63 Structure Structure
ECL2 171 V - Structure Structure
ECL2 172 G - Structure Structure
ECL2 173 R - Structure Structure
ECL2 174 Y - Structure Structure
ECL2 175 T - Structure Structure
ECL2 176 V - Structure Structure
ECL2 177 Q - Structure Structure
ECL2 178 Y - Structure Structure
ECL2 179 P - Structure Structure
ECL2 180 G - Structure Structure
ECL2 181 S - Structure Structure
ECL2 182 W - Structure Structure
ECL2 183 C 45.50x50 Structure Structure
ECL2 184 F 45.51x51 Structure Structure
ECL2 185 L 45.52x52 Structure Structure
ECL2 186 T - Structure Structure
ECL2 187 L - Structure Structure
ECL2 188 G - Structure Structure
ECL2 189 A - Structure Structure
TM5 190 E 5.33x33 Structure Structure
TM5 191 S 5.34x34 Structure Structure
TM5 192 G 5.35x35 Structure Structure
TM5 193 D 5.36x36 Structure Structure
TM5 194 V 5.37x37 Structure Structure
TM5 195 A 5.38x38 Structure Structure
TM5 196 F 5.39x39 Structure Structure
TM5 197 G 5.40x40 Structure Structure
TM5 198 L 5.41x41 Structure Structure
TM5 199 L 5.42x42 Structure Structure
TM5 200 F 5.43x43 Structure Structure
TM5 201 S 5.44x44 Structure Structure
TM5 202 M 5.45x45 Structure Structure
TM5 203 L 5.46x46 Structure Structure
TM5 204 G 5.47x47 Structure Structure
TM5 205 G 5.48x48 Structure Structure
TM5 206 L 5.49x49 Structure Structure
TM5 207 S 5.50x50 Structure Structure
TM5 208 V 5.51x51 Structure Structure
TM5 209 G 5.52x52 Structure Structure
TM5 210 L 5.53x53 Structure Structure
TM5 211 S 5.54x54 Structure Structure
TM5 212 F 5.55x55 Structure Structure
TM5 213 L 5.56x56 Structure Structure
TM5 214 L 5.57x57 Structure Structure
TM5 215 N 5.58x58 Structure Structure
TM5 216 T 5.59x59 Structure Structure
TM5 217 V 5.60x60 Structure Structure
TM5 218 S 5.61x61 Structure Structure
TM5 219 V 5.62x62 Structure Structure
TM5 220 A 5.63x63 Structure Structure
TM5 221 T 5.64x64 Structure Structure
TM5 222 L 5.65x65 Structure Structure
TM5 223 C 5.66x66 Structure Structure
TM5 224 H 5.67x67 Structure Structure
TM5 225 V 5.68x68 Structure Structure
TM5 226 Y 5.69x69 Structure Structure
TM5 227 H 5.70x70 Structure Structure
TM5 228 G 5.71x71 Structure Structure
TM5 229 Q 5.72x72 Structure AF2
ICL3 230 E - Structure AF2
ICL3 231 A - Structure Structure
ICL3 232 A - Structure Structure
ICL3 233 Q - Structure AF2
TM6 234 Q 6.24x24 Structure AF2
TM6 235 R 6.25x25 Structure Structure
TM6 236 P 6.26x26 Structure Structure
TM6 237 R 6.27x27 Structure Structure
TM6 238 D 6.28x28 Structure Structure
TM6 239 S 6.29x29 Structure Structure
TM6 240 E 6.30x30 Structure Structure
TM6 241 V 6.31x31 Structure Structure
TM6 242 E 6.32x32 Structure Structure
TM6 243 M 6.33x33 Structure Structure
TM6 244 M 6.34x34 Structure Structure
TM6 245 A 6.35x35 Structure Structure
TM6 246 Q 6.36x36 Structure Structure
TM6 247 L 6.37x37 Structure Structure
TM6 248 L 6.38x38 Structure Structure
TM6 249 G 6.39x39 Structure Structure
TM6 250 I 6.40x40 Structure Structure
TM6 251 M 6.41x41 Structure Structure
TM6 252 V 6.42x42 Structure Structure
TM6 253 V 6.43x43 Structure Structure
TM6 254 A 6.44x44 Structure Structure
TM6 255 S 6.45x45 Structure Structure
TM6 256 V 6.46x46 Structure Structure
TM6 257 C 6.47x47 Structure Structure
TM6 258 W 6.48x48 Structure Structure
TM6 259 L 6.49x49 Structure Structure
TM6 260 P 6.50x50 Structure Structure
TM6 261 L 6.51x51 Structure Structure
TM6 262 L 6.52x52 Structure Structure
TM6 263 V 6.53x53 Structure Structure
TM6 264 F 6.54x54 Structure Structure
TM6 265 I 6.55x55 Structure Structure
TM6 266 A 6.56x56 Structure Structure
TM6 267 Q 6.57x57 Structure Structure
TM6 268 T 6.58x58 Structure Structure
TM6 269 V 6.59x59 Structure Structure
TM6 270 L 6.60x60 Structure Structure
TM6 271 R 6.61x61 Structure Structure
ECL3 272 N - Structure Structure
ECL3 273 P - Structure Structure
ECL3 274 P - Structure Structure
ECL3 275 A - Structure Structure
ECL3 276 M - Structure Structure
ECL3 277 S - Structure Structure
ECL3 278 P - Structure Structure
ECL3 279 A - Structure Structure
ECL3 280 G - Structure Structure
ECL3 281 Q - Structure AF2
ECL3 282 L - Structure Structure
TM7 283 S 7.28x27 Structure Structure
TM7 284 R 7.29x28 Structure Structure
TM7 285 T 7.30x29 Structure Structure
TM7 286 T 7.31x30 Structure Structure
TM7 287 E 7.32x31 Structure Structure
TM7 288 K 7.33x32 Structure Structure
TM7 289 E 7.34x33 Structure Structure
TM7 290 L 7.35x34 Structure Structure
TM7 291 L 7.36x35 Structure Structure
TM7 292 I 7.37x36 Structure Structure
TM7 293 Y 7.38x37 Structure Structure
TM7 294 L 7.39x38 Structure Structure
TM7 295 R 7.40x39 Structure Structure
TM7 296 V 7.41x40 Structure Structure
TM7 297 A 7.42x41 Structure Structure
TM7 298 T 7.43x42 Structure Structure
TM7 299 W 7.44x43 Structure Structure
TM7 300 N 7.45x45 Structure Structure
TM7 301 Q 7.46x46 Structure Structure
TM7 302 I 7.47x47 Structure Structure
TM7 303 L 7.48x48 Structure Structure
TM7 304 D 7.49x49 Structure Structure
TM7 305 P 7.50x50 Structure Structure
TM7 306 W 7.51x51 Structure Structure
TM7 307 V 7.52x52 Structure Structure
TM7 308 Y 7.53x53 Structure Structure
TM7 309 I 7.54x54 Structure Structure
TM7 310 L 7.55x55 Structure Structure
TM7 311 F 7.56x56 Structure Structure
H8 312 R 8.47x47 Structure Structure
H8 313 R 8.48x48 Structure AF2
H8 314 A 8.49x49 Structure Structure
H8 315 V 8.50x50 Structure Structure
H8 316 L 8.51x51 Structure Structure
H8 317 R 8.52x52 Structure AF2
H8 318 R 8.53x53 Structure Structure
H8 319 L 8.54x54 Structure Structure
H8 320 Q 8.55x55 Structure Structure
H8 321 P 8.56x56 AF2 AF2
H8 322 R 8.57x57 AF2 AF2
H8 323 L 8.58x58 AF2 AF2
H8 324 S 8.59x59 AF2 AF2
H8 325 T 8.60x60 AF2 AF2
H8 326 R 8.61x61 AF2 AF2
H8 327 P 8.62x62 AF2 AF2
H8 328 R 8.63x63 AF2 AF2
H8 329 S 8.64x64 AF2 AF2
H8 330 L 8.65x65 AF2 AF2
H8 331 S 8.66x66 AF2 AF2
C-term 332 L - AF2 AF2
C-term 333 Q - AF2 AF2
C-term 334 P - AF2 AF2
C-term 335 Q - AF2 AF2
C-term 336 L - AF2 AF2
C-term 337 T - AF2 AF2
C-term 338 Q - AF2 AF2
C-term 339 R - AF2 AF2
C-term 340 S - AF2 AF2
C-term 341 G - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL1 H 58 - G.H5 L 358 G.H5.25
Hydrophobic ICL1 R 60 - G.H5 E 355 G.H5.22
Van-der-waals ICL1 R 60 - G.H5 E 355 G.H5.22
Hydrophobic H8 A 314 8x49 G.H5 L 358 G.H5.25
Hydrophobic ICL2 F 138 34x51 G.S3 V 199 G.S3.01
Van-der-waals ICL2 F 138 34x51 G.S3 V 199 G.S3.01
Hydrophobic TM2 S 61 2x37 G.H5 E 355 G.H5.22
Van-der-waals TM2 S 61 2x37 G.H5 E 355 G.H5.22
Hydrophobic C-term L 332 - G.H4 D 315 G.H4.17
Aromatic TM2 F 63 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM2 F 63 2x39 G.H5 Y 356 G.H5.23
Van-der-waals ICL1 S 57 - G.H5 E 355 G.H5.22
Polar TM6 S 239 6x29 G.H5 N 357 G.H5.24
Polar H8 R 328 8x63 G.h4s6 S 320 G.h4s6.11
Hydrophobic H8 R 328 8x63 G.h4s6 S 320 G.h4s6.11
Van-der-waals H8 R 328 8x63 G.h4s6 S 320 G.h4s6.11
Hydrophobic ICL2 V 143 34x56 G.HN K 33 G.HN.51
Polar ICL1 T 59 - G.H5 E 355 G.H5.22
Hydrophobic TM3 I 134 3x54 G.H5 L 349 G.H5.16
Polar TM6 E 240 6x30 G.H5 Q 350 G.H5.17
Polar H8 R 318 8x53 G.H5 V 359 G.H5.26
Hydrophobic TM6 R 235 6x25 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM6 R 235 6x25 G.h4s6 I 323 G.h4s6.20
Hydrophobic TM6 E 242 6x32 G.H5 N 357 G.H5.24
Ionic ICL1 H 58 - G.H5 E 355 G.H5.22
Hydrophobic ICL1 H 58 - G.H5 E 355 G.H5.22
Van-der-waals ICL1 H 58 - G.H5 E 355 G.H5.22
Hydrophobic ICL2 V 143 34x56 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 V 143 34x56 G.hns1 R 37 G.hns1.02
Polar TM6 Q 246 6x36 G.H5 Y 356 G.H5.23
Polar TM3 E 129 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 E 129 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 E 129 3x49 G.H5 Y 356 G.H5.23
Polar TM6 S 239 6x29 G.H5 Q 350 G.H5.17
Van-der-waals ICL1 H 58 - G.H5 V 359 G.H5.26
Hydrophobic H8 A 314 8x49 G.H5 V 359 G.H5.26
Van-der-waals H8 A 314 8x49 G.H5 V 359 G.H5.26
Ionic H8 R 328 8x63 G.h4s6 D 319 G.h4s6.10
Polar H8 R 328 8x63 G.h4s6 D 319 G.h4s6.10
Hydrophobic H8 R 328 8x63 G.h4s6 D 319 G.h4s6.10
Van-der-waals H8 R 328 8x63 G.h4s6 D 319 G.h4s6.10
Hydrophobic ICL1 R 60 - G.H5 L 351 G.H5.18
Hydrophobic TM7 I 309 7x54 G.H5 L 358 G.H5.25
Hydrophobic TM3 I 134 3x54 G.H5 Y 356 G.H5.23
Polar TM3 G 133 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 G 133 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 G 133 3x53 G.H5 N 352 G.H5.19
Hydrophobic C-term R 339 - G.H4 R 300 G.H4.02
Van-der-waals C-term R 339 - G.H4 R 300 G.H4.02
Polar H8 R 318 8x53 G.H5 L 358 G.H5.25
Van-der-waals H8 R 318 8x53 G.H5 L 358 G.H5.25
Hydrophobic TM2 F 63 2x39 G.H5 L 358 G.H5.25
Hydrophobic TM6 E 240 6x30 G.H5 L 353 G.H5.20
Van-der-waals TM6 E 240 6x30 G.H5 L 353 G.H5.20
Hydrophobic TM6 M 243 6x33 G.H5 Y 356 G.H5.23
Van-der-waals TM6 M 243 6x33 G.H5 Y 356 G.H5.23
Hydrophobic H8 R 312 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 R 312 8x47 G.H5 N 357 G.H5.24
Hydrophobic TM2 S 61 2x37 G.H5 Y 356 G.H5.23
Van-der-waals TM2 S 61 2x37 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 F 138 34x51 G.H5 I 348 G.H5.15
Hydrophobic ICL2 P 137 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 137 34x50 G.H5 I 348 G.H5.15
Hydrophobic ICL2 F 138 34x51 G.H5 K 345 G.H5.12
Van-der-waals ICL2 F 138 34x51 G.H5 K 345 G.H5.12
Hydrophobic TM6 R 235 6x25 G.H5 Q 350 G.H5.17
Van-der-waals TM6 R 235 6x25 G.H5 Q 350 G.H5.17
Hydrophobic C-term L 332 - G.H4 V 314 G.H4.16
Hydrophobic ICL2 P 141 34x54 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 P 141 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic TM2 L 64 2x40 G.H5 L 358 G.H5.25
Hydrophobic ICL2 F 138 34x51 G.H5 V 344 G.H5.11
Ionic ICL3 E 230 - G.S6 H 327 G.S6.04
Polar ICL3 E 230 - G.S6 H 327 G.S6.04
Van-der-waals ICL1 R 60 - G.H5 N 352 G.H5.19
Polar ICL1 R 60 - G.H5 N 352 G.H5.19
Aromatic ICL2 F 138 34x51 G.H5 F 341 G.H5.08
Hydrophobic ICL2 F 138 34x51 G.H5 F 341 G.H5.08
Van-der-waals ICL2 F 138 34x51 G.H5 F 341 G.H5.08
Aromatic TM3 R 130 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 130 3x50 G.H5 Y 356 G.H5.23
Polar TM6 Q 234 6x24 G.S6 S 326 G.S6.03
Polar TM6 Q 246 6x36 G.H5 N 357 G.H5.24
Van-der-waals TM6 Q 246 6x36 G.H5 N 357 G.H5.24
Hydrophobic ICL2 F 138 34x51 G.S1 L 40 G.S1.02
Van-der-waals ICL2 F 138 34x51 G.S1 L 40 G.S1.02
Hydrophobic H8 V 315 8x50 G.H5 L 358 G.H5.25
Ionic TM6 R 235 6x25 G.H5 D 346 G.H5.13
Polar TM6 R 235 6x25 G.H5 D 346 G.H5.13
Hydrophobic TM6 R 235 6x25 G.H5 D 346 G.H5.13
Van-der-waals TM6 R 235 6x25 G.H5 D 346 G.H5.13
Hydrophobic TM6 M 243 6x33 G.H5 L 353 G.H5.20
Hydrophobic TM2 L 67 2x43 G.H5 L 358 G.H5.25
Hydrophobic ICL2 P 137 34x50 G.H5 L 349 G.H5.16
Hydrophobic TM6 M 243 6x33 G.H5 N 357 G.H5.24
Van-der-waals TM6 M 243 6x33 G.H5 N 357 G.H5.24
Hydrophobic TM3 I 134 3x54 G.H5 L 353 G.H5.20
Hydrophobic ICL2 P 137 34x50 G.H5 K 345 G.H5.12