Structure information

μ receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6DDE

SPECIES

Mus musculus

RESOLUTION

3.500

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-018-0219-7

PUBLICATION DATE

June 13, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
DAMGO W133 23.50x50 ECL1 hydrophobic
DAMGO I144 3.29x29 TM3 hydrophobic
DAMGO D147 3.32x32 TM3 polar (charge-assisted hydrogen bond)
DAMGO Y148 3.33x33 TM3 Van der Waals
DAMGO Y148 3.33x33 TM3 aromatic (face-to-edge)
DAMGO M151 3.36x36 TM3 Van der Waals
DAMGO M151 3.36x36 TM3 hydrophobic
DAMGO C217 45.50x50 ECL2 Van der Waals
DAMGO V236 5.42x43 TM5 Van der Waals
DAMGO I296 6.51x51 TM6 hydrophobic
DAMGO I296 6.51x51 TM6 Van der Waals
DAMGO H297 6.52x52 TM6 Van der Waals
DAMGO V300 6.55x55 TM6 hydrophobic
DAMGO V300 6.55x55 TM6 Van der Waals
DAMGO K303 6.58x58 TM6 polar (charge-assisted hydrogen bond)
DAMGO W318 7.35x34 TM7 hydrophobic
DAMGO W318 7.35x34 TM7 Van der Waals
DAMGO I322 7.39x38 TM7 hydrophobic
DAMGO I322 7.39x38 TM7 Van der Waals
DAMGO Y326 7.43x42 TM7 polar (hydrogen bond)

Ligands

DAMGO

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Residue Diagrams

F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I V N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7
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ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A G P G N I S D C S D P L A P A S C S P A P G S W L N L S H V D G N Q S D P C G P N R T G L G G S H S L C P Q T G S P S N-termC-term P T S S T I E Q Q N S A R I R Q N T R E H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I V N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
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Residue Table


GPCRdb(A)
GPCRdb(A)
μ receptor
ECL1
23x50 23.50x50 W133
TM3
3x29 3.29x29 I144
3x32 3.32x32 D147
3x33 3.33x33 Y148
3x36 3.36x36 M151
ECL2
45x50 45.50x50 C217
TM5
5x43 5.42x43 V236
TM6
6x51 6.51x51 I296
6x52 6.52x52 H297
6x55 6.55x55 V300
6x58 6.58x58 K303
TM7
7x34 7.35x34 W318
7x38 7.39x38 I322
7x42 7.43x42 Y326