Refined structure (8XZF) of Gi1 - apelin receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-11-27

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 217 from structure (61.3%), 137 from model (38.7%)
Residue sidechains - 209 from structure (59.0%), 145 from model (41.0%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 Structure Structure
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure AF2
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 AF2 AF2
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 AF2 AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure AF2
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure AF2
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure AF2
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 303 from structure (89.9%), 34 from model (10.1%)
Residue sidechains - 296 from structure (87.8%), 41 from model (12.2%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 E - AF2 AF2
N-term 3 E - AF2 AF2
N-term 4 G - AF2 AF2
N-term 5 G - AF2 AF2
N-term 6 D - AF2 AF2
N-term 7 F - AF2 AF2
N-term 8 D - AF2 AF2
N-term 9 N - AF2 AF2
N-term 10 Y - AF2 AF2
N-term 11 Y - AF2 AF2
N-term 12 G - AF2 AF2
N-term 13 A - AF2 AF2
N-term 14 D - AF2 AF2
N-term 15 N - AF2 AF2
N-term 16 Q - AF2 AF2
N-term 17 S - AF2 AF2
N-term 18 E - Structure AF2
N-term 19 C - Structure Structure
N-term 20 E - Structure Structure
N-term 21 Y - Structure Structure
N-term 22 T - Structure Structure
N-term 23 D - Structure Structure
N-term 24 W - Structure Structure
N-term 25 K - Structure Structure
N-term 26 S - Structure Structure
N-term 27 S - Structure Structure
N-term 28 G - Structure Structure
TM1 29 A 1.33x33 Structure Structure
TM1 30 L 1.34x34 Structure Structure
TM1 31 I 1.35x35 Structure Structure
TM1 32 P 1.36x36 Structure Structure
TM1 33 A 1.37x37 Structure Structure
TM1 34 I 1.38x38 Structure Structure
TM1 35 Y 1.39x39 Structure Structure
TM1 36 M 1.40x40 Structure Structure
TM1 37 L 1.41x41 Structure Structure
TM1 38 V 1.42x42 Structure Structure
TM1 39 F 1.43x43 Structure Structure
TM1 40 L 1.44x44 Structure Structure
TM1 41 L 1.45x45 Structure Structure
TM1 42 G 1.46x46 Structure Structure
TM1 43 T 1.47x47 Structure Structure
TM1 44 T 1.48x48 Structure Structure
TM1 45 G 1.49x49 Structure Structure
TM1 46 N 1.50x50 Structure Structure
TM1 47 G 1.51x51 Structure Structure
TM1 48 L 1.52x52 Structure Structure
TM1 49 V 1.53x53 Structure Structure
TM1 50 L 1.54x54 Structure Structure
TM1 51 W 1.55x55 Structure Structure
TM1 52 T 1.56x56 Structure Structure
TM1 53 V 1.57x57 Structure Structure
TM1 54 F 1.58x58 Structure Structure
TM1 55 R 1.59x59 Structure Structure
TM1 56 S 1.60x60 Structure Structure
ICL1 57 S 12.48x48 AF2 AF2
ICL1 58 R 12.49x49 AF2 AF2
ICL1 59 E 12.50x50 AF2 AF2
ICL1 60 K 12.51x51 AF2 AF2
ICL1 61 R 12.52x52 AF2 AF2
TM2 62 R 2.37x37 Structure Structure
TM2 63 S 2.38x38 Structure Structure
TM2 64 A 2.39x39 Structure Structure
TM2 65 D 2.40x40 Structure Structure
TM2 66 I 2.41x41 Structure Structure
TM2 67 F 2.42x42 Structure Structure
TM2 68 I 2.43x43 Structure Structure
TM2 69 A 2.44x44 Structure Structure
TM2 70 S 2.45x45 Structure Structure
TM2 71 L 2.46x46 Structure Structure
TM2 72 A 2.47x47 Structure Structure
TM2 73 V 2.48x48 Structure Structure
TM2 74 A 2.49x49 Structure Structure
TM2 75 D 2.50x50 Structure Structure
TM2 76 L 2.51x51 Structure Structure
TM2 77 T 2.52x52 Structure Structure
TM2 78 F 2.53x53 Structure Structure
TM2 79 V 2.54x54 Structure Structure
TM2 80 V 2.55x55 Structure Structure
TM2 81 T 2.56x56 Structure Structure
TM2 82 L 2.57x57 Structure Structure
TM2 83 P 2.58x58 Structure Structure
TM2 84 L 2.59x59 Structure Structure
TM2 85 W 2.60x60 Structure Structure
TM2 86 A 2.61x61 Structure Structure
TM2 87 T 2.62x62 Structure Structure
TM2 88 Y 2.63x63 Structure Structure
TM2 89 T 2.64x64 Structure Structure
TM2 90 Y 2.65x65 Structure Structure
TM2 91 R 2.66x66 Structure Structure
TM2 92 D 2.67x67 Structure Structure
ECL1 93 Y - Structure Structure
ECL1 94 D 23.49x49 Structure Structure
ECL1 95 W 23.50x50 Structure Structure
ECL1 96 P 23.51x51 Structure Structure
ECL1 97 F 23.52x52 Structure Structure
TM3 98 G 3.21x21 Structure Structure
TM3 99 T 3.22x22 Structure Structure
TM3 100 F 3.23x23 Structure Structure
TM3 101 F 3.24x24 Structure Structure
TM3 102 C 3.25x25 Structure Structure
TM3 103 K 3.26x26 Structure Structure
TM3 104 L 3.27x27 Structure Structure
TM3 105 S 3.28x28 Structure Structure
TM3 106 S 3.29x29 Structure Structure
TM3 107 Y 3.30x30 Structure Structure
TM3 108 L 3.31x31 Structure Structure
TM3 109 I 3.32x32 Structure Structure
TM3 110 F 3.33x33 Structure Structure
TM3 111 V 3.34x34 Structure Structure
TM3 112 N 3.35x35 Structure Structure
TM3 113 M 3.36x36 Structure Structure
TM3 114 Y 3.37x37 Structure Structure
TM3 115 A 3.38x38 Structure Structure
TM3 116 S 3.39x39 Structure Structure
TM3 117 V 3.40x40 Structure Structure
TM3 118 F 3.41x41 Structure Structure
TM3 119 C 3.42x42 Structure Structure
TM3 120 L 3.43x43 Structure Structure
TM3 121 T 3.44x44 Structure Structure
TM3 122 G 3.45x45 Structure Structure
TM3 123 L 3.46x46 Structure Structure
TM3 124 S 3.47x47 Structure Structure
TM3 125 F 3.48x48 Structure Structure
TM3 126 D 3.49x49 Structure Structure
TM3 127 R 3.50x50 Structure Structure
TM3 128 Y 3.51x51 Structure Structure
TM3 129 L 3.52x52 Structure Structure
TM3 130 A 3.53x53 Structure Structure
TM3 131 I 3.54x54 Structure Structure
TM3 132 V 3.55x55 Structure Structure
TM3 133 R 3.56x56 Structure Structure
ICL2 134 P 34.50x50 Structure Structure
ICL2 135 V 34.51x51 Structure Structure
ICL2 136 A 34.52x52 Structure Structure
ICL2 137 N 34.53x53 Structure Structure
ICL2 138 A 34.54x54 Structure Structure
ICL2 139 R 34.55x55 Structure Structure
ICL2 140 L 34.56x56 Structure Structure
ICL2 141 R 34.57x57 Structure Structure
TM4 142 L 4.38x38 Structure Structure
TM4 143 R 4.39x39 Structure Structure
TM4 144 V 4.40x40 Structure Structure
TM4 145 S 4.41x41 Structure Structure
TM4 146 G 4.42x42 Structure Structure
TM4 147 A 4.43x43 Structure Structure
TM4 148 V 4.44x44 Structure Structure
TM4 149 A 4.45x45 Structure Structure
TM4 150 T 4.46x46 Structure Structure
TM4 151 A 4.47x47 Structure Structure
TM4 152 V 4.48x48 Structure Structure
TM4 153 L 4.49x49 Structure Structure
TM4 154 W 4.50x50 Structure Structure
TM4 155 V 4.51x51 Structure Structure
TM4 156 L 4.52x52 Structure Structure
TM4 157 A 4.53x53 Structure Structure
TM4 158 A 4.54x54 Structure Structure
TM4 159 L 4.55x55 Structure Structure
TM4 160 L 4.56x56 Structure Structure
TM4 161 A 4.57x57 Structure Structure
TM4 162 M 4.58x59 Structure Structure
TM4 163 P 4.59x60 Structure Structure
TM4 164 V 4.60x61 Structure Structure
TM4 165 M 4.61x62 Structure Structure
TM4 166 V 4.62x63 Structure Structure
TM4 167 L 4.63x64 Structure Structure
TM4 168 R 4.64x65 Structure Structure
ECL2 169 T - Structure Structure
ECL2 170 T - Structure Structure
ECL2 171 G - Structure Structure
ECL2 172 D - Structure Structure
ECL2 173 L - Structure Structure
ECL2 174 E - Structure Structure
ECL2 175 N - Structure Structure
ECL2 176 T - Structure AF2
ECL2 177 T - Structure Structure
ECL2 178 K - Structure AF2
ECL2 179 V - Structure Structure
ECL2 180 Q - Structure Structure
ECL2 181 C 45.50x50 Structure Structure
ECL2 182 Y 45.51x51 Structure Structure
ECL2 183 M 45.52x52 Structure Structure
ECL2 184 D - Structure Structure
ECL2 185 Y - Structure Structure
ECL2 186 S - Structure Structure
ECL2 187 M - Structure Structure
ECL2 188 V - Structure AF2
ECL2 189 A - Structure Structure
ECL2 190 T - Structure Structure
ECL2 191 V - Structure Structure
ECL2 192 S - Structure Structure
TM5 193 S 5.30x31 Structure Structure
TM5 194 E 5.31x32 Structure Structure
TM5 195 W 5.32x33 Structure Structure
TM5 196 A 5.33x34 Structure Structure
TM5 197 W 5.34x35 Structure Structure
TM5 198 E 5.35x36 Structure Structure
TM5 199 V 5.36x37 Structure Structure
TM5 200 G 5.37x38 Structure Structure
TM5 201 L 5.38x39 Structure Structure
TM5 202 G 5.39x40 Structure Structure
TM5 203 V 5.40x41 Structure Structure
TM5 204 S 5.41x42 Structure Structure
TM5 205 S 5.42x43 Structure Structure
TM5 206 T 5.43x44 Structure Structure
TM5 207 T 5.44x45 Structure Structure
TM5 208 V 5.45x46 Structure Structure
TM5 209 G 5.46x461 Structure Structure
TM5 210 F 5.47x47 Structure Structure
TM5 211 V 5.48x48 Structure Structure
TM5 212 V 5.49x49 Structure Structure
TM5 213 P 5.50x50 Structure Structure
TM5 214 F 5.51x51 Structure Structure
TM5 215 T 5.52x52 Structure Structure
TM5 216 I 5.53x53 Structure Structure
TM5 217 M 5.54x54 Structure Structure
TM5 218 L 5.55x55 Structure Structure
TM5 219 T 5.56x56 Structure Structure
TM5 220 C 5.57x57 Structure Structure
TM5 221 Y 5.58x58 Structure Structure
TM5 222 F 5.59x59 Structure Structure
TM5 223 F 5.60x60 Structure Structure
TM5 224 I 5.61x61 Structure Structure
TM5 225 A 5.62x62 Structure Structure
TM5 226 Q 5.63x63 Structure Structure
TM5 227 T 5.64x64 Structure Structure
TM5 228 I 5.65x65 Structure Structure
TM5 229 A 5.66x66 Structure Structure
TM5 230 G 5.67x67 Structure Structure
TM5 231 H 5.68x68 Structure Structure
TM5 232 F 5.69x69 Structure Structure
ICL3 233 R - Structure Structure
ICL3 234 K - Structure Structure
ICL3 235 E - Structure Structure
TM6 236 R 6.23x23 Structure Structure
TM6 237 I 6.24x24 Structure Structure
TM6 238 E 6.25x25 Structure Structure
TM6 239 G 6.26x26 Structure Structure
TM6 240 L 6.27x27 Structure Structure
TM6 241 R 6.28x28 Structure Structure
TM6 242 K 6.29x29 Structure AF2
TM6 243 R 6.30x30 Structure Structure
TM6 244 R 6.31x31 Structure Structure
TM6 245 R 6.32x32 Structure Structure
TM6 246 L 6.33x33 Structure Structure
TM6 247 L 6.34x34 Structure Structure
TM6 248 S 6.35x35 Structure Structure
TM6 249 I 6.36x36 Structure Structure
TM6 250 I 6.37x37 Structure Structure
TM6 251 V 6.38x38 Structure Structure
TM6 252 V 6.39x39 Structure Structure
TM6 253 L 6.40x40 Structure Structure
TM6 254 V 6.41x41 Structure Structure
TM6 255 V 6.42x42 Structure Structure
TM6 256 T 6.43x43 Structure Structure
TM6 257 F 6.44x44 Structure Structure
TM6 258 A 6.45x45 Structure Structure
TM6 259 L 6.46x46 Structure Structure
TM6 260 C 6.47x47 Structure Structure
TM6 261 W 6.48x48 Structure Structure
TM6 262 M 6.49x49 Structure Structure
TM6 263 P 6.50x50 Structure Structure
TM6 264 Y 6.51x51 Structure Structure
TM6 265 H 6.52x52 Structure Structure
TM6 266 L 6.53x53 Structure Structure
TM6 267 V 6.54x54 Structure Structure
TM6 268 K 6.55x55 Structure Structure
TM6 269 T 6.56x56 Structure Structure
TM6 270 L 6.57x57 Structure Structure
TM6 271 Y 6.58x58 Structure Structure
TM6 272 M 6.59x59 Structure Structure
TM6 273 L 6.60x60 Structure Structure
TM6 274 G 6.61x61 Structure Structure
TM6 275 S 6.62x62 Structure Structure
TM6 276 L 6.63x63 Structure Structure
ECL3 277 L - Structure Structure
ECL3 278 H - Structure Structure
ECL3 279 W - Structure Structure
TM7 280 P 7.24x23 Structure Structure
TM7 281 C 7.25x24 Structure Structure
TM7 282 D 7.26x25 Structure Structure
TM7 283 F 7.27x26 Structure Structure
TM7 284 D 7.28x27 Structure Structure
TM7 285 L 7.29x28 Structure AF2
TM7 286 F 7.30x29 Structure Structure
TM7 287 L 7.31x30 Structure Structure
TM7 288 M 7.32x31 Structure Structure
TM7 289 N 7.33x32 Structure AF2
TM7 290 I 7.34x33 Structure Structure
TM7 291 F 7.35x34 Structure Structure
TM7 292 P 7.36x35 Structure Structure
TM7 293 Y 7.37x36 Structure Structure
TM7 294 C 7.38x37 Structure Structure
TM7 295 T 7.39x38 Structure Structure
TM7 296 C 7.40x39 Structure Structure
TM7 297 I 7.41x40 Structure Structure
TM7 298 S 7.42x41 Structure Structure
TM7 299 Y 7.43x42 Structure Structure
TM7 300 V 7.44x43 Structure Structure
TM7 301 N 7.45x45 Structure Structure
TM7 302 S 7.46x46 Structure Structure
TM7 303 C 7.47x47 Structure Structure
TM7 304 L 7.48x48 Structure Structure
TM7 305 N 7.49x49 Structure Structure
TM7 306 P 7.50x50 Structure Structure
TM7 307 F 7.51x51 Structure Structure
TM7 308 L 7.52x52 Structure Structure
TM7 309 Y 7.53x53 Structure Structure
TM7 310 A 7.54x54 Structure Structure
TM7 311 F 7.55x55 Structure Structure
TM7 312 F 7.56x56 Structure Structure
H8 313 D 8.47x47 Structure Structure
H8 314 P 8.48x48 Structure Structure
H8 315 R 8.49x49 Structure Structure
H8 316 F 8.50x50 Structure Structure
H8 317 R 8.51x51 Structure Structure
H8 318 Q 8.52x52 Structure Structure
H8 319 A 8.53x53 Structure Structure
H8 320 C 8.54x54 Structure Structure
H8 321 T 8.55x55 Structure Structure
H8 322 S 8.56x56 Structure Structure
H8 323 M 8.57x57 Structure Structure
H8 324 L 8.58x58 Structure Structure
H8 325 C 8.59x59 Structure Structure
H8 326 C 8.60x60 AF2 AF2
H8 327 G 8.61x61 AF2 AF2
C-term 328 Q - AF2 AF2
C-term 329 S - AF2 AF2
C-term 330 R - AF2 AF2
C-term 331 C - AF2 AF2
C-term 332 A - AF2 AF2
C-term 333 G - AF2 AF2
C-term 334 T - AF2 AF2
C-term 335 S - AF2 AF2
C-term 336 H - AF2 AF2
C-term 337 S - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 E 238 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM2 A 64 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 L 246 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 L 246 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 134 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 134 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM3 A 130 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 130 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 131 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 131 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 A 138 34x54 G.hns1 R 32 G.hns1.03
Polar TM3 A 130 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 130 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 130 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 V 135 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 V 135 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM6 L 246 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 246 6x33 G.H5 L 353 G.H5.25
Ionic TM6 R 236 6x23 G.H4 E 308 G.H4.16
Polar TM6 R 236 6x23 G.H4 E 308 G.H4.16
Hydrophobic TM6 R 236 6x23 G.H4 E 308 G.H4.16
Van-der-waals TM6 R 236 6x23 G.H4 E 308 G.H4.16
Hydrophobic TM3 I 131 3x54 G.H5 N 347 G.H5.19
Aromatic TM5 F 232 5x69 G.H5 K 345 G.H5.17
Hydrophobic TM5 F 232 5x69 G.H5 K 345 G.H5.17
Hydrophobic TM4 L 142 4x38 G.HN E 28 G.HN.52
Hydrophobic TM6 I 249 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 249 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 131 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 131 3x54 G.H5 C 351 G.H5.23
Hydrophobic H8 R 315 8x49 G.H5 F 354 G.H5.26
Van-der-waals H8 R 315 8x49 G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 134 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 134 34x50 G.H5 I 343 G.H5.15
Polar TM5 H 231 5x68 G.H5 K 345 G.H5.17
Hydrophobic TM5 H 231 5x68 G.H5 K 345 G.H5.17
Van-der-waals TM5 H 231 5x68 G.H5 K 345 G.H5.17
Hydrophobic H8 D 313 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM7 F 312 7x56 G.H5 L 353 G.H5.25
Van-der-waals TM7 F 312 7x56 G.H5 L 353 G.H5.25
Ionic TM5 H 231 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 231 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 231 5x68 G.H5 D 341 G.H5.13
Hydrophobic H8 D 313 8x47 G.H5 F 354 G.H5.26
Van-der-waals H8 D 313 8x47 G.H5 F 354 G.H5.26
Hydrophobic TM5 H 231 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 231 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 F 232 5x69 G.H5 L 348 G.H5.20
Van-der-waals TM5 F 232 5x69 G.H5 L 348 G.H5.20
Hydrophobic ICL2 R 139 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 L 246 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM6 I 250 6x37 G.H5 L 353 G.H5.25
Polar TM3 R 127 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 127 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 135 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 V 135 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM6 R 245 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 245 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM5 I 224 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 228 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 I 228 5x65 G.H5 L 348 G.H5.20
Polar TM6 R 245 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 245 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 228 5x65 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 127 3x50 G.H5 L 353 G.H5.25
Hydrophobic H8 P 314 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 P 314 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 131 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 131 3x54 G.H5 L 348 G.H5.20
Van-der-waals ICL2 P 134 34x50 G.H5 N 347 G.H5.19
Polar TM6 K 242 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 K 242 6x29 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 K 242 6x29 G.h4s6 D 315 G.h4s6.09
Polar H8 R 315 8x49 G.H5 K 349 G.H5.21
Hydrophobic H8 R 315 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 R 315 8x49 G.H5 K 349 G.H5.21