Structure information

CXCR2

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6LFO

SPECIES

Homo sapiens

RESOLUTION

3.400

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-020-2492-5

PUBLICATION DATE

Sept. 2, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Interleukin-8 S27 N-term polar (hydrogen bond with backbone)
Interleukin-8 S27 N-term Van der Waals
Interleukin-8 T28 N-term Van der Waals
Interleukin-8 L29 N-term Van der Waals
Interleukin-8 P31 N-term Van der Waals
Interleukin-8 F32 N-term Van der Waals
Interleukin-8 F32 N-term polar (hydrogen bond with backbone)
Interleukin-8 L33 N-term hydrophobic
Interleukin-8 L33 N-term Van der Waals
Interleukin-8 L34 N-term hydrophobic
Interleukin-8 L34 N-term Van der Waals
Interleukin-8 D35 N-term polar (hydrogen bond with backbone)
Interleukin-8 D35 N-term polar (charge-assisted hydrogen bond)
Interleukin-8 A36 N-term Van der Waals
Interleukin-8 A36 N-term hydrophobic
Interleukin-8 A37 N-term Van der Waals
Interleukin-8 P38 N-term hydrophobic
Interleukin-8 P38 N-term Van der Waals
Interleukin-8 C39 N-term Van der Waals
Interleukin-8 E40 N-term Van der Waals
Interleukin-8 W104 2.60x60 TM2 hydrophobic
Interleukin-8 K108 2.64x64 TM2 Van der Waals
Interleukin-8 V187 ECL2 Van der Waals
Interleukin-8 V187 ECL2 hydrophobic
Interleukin-8 Y197 45.51x51 ECL2 polar (hydrogen bond)
Interleukin-8 Y197 45.51x51 ECL2 Van der Waals
Interleukin-8 G201 ECL2 polar (hydrogen bond with backbone)
Interleukin-8 G201 ECL2 Van der Waals
Interleukin-8 N202 ECL2 Van der Waals
Interleukin-8 T204 5.31x32 TM5 polar (hydrogen bond)
Interleukin-8 T204 5.31x32 TM5 Van der Waals
Interleukin-8 D274 6.58x58 TM6 Van der Waals
Interleukin-8 R278 6.62x62 TM6 polar (charge-assisted hydrogen bond)
Interleukin-8 R289 7.28x27 TM7 polar (charge-assisted hydrogen bond)

Ligands

Interleukin-8

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Residue Diagrams

S N G L L S L L F V L A Y I I V V F Y K 1 L N L A L A D L L F A L T L P I W A A S 2 C A L L L I G S Y F N V E K L L S V V K 3 V K F I C L S I W G L S L L L A L P V 4 Y C F L M I L L P V I F G F S Q P L I R L 5 F A V V L I F L L C W L P Y N L V L L A 6 L P N L C S H L I G L I E T A D L A R 7
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ICL1 R V G R ICL1ECL1 G W I F ECL1ICL2 A T R T L T Q K R Y ICL2ECL2 R T V Y S S N V S P A C Y E D M G N ECL2ICL3 H M G ICL3ECL3 V I Q E ECL3N-term M E D F N M E S D S F E D F W K G E D L S N Y S Y S S T L P P F L L D A A P C E P E S L N-termC-term G L I S K D S L P K D S R P S F V G S S S G H T S T T L C-term E I N K Y F V V I I Y A L V F L L S L L G N S L V M L V I L Y S S V T D V Y L L N L A L A D L L F A L T L P I W A A S K V N G T F L C K V V S L L K E V N F Y S G I L L L A C I S V D R Y L A I V H L V K F I C L S I W G L S L L L A L P V L L F R N T A N W R M L L R I L P Q S F G F I V P L L I M L F C Y G F T L R T L F K A Q K H R A M R V I F A V V L I F L L C W L P Y N L V L L A D T L M R T Q T C E R R N H I D R A L D A T E I L G I L H S C L N P L I Y A F I G Q K L L K H F R H G I L A I
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Residue Table


GPCRdb(A)
GPCRdb(A)
CXCR2
TM2
2x60 2.60x60 W104
2x64 2.64x64 K108
ECL2
45x51 45.51x51 Y197
TM5
5x32 5.31x32 T204
TM6
6x58 6.58x58 D274
6x62 6.62x62 R278
TM7
7x27 7.28x27 R289