Refined structure (8YKX) of Gi1 - succinate receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-11-26

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 213 from structure (60.2%), 141 from model (39.8%)
Residue sidechains - 204 from structure (57.6%), 150 from model (42.4%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure AF2
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 AF2 AF2
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure AF2
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 AF2 AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure AF2
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure AF2
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure AF2
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure AF2
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 AF2 AF2
G.s6h5 326 A G.s6h5.03 AF2 AF2
G.s6h5 327 T G.s6h5.04 AF2 AF2
G.s6h5 328 D G.s6h5.05 AF2 AF2
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 281 from structure (85.9%), 46 from model (14.1%)
Residue sidechains - 278 from structure (85.0%), 49 from model (15.0%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 L - AF2 AF2
N-term 3 G - AF2 AF2
N-term 4 I - AF2 AF2
N-term 5 M - AF2 AF2
N-term 6 A - AF2 AF2
N-term 7 W - AF2 AF2
N-term 8 N - AF2 AF2
N-term 9 A - AF2 AF2
N-term 10 T - AF2 AF2
TM1 11 C 1.20x20 Structure Structure
TM1 12 K 1.21x21 Structure Structure
TM1 13 N 1.22x22 Structure Structure
TM1 14 W 1.23x23 Structure Structure
TM1 15 L 1.24x24 Structure Structure
TM1 16 A 1.25x25 Structure Structure
TM1 17 A 1.26x26 Structure Structure
TM1 18 E 1.27x27 Structure Structure
TM1 19 A 1.28x28 Structure Structure
TM1 20 A 1.29x29 Structure Structure
TM1 21 L 1.30x30 Structure Structure
TM1 22 E 1.31x31 Structure Structure
TM1 23 K 1.32x32 Structure Structure
TM1 24 Y 1.33x33 Structure Structure
TM1 25 Y 1.34x34 Structure Structure
TM1 26 L 1.35x35 Structure Structure
TM1 27 S 1.36x36 Structure Structure
TM1 28 I 1.37x37 Structure Structure
TM1 29 F 1.38x38 Structure AF2
TM1 30 Y 1.39x39 Structure Structure
TM1 31 G 1.40x40 Structure Structure
TM1 32 I 1.41x41 Structure Structure
TM1 33 E 1.42x42 Structure Structure
TM1 34 F 1.43x43 Structure Structure
TM1 35 V 1.44x44 Structure Structure
TM1 36 V 1.45x45 Structure Structure
TM1 37 G 1.46x46 Structure Structure
TM1 38 V 1.47x47 Structure Structure
TM1 39 L 1.48x48 Structure Structure
TM1 40 G 1.49x49 Structure Structure
TM1 41 N 1.50x50 Structure Structure
TM1 42 T 1.51x51 Structure Structure
TM1 43 I 1.52x52 Structure Structure
TM1 44 V 1.53x53 Structure Structure
TM1 45 V 1.54x54 Structure Structure
TM1 46 Y 1.55x55 Structure Structure
TM1 47 G 1.56x56 Structure Structure
TM1 48 Y 1.57x57 Structure Structure
TM1 49 I 1.58x58 Structure Structure
TM1 50 F 1.59x59 AF2 AF2
TM1 51 S 1.60x60 AF2 AF2
TM1 52 L 1.61x61 AF2 AF2
ICL1 53 K - AF2 AF2
ICL1 54 N - AF2 AF2
ICL1 55 W - Structure Structure
TM2 56 N 2.37x37 Structure Structure
TM2 57 S 2.38x38 Structure Structure
TM2 58 S 2.39x39 Structure Structure
TM2 59 N 2.40x40 Structure Structure
TM2 60 I 2.41x41 Structure Structure
TM2 61 Y 2.42x42 Structure Structure
TM2 62 L 2.43x43 Structure Structure
TM2 63 F 2.44x44 Structure Structure
TM2 64 N 2.45x45 Structure Structure
TM2 65 L 2.46x46 Structure Structure
TM2 66 S 2.47x47 Structure Structure
TM2 67 V 2.48x48 Structure Structure
TM2 68 S 2.49x49 Structure Structure
TM2 69 D 2.50x50 Structure Structure
TM2 70 L 2.51x51 Structure Structure
TM2 71 A 2.52x52 Structure Structure
TM2 72 F 2.53x53 Structure Structure
TM2 73 L 2.54x54 Structure Structure
TM2 74 C 2.55x55 Structure Structure
TM2 75 T 2.56x56 Structure Structure
TM2 76 L 2.57x57 Structure Structure
TM2 77 P 2.58x58 Structure Structure
TM2 78 M 2.59x59 Structure Structure
TM2 79 L 2.60x60 Structure Structure
TM2 80 I 2.61x61 Structure Structure
TM2 81 R 2.62x62 Structure AF2
TM2 82 S 2.63x63 Structure Structure
TM2 83 Y 2.64x64 Structure Structure
TM2 84 A 2.65x65 Structure Structure
TM2 85 N 2.66x66 Structure Structure
ECL1 86 G - Structure Structure
ECL1 87 N 23.49x49 Structure Structure
ECL1 88 W 23.50x50 Structure Structure
ECL1 89 I 23.51x51 Structure Structure
ECL1 90 Y 23.52x52 Structure Structure
TM3 91 G 3.21x21 Structure Structure
TM3 92 D 3.22x22 Structure Structure
TM3 93 V 3.23x23 Structure Structure
TM3 94 L 3.24x24 Structure Structure
TM3 95 C 3.25x25 Structure Structure
TM3 96 I 3.26x26 Structure Structure
TM3 97 S 3.27x27 Structure Structure
TM3 98 N 3.28x28 Structure Structure
TM3 99 R 3.29x29 Structure Structure
TM3 100 Y 3.30x30 Structure Structure
TM3 101 V 3.31x31 Structure Structure
TM3 102 L 3.32x32 Structure Structure
TM3 103 H 3.33x33 Structure Structure
TM3 104 A 3.34x34 Structure Structure
TM3 105 N 3.35x35 Structure Structure
TM3 106 L 3.36x36 Structure Structure
TM3 107 Y 3.37x37 Structure Structure
TM3 108 T 3.38x38 Structure Structure
TM3 109 S 3.39x39 Structure Structure
TM3 110 I 3.40x40 Structure Structure
TM3 111 L 3.41x41 Structure Structure
TM3 112 F 3.42x42 Structure Structure
TM3 113 L 3.43x43 Structure Structure
TM3 114 T 3.44x44 Structure Structure
TM3 115 F 3.45x45 Structure Structure
TM3 116 I 3.46x46 Structure Structure
TM3 117 S 3.47x47 Structure Structure
TM3 118 I 3.48x48 Structure Structure
TM3 119 D 3.49x49 Structure Structure
TM3 120 R 3.50x50 Structure Structure
TM3 121 Y 3.51x51 Structure Structure
TM3 122 L 3.52x52 Structure Structure
TM3 123 I 3.53x53 Structure Structure
TM3 124 I 3.54x54 Structure Structure
TM3 125 K 3.55x55 Structure Structure
TM3 126 Y 3.56x56 Structure Structure
ICL2 127 P 34.50x50 Structure Structure
ICL2 128 F 34.51x51 Structure Structure
ICL2 129 R 34.52x52 Structure Structure
ICL2 130 E 34.53x53 Structure Structure
ICL2 131 H 34.54x54 Structure Structure
ICL2 132 L 34.55x55 Structure Structure
ICL2 133 L 34.56x56 Structure Structure
ICL2 134 Q 34.57x57 Structure Structure
TM4 135 K 4.38x38 Structure Structure
TM4 136 K 4.39x39 Structure Structure
TM4 137 E 4.40x40 Structure Structure
TM4 138 F 4.41x41 Structure Structure
TM4 139 A 4.42x42 Structure Structure
TM4 140 I 4.43x43 Structure Structure
TM4 141 L 4.44x44 Structure Structure
TM4 142 I 4.45x45 Structure Structure
TM4 143 S 4.46x46 Structure Structure
TM4 144 L 4.47x47 Structure Structure
TM4 145 A 4.48x48 Structure Structure
TM4 146 I 4.49x49 Structure Structure
TM4 147 W 4.50x50 Structure Structure
TM4 148 V 4.51x51 Structure Structure
TM4 149 L 4.52x52 Structure Structure
TM4 150 V 4.53x53 Structure Structure
TM4 151 T 4.54x54 Structure Structure
TM4 152 L 4.55x55 Structure Structure
TM4 153 E 4.56x56 Structure Structure
TM4 154 L 4.57x57 Structure Structure
TM4 155 L 4.58x59 Structure Structure
TM4 156 P 4.59x60 Structure Structure
TM4 157 I 4.60x61 Structure Structure
TM4 158 L 4.61x62 Structure Structure
TM4 159 P 4.62x63 Structure Structure
TM4 160 L 4.63x64 Structure Structure
TM4 161 I 4.64x65 Structure Structure
TM4 162 N 4.65x66 Structure Structure
TM4 163 P 4.66x67 Structure Structure
TM4 164 V 4.67x68 Structure Structure
ECL2 165 I - AF2 AF2
ECL2 166 T - AF2 AF2
ECL2 167 D - AF2 AF2
ECL2 168 N - AF2 AF2
ECL2 169 G - AF2 AF2
ECL2 170 T - AF2 AF2
ECL2 171 T - Structure Structure
ECL2 172 C 45.50x50 Structure Structure
ECL2 173 N 45.51x51 Structure Structure
ECL2 174 D 45.52x52 Structure Structure
ECL2 175 F - Structure Structure
ECL2 176 A - Structure Structure
ECL2 177 S - Structure Structure
ECL2 178 S - Structure Structure
ECL2 179 G - Structure Structure
TM5 180 D 5.31x32 Structure Structure
TM5 181 P 5.32x33 Structure Structure
TM5 182 N 5.33x34 Structure Structure
TM5 183 Y 5.34x35 Structure Structure
TM5 184 N 5.35x36 Structure Structure
TM5 185 L 5.36x37 Structure Structure
TM5 186 I 5.37x38 Structure Structure
TM5 187 Y 5.38x39 Structure Structure
TM5 188 S 5.39x40 Structure Structure
TM5 189 M 5.40x41 Structure Structure
TM5 190 C 5.41x42 Structure Structure
TM5 191 L 5.42x43 Structure Structure
TM5 192 T 5.43x44 Structure Structure
TM5 193 L 5.44x45 Structure Structure
TM5 194 L 5.45x46 Structure Structure
TM5 195 G 5.46x461 Structure Structure
TM5 196 F 5.47x47 Structure Structure
TM5 197 L 5.48x48 Structure Structure
TM5 198 I 5.49x49 Structure Structure
TM5 199 P 5.50x50 Structure Structure
TM5 200 L 5.51x51 Structure Structure
TM5 201 F 5.52x52 Structure Structure
TM5 202 V 5.53x53 Structure Structure
TM5 203 M 5.54x54 Structure Structure
TM5 204 C 5.55x55 Structure Structure
TM5 205 F 5.56x56 Structure Structure
TM5 206 F 5.57x57 Structure Structure
TM5 207 Y 5.58x58 Structure Structure
TM5 208 Y 5.59x59 Structure Structure
TM5 209 K 5.60x60 Structure Structure
TM5 210 I 5.61x61 Structure Structure
TM5 211 A 5.62x62 Structure Structure
TM5 212 L 5.63x63 Structure Structure
TM5 213 F 5.64x64 Structure Structure
TM5 214 L 5.65x65 Structure Structure
TM5 215 K 5.66x66 Structure Structure
TM5 216 Q 5.67x67 Structure Structure
TM5 217 R 5.68x68 Structure Structure
TM5 218 N 5.69x69 Structure Structure
TM5 219 R 5.70x70 Structure Structure
TM5 220 Q 5.71x71 Structure Structure
TM5 221 V 5.72x72 Structure Structure
TM5 222 A 5.73x73 Structure Structure
ICL3 223 T - Structure Structure
ICL3 224 A - Structure Structure
ICL3 225 L - Structure Structure
ICL3 226 P - Structure Structure
TM6 227 L 6.30x30 Structure Structure
TM6 228 E 6.31x31 Structure Structure
TM6 229 K 6.32x32 Structure Structure
TM6 230 P 6.33x33 Structure Structure
TM6 231 L 6.34x34 Structure Structure
TM6 232 N 6.35x35 Structure Structure
TM6 233 L 6.36x36 Structure Structure
TM6 234 V 6.37x37 Structure Structure
TM6 235 I 6.38x38 Structure Structure
TM6 236 M 6.39x39 Structure Structure
TM6 237 A 6.40x40 Structure Structure
TM6 238 V 6.41x41 Structure Structure
TM6 239 V 6.42x42 Structure Structure
TM6 240 I 6.43x43 Structure Structure
TM6 241 F 6.44x44 Structure Structure
TM6 242 S 6.45x45 Structure Structure
TM6 243 V 6.46x46 Structure Structure
TM6 244 L 6.47x47 Structure Structure
TM6 245 F 6.48x48 Structure Structure
TM6 246 T 6.49x49 Structure Structure
TM6 247 P 6.50x50 Structure Structure
TM6 248 Y 6.51x51 Structure Structure
TM6 249 H 6.52x52 Structure Structure
TM6 250 V 6.53x53 Structure Structure
TM6 251 M 6.54x54 Structure Structure
TM6 252 R 6.55x55 Structure Structure
TM6 253 N 6.56x56 Structure Structure
TM6 254 V 6.57x57 Structure Structure
TM6 255 R 6.58x58 Structure Structure
TM6 256 I 6.59x59 Structure Structure
TM6 257 A 6.60x60 Structure Structure
TM6 258 S 6.61x61 Structure Structure
TM6 259 R 6.62x62 Structure Structure
TM6 260 L 6.63x63 Structure Structure
TM6 261 G 6.64x64 Structure Structure
ECL3 262 S - AF2 AF2
ECL3 263 W - AF2 AF2
ECL3 264 K - AF2 AF2
ECL3 265 Q - AF2 AF2
TM7 266 Y 7.24x23 AF2 AF2
TM7 267 Q 7.25x24 AF2 AF2
TM7 268 C 7.26x25 AF2 AF2
TM7 269 T 7.27x26 Structure Structure
TM7 270 Q 7.28x27 Structure Structure
TM7 271 V 7.29x28 Structure Structure
TM7 272 V 7.30x29 Structure Structure
TM7 273 I 7.31x30 Structure Structure
TM7 274 N 7.32x31 Structure Structure
TM7 275 S 7.33x32 Structure Structure
TM7 276 F 7.34x33 Structure Structure
TM7 277 Y 7.35x34 Structure Structure
TM7 278 I 7.36x35 Structure Structure
TM7 279 V 7.37x36 Structure Structure
TM7 280 T 7.38x37 Structure Structure
TM7 281 R 7.39x38 Structure Structure
TM7 282 P 7.40x39 Structure Structure
TM7 283 L 7.41x40 Structure Structure
TM7 284 A 7.42x41 Structure Structure
TM7 285 F 7.43x42 Structure Structure
TM7 286 L 7.44x43 Structure Structure
TM7 287 N 7.45x45 Structure Structure
TM7 288 S 7.46x46 Structure Structure
TM7 289 V 7.47x47 Structure Structure
TM7 290 I 7.48x48 Structure Structure
TM7 291 N 7.49x49 Structure Structure
TM7 292 P 7.50x50 Structure Structure
TM7 293 V 7.51x51 Structure Structure
TM7 294 F 7.52x52 Structure Structure
TM7 295 Y 7.53x53 Structure Structure
TM7 296 F 7.54x54 Structure Structure
TM7 297 L 7.55x55 Structure Structure
TM7 298 L 7.56x56 Structure Structure
H8 299 G 8.47x47 Structure Structure
H8 300 D 8.48x48 Structure AF2
H8 301 H 8.49x49 Structure Structure
H8 302 F 8.50x50 Structure Structure
H8 303 R 8.51x51 Structure Structure
H8 304 D 8.52x52 Structure Structure
H8 305 M 8.53x53 Structure Structure
H8 306 L 8.54x54 Structure Structure
H8 307 M 8.55x55 Structure Structure
H8 308 N 8.56x56 Structure Structure
H8 309 Q 8.57x57 Structure Structure
H8 310 L 8.58x58 AF2 AF2
H8 311 R 8.59x59 AF2 AF2
H8 312 H 8.60x60 AF2 AF2
H8 313 N 8.61x61 AF2 AF2
H8 314 F 8.62x62 AF2 AF2
H8 315 K 8.63x63 AF2 AF2
H8 316 S 8.64x64 AF2 AF2
H8 317 L 8.65x65 AF2 AF2
C-term 318 T - AF2 AF2
C-term 319 S - AF2 AF2
C-term 320 F - AF2 AF2
C-term 321 S - AF2 AF2
C-term 322 R - AF2 AF2
C-term 323 W - AF2 AF2
C-term 324 A - AF2 AF2
C-term 325 H - AF2 AF2
C-term 326 E - AF2 AF2
C-term 327 L - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 E 130 34x53 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 F 128 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 F 128 34x51 G.H5 I 343 G.H5.15
Polar TM3 I 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 123 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 124 3x54 G.H5 I 344 G.H5.16
Hydrophobic H8 F 302 8x50 G.H5 C 351 G.H5.23
Hydrophobic H8 H 301 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 H 301 8x49 G.H5 K 349 G.H5.21
Hydrophobic TM6 P 230 6x33 G.H5 L 348 G.H5.20
Polar TM6 P 230 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 P 230 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 P 230 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 F 213 5x64 G.H5 I 344 G.H5.16
Hydrophobic ICL2 F 128 34x51 G.S1 V 34 G.S1.02
Polar ICL3 L 225 - G.H5 K 345 G.H5.17
Hydrophobic H8 G 299 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 G 299 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM5 L 214 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 V 221 5x72 G.H5 F 334 G.H5.06
Van-der-waals TM5 V 221 5x72 G.H5 F 334 G.H5.06
Hydrophobic TM6 L 227 6x30 G.H5 K 345 G.H5.17
Hydrophobic TM6 L 233 6x36 G.H5 L 353 G.H5.25
Hydrophobic H8 F 302 8x50 G.H5 G 352 G.H5.24
Van-der-waals H8 F 302 8x50 G.H5 G 352 G.H5.24
Polar ICL3 L 225 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 L 225 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 R 217 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 217 5x68 G.H5 I 344 G.H5.16
Hydrophobic H8 F 302 8x50 G.H5 D 350 G.H5.22
Van-der-waals H8 F 302 8x50 G.H5 D 350 G.H5.22
Hydrophobic ICL2 F 128 34x51 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 F 128 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 A 224 - G.S6 Y 320 G.S6.02
Hydrophobic TM6 L 227 6x30 G.H5 L 348 G.H5.20
Aromatic TM6 K 229 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM5 V 221 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 V 221 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM6 V 234 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 234 6x37 G.H5 L 353 G.H5.25
Polar TM3 R 120 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 120 3x50 G.H5 C 351 G.H5.23
Polar ICL2 P 127 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 127 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 127 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM5 Q 220 5x71 G.H5 D 337 G.H5.09
Hydrophobic ICL2 P 127 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 127 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 P 230 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM5 R 217 5x68 G.H5 T 340 G.H5.12
Hydrophobic H8 D 300 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 227 6x30 G.H5 F 354 G.H5.26
Hydrophobic TM3 R 120 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 120 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 124 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 V 221 5x72 G.H5 D 337 G.H5.09