GproteinDb

Refined structure (8XZH) of G_i1 - apelin receptor

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G_i/o

DATE

2024-11-26

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Structure

GPCR

Gα

Gβ

Gγ
Model

AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 218 from structure (61.6%), 136 from model (38.4%)
Residue sidechains - 210 from structure (59.3%), 144 from model (40.7%)

Showing 1 to 354 of 354 entries

Search:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from
	:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from

G.HN	1	M	G.HN.01	AF2	AF2
G.HN	2	G	G.HN.02	AF2	AF2
G.HN	3	C	G.HN.09	Structure	Structure
G.HN	4	T	G.HN.10	Structure	Structure
G.HN	5	L	G.HN.11	Structure	Structure
G.HN	6	S	G.HN.30	Structure	Structure
G.HN	7	A	G.HN.31	Structure	Structure
G.HN	8	E	G.HN.32	Structure	Structure
G.HN	9	D	G.HN.33	Structure	Structure
G.HN	10	K	G.HN.34	Structure	Structure
G.HN	11	A	G.HN.35	Structure	Structure
G.HN	12	A	G.HN.36	Structure	Structure
G.HN	13	V	G.HN.37	Structure	Structure
G.HN	14	E	G.HN.38	Structure	Structure
G.HN	15	R	G.HN.39	Structure	Structure
G.HN	16	S	G.HN.40	Structure	Structure
G.HN	17	K	G.HN.41	Structure	Structure
G.HN	18	M	G.HN.42	Structure	Structure
G.HN	19	I	G.HN.43	Structure	Structure
G.HN	20	D	G.HN.44	Structure	Structure
G.HN	21	R	G.HN.45	Structure	Structure
G.HN	22	N	G.HN.46	Structure	Structure
G.HN	23	L	G.HN.47	Structure	Structure
G.HN	24	R	G.HN.48	Structure	Structure
G.HN	25	E	G.HN.49	Structure	Structure
G.HN	26	D	G.HN.50	Structure	Structure
G.HN	27	G	G.HN.51	Structure	Structure
G.HN	28	E	G.HN.52	Structure	Structure
G.HN	29	K	G.HN.53	Structure	Structure
G.hns1	30	A	G.hns1.01	Structure	Structure
G.hns1	31	A	G.hns1.02	Structure	Structure
G.hns1	32	R	G.hns1.03	Structure	Structure
G.S1	33	E	G.S1.01	Structure	Structure
G.S1	34	V	G.S1.02	Structure	Structure
G.S1	35	K	G.S1.03	Structure	Structure
G.S1	36	L	G.S1.04	Structure	Structure
G.S1	37	L	G.S1.05	Structure	Structure
G.S1	38	L	G.S1.06	Structure	Structure
G.S1	39	L	G.S1.07	Structure	Structure
G.s1h1	40	G	G.s1h1.01	Structure	Structure
G.s1h1	41	A	G.s1h1.02	Structure	Structure
G.s1h1	42	G	G.s1h1.03	Structure	Structure
G.s1h1	43	E	G.s1h1.04	Structure	Structure
G.s1h1	44	S	G.s1h1.05	Structure	Structure
G.s1h1	45	G	G.s1h1.06	Structure	Structure
G.H1	46	K	G.H1.01	Structure	Structure
G.H1	47	S	G.H1.02	Structure	AF2
G.H1	48	T	G.H1.03	Structure	Structure
G.H1	49	I	G.H1.04	Structure	Structure
G.H1	50	V	G.H1.05	Structure	Structure
G.H1	51	K	G.H1.06	Structure	Structure
G.H1	52	Q	G.H1.07	Structure	Structure
G.H1	53	M	G.H1.08	Structure	Structure
G.H1	54	K	G.H1.09	Structure	Structure
G.H1	55	I	G.H1.10	AF2	AF2
G.H1	56	I	G.H1.11	AF2	AF2
G.H1	57	H	G.H1.12	AF2	AF2
G.h1ha	58	E	G.h1ha.01	AF2	AF2
G.h1ha	59	A	G.h1ha.02	AF2	AF2
G.h1ha	60	G	G.h1ha.03	AF2	AF2
G.h1ha	61	Y	G.h1ha.04	AF2	AF2
G.h1ha	62	S	G.h1ha.05	AF2	AF2
H.HA	63	E	H.HA.01	AF2	AF2
H.HA	64	E	H.HA.02	AF2	AF2
H.HA	65	E	H.HA.03	AF2	AF2
H.HA	66	C	H.HA.04	AF2	AF2
H.HA	67	K	H.HA.05	AF2	AF2
H.HA	68	Q	H.HA.06	AF2	AF2
H.HA	69	Y	H.HA.07	AF2	AF2
H.HA	70	K	H.HA.08	AF2	AF2
H.HA	71	A	H.HA.09	AF2	AF2
H.HA	72	V	H.HA.10	AF2	AF2
H.HA	73	V	H.HA.11	AF2	AF2
H.HA	74	Y	H.HA.12	AF2	AF2
H.HA	75	S	H.HA.13	AF2	AF2
H.HA	76	N	H.HA.14	AF2	AF2
H.HA	77	T	H.HA.15	AF2	AF2
H.HA	78	I	H.HA.16	AF2	AF2
H.HA	79	Q	H.HA.17	AF2	AF2
H.HA	80	S	H.HA.18	AF2	AF2
H.HA	81	I	H.HA.19	AF2	AF2
H.HA	82	I	H.HA.20	AF2	AF2
H.HA	83	A	H.HA.21	AF2	AF2
H.HA	84	I	H.HA.22	AF2	AF2
H.HA	85	I	H.HA.23	AF2	AF2
H.HA	86	R	H.HA.24	AF2	AF2
H.HA	87	A	H.HA.25	AF2	AF2
H.HA	88	M	H.HA.26	AF2	AF2
H.HA	89	G	H.HA.27	AF2	AF2
H.HA	90	R	H.HA.28	AF2	AF2
H.HA	91	L	H.HA.29	AF2	AF2
H.hahb	92	K	H.hahb.01	AF2	AF2
H.hahb	93	I	H.hahb.04	AF2	AF2
H.hahb	94	D	H.hahb.05	AF2	AF2
H.hahb	95	F	H.hahb.06	AF2	AF2
H.hahb	96	G	H.hahb.07	AF2	AF2
H.hahb	97	D	H.hahb.08	AF2	AF2
H.hahb	98	S	H.hahb.09	AF2	AF2
H.HB	99	A	H.HB.01	AF2	AF2
H.HB	100	R	H.HB.02	AF2	AF2
H.HB	101	A	H.HB.03	AF2	AF2
H.HB	102	D	H.HB.04	AF2	AF2
H.HB	103	D	H.HB.05	AF2	AF2
H.HB	104	A	H.HB.06	AF2	AF2
H.HB	105	R	H.HB.07	AF2	AF2
H.HB	106	Q	H.HB.08	AF2	AF2
H.HB	107	L	H.HB.09	AF2	AF2
H.HB	108	F	H.HB.10	AF2	AF2
H.HB	109	V	H.HB.11	AF2	AF2
H.HB	110	L	H.HB.12	AF2	AF2
H.HB	111	A	H.HB.13	AF2	AF2
H.HB	112	G	H.HB.14	AF2	AF2
H.hbhc	113	A	H.hbhc.01	AF2	AF2
H.hbhc	114	A	H.hbhc.02	AF2	AF2
H.hbhc	115	E	H.hbhc.03	AF2	AF2
H.hbhc	116	E	H.hbhc.04	AF2	AF2
H.hbhc	117	G	H.hbhc.12	AF2	AF2
H.hbhc	118	F	H.hbhc.13	AF2	AF2
H.hbhc	119	M	H.hbhc.14	AF2	AF2
H.hbhc	120	T	H.hbhc.15	AF2	AF2
H.HC	121	A	H.HC.01	AF2	AF2
H.HC	122	E	H.HC.02	AF2	AF2
H.HC	123	L	H.HC.03	AF2	AF2
H.HC	124	A	H.HC.04	AF2	AF2
H.HC	125	G	H.HC.05	AF2	AF2
H.HC	126	V	H.HC.06	AF2	AF2
H.HC	127	I	H.HC.07	AF2	AF2
H.HC	128	K	H.HC.08	AF2	AF2
H.HC	129	R	H.HC.09	AF2	AF2
H.HC	130	L	H.HC.10	AF2	AF2
H.HC	131	W	H.HC.11	AF2	AF2
H.HC	132	K	H.HC.12	AF2	AF2
H.hchd	133	D	H.hchd.01	AF2	AF2
H.HD	134	S	H.HD.01	AF2	AF2
H.HD	135	G	H.HD.02	AF2	AF2
H.HD	136	V	H.HD.03	AF2	AF2
H.HD	137	Q	H.HD.04	AF2	AF2
H.HD	138	A	H.HD.05	AF2	AF2
H.HD	139	C	H.HD.06	AF2	AF2
H.HD	140	F	H.HD.07	AF2	AF2
H.HD	141	N	H.HD.08	AF2	AF2
H.HD	142	R	H.HD.09	AF2	AF2
H.HD	143	S	H.HD.10	AF2	AF2
H.HD	144	R	H.HD.11	AF2	AF2
H.HD	145	E	H.HD.12	AF2	AF2
H.hdhe	146	Y	H.hdhe.01	AF2	AF2
H.hdhe	147	Q	H.hdhe.02	AF2	AF2
H.hdhe	148	L	H.hdhe.03	AF2	AF2
H.hdhe	149	N	H.hdhe.04	AF2	AF2
H.hdhe	150	D	H.hdhe.05	AF2	AF2
H.HE	151	S	H.HE.01	AF2	AF2
H.HE	152	A	H.HE.02	AF2	AF2
H.HE	153	A	H.HE.03	AF2	AF2
H.HE	154	Y	H.HE.04	AF2	AF2
H.HE	155	Y	H.HE.05	AF2	AF2
H.HE	156	L	H.HE.06	AF2	AF2
H.HE	157	N	H.HE.07	AF2	AF2
H.HE	158	D	H.HE.08	AF2	AF2
H.HE	159	L	H.HE.09	AF2	AF2
H.HE	160	D	H.HE.10	AF2	AF2
H.HE	161	R	H.HE.11	AF2	AF2
H.HE	162	I	H.HE.12	AF2	AF2
H.HE	163	A	H.HE.13	AF2	AF2
H.hehf	164	Q	H.hehf.01	AF2	AF2
H.hehf	165	P	H.hehf.02	AF2	AF2
H.hehf	166	N	H.hehf.03	AF2	AF2
H.hehf	167	Y	H.hehf.04	AF2	AF2
H.hehf	168	I	H.hehf.05	AF2	AF2
H.hehf	169	P	H.hehf.06	AF2	AF2
H.hehf	170	T	H.hehf.07	AF2	AF2
H.HF	171	Q	H.HF.01	AF2	AF2
H.HF	172	Q	H.HF.02	AF2	AF2
H.HF	173	D	H.HF.03	AF2	AF2
H.HF	174	V	H.HF.04	AF2	AF2
H.HF	175	L	H.HF.05	AF2	AF2
H.HF	176	R	H.HF.06	AF2	AF2
G.hfs2	177	T	G.hfs2.01	AF2	AF2
G.hfs2	178	R	G.hfs2.02	AF2	AF2
G.hfs2	179	V	G.hfs2.03	AF2	AF2
G.hfs2	180	K	G.hfs2.04	AF2	AF2
G.hfs2	181	T	G.hfs2.05	AF2	AF2
G.hfs2	182	T	G.hfs2.06	Structure	Structure
G.hfs2	183	G	G.hfs2.07	Structure	Structure
G.S2	184	I	G.S2.01	Structure	Structure
G.S2	185	V	G.S2.02	Structure	Structure
G.S2	186	E	G.S2.03	Structure	AF2
G.S2	187	T	G.S2.04	Structure	Structure
G.S2	188	H	G.S2.05	Structure	Structure
G.S2	189	F	G.S2.06	Structure	Structure
G.S2	190	T	G.S2.07	Structure	Structure
G.S2	191	F	G.S2.08	Structure	Structure
G.s2s3	192	K	G.s2s3.01	Structure	Structure
G.s2s3	193	D	G.s2s3.02	Structure	Structure
G.S3	194	L	G.S3.01	Structure	Structure
G.S3	195	H	G.S3.02	Structure	Structure
G.S3	196	F	G.S3.03	Structure	Structure
G.S3	197	K	G.S3.04	Structure	Structure
G.S3	198	M	G.S3.05	Structure	Structure
G.S3	199	F	G.S3.06	Structure	Structure
G.S3	200	D	G.S3.07	Structure	Structure
G.S3	201	V	G.S3.08	Structure	Structure
G.s3h2	202	G	G.s3h2.01	Structure	Structure
G.s3h2	203	G	G.s3h2.02	Structure	AF2
G.s3h2	204	Q	G.s3h2.03	Structure	Structure
G.H2	205	R	G.H2.01	Structure	Structure
G.H2	206	S	G.H2.02	Structure	Structure
G.H2	207	E	G.H2.03	Structure	Structure
G.H2	208	R	G.H2.04	Structure	Structure
G.H2	209	K	G.H2.05	Structure	Structure
G.H2	210	K	G.H2.06	Structure	Structure
G.H2	211	W	G.H2.07	Structure	Structure
G.H2	212	I	G.H2.08	Structure	Structure
G.H2	213	H	G.H2.09	Structure	Structure
G.H2	214	C	G.H2.10	Structure	Structure
G.h2s4	215	F	G.h2s4.01	Structure	Structure
G.h2s4	216	E	G.h2s4.02	Structure	Structure
G.h2s4	217	G	G.h2s4.03	Structure	Structure
G.h2s4	218	V	G.h2s4.04	Structure	Structure
G.h2s4	219	T	G.h2s4.05	Structure	Structure
G.S4	220	A	G.S4.01	Structure	Structure
G.S4	221	I	G.S4.02	Structure	Structure
G.S4	222	I	G.S4.03	Structure	Structure
G.S4	223	F	G.S4.04	Structure	Structure
G.S4	224	C	G.S4.05	Structure	Structure
G.S4	225	V	G.S4.06	Structure	Structure
G.S4	226	A	G.S4.07	Structure	Structure
G.s4h3	227	L	G.s4h3.01	Structure	Structure
G.s4h3	228	S	G.s4h3.02	Structure	Structure
G.s4h3	229	D	G.s4h3.03	Structure	Structure
G.s4h3	230	Y	G.s4h3.04	Structure	Structure
G.s4h3	231	D	G.s4h3.05	Structure	Structure
G.s4h3	232	L	G.s4h3.06	Structure	Structure
G.s4h3	233	V	G.s4h3.07	AF2	AF2
G.s4h3	234	L	G.s4h3.08	AF2	AF2
G.s4h3	235	A	G.s4h3.09	AF2	AF2
G.s4h3	236	E	G.s4h3.10	AF2	AF2
G.s4h3	237	D	G.s4h3.11	AF2	AF2
G.s4h3	238	E	G.s4h3.12	AF2	AF2
G.s4h3	239	E	G.s4h3.13	AF2	AF2
G.s4h3	240	M	G.s4h3.14	Structure	Structure
G.s4h3	241	N	G.s4h3.15	Structure	Structure
G.H3	242	R	G.H3.01	Structure	Structure
G.H3	243	M	G.H3.02	Structure	Structure
G.H3	244	H	G.H3.03	Structure	Structure
G.H3	245	E	G.H3.04	Structure	AF2
G.H3	246	S	G.H3.05	Structure	Structure
G.H3	247	M	G.H3.06	Structure	Structure
G.H3	248	K	G.H3.07	Structure	AF2
G.H3	249	L	G.H3.08	Structure	Structure
G.H3	250	F	G.H3.09	Structure	Structure
G.H3	251	D	G.H3.10	Structure	Structure
G.H3	252	S	G.H3.11	Structure	Structure
G.H3	253	I	G.H3.12	Structure	Structure
G.H3	254	C	G.H3.13	Structure	Structure
G.H3	255	N	G.H3.14	Structure	Structure
G.H3	256	N	G.H3.15	Structure	Structure
G.H3	257	K	G.H3.16	Structure	Structure
G.H3	258	W	G.H3.17	Structure	Structure
G.H3	259	F	G.H3.18	Structure	Structure
G.h3s5	260	T	G.h3s5.01	Structure	Structure
G.h3s5	261	D	G.h3s5.02	Structure	Structure
G.h3s5	262	T	G.h3s5.03	Structure	Structure
G.S5	263	S	G.S5.01	Structure	Structure
G.S5	264	I	G.S5.02	Structure	Structure
G.S5	265	I	G.S5.03	Structure	Structure
G.S5	266	L	G.S5.04	Structure	Structure
G.S5	267	F	G.S5.05	Structure	Structure
G.S5	268	L	G.S5.06	Structure	Structure
G.S5	269	N	G.S5.07	Structure	Structure
G.s5hg	270	K	G.s5hg.01	Structure	Structure
G.HG	271	K	G.HG.01	Structure	Structure
G.HG	272	D	G.HG.02	Structure	Structure
G.HG	273	L	G.HG.03	Structure	Structure
G.HG	274	F	G.HG.04	Structure	Structure
G.HG	275	E	G.HG.05	Structure	AF2
G.HG	276	E	G.HG.06	Structure	Structure
G.HG	277	K	G.HG.07	Structure	Structure
G.HG	278	I	G.HG.08	Structure	Structure
G.HG	279	K	G.HG.09	Structure	Structure
G.HG	280	K	G.HG.12	Structure	Structure
G.HG	281	S	G.HG.13	Structure	Structure
G.HG	282	P	G.HG.14	Structure	Structure
G.HG	283	L	G.HG.15	Structure	Structure
G.HG	284	T	G.HG.16	Structure	Structure
G.HG	285	I	G.HG.17	Structure	Structure
G.hgh4	286	C	G.hgh4.01	Structure	Structure
G.hgh4	287	Y	G.hgh4.02	Structure	Structure
G.hgh4	288	P	G.hgh4.03	Structure	Structure
G.hgh4	289	E	G.hgh4.04	Structure	Structure
G.hgh4	290	Y	G.hgh4.05	Structure	Structure
G.hgh4	291	A	G.hgh4.06	Structure	Structure
G.hgh4	292	G	G.hgh4.07	Structure	Structure
G.hgh4	293	S	G.hgh4.08	Structure	Structure
G.H4	294	N	G.H4.01	Structure	Structure
G.H4	295	T	G.H4.02	Structure	Structure
G.H4	296	Y	G.H4.03	Structure	Structure
G.H4	297	E	G.H4.04	Structure	Structure
G.H4	298	E	G.H4.05	Structure	Structure
G.H4	299	A	G.H4.06	Structure	Structure
G.H4	300	A	G.H4.07	Structure	Structure
G.H4	301	A	G.H4.08	Structure	Structure
G.H4	302	Y	G.H4.10	Structure	Structure
G.H4	303	I	G.H4.11	Structure	Structure
G.H4	304	Q	G.H4.12	Structure	Structure
G.H4	305	C	G.H4.13	Structure	Structure
G.H4	306	Q	G.H4.14	Structure	Structure
G.H4	307	F	G.H4.15	Structure	Structure
G.H4	308	E	G.H4.16	Structure	Structure
G.H4	309	D	G.H4.17	Structure	Structure
G.h4s6	310	L	G.h4s6.01	Structure	Structure
G.h4s6	311	N	G.h4s6.02	Structure	Structure
G.h4s6	312	K	G.h4s6.03	Structure	Structure
G.h4s6	313	R	G.h4s6.04	Structure	Structure
G.h4s6	314	K	G.h4s6.08	Structure	Structure
G.h4s6	315	D	G.h4s6.09	Structure	Structure
G.h4s6	316	T	G.h4s6.10	Structure	Structure
G.h4s6	317	K	G.h4s6.11	Structure	Structure
G.h4s6	318	E	G.h4s6.12	Structure	Structure
G.S6	319	I	G.S6.01	Structure	Structure
G.S6	320	Y	G.S6.02	Structure	Structure
G.S6	321	T	G.S6.03	Structure	Structure
G.S6	322	H	G.S6.04	Structure	Structure
G.S6	323	F	G.S6.05	Structure	Structure
G.s6h5	324	T	G.s6h5.01	Structure	Structure
G.s6h5	325	C	G.s6h5.02	Structure	AF2
G.s6h5	326	A	G.s6h5.03	Structure	AF2
G.s6h5	327	T	G.s6h5.04	Structure	Structure
G.s6h5	328	D	G.s6h5.05	Structure	Structure
G.H5	329	T	G.H5.01	Structure	Structure
G.H5	330	K	G.H5.02	Structure	Structure
G.H5	331	N	G.H5.03	Structure	Structure
G.H5	332	V	G.H5.04	Structure	Structure
G.H5	333	Q	G.H5.05	Structure	Structure
G.H5	334	F	G.H5.06	Structure	Structure
G.H5	335	V	G.H5.07	Structure	Structure
G.H5	336	F	G.H5.08	Structure	Structure
G.H5	337	D	G.H5.09	Structure	Structure
G.H5	338	A	G.H5.10	Structure	Structure
G.H5	339	V	G.H5.11	Structure	Structure
G.H5	340	T	G.H5.12	Structure	Structure
G.H5	341	D	G.H5.13	Structure	Structure
G.H5	342	V	G.H5.14	Structure	Structure
G.H5	343	I	G.H5.15	Structure	Structure
G.H5	344	I	G.H5.16	Structure	Structure
G.H5	345	K	G.H5.17	Structure	Structure
G.H5	346	N	G.H5.18	Structure	Structure
G.H5	347	N	G.H5.19	Structure	Structure
G.H5	348	L	G.H5.20	Structure	Structure
G.H5	349	K	G.H5.21	Structure	Structure
G.H5	350	D	G.H5.22	Structure	Structure
G.H5	351	C	G.H5.23	Structure	Structure
G.H5	352	G	G.H5.24	Structure	Structure
G.H5	353	L	G.H5.25	Structure	Structure
G.H5	354	F	G.H5.26	Structure	Structure

REFINED GPCR RESIDUES

Residue backbones - 303 from structure (89.9%), 34 from model (10.1%)
Residue sidechains - 301 from structure (89.3%), 36 from model (10.7%)

Showing 1 to 337 of 337 entries

Search:

Segment	Seq.num.	AA	GPCRdb#	Backbone from	Sidechain from

N-term	1	M	-	AF2	AF2
N-term	2	E	-	AF2	AF2
N-term	3	E	-	AF2	AF2
N-term	4	G	-	AF2	AF2
N-term	5	G	-	AF2	AF2
N-term	6	D	-	AF2	AF2
N-term	7	F	-	AF2	AF2
N-term	8	D	-	AF2	AF2
N-term	9	N	-	AF2	AF2
N-term	10	Y	-	AF2	AF2
N-term	11	Y	-	AF2	AF2
N-term	12	G	-	AF2	AF2
N-term	13	A	-	AF2	AF2
N-term	14	D	-	AF2	AF2
N-term	15	N	-	AF2	AF2
N-term	16	Q	-	AF2	AF2
N-term	17	S	-	AF2	AF2
N-term	18	E	-	Structure	AF2
N-term	19	C	-	Structure	Structure
N-term	20	E	-	Structure	Structure
N-term	21	Y	-	Structure	Structure
N-term	22	T	-	Structure	Structure
N-term	23	D	-	Structure	Structure
N-term	24	W	-	Structure	Structure
N-term	25	K	-	Structure	Structure
N-term	26	S	-	Structure	Structure
N-term	27	S	-	Structure	Structure
N-term	28	G	-	Structure	Structure
TM1	29	A	1.33x33	Structure	Structure
TM1	30	L	1.34x34	Structure	Structure
TM1	31	I	1.35x35	Structure	Structure
TM1	32	P	1.36x36	Structure	Structure
TM1	33	A	1.37x37	Structure	Structure
TM1	34	I	1.38x38	Structure	Structure
TM1	35	Y	1.39x39	Structure	Structure
TM1	36	M	1.40x40	Structure	Structure
TM1	37	L	1.41x41	Structure	Structure
TM1	38	V	1.42x42	Structure	Structure
TM1	39	F	1.43x43	Structure	Structure
TM1	40	L	1.44x44	Structure	Structure
TM1	41	L	1.45x45	Structure	Structure
TM1	42	G	1.46x46	Structure	Structure
TM1	43	T	1.47x47	Structure	Structure
TM1	44	T	1.48x48	Structure	Structure
TM1	45	G	1.49x49	Structure	Structure
TM1	46	N	1.50x50	Structure	Structure
TM1	47	G	1.51x51	Structure	Structure
TM1	48	L	1.52x52	Structure	Structure
TM1	49	V	1.53x53	Structure	Structure
TM1	50	L	1.54x54	Structure	Structure
TM1	51	W	1.55x55	Structure	Structure
TM1	52	T	1.56x56	Structure	Structure
TM1	53	V	1.57x57	Structure	Structure
TM1	54	F	1.58x58	Structure	Structure
TM1	55	R	1.59x59	Structure	Structure
TM1	56	S	1.60x60	Structure	Structure
ICL1	57	S	12.48x48	AF2	AF2
ICL1	58	R	12.49x49	AF2	AF2
ICL1	59	E	12.50x50	AF2	AF2
ICL1	60	K	12.51x51	AF2	AF2
ICL1	61	R	12.52x52	AF2	AF2
TM2	62	R	2.37x37	Structure	Structure
TM2	63	S	2.38x38	Structure	Structure
TM2	64	A	2.39x39	Structure	Structure
TM2	65	D	2.40x40	Structure	Structure
TM2	66	I	2.41x41	Structure	Structure
TM2	67	F	2.42x42	Structure	Structure
TM2	68	I	2.43x43	Structure	Structure
TM2	69	A	2.44x44	Structure	Structure
TM2	70	S	2.45x45	Structure	Structure
TM2	71	L	2.46x46	Structure	Structure
TM2	72	A	2.47x47	Structure	Structure
TM2	73	V	2.48x48	Structure	Structure
TM2	74	A	2.49x49	Structure	Structure
TM2	75	D	2.50x50	Structure	Structure
TM2	76	L	2.51x51	Structure	Structure
TM2	77	T	2.52x52	Structure	Structure
TM2	78	F	2.53x53	Structure	Structure
TM2	79	V	2.54x54	Structure	Structure
TM2	80	V	2.55x55	Structure	Structure
TM2	81	T	2.56x56	Structure	Structure
TM2	82	L	2.57x57	Structure	Structure
TM2	83	P	2.58x58	Structure	Structure
TM2	84	L	2.59x59	Structure	Structure
TM2	85	W	2.60x60	Structure	Structure
TM2	86	A	2.61x61	Structure	Structure
TM2	87	T	2.62x62	Structure	Structure
TM2	88	Y	2.63x63	Structure	Structure
TM2	89	T	2.64x64	Structure	Structure
TM2	90	Y	2.65x65	Structure	Structure
TM2	91	R	2.66x66	Structure	Structure
TM2	92	D	2.67x67	Structure	Structure
ECL1	93	Y	-	Structure	Structure
ECL1	94	D	23.49x49	Structure	Structure
ECL1	95	W	23.50x50	Structure	Structure
ECL1	96	P	23.51x51	Structure	Structure
ECL1	97	F	23.52x52	Structure	Structure
TM3	98	G	3.21x21	Structure	Structure
TM3	99	T	3.22x22	Structure	Structure
TM3	100	F	3.23x23	Structure	Structure
TM3	101	F	3.24x24	Structure	Structure
TM3	102	C	3.25x25	Structure	Structure
TM3	103	K	3.26x26	Structure	Structure
TM3	104	L	3.27x27	Structure	Structure
TM3	105	S	3.28x28	Structure	Structure
TM3	106	S	3.29x29	Structure	Structure
TM3	107	Y	3.30x30	Structure	Structure
TM3	108	L	3.31x31	Structure	Structure
TM3	109	I	3.32x32	Structure	Structure
TM3	110	F	3.33x33	Structure	Structure
TM3	111	V	3.34x34	Structure	Structure
TM3	112	N	3.35x35	Structure	Structure
TM3	113	M	3.36x36	Structure	Structure
TM3	114	Y	3.37x37	Structure	Structure
TM3	115	A	3.38x38	Structure	Structure
TM3	116	S	3.39x39	Structure	Structure
TM3	117	V	3.40x40	Structure	Structure
TM3	118	F	3.41x41	Structure	Structure
TM3	119	C	3.42x42	Structure	Structure
TM3	120	L	3.43x43	Structure	Structure
TM3	121	T	3.44x44	Structure	Structure
TM3	122	G	3.45x45	Structure	Structure
TM3	123	L	3.46x46	Structure	Structure
TM3	124	S	3.47x47	Structure	Structure
TM3	125	F	3.48x48	Structure	Structure
TM3	126	D	3.49x49	Structure	Structure
TM3	127	R	3.50x50	Structure	Structure
TM3	128	Y	3.51x51	Structure	Structure
TM3	129	L	3.52x52	Structure	Structure
TM3	130	A	3.53x53	Structure	Structure
TM3	131	I	3.54x54	Structure	Structure
TM3	132	V	3.55x55	Structure	Structure
TM3	133	R	3.56x56	Structure	Structure
ICL2	134	P	34.50x50	Structure	Structure
ICL2	135	V	34.51x51	Structure	Structure
ICL2	136	A	34.52x52	Structure	Structure
ICL2	137	N	34.53x53	Structure	Structure
ICL2	138	A	34.54x54	Structure	Structure
ICL2	139	R	34.55x55	Structure	Structure
ICL2	140	L	34.56x56	Structure	Structure
ICL2	141	R	34.57x57	Structure	Structure
TM4	142	L	4.38x38	Structure	Structure
TM4	143	R	4.39x39	Structure	Structure
TM4	144	V	4.40x40	Structure	Structure
TM4	145	S	4.41x41	Structure	Structure
TM4	146	G	4.42x42	Structure	Structure
TM4	147	A	4.43x43	Structure	Structure
TM4	148	V	4.44x44	Structure	Structure
TM4	149	A	4.45x45	Structure	Structure
TM4	150	T	4.46x46	Structure	Structure
TM4	151	A	4.47x47	Structure	Structure
TM4	152	V	4.48x48	Structure	Structure
TM4	153	L	4.49x49	Structure	Structure
TM4	154	W	4.50x50	Structure	Structure
TM4	155	V	4.51x51	Structure	Structure
TM4	156	L	4.52x52	Structure	Structure
TM4	157	A	4.53x53	Structure	Structure
TM4	158	A	4.54x54	Structure	Structure
TM4	159	L	4.55x55	Structure	Structure
TM4	160	L	4.56x56	Structure	Structure
TM4	161	A	4.57x57	Structure	Structure
TM4	162	M	4.58x59	Structure	Structure
TM4	163	P	4.59x60	Structure	Structure
TM4	164	V	4.60x61	Structure	Structure
TM4	165	M	4.61x62	Structure	Structure
TM4	166	V	4.62x63	Structure	Structure
TM4	167	L	4.63x64	Structure	Structure
TM4	168	R	4.64x65	Structure	Structure
ECL2	169	T	-	Structure	Structure
ECL2	170	T	-	Structure	Structure
ECL2	171	G	-	Structure	Structure
ECL2	172	D	-	Structure	Structure
ECL2	173	L	-	Structure	Structure
ECL2	174	E	-	Structure	Structure
ECL2	175	N	-	Structure	Structure
ECL2	176	T	-	Structure	Structure
ECL2	177	T	-	Structure	Structure
ECL2	178	K	-	Structure	Structure
ECL2	179	V	-	Structure	Structure
ECL2	180	Q	-	Structure	Structure
ECL2	181	C	45.50x50	Structure	Structure
ECL2	182	Y	45.51x51	Structure	Structure
ECL2	183	M	45.52x52	Structure	Structure
ECL2	184	D	-	Structure	Structure
ECL2	185	Y	-	Structure	Structure
ECL2	186	S	-	Structure	Structure
ECL2	187	M	-	Structure	Structure
ECL2	188	V	-	Structure	Structure
ECL2	189	A	-	Structure	Structure
ECL2	190	T	-	Structure	Structure
ECL2	191	V	-	Structure	Structure
ECL2	192	S	-	Structure	Structure
TM5	193	S	5.30x31	Structure	Structure
TM5	194	E	5.31x32	Structure	Structure
TM5	195	W	5.32x33	Structure	Structure
TM5	196	A	5.33x34	Structure	Structure
TM5	197	W	5.34x35	Structure	Structure
TM5	198	E	5.35x36	Structure	Structure
TM5	199	V	5.36x37	Structure	Structure
TM5	200	G	5.37x38	Structure	Structure
TM5	201	L	5.38x39	Structure	Structure
TM5	202	G	5.39x40	Structure	Structure
TM5	203	V	5.40x41	Structure	Structure
TM5	204	S	5.41x42	Structure	Structure
TM5	205	S	5.42x43	Structure	Structure
TM5	206	T	5.43x44	Structure	Structure
TM5	207	T	5.44x45	Structure	Structure
TM5	208	V	5.45x46	Structure	Structure
TM5	209	G	5.46x461	Structure	Structure
TM5	210	F	5.47x47	Structure	Structure
TM5	211	V	5.48x48	Structure	Structure
TM5	212	V	5.49x49	Structure	Structure
TM5	213	P	5.50x50	Structure	Structure
TM5	214	F	5.51x51	Structure	Structure
TM5	215	T	5.52x52	Structure	Structure
TM5	216	I	5.53x53	Structure	Structure
TM5	217	M	5.54x54	Structure	Structure
TM5	218	L	5.55x55	Structure	Structure
TM5	219	T	5.56x56	Structure	Structure
TM5	220	C	5.57x57	Structure	Structure
TM5	221	Y	5.58x58	Structure	Structure
TM5	222	F	5.59x59	Structure	Structure
TM5	223	F	5.60x60	Structure	Structure
TM5	224	I	5.61x61	Structure	Structure
TM5	225	A	5.62x62	Structure	Structure
TM5	226	Q	5.63x63	Structure	Structure
TM5	227	T	5.64x64	Structure	Structure
TM5	228	I	5.65x65	Structure	Structure
TM5	229	A	5.66x66	Structure	Structure
TM5	230	G	5.67x67	Structure	Structure
TM5	231	H	5.68x68	Structure	Structure
TM5	232	F	5.69x69	Structure	Structure
ICL3	233	R	-	Structure	Structure
ICL3	234	K	-	Structure	Structure
ICL3	235	E	-	Structure	Structure
TM6	236	R	6.23x23	Structure	Structure
TM6	237	I	6.24x24	Structure	Structure
TM6	238	E	6.25x25	Structure	Structure
TM6	239	G	6.26x26	Structure	Structure
TM6	240	L	6.27x27	Structure	Structure
TM6	241	R	6.28x28	Structure	Structure
TM6	242	K	6.29x29	Structure	Structure
TM6	243	R	6.30x30	Structure	Structure
TM6	244	R	6.31x31	Structure	Structure
TM6	245	R	6.32x32	Structure	Structure
TM6	246	L	6.33x33	Structure	Structure
TM6	247	L	6.34x34	Structure	Structure
TM6	248	S	6.35x35	Structure	Structure
TM6	249	I	6.36x36	Structure	Structure
TM6	250	I	6.37x37	Structure	Structure
TM6	251	V	6.38x38	Structure	Structure
TM6	252	V	6.39x39	Structure	Structure
TM6	253	L	6.40x40	Structure	Structure
TM6	254	V	6.41x41	Structure	Structure
TM6	255	V	6.42x42	Structure	Structure
TM6	256	T	6.43x43	Structure	Structure
TM6	257	F	6.44x44	Structure	Structure
TM6	258	A	6.45x45	Structure	Structure
TM6	259	L	6.46x46	Structure	Structure
TM6	260	C	6.47x47	Structure	Structure
TM6	261	W	6.48x48	Structure	Structure
TM6	262	M	6.49x49	Structure	Structure
TM6	263	P	6.50x50	Structure	Structure
TM6	264	Y	6.51x51	Structure	Structure
TM6	265	H	6.52x52	Structure	Structure
TM6	266	L	6.53x53	Structure	Structure
TM6	267	V	6.54x54	Structure	Structure
TM6	268	K	6.55x55	Structure	Structure
TM6	269	T	6.56x56	Structure	Structure
TM6	270	L	6.57x57	Structure	Structure
TM6	271	Y	6.58x58	Structure	Structure
TM6	272	M	6.59x59	Structure	Structure
TM6	273	L	6.60x60	Structure	Structure
TM6	274	G	6.61x61	Structure	Structure
TM6	275	S	6.62x62	Structure	Structure
TM6	276	L	6.63x63	Structure	Structure
ECL3	277	L	-	Structure	Structure
ECL3	278	H	-	Structure	Structure
ECL3	279	W	-	Structure	Structure
TM7	280	P	7.24x23	Structure	Structure
TM7	281	C	7.25x24	Structure	Structure
TM7	282	D	7.26x25	Structure	Structure
TM7	283	F	7.27x26	Structure	Structure
TM7	284	D	7.28x27	Structure	Structure
TM7	285	L	7.29x28	Structure	Structure
TM7	286	F	7.30x29	Structure	Structure
TM7	287	L	7.31x30	Structure	Structure
TM7	288	M	7.32x31	Structure	Structure
TM7	289	N	7.33x32	Structure	Structure
TM7	290	I	7.34x33	Structure	Structure
TM7	291	F	7.35x34	Structure	Structure
TM7	292	P	7.36x35	Structure	Structure
TM7	293	Y	7.37x36	Structure	Structure
TM7	294	C	7.38x37	Structure	Structure
TM7	295	T	7.39x38	Structure	Structure
TM7	296	C	7.40x39	Structure	Structure
TM7	297	I	7.41x40	Structure	Structure
TM7	298	S	7.42x41	Structure	Structure
TM7	299	Y	7.43x42	Structure	Structure
TM7	300	V	7.44x43	Structure	Structure
TM7	301	N	7.45x45	Structure	Structure
TM7	302	S	7.46x46	Structure	Structure
TM7	303	C	7.47x47	Structure	Structure
TM7	304	L	7.48x48	Structure	Structure
TM7	305	N	7.49x49	Structure	Structure
TM7	306	P	7.50x50	Structure	Structure
TM7	307	F	7.51x51	Structure	Structure
TM7	308	L	7.52x52	Structure	Structure
TM7	309	Y	7.53x53	Structure	Structure
TM7	310	A	7.54x54	Structure	Structure
TM7	311	F	7.55x55	Structure	Structure
TM7	312	F	7.56x56	Structure	Structure
H8	313	D	8.47x47	Structure	Structure
H8	314	P	8.48x48	Structure	Structure
H8	315	R	8.49x49	Structure	Structure
H8	316	F	8.50x50	Structure	Structure
H8	317	R	8.51x51	Structure	Structure
H8	318	Q	8.52x52	Structure	Structure
H8	319	A	8.53x53	Structure	Structure
H8	320	C	8.54x54	Structure	Structure
H8	321	T	8.55x55	Structure	Structure
H8	322	S	8.56x56	Structure	Structure
H8	323	M	8.57x57	Structure	AF2
H8	324	L	8.58x58	Structure	Structure
H8	325	C	8.59x59	Structure	Structure
H8	326	C	8.60x60	AF2	AF2
H8	327	G	8.61x61	AF2	AF2
C-term	328	Q	-	AF2	AF2
C-term	329	S	-	AF2	AF2
C-term	330	R	-	AF2	AF2
C-term	331	C	-	AF2	AF2
C-term	332	A	-	AF2	AF2
C-term	333	G	-	AF2	AF2
C-term	334	T	-	AF2	AF2
C-term	335	S	-	AF2	AF2
C-term	336	H	-	AF2	AF2
C-term	337	S	-	AF2	AF2

GPCR - G protein interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Aromatic	TM5	F	232	5x69	G.H5	K	345	G.H5.17
Hydrophobic	TM4	L	142	4x38	G.HN	E	28	G.HN.52
Hydrophobic	TM5	F	232	5x69	G.H5	L	348	G.H5.20
Hydrophobic	TM6	E	238	6x25	G.h4s6	K	314	G.h4s6.08
Hydrophobic	H8	D	313	8x47	G.H5	F	354	G.H5.26
Hydrophobic	TM3	A	130	3x53	G.H5	C	351	G.H5.23
Hydrophobic	ICL2	A	138	34x54	G.hns1	R	32	G.hns1.03
Hydrophobic	TM5	H	231	5x68	G.H5	I	344	G.H5.16
Hydrophobic	TM6	E	238	6x25	G.h4s6	D	315	G.h4s6.09
Hydrophobic	TM5	I	224	5x61	G.H5	L	353	G.H5.25
Hydrophobic	TM3	R	127	3x50	G.H5	C	351	G.H5.23
Hydrophobic	TM5	F	232	5x69	G.H5	K	345	G.H5.17
Hydrophobic	TM3	A	130	3x53	G.H5	N	347	G.H5.19
Hydrophobic	H8	P	314	8x48	G.H5	F	354	G.H5.26
Hydrophobic	H8	R	315	8x49	G.H5	F	354	G.H5.26
Hydrophobic	TM7	F	312	7x56	G.H5	L	353	G.H5.25
Hydrophobic	TM2	A	64	2x39	G.H5	C	351	G.H5.23
Hydrophobic	TM3	I	131	3x54	G.H5	L	348	G.H5.20
Hydrophobic	ICL2	V	135	34x51	G.S3	L	194	G.S3.01
Hydrophobic	TM6	R	236	6x23	G.h4s6	E	318	G.h4s6.12
Hydrophobic	TM6	L	246	6x33	G.H5	L	353	G.H5.25
Hydrophobic	TM3	I	131	3x54	G.H5	I	344	G.H5.16
Hydrophobic	ICL2	P	134	34x50	G.H5	I	343	G.H5.15
Hydrophobic	ICL2	P	134	34x50	G.H5	I	344	G.H5.16
Hydrophobic	TM5	I	228	5x65	G.H5	L	348	G.H5.20
Hydrophobic	TM6	L	246	6x33	G.H5	L	348	G.H5.20
Hydrophobic	ICL2	R	139	34x55	G.hns1	R	32	G.hns1.03
Hydrophobic	TM3	R	127	3x50	G.H5	L	353	G.H5.25
Hydrophobic	TM6	I	249	6x36	G.H5	L	353	G.H5.25
Hydrophobic	TM3	I	131	3x54	G.H5	L	353	G.H5.25
Hydrophobic	TM5	T	227	5x64	G.H5	I	344	G.H5.16
Hydrophobic	TM6	L	246	6x33	G.H5	F	354	G.H5.26
Hydrophobic	ICL2	V	135	34x51	G.H5	I	343	G.H5.15
Ionic	ICL3	R	233	-	G.h4s6	E	318	G.h4s6.12
Ionic	TM5	H	231	5x68	G.H5	D	341	G.H5.13
Ionic	ICL2	R	141	34x57	G.H5	D	350	G.H5.22
Ionic	TM6	R	236	6x23	G.h4s6	E	318	G.h4s6.12
Polar	TM5	H	231	5x68	G.H5	K	345	G.H5.17
Polar	ICL2	R	141	34x57	G.H5	C	351	G.H5.23
Polar	H8	R	315	8x49	G.H5	K	349	G.H5.21
Polar	TM5	H	231	5x68	G.H5	D	341	G.H5.13
Polar	TM3	R	127	3x50	G.H5	C	351	G.H5.23
Polar	TM6	R	236	6x23	G.h4s6	K	314	G.h4s6.08
Polar	ICL2	R	141	34x57	G.H5	D	350	G.H5.22
Polar	TM3	A	130	3x53	G.H5	N	347	G.H5.19
Polar	TM6	K	242	6x29	G.h4s6	D	315	G.h4s6.09
Van-der-waals	TM5	F	232	5x69	G.H5	L	348	G.H5.20
Van-der-waals	H8	D	313	8x47	G.H5	F	354	G.H5.26
Van-der-waals	TM3	A	130	3x53	G.H5	C	351	G.H5.23
Van-der-waals	H8	R	315	8x49	G.H5	K	349	G.H5.21
Van-der-waals	TM5	H	231	5x68	G.H5	I	344	G.H5.16
Van-der-waals	TM5	H	231	5x68	G.H5	D	341	G.H5.13
Van-der-waals	TM6	E	238	6x25	G.h4s6	D	315	G.h4s6.09
Van-der-waals	TM3	R	127	3x50	G.H5	C	351	G.H5.23
Van-der-waals	TM6	R	236	6x23	G.h4s6	K	314	G.h4s6.08
Van-der-waals	TM3	A	130	3x53	G.H5	N	347	G.H5.19
Van-der-waals	H8	P	314	8x48	G.H5	F	354	G.H5.26
Van-der-waals	H8	R	315	8x49	G.H5	F	354	G.H5.26
Van-der-waals	TM6	R	236	6x23	G.h4s6	E	318	G.h4s6.12
Van-der-waals	TM6	L	246	6x33	G.H5	L	353	G.H5.25
Van-der-waals	TM5	I	228	5x65	G.H5	L	348	G.H5.20
Van-der-waals	TM3	I	131	3x54	G.H5	L	353	G.H5.25

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Main reference

Refined structure (8XZH) of Gi1 - apelin receptor Download Full

GPCR CLASS (FAMILY)

SPECIES

G PROTEIN FAMILY

DATE

3D VIEW

REFINED G PROTEIN RESIDUES

REFINED GPCR RESIDUES

GPCR - G protein interface interactions

Structures

Refined structure (8XZH) of G_i1 - apelin receptor

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