Refined structure (8XOJ) of Gq - GPER

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-11-26

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 203 from structure (56.5%), 156 from model (43.5%)
Residue sidechains - 105 from structure (29.2%), 254 from model (70.8%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 T G.HN.02 AF2 AF2
G.HN 3 L G.HN.03 AF2 AF2
G.HN 4 E G.HN.04 AF2 AF2
G.HN 5 S G.HN.05 AF2 AF2
G.HN 6 I G.HN.06 AF2 AF2
G.HN 7 M G.HN.07 AF2 AF2
G.HN 8 A G.HN.08 AF2 AF2
G.HN 9 C G.HN.09 AF2 AF2
G.HN 10 C G.HN.10 AF2 AF2
G.HN 11 L G.HN.11 AF2 AF2
G.HN 12 S G.HN.30 AF2 AF2
G.HN 13 E G.HN.31 AF2 AF2
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 A G.HN.33 Structure AF2
G.HN 16 K G.HN.34 Structure Structure
G.HN 17 E G.HN.35 Structure AF2
G.HN 18 A G.HN.36 Structure Structure
G.HN 19 R G.HN.37 Structure AF2
G.HN 20 R G.HN.38 Structure AF2
G.HN 21 I G.HN.39 Structure AF2
G.HN 22 N G.HN.40 Structure AF2
G.HN 23 D G.HN.41 Structure AF2
G.HN 24 E G.HN.42 Structure AF2
G.HN 25 I G.HN.43 Structure Structure
G.HN 26 E G.HN.44 Structure Structure
G.HN 27 R G.HN.45 Structure AF2
G.HN 28 Q G.HN.46 Structure Structure
G.HN 29 L G.HN.47 Structure Structure
G.HN 30 R G.HN.48 Structure AF2
G.HN 31 R G.HN.49 Structure AF2
G.HN 32 D G.HN.50 Structure Structure
G.HN 33 K G.HN.51 Structure Structure
G.HN 34 R G.HN.52 Structure AF2
G.HN 35 D G.HN.53 Structure AF2
G.hns1 36 A G.hns1.01 Structure AF2
G.hns1 37 R G.hns1.02 Structure Structure
G.hns1 38 R G.hns1.03 Structure Structure
G.S1 39 E G.S1.01 Structure AF2
G.S1 40 L G.S1.02 Structure Structure
G.S1 41 K G.S1.03 Structure AF2
G.S1 42 L G.S1.04 Structure Structure
G.S1 43 L G.S1.05 Structure Structure
G.S1 44 L G.S1.06 Structure Structure
G.S1 45 L G.S1.07 Structure Structure
G.s1h1 46 G G.s1h1.01 Structure Structure
G.s1h1 47 T G.s1h1.02 Structure AF2
G.s1h1 48 G G.s1h1.03 Structure AF2
G.s1h1 49 E G.s1h1.04 Structure AF2
G.s1h1 50 S G.s1h1.05 Structure Structure
G.s1h1 51 G G.s1h1.06 Structure Structure
G.H1 52 K G.H1.01 Structure Structure
G.H1 53 S G.H1.02 Structure Structure
G.H1 54 T G.H1.03 Structure Structure
G.H1 55 F G.H1.04 Structure AF2
G.H1 56 I G.H1.05 Structure AF2
G.H1 57 K G.H1.06 Structure Structure
G.H1 58 Q G.H1.07 Structure AF2
G.H1 59 M G.H1.08 Structure Structure
G.H1 60 R G.H1.09 Structure Structure
G.H1 61 I G.H1.10 Structure Structure
G.H1 62 I G.H1.11 AF2 AF2
G.H1 63 H G.H1.12 AF2 AF2
G.h1ha 64 G G.h1ha.01 AF2 AF2
G.h1ha 65 S G.h1ha.02 AF2 AF2
G.h1ha 66 G G.h1ha.03 AF2 AF2
G.h1ha 67 Y G.h1ha.04 AF2 AF2
G.h1ha 68 S G.h1ha.05 AF2 AF2
H.HA 69 D H.HA.01 AF2 AF2
H.HA 70 E H.HA.02 AF2 AF2
H.HA 71 D H.HA.03 AF2 AF2
H.HA 72 K H.HA.04 AF2 AF2
H.HA 73 R H.HA.05 AF2 AF2
H.HA 74 G H.HA.06 AF2 AF2
H.HA 75 F H.HA.07 AF2 AF2
H.HA 76 T H.HA.08 AF2 AF2
H.HA 77 K H.HA.09 AF2 AF2
H.HA 78 L H.HA.10 AF2 AF2
H.HA 79 V H.HA.11 AF2 AF2
H.HA 80 Y H.HA.12 AF2 AF2
H.HA 81 Q H.HA.13 AF2 AF2
H.HA 82 N H.HA.14 AF2 AF2
H.HA 83 I H.HA.15 AF2 AF2
H.HA 84 F H.HA.16 AF2 AF2
H.HA 85 T H.HA.17 AF2 AF2
H.HA 86 A H.HA.18 AF2 AF2
H.HA 87 M H.HA.19 AF2 AF2
H.HA 88 Q H.HA.20 AF2 AF2
H.HA 89 A H.HA.21 AF2 AF2
H.HA 90 M H.HA.22 AF2 AF2
H.HA 91 I H.HA.23 AF2 AF2
H.HA 92 R H.HA.24 AF2 AF2
H.HA 93 A H.HA.25 AF2 AF2
H.HA 94 M H.HA.26 AF2 AF2
H.HA 95 D H.HA.27 AF2 AF2
H.HA 96 T H.HA.28 AF2 AF2
H.HA 97 L H.HA.29 AF2 AF2
H.hahb 98 K H.hahb.01 AF2 AF2
H.hahb 99 I H.hahb.04 AF2 AF2
H.hahb 100 P H.hahb.05 AF2 AF2
H.hahb 101 Y H.hahb.06 AF2 AF2
H.hahb 102 K H.hahb.07 AF2 AF2
H.hahb 103 Y H.hahb.08 AF2 AF2
H.hahb 104 E H.hahb.09 AF2 AF2
H.HB 105 H H.HB.01 AF2 AF2
H.HB 106 N H.HB.02 AF2 AF2
H.HB 107 K H.HB.03 AF2 AF2
H.HB 108 A H.HB.04 AF2 AF2
H.HB 109 H H.HB.05 AF2 AF2
H.HB 110 A H.HB.06 AF2 AF2
H.HB 111 Q H.HB.07 AF2 AF2
H.HB 112 L H.HB.08 AF2 AF2
H.HB 113 V H.HB.09 AF2 AF2
H.HB 114 R H.HB.10 AF2 AF2
H.HB 115 E H.HB.11 AF2 AF2
H.HB 116 V H.HB.12 AF2 AF2
H.HB 117 D H.HB.13 AF2 AF2
H.HB 118 V H.HB.14 AF2 AF2
H.hbhc 119 E H.hbhc.01 AF2 AF2
H.hbhc 120 K H.hbhc.02 AF2 AF2
H.hbhc 121 V H.hbhc.03 AF2 AF2
H.hbhc 122 S H.hbhc.04 AF2 AF2
H.hbhc 123 A H.hbhc.05 AF2 AF2
H.hbhc 124 F H.hbhc.14 AF2 AF2
H.hbhc 125 E H.hbhc.15 AF2 AF2
H.HC 126 N H.HC.01 AF2 AF2
H.HC 127 P H.HC.02 AF2 AF2
H.HC 128 Y H.HC.03 AF2 AF2
H.HC 129 V H.HC.04 AF2 AF2
H.HC 130 D H.HC.05 AF2 AF2
H.HC 131 A H.HC.06 AF2 AF2
H.HC 132 I H.HC.07 AF2 AF2
H.HC 133 K H.HC.08 AF2 AF2
H.HC 134 S H.HC.09 AF2 AF2
H.HC 135 L H.HC.10 AF2 AF2
H.HC 136 W H.HC.11 AF2 AF2
H.HC 137 N H.HC.12 AF2 AF2
H.hchd 138 D H.hchd.01 AF2 AF2
H.HD 139 P H.HD.01 AF2 AF2
H.HD 140 G H.HD.02 AF2 AF2
H.HD 141 I H.HD.03 AF2 AF2
H.HD 142 Q H.HD.04 AF2 AF2
H.HD 143 E H.HD.05 AF2 AF2
H.HD 144 C H.HD.06 AF2 AF2
H.HD 145 Y H.HD.07 AF2 AF2
H.HD 146 D H.HD.08 AF2 AF2
H.HD 147 R H.HD.09 AF2 AF2
H.HD 148 R H.HD.10 AF2 AF2
H.HD 149 R H.HD.11 AF2 AF2
H.HD 150 E H.HD.12 AF2 AF2
H.hdhe 151 Y H.hdhe.01 AF2 AF2
H.hdhe 152 Q H.hdhe.02 AF2 AF2
H.hdhe 153 L H.hdhe.03 AF2 AF2
H.hdhe 154 S H.hdhe.04 AF2 AF2
H.hdhe 155 D H.hdhe.05 AF2 AF2
H.HE 156 S H.HE.01 AF2 AF2
H.HE 157 T H.HE.02 AF2 AF2
H.HE 158 K H.HE.03 AF2 AF2
H.HE 159 Y H.HE.04 AF2 AF2
H.HE 160 Y H.HE.05 AF2 AF2
H.HE 161 L H.HE.06 AF2 AF2
H.HE 162 N H.HE.07 AF2 AF2
H.HE 163 D H.HE.08 AF2 AF2
H.HE 164 L H.HE.09 AF2 AF2
H.HE 165 D H.HE.10 AF2 AF2
H.HE 166 R H.HE.11 AF2 AF2
H.HE 167 V H.HE.12 AF2 AF2
H.HE 168 A H.HE.13 AF2 AF2
H.hehf 169 D H.hehf.01 AF2 AF2
H.hehf 170 P H.hehf.02 AF2 AF2
H.hehf 171 A H.hehf.03 AF2 AF2
H.hehf 172 Y H.hehf.04 AF2 AF2
H.hehf 173 L H.hehf.05 AF2 AF2
H.hehf 174 P H.hehf.06 AF2 AF2
H.hehf 175 T H.hehf.07 AF2 AF2
H.HF 176 Q H.HF.01 AF2 AF2
H.HF 177 Q H.HF.02 AF2 AF2
H.HF 178 D H.HF.03 AF2 AF2
H.HF 179 V H.HF.04 AF2 AF2
H.HF 180 L H.HF.05 AF2 AF2
H.HF 181 R H.HF.06 AF2 AF2
G.hfs2 182 V G.hfs2.01 AF2 AF2
G.hfs2 183 R G.hfs2.02 AF2 AF2
G.hfs2 184 V G.hfs2.03 AF2 AF2
G.hfs2 185 P G.hfs2.04 AF2 AF2
G.hfs2 186 T G.hfs2.05 Structure Structure
G.hfs2 187 T G.hfs2.06 Structure Structure
G.hfs2 188 G G.hfs2.07 Structure Structure
G.S2 189 I G.S2.01 Structure Structure
G.S2 190 I G.S2.02 Structure AF2
G.S2 191 E G.S2.03 Structure Structure
G.S2 192 Y G.S2.04 Structure AF2
G.S2 193 P G.S2.05 Structure AF2
G.S2 194 F G.S2.06 Structure Structure
G.S2 195 D G.S2.07 Structure AF2
G.S2 196 L G.S2.08 Structure AF2
G.s2s3 197 Q G.s2s3.01 Structure AF2
G.s2s3 198 S G.s2s3.02 Structure AF2
G.S3 199 V G.S3.01 Structure Structure
G.S3 200 I G.S3.02 Structure AF2
G.S3 201 F G.S3.03 Structure Structure
G.S3 202 R G.S3.04 Structure AF2
G.S3 203 M G.S3.05 Structure Structure
G.S3 204 V G.S3.06 Structure AF2
G.S3 205 D G.S3.07 Structure Structure
G.S3 206 V G.S3.08 Structure Structure
G.s3h2 207 G G.s3h2.01 Structure Structure
G.s3h2 208 G G.s3h2.02 Structure AF2
G.s3h2 209 Q G.s3h2.03 Structure Structure
G.H2 210 R G.H2.01 Structure Structure
G.H2 211 S G.H2.02 Structure AF2
G.H2 212 E G.H2.03 Structure Structure
G.H2 213 R G.H2.04 Structure Structure
G.H2 214 R G.H2.05 Structure Structure
G.H2 215 K G.H2.06 Structure Structure
G.H2 216 W G.H2.07 Structure Structure
G.H2 217 I G.H2.08 Structure Structure
G.H2 218 H G.H2.09 Structure AF2
G.H2 219 C G.H2.10 Structure Structure
G.h2s4 220 F G.h2s4.01 Structure Structure
G.h2s4 221 E G.h2s4.02 Structure AF2
G.h2s4 222 N G.h2s4.03 Structure AF2
G.h2s4 223 V G.h2s4.04 Structure Structure
G.h2s4 224 T G.h2s4.05 Structure Structure
G.S4 225 S G.S4.01 Structure AF2
G.S4 226 I G.S4.02 Structure Structure
G.S4 227 M G.S4.03 Structure AF2
G.S4 228 F G.S4.04 Structure Structure
G.S4 229 L G.S4.05 Structure AF2
G.S4 230 V G.S4.06 Structure Structure
G.S4 231 A G.S4.07 Structure AF2
G.s4h3 232 L G.s4h3.01 Structure AF2
G.s4h3 233 S G.s4h3.02 Structure Structure
G.s4h3 234 E G.s4h3.03 Structure AF2
G.s4h3 235 Y G.s4h3.04 Structure AF2
G.s4h3 236 D G.s4h3.05 AF2 AF2
G.s4h3 237 Q G.s4h3.06 AF2 AF2
G.s4h3 238 V G.s4h3.07 AF2 AF2
G.s4h3 239 L G.s4h3.08 AF2 AF2
G.s4h3 240 V G.s4h3.09 AF2 AF2
G.s4h3 241 E G.s4h3.10 AF2 AF2
G.s4h3 242 S G.s4h3.11 AF2 AF2
G.s4h3 243 D G.s4h3.12 AF2 AF2
G.s4h3 244 N G.s4h3.13 AF2 AF2
G.s4h3 245 E G.s4h3.14 AF2 AF2
G.s4h3 246 N G.s4h3.15 AF2 AF2
G.H3 247 R G.H3.01 Structure Structure
G.H3 248 M G.H3.02 Structure AF2
G.H3 249 E G.H3.03 Structure AF2
G.H3 250 E G.H3.04 Structure Structure
G.H3 251 S G.H3.05 Structure AF2
G.H3 252 K G.H3.06 Structure AF2
G.H3 253 A G.H3.07 Structure AF2
G.H3 254 L G.H3.08 Structure AF2
G.H3 255 F G.H3.09 Structure Structure
G.H3 256 R G.H3.10 Structure AF2
G.H3 257 T G.H3.11 Structure AF2
G.H3 258 I G.H3.12 Structure Structure
G.H3 259 I G.H3.13 Structure AF2
G.H3 260 T G.H3.14 Structure AF2
G.H3 261 Y G.H3.15 Structure AF2
G.H3 262 P G.H3.16 Structure AF2
G.H3 263 W G.H3.17 Structure Structure
G.H3 264 F G.H3.18 Structure AF2
G.h3s5 265 Q G.h3s5.01 Structure AF2
G.h3s5 266 N G.h3s5.02 Structure AF2
G.h3s5 267 S G.h3s5.03 Structure AF2
G.S5 268 S G.S5.01 Structure Structure
G.S5 269 V G.S5.02 Structure Structure
G.S5 270 I G.S5.03 Structure Structure
G.S5 271 L G.S5.04 Structure Structure
G.S5 272 F G.S5.05 Structure Structure
G.S5 273 L G.S5.06 Structure AF2
G.S5 274 N G.S5.07 Structure Structure
G.s5hg 275 K G.s5hg.01 Structure Structure
G.HG 276 K G.HG.01 Structure AF2
G.HG 277 D G.HG.02 Structure Structure
G.HG 278 L G.HG.03 Structure Structure
G.HG 279 L G.HG.04 Structure Structure
G.HG 280 E G.HG.05 Structure AF2
G.HG 281 E G.HG.06 Structure Structure
G.HG 282 K G.HG.07 Structure Structure
G.HG 283 I G.HG.08 Structure AF2
G.HG 284 M G.HG.09 Structure AF2
G.HG 285 Y G.HG.12 Structure AF2
G.HG 286 S G.HG.13 Structure Structure
G.HG 287 H G.HG.14 Structure AF2
G.HG 288 L G.HG.15 Structure AF2
G.HG 289 V G.HG.16 Structure AF2
G.HG 290 D G.HG.17 Structure Structure
G.hgh4 291 Y G.hgh4.01 AF2 AF2
G.hgh4 292 F G.hgh4.02 AF2 AF2
G.hgh4 293 P G.hgh4.03 AF2 AF2
G.hgh4 294 E G.hgh4.04 AF2 AF2
G.hgh4 295 Y G.hgh4.05 AF2 AF2
G.hgh4 296 D G.hgh4.06 AF2 AF2
G.hgh4 297 G G.hgh4.07 AF2 AF2
G.hgh4 298 P G.hgh4.08 AF2 AF2
G.H4 299 Q G.H4.01 Structure AF2
G.H4 300 R G.H4.02 Structure AF2
G.H4 301 D G.H4.03 Structure AF2
G.H4 302 A G.H4.04 Structure AF2
G.H4 303 Q G.H4.05 Structure AF2
G.H4 304 A G.H4.06 Structure AF2
G.H4 305 A G.H4.07 Structure Structure
G.H4 306 R G.H4.08 Structure AF2
G.H4 307 E G.H4.09 Structure AF2
G.H4 308 F G.H4.10 Structure Structure
G.H4 309 I G.H4.11 Structure Structure
G.H4 310 L G.H4.12 Structure AF2
G.H4 311 K G.H4.13 Structure Structure
G.H4 312 M G.H4.14 Structure AF2
G.H4 313 F G.H4.15 Structure Structure
G.H4 314 V G.H4.16 Structure Structure
G.H4 315 D G.H4.17 Structure AF2
G.h4s6 316 L G.h4s6.01 Structure AF2
G.h4s6 317 N G.h4s6.08 Structure AF2
G.h4s6 318 P G.h4s6.09 Structure AF2
G.h4s6 319 D G.h4s6.10 Structure Structure
G.h4s6 320 S G.h4s6.11 Structure AF2
G.h4s6 321 D G.h4s6.12 Structure AF2
G.h4s6 322 K G.h4s6.13 Structure AF2
G.h4s6 323 I G.h4s6.20 Structure Structure
G.S6 324 I G.S6.01 Structure AF2
G.S6 325 Y G.S6.02 Structure Structure
G.S6 326 S G.S6.03 Structure AF2
G.S6 327 H G.S6.04 Structure Structure
G.S6 328 F G.S6.05 Structure Structure
G.s6h5 329 T G.s6h5.01 Structure Structure
G.s6h5 330 C G.s6h5.02 Structure Structure
G.s6h5 331 A G.s6h5.03 Structure Structure
G.s6h5 332 T G.s6h5.04 Structure AF2
G.s6h5 333 D G.s6h5.05 Structure Structure
G.H5 334 T G.H5.01 Structure Structure
G.H5 335 E G.H5.02 Structure Structure
G.H5 336 N G.H5.03 Structure Structure
G.H5 337 I G.H5.04 Structure AF2
G.H5 338 R G.H5.05 Structure Structure
G.H5 339 F G.H5.06 Structure AF2
G.H5 340 V G.H5.07 Structure AF2
G.H5 341 F G.H5.08 Structure Structure
G.H5 342 A G.H5.09 Structure AF2
G.H5 343 A G.H5.10 Structure AF2
G.H5 344 V G.H5.11 Structure AF2
G.H5 345 K G.H5.12 Structure Structure
G.H5 346 D G.H5.13 Structure Structure
G.H5 347 T G.H5.14 Structure AF2
G.H5 348 I G.H5.15 Structure Structure
G.H5 349 L G.H5.16 Structure Structure
G.H5 350 Q G.H5.17 Structure Structure
G.H5 351 L G.H5.18 Structure AF2
G.H5 352 N G.H5.19 Structure Structure
G.H5 353 L G.H5.20 Structure Structure
G.H5 354 K G.H5.21 Structure AF2
G.H5 355 E G.H5.22 Structure Structure
G.H5 356 Y G.H5.23 Structure Structure
G.H5 357 N G.H5.24 Structure Structure
G.H5 358 L G.H5.25 Structure Structure
G.H5 359 V G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 265 from structure (75.3%), 87 from model (24.7%)
Residue sidechains - 265 from structure (75.3%), 87 from model (24.7%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 V - AF2 AF2
N-term 4 T - AF2 AF2
N-term 5 S - AF2 AF2
N-term 6 Q - AF2 AF2
N-term 7 A - AF2 AF2
N-term 8 R - AF2 AF2
N-term 9 G - AF2 AF2
N-term 10 V - AF2 AF2
N-term 11 G - AF2 AF2
N-term 12 L - AF2 AF2
N-term 13 E - AF2 AF2
N-term 14 M - AF2 AF2
N-term 15 Y - AF2 AF2
N-term 16 P - AF2 AF2
N-term 17 G - AF2 AF2
N-term 18 T - AF2 AF2
N-term 19 A - AF2 AF2
N-term 20 Q - AF2 AF2
N-term 21 P - AF2 AF2
N-term 22 A - AF2 AF2
N-term 23 A - AF2 AF2
N-term 24 P - AF2 AF2
N-term 25 N - AF2 AF2
N-term 26 T - AF2 AF2
N-term 27 T - AF2 AF2
N-term 28 S - AF2 AF2
N-term 29 P - AF2 AF2
N-term 30 E - AF2 AF2
N-term 31 L - AF2 AF2
N-term 32 N - AF2 AF2
N-term 33 L - AF2 AF2
N-term 34 S - AF2 AF2
N-term 35 H - AF2 AF2
N-term 36 P - AF2 AF2
N-term 37 L - AF2 AF2
N-term 38 L - AF2 AF2
N-term 39 G - AF2 AF2
N-term 40 T - AF2 AF2
N-term 41 A - AF2 AF2
N-term 42 L - AF2 AF2
N-term 43 A - AF2 AF2
N-term 44 N - AF2 AF2
N-term 45 G - AF2 AF2
N-term 46 T - AF2 AF2
N-term 47 G - AF2 AF2
N-term 48 E - AF2 AF2
N-term 49 L - AF2 AF2
N-term 50 S - AF2 AF2
TM1 51 E 1.24x24 Structure Structure
TM1 52 H 1.25x25 Structure Structure
TM1 53 Q 1.26x26 Structure Structure
TM1 54 Q 1.27x27 Structure Structure
TM1 55 Y 1.28x28 Structure Structure
TM1 56 V 1.29x29 Structure Structure
TM1 57 I 1.30x30 Structure Structure
TM1 58 G 1.31x31 Structure Structure
TM1 59 L 1.32x32 Structure Structure
TM1 60 F 1.33x33 Structure Structure
TM1 61 L 1.34x34 Structure Structure
TM1 62 S 1.35x35 Structure Structure
TM1 63 C 1.36x36 Structure Structure
TM1 64 L 1.37x37 Structure Structure
TM1 65 Y 1.38x38 Structure Structure
TM1 66 T 1.39x39 Structure Structure
TM1 67 I 1.40x40 Structure Structure
TM1 68 F 1.41x41 Structure Structure
TM1 69 L 1.42x42 Structure Structure
TM1 70 F 1.43x43 Structure Structure
TM1 71 P 1.44x44 Structure Structure
TM1 72 I 1.45x45 Structure Structure
TM1 73 G 1.46x46 Structure Structure
TM1 74 F 1.47x47 Structure Structure
TM1 75 V 1.48x48 Structure Structure
TM1 76 G 1.49x49 Structure Structure
TM1 77 N 1.50x50 Structure Structure
TM1 78 I 1.51x51 Structure Structure
TM1 79 L 1.52x52 Structure Structure
TM1 80 I 1.53x53 Structure Structure
TM1 81 L 1.54x54 Structure Structure
TM1 82 V 1.55x55 Structure Structure
TM1 83 V 1.56x56 Structure Structure
TM1 84 N 1.57x57 Structure Structure
TM1 85 I 1.58x58 Structure Structure
TM1 86 S 1.59x59 Structure Structure
TM1 87 F 1.60x60 Structure Structure
ICL1 88 R 12.48x48 Structure Structure
ICL1 89 E 12.49x49 Structure Structure
ICL1 90 K 12.50x50 Structure Structure
ICL1 91 M 12.51x51 Structure Structure
TM2 92 T 2.37x37 Structure Structure
TM2 93 I 2.38x38 Structure Structure
TM2 94 P 2.39x39 Structure Structure
TM2 95 D 2.40x40 Structure Structure
TM2 96 L 2.41x41 Structure Structure
TM2 97 Y 2.42x42 Structure Structure
TM2 98 F 2.43x43 Structure Structure
TM2 99 I 2.44x44 Structure Structure
TM2 100 N 2.45x45 Structure Structure
TM2 101 L 2.46x46 Structure Structure
TM2 102 A 2.47x47 Structure Structure
TM2 103 V 2.48x48 Structure Structure
TM2 104 A 2.49x49 Structure Structure
TM2 105 D 2.50x50 Structure Structure
TM2 106 L 2.51x51 Structure Structure
TM2 107 I 2.52x52 Structure Structure
TM2 108 L 2.53x53 Structure Structure
TM2 109 V 2.54x54 Structure Structure
TM2 110 A 2.55x55 Structure Structure
TM2 111 D 2.56x56 Structure Structure
TM2 112 S 2.57x57 Structure Structure
TM2 113 L 2.58x58 Structure Structure
TM2 114 I 2.59x59 Structure Structure
TM2 115 E 2.60x60 Structure Structure
TM2 116 V 2.61x61 Structure Structure
TM2 117 F 2.62x62 Structure Structure
TM2 118 N 2.63x63 Structure Structure
ECL1 119 L - Structure Structure
ECL1 120 H - Structure Structure
ECL1 121 E - Structure Structure
ECL1 122 R - Structure Structure
ECL1 123 Y 23.49x49 Structure Structure
ECL1 124 Y 23.50x50 Structure Structure
ECL1 125 D 23.51x51 Structure Structure
TM3 126 I 3.21x21 Structure Structure
TM3 127 A 3.22x22 Structure Structure
TM3 128 V 3.23x23 Structure Structure
TM3 129 L 3.24x24 Structure Structure
TM3 130 C 3.25x25 Structure Structure
TM3 131 T 3.26x26 Structure Structure
TM3 132 F 3.27x27 Structure Structure
TM3 133 M 3.28x28 Structure Structure
TM3 134 S 3.29x29 Structure Structure
TM3 135 L 3.30x30 Structure Structure
TM3 136 F 3.31x31 Structure Structure
TM3 137 L 3.32x32 Structure Structure
TM3 138 Q 3.33x33 Structure Structure
TM3 139 V 3.34x34 Structure Structure
TM3 140 N 3.35x35 Structure Structure
TM3 141 M 3.36x36 Structure Structure
TM3 142 Y 3.37x37 Structure Structure
TM3 143 S 3.38x38 Structure Structure
TM3 144 S 3.39x39 Structure Structure
TM3 145 V 3.40x40 Structure Structure
TM3 146 F 3.41x41 Structure Structure
TM3 147 F 3.42x42 Structure Structure
TM3 148 L 3.43x43 Structure Structure
TM3 149 T 3.44x44 Structure Structure
TM3 150 W 3.45x45 Structure Structure
TM3 151 M 3.46x46 Structure Structure
TM3 152 S 3.47x47 Structure Structure
TM3 153 F 3.48x48 Structure Structure
TM3 154 D 3.49x49 Structure Structure
TM3 155 R 3.50x50 Structure Structure
TM3 156 Y 3.51x51 Structure Structure
TM3 157 I 3.52x52 Structure Structure
TM3 158 A 3.53x53 Structure Structure
TM3 159 L 3.54x54 Structure Structure
TM3 160 A 3.55x55 Structure Structure
TM3 161 R 3.56x56 Structure Structure
ICL2 162 A 34.50x50 Structure Structure
ICL2 163 M 34.51x51 Structure Structure
ICL2 164 R 34.52x52 Structure Structure
ICL2 165 C 34.53x53 Structure Structure
ICL2 166 S 34.54x54 Structure Structure
ICL2 167 L 34.55x55 Structure Structure
ICL2 168 F 34.56x56 Structure Structure
ICL2 169 R 34.57x57 Structure Structure
TM4 170 T 4.38x38 Structure Structure
TM4 171 K 4.39x39 Structure Structure
TM4 172 H 4.40x40 Structure Structure
TM4 173 H 4.41x41 Structure Structure
TM4 174 A 4.42x42 Structure Structure
TM4 175 R 4.43x43 Structure Structure
TM4 176 L 4.44x44 Structure Structure
TM4 177 S 4.45x45 Structure Structure
TM4 178 C 4.46x46 Structure Structure
TM4 179 G 4.47x47 Structure Structure
TM4 180 L 4.48x48 Structure Structure
TM4 181 I 4.49x49 Structure Structure
TM4 182 W 4.50x50 Structure Structure
TM4 183 M 4.51x51 Structure Structure
TM4 184 A 4.52x52 Structure Structure
TM4 185 S 4.53x53 Structure Structure
TM4 186 V 4.54x54 Structure Structure
TM4 187 S 4.55x55 Structure Structure
TM4 188 A 4.56x56 Structure Structure
TM4 189 T 4.57x57 Structure Structure
TM4 190 L 4.58x58 Structure Structure
TM4 191 V 4.59x59 Structure Structure
TM4 192 P 4.60x60 Structure Structure
TM4 193 F 4.61x61 Structure Structure
TM4 194 T 4.62x62 Structure Structure
TM4 195 A 4.63x63 Structure Structure
TM4 196 V 4.64x64 Structure Structure
TM4 197 H 4.65x65 Structure Structure
TM4 198 L 4.66x66 Structure Structure
TM4 199 Q 4.67x67 Structure Structure
TM4 200 H 4.68x68 Structure Structure
ECL2 201 T - AF2 AF2
ECL2 202 D - AF2 AF2
ECL2 203 E - AF2 AF2
ECL2 204 A - AF2 AF2
ECL2 205 C 45.50x50 AF2 AF2
ECL2 206 F 45.51x51 AF2 AF2
ECL2 207 C 45.52x52 AF2 AF2
ECL2 208 F - AF2 AF2
ECL2 209 A - AF2 AF2
ECL2 210 D - Structure Structure
TM5 211 V 5.35x36 Structure Structure
TM5 212 R 5.36x37 Structure Structure
TM5 213 E 5.37x38 Structure Structure
TM5 214 V 5.38x39 Structure Structure
TM5 215 Q 5.39x40 Structure Structure
TM5 216 W 5.40x41 Structure Structure
TM5 217 L 5.41x42 Structure Structure
TM5 218 E 5.42x43 Structure Structure
TM5 219 V 5.43x44 Structure Structure
TM5 220 T 5.44x45 Structure Structure
TM5 221 L 5.45x46 Structure Structure
TM5 222 G 5.46x461 Structure Structure
TM5 223 F 5.47x47 Structure Structure
TM5 224 I 5.48x48 Structure Structure
TM5 225 V 5.49x49 Structure Structure
TM5 226 P 5.50x50 Structure Structure
TM5 227 F 5.51x51 Structure Structure
TM5 228 A 5.52x52 Structure Structure
TM5 229 I 5.53x53 Structure Structure
TM5 230 I 5.54x54 Structure Structure
TM5 231 G 5.55x55 Structure Structure
TM5 232 L 5.56x56 Structure Structure
TM5 233 C 5.57x57 Structure Structure
TM5 234 Y 5.58x58 Structure Structure
TM5 235 S 5.59x59 Structure Structure
TM5 236 L 5.60x60 Structure Structure
TM5 237 I 5.61x61 Structure Structure
TM5 238 V 5.62x62 Structure Structure
TM5 239 R 5.63x63 Structure Structure
TM5 240 V 5.64x64 Structure Structure
TM5 241 L 5.65x65 Structure Structure
TM5 242 V 5.66x66 Structure Structure
TM5 243 R 5.67x67 Structure Structure
TM5 244 A 5.68x68 Structure Structure
TM5 245 H 5.69x69 Structure Structure
TM5 246 R 5.70x70 Structure Structure
ICL3 247 H - Structure Structure
ICL3 248 R - Structure Structure
ICL3 249 G - AF2 AF2
ICL3 250 L - AF2 AF2
ICL3 251 R - AF2 AF2
ICL3 252 P - AF2 AF2
ICL3 253 R - Structure Structure
TM6 254 R 6.30x30 Structure Structure
TM6 255 Q 6.31x31 Structure Structure
TM6 256 K 6.32x32 Structure Structure
TM6 257 A 6.33x33 Structure Structure
TM6 258 L 6.34x34 Structure Structure
TM6 259 R 6.35x35 Structure Structure
TM6 260 M 6.36x36 Structure Structure
TM6 261 I 6.37x37 Structure Structure
TM6 262 L 6.38x38 Structure Structure
TM6 263 A 6.39x39 Structure Structure
TM6 264 V 6.40x40 Structure Structure
TM6 265 V 6.41x41 Structure Structure
TM6 266 L 6.42x42 Structure Structure
TM6 267 V 6.43x43 Structure Structure
TM6 268 F 6.44x44 Structure Structure
TM6 269 F 6.45x45 Structure Structure
TM6 270 V 6.46x46 Structure Structure
TM6 271 C 6.47x47 Structure Structure
TM6 272 W 6.48x48 Structure Structure
TM6 273 L 6.49x49 Structure Structure
TM6 274 P 6.50x50 Structure Structure
TM6 275 E 6.51x51 Structure Structure
TM6 276 N 6.52x52 Structure Structure
TM6 277 V 6.53x53 Structure Structure
TM6 278 F 6.54x54 Structure Structure
TM6 279 I 6.55x55 Structure Structure
TM6 280 S 6.56x56 Structure Structure
TM6 281 V 6.57x57 Structure Structure
TM6 282 H 6.58x58 Structure Structure
TM6 283 L 6.59x59 Structure Structure
TM6 284 L 6.60x60 Structure Structure
TM6 285 Q 6.61x61 Structure Structure
TM6 286 R 6.62x62 AF2 AF2
TM6 287 T 6.63x63 AF2 AF2
TM6 288 Q 6.64x64 AF2 AF2
ECL3 289 P - AF2 AF2
ECL3 290 G - AF2 AF2
ECL3 291 A - AF2 AF2
ECL3 292 A - AF2 AF2
ECL3 293 P - AF2 AF2
ECL3 294 C - AF2 AF2
TM7 295 K 7.24x23 AF2 AF2
TM7 296 Q 7.25x24 AF2 AF2
TM7 297 S 7.26x25 AF2 AF2
TM7 298 F 7.27x26 AF2 AF2
TM7 299 R 7.28x27 AF2 AF2
TM7 300 H 7.29x28 Structure Structure
TM7 301 A 7.30x29 Structure Structure
TM7 302 H 7.31x30 Structure Structure
TM7 303 P 7.32x31 Structure Structure
TM7 304 L 7.33x32 Structure Structure
TM7 305 T 7.34x33 Structure Structure
TM7 306 G 7.35x34 Structure Structure
TM7 307 H 7.36x35 Structure Structure
TM7 308 I 7.37x36 Structure Structure
TM7 309 V 7.38x37 Structure Structure
TM7 310 N 7.39x38 Structure Structure
TM7 311 L 7.40x39 Structure Structure
TM7 312 A 7.41x40 Structure Structure
TM7 313 A 7.42x41 Structure Structure
TM7 314 F 7.43x42 Structure Structure
TM7 315 S 7.44x43 Structure Structure
TM7 316 N 7.45x45 Structure Structure
TM7 317 S 7.46x46 Structure Structure
TM7 318 C 7.47x47 Structure Structure
TM7 319 L 7.48x48 Structure Structure
TM7 320 N 7.49x49 Structure Structure
TM7 321 P 7.50x50 Structure Structure
TM7 322 L 7.51x51 Structure Structure
TM7 323 I 7.52x52 Structure Structure
TM7 324 Y 7.53x53 Structure Structure
TM7 325 S 7.54x54 Structure Structure
TM7 326 F 7.55x55 Structure Structure
TM7 327 L 7.56x56 Structure Structure
H8 328 G 8.47x47 Structure Structure
H8 329 E 8.48x48 Structure Structure
H8 330 T 8.49x49 Structure Structure
H8 331 F 8.50x50 Structure Structure
H8 332 R 8.51x51 Structure Structure
H8 333 D 8.52x52 Structure Structure
H8 334 K 8.53x53 Structure Structure
H8 335 L 8.54x54 Structure Structure
H8 336 R 8.55x55 Structure Structure
H8 337 L 8.56x56 Structure Structure
H8 338 Y 8.57x57 Structure Structure
H8 339 I 8.58x58 Structure Structure
H8 340 E 8.59x59 Structure Structure
H8 341 Q 8.60x60 Structure Structure
H8 342 K 8.61x61 Structure Structure
C-term 343 T - AF2 AF2
C-term 344 N - AF2 AF2
C-term 345 L - AF2 AF2
C-term 346 P - AF2 AF2
C-term 347 A - AF2 AF2
C-term 348 L - AF2 AF2
C-term 349 N - AF2 AF2
C-term 350 R - AF2 AF2
C-term 351 F - AF2 AF2
C-term 352 C - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic ICL2 R 169 34x57 G.H5 E 355 G.H5.22
Polar ICL2 F 168 34x56 G.hns1 R 37 G.hns1.02
Polar TM3 A 158 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 158 3x53 G.H5 N 352 G.H5.19
Polar TM7 Y 324 7x53 G.H5 N 357 G.H5.24
Van-der-waals TM7 Y 324 7x53 G.H5 N 357 G.H5.24
Polar TM3 R 155 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 155 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 155 3x50 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 M 163 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 M 163 34x51 G.H5 I 348 G.H5.15
Hydrophobic TM2 F 98 2x43 G.H5 Y 356 G.H5.23
Polar ICL2 R 164 34x52 G.s2s3 S 198 G.s2s3.02
Hydrophobic TM3 R 155 3x50 G.H5 L 358 G.H5.25
Hydrophobic TM5 L 241 5x65 G.H5 L 349 G.H5.16
Hydrophobic TM6 M 260 6x36 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 257 6x33 G.H5 V 359 G.H5.26
Hydrophobic ICL2 A 162 34x50 G.H5 I 348 G.H5.15
Polar TM7 S 325 7x54 G.H5 N 357 G.H5.24
Hydrophobic TM7 S 325 7x54 G.H5 N 357 G.H5.24
Van-der-waals TM7 S 325 7x54 G.H5 N 357 G.H5.24
Hydrophobic ICL2 M 163 34x51 G.H5 F 341 G.H5.08
Van-der-waals ICL2 M 163 34x51 G.H5 F 341 G.H5.08
Hydrophobic TM2 T 92 2x37 G.H5 E 355 G.H5.22
Polar ICL2 S 166 34x54 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 S 166 34x54 G.hns1 R 37 G.hns1.02
Polar TM6 A 257 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 257 6x33 G.H5 L 358 G.H5.25
Polar H8 G 328 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 G 328 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 G 328 8x47 G.H5 N 357 G.H5.24
Hydrophobic ICL2 M 163 34x51 G.H5 V 344 G.H5.11
Hydrophobic TM3 A 158 3x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 R 169 34x57 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 R 169 34x57 G.H5 Y 356 G.H5.23
Polar H8 F 331 8x50 G.H5 N 357 G.H5.24
Hydrophobic H8 F 331 8x50 G.H5 N 357 G.H5.24
Van-der-waals H8 F 331 8x50 G.H5 N 357 G.H5.24
Hydrophobic TM6 R 254 6x30 G.H5 L 353 G.H5.20
Hydrophobic ICL2 M 163 34x51 G.S1 L 40 G.S1.02
Hydrophobic ICL3 R 253 - G.h4s6 S 320 G.h4s6.11
Hydrophobic ICL2 M 163 34x51 G.S3 V 199 G.S3.01
Hydrophobic TM3 L 159 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 L 159 3x54 G.H5 L 353 G.H5.20
Polar ICL2 R 169 34x57 G.H5 N 352 G.H5.19
Van-der-waals TM6 M 260 6x36 G.H5 N 357 G.H5.24
Hydrophobic TM5 A 244 5x68 G.H5 L 349 G.H5.16
Hydrophobic TM3 L 159 3x54 G.H5 N 352 G.H5.19
Hydrophobic TM5 V 240 5x64 G.H5 L 349 G.H5.16
Polar H8 E 329 8x48 G.H5 N 357 G.H5.24
Hydrophobic TM3 M 151 3x46 G.H5 Y 356 G.H5.23
Hydrophobic TM4 T 170 4x38 G.hns1 R 37 G.hns1.02
Van-der-waals TM4 T 170 4x38 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 A 162 34x50 G.H5 N 352 G.H5.19
Van-der-waals ICL2 A 162 34x50 G.H5 N 352 G.H5.19
Hydrophobic TM2 P 94 2x39 G.H5 E 355 G.H5.22
Polar H8 T 330 8x49 G.H5 V 359 G.H5.26
Hydrophobic TM2 P 94 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 P 94 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM3 L 159 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 L 159 3x54 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 257 6x33 G.H5 L 353 G.H5.20
Hydrophobic TM6 I 261 6x37 G.H5 L 358 G.H5.25
Hydrophobic ICL2 M 163 34x51 G.H5 K 345 G.H5.12
Van-der-waals ICL2 M 163 34x51 G.H5 K 345 G.H5.12
Ionic TM6 R 254 6x30 G.H5 D 346 G.H5.13
Polar TM6 R 254 6x30 G.H5 D 346 G.H5.13
Hydrophobic ICL2 S 166 34x54 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 S 166 34x54 G.hns1 R 38 G.hns1.03
Hydrophobic TM6 R 254 6x30 G.H5 Q 350 G.H5.17
Van-der-waals TM6 R 254 6x30 G.H5 Q 350 G.H5.17
Polar TM3 D 154 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 154 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 154 3x49 G.H5 Y 356 G.H5.23
Polar H8 T 330 8x49 G.H5 K 354 G.H5.21
Van-der-waals H8 T 330 8x49 G.H5 K 354 G.H5.21
Hydrophobic H8 E 329 8x48 G.H5 V 359 G.H5.26
Polar H8 T 330 8x49 G.H5 N 357 G.H5.24
Hydrophobic H8 T 330 8x49 G.H5 N 357 G.H5.24
Van-der-waals H8 T 330 8x49 G.H5 N 357 G.H5.24
Hydrophobic TM5 L 241 5x65 G.H5 L 353 G.H5.20