Structure information

M1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6OIJ

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIENCE.AAW5188

PUBLICATION DATE

May 8, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
iperoxo Y106 3.33x33 TM3 hydrophobic
iperoxo Q110 3.37x37 TM3 polar (hydrogen bond)
iperoxo Q110 3.37x37 TM3 polar (hydrogen bond)
iperoxo V113 3.40x40 TM3 hydrophobic
iperoxo V113 3.40x40 TM3 Van der Waals
iperoxo W157 4.57x57 TM4 Van der Waals
iperoxo A196 5.46x461 TM5 polar (hydrogen bond with backbone)
iperoxo A196 5.46x461 TM5 Van der Waals
iperoxo F197 5.47x47 TM5 polar (hydrogen bond with backbone)
iperoxo F197 5.47x47 TM5 Van der Waals
iperoxo W378 6.48x48 TM6 Van der Waals
iperoxo W378 6.48x48 TM6 hydrophobic
iperoxo Y381 6.51x51 TM6 Van der Waals
iperoxo Y381 6.51x51 TM6 hydrophobic
iperoxo Y404 7.39x38 TM7 hydrophobic
iperoxo Y404 7.39x38 TM7 Van der Waals
iperoxo C407 7.42x41 TM7 Van der Waals
iperoxo Y408 7.43x42 TM7 hydrophobic

Ligands

iperoxo

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Residue Diagrams

L N G T V T A L S L L G T T I G I F A V 1 L S L A C A D L I I G F T S M N L Y T T Y 2 L L L N M V S A N S A V Y D L A L W L D 3 A A L M I G L A W L V S F V L W A P A I 4 Y L T C M V T V P L Y F A A M A T G F T I 5 S A I L L A F I L T W T P Y N I M V L V 6 M P N I T S N V Y C L W Y G L E W L T 7
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ICL1 T E L K ICL1ECL1 H W A L ECL1ICL2 P L S Y R A K R ICL2ECL2 E R T V L A G Q C Y I Q F L S ECL2ICL3 Q G S E T P G K G G G S S S S S E R S Q P G A E G S P E T P P G R C C R C C R A P R L L Q A Y S W K E E E E E D E G S M E S L T S S E G E E P G S E V V I K M P M V D P E A Q A P T K Q P P R S S P N T V K R P T K K G R D R A G K G Q K P R G K E Q L A K R K ICL3ECL3 K D C V ECL3N-term M N T S A P P A V S P N I T V L A P G K N-termC-term R W D K R R W R K I P K R P G S V H R T P S R Q C C-term G P W Q V A F I G I T T G L L S L A T V T G N L L V L I S F K V N T V N N Y F L L S L A C A D L I I G T F S M N L Y T T Y L L M G G T L A C D L W L A L D Y V A S N A S V M N L L L I S F D R Y F S V T R T P R R A A L M I G L A W L V S F V L W A P A I L F W Q Y L V G Q P I I T F G T A M A A F Y L P V T V M C T L Y W R I Y R E T E N R A R E L A A L T F S L V K E K K A A R T L S A I L L A F I L T W T P Y N I M V L V S T F C P E T L W E L G Y W L C Y V N S T I N P M C Y A L C N K A F R L F R D T L L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
M1 receptor
TM3
3x33 3.33x33 Y106
3x37 3.37x37 N110
3x40 3.40x40 V113
TM4
4x57 4.57x57 W157
TM5
5x461 5.46x461 A196
5x47 5.47x47 F197
TM6
6x48 6.48x48 W378
6x51 6.51x51 Y381
TM7
7x38 7.39x38 Y404
7x41 7.42x41 C407
7x42 7.43x42 Y408