CXCR2 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

6LFO

RESOLUTION

3.4 Å

REFERENCE

10.1038/S41586-020-2492-5

PUBLICATION DATE

Sept. 2, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

71 interactions (Click to see)

LIGANDS

Interleukin-8 - Agonist pubchem

PHYSIOLOGICAL LIGANDS

CXCL3, CXCL8, CXCL7, CXCL2, CXCL1, CXCL6, CXCL5



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 A 249 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 148 3x54 G.H5 L 353 G.H5.25
Polar TM2 T 83 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 83 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 83 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM6 Q 245 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 Q 245 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL3 M 243 - G.H5 K 345 G.H5.17
Hydrophobic ICL3 H 242 - G.S6 Y 320 G.S6.02
Polar H8 G 318 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 G 318 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 G 318 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 R 144 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 A 151 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 T 152 34x51 G.S3 L 194 G.S3.01
Polar TM2 T 83 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 83 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 83 2x39 G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 159 34x58 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 A 249 6x33 G.H5 L 353 G.H5.25
Polar TM3 A 147 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 147 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 147 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 L 238 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 V 252 6x36 G.H5 L 353 G.H5.25
Polar ICL2 L 155 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 148 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 148 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 T 152 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 T 152 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM3 I 148 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 148 3x54 G.H5 I 344 G.H5.16
Polar TM6 R 248 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 248 6x32 G.H5 L 353 G.H5.25
Polar TM3 R 144 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 144 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 144 3x50 G.H5 C 351 G.H5.23
Polar H8 Q 319 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 Q 319 8x48 G.H5 F 354 G.H5.26
Hydrophobic ICL3 M 243 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 M 243 - G.H5 I 344 G.H5.16
Polar TM6 R 248 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 A 151 34x50 G.H5 I 344 G.H5.16
Polar ICL3 M 243 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 M 243 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 M 243 - G.H5 D 341 G.H5.13
Polar ICL2 T 156 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 156 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 156 34x55 G.hns1 R 32 G.hns1.03
Ionic ICL3 H 242 - G.H5 D 341 G.H5.13
Polar ICL3 H 242 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 H 242 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 H 242 - G.H5 D 341 G.H5.13
Hydrophobic TM6 I 253 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 253 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 T 152 34x51 G.H5 T 340 G.H5.12