M1 receptor - G11

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

6OIJ

RESOLUTION

3.3 Å

REFERENCE

10.1126/SCIENCE.AAW5188

PUBLICATION DATE

May 8, 2019

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

32 interactions (Click to see)

LIGANDS

iperoxo - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

acetylcholine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
R02G.hns1D13E22Y23N24L25G.H5GproteinD3x49C7x56N8x47A34x55R34x57K6x32T5x65R5x68GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.hns1G.H5GPCR segments:ICL2TM3TM5TM6TM7H8

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x393x493x503x533x5434x5034x5134x5434x5534x574x395x615x655x685x725x756x326x336x366x377x568x47G.H5.25G.H5.24G.H5.23G.H5.22G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.13G.H5.12G.H5.11G.H5.09G.H5.08G.H5.06G.S6.05G.S6.03G.S6.02G.h4s6.20G.H4.12G.S3.01G.S1.02G.hns1.03G.hns1.02G.HN.52Res. Pos.M1 (6OIJ)- (6OIJ)-----------------------NDRSVPLRARPITRLLKATLCNNPLRARDRSVPITRLLKATLCNGEKILFVLIRRYNLELDQYIFASNLF

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.