Structure information

calcitonin receptor-like receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6UVA

SPECIES

Homo sapiens

RESOLUTION

2.300

PREFERRED CHAIN

R

REFERENCE

10.1021/ACSPTSCI.9B00080

PUBLICATION DATE

April 1, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
adrenomedullin 2/intermedin V36 N-term hydrophobic
adrenomedullin 2/intermedin V36 N-term Van der Waals
adrenomedullin 2/intermedin T37 N-term polar (hydrogen bond)
adrenomedullin 2/intermedin D70 N-term Van der Waals
adrenomedullin 2/intermedin W72 N-term aromatic (face-to-edge)
adrenomedullin 2/intermedin W72 N-term Van der Waals
adrenomedullin 2/intermedin D90 N-term polar (hydrogen bond with backbone)
adrenomedullin 2/intermedin D90 N-term polar (charge-assisted hydrogen bond)
adrenomedullin 2/intermedin Y91 N-term polar (hydrogen bond with backbone)
adrenomedullin 2/intermedin Y91 N-term Van der Waals
adrenomedullin 2/intermedin F92 N-term polar (hydrogen bond with backbone)
adrenomedullin 2/intermedin F92 N-term Van der Waals
adrenomedullin 2/intermedin Q93 N-term polar (hydrogen bond)
adrenomedullin 2/intermedin Q93 N-term polar (hydrogen bond with backbone)
adrenomedullin 2/intermedin Q93 N-term polar (hydrogen bond)
adrenomedullin 2/intermedin D96 N-term polar (charge-assisted hydrogen bond)
adrenomedullin 2/intermedin P97 N-term hydrophobic
adrenomedullin 2/intermedin P97 N-term Van der Waals
adrenomedullin 2/intermedin S98 N-term Van der Waals
adrenomedullin 2/intermedin A116 N-term Van der Waals
adrenomedullin 2/intermedin S117 N-term Van der Waals
adrenomedullin 2/intermedin S117 N-term polar (hydrogen bond)
adrenomedullin 2/intermedin T120 N-term polar (hydrogen bond with backbone)
adrenomedullin 2/intermedin T120 N-term Van der Waals
adrenomedullin 2/intermedin W121 N-term polar (hydrogen bond)
adrenomedullin 2/intermedin W121 N-term Van der Waals
adrenomedullin 2/intermedin T122 N-term Van der Waals
adrenomedullin 2/intermedin Y124 N-term Van der Waals
adrenomedullin 2/intermedin Y124 N-term polar (hydrogen bond with backbone)
adrenomedullin 2/intermedin T125 N-term Van der Waals
adrenomedullin 2/intermedin N128 N-term Van der Waals
adrenomedullin 2/intermedin N128 N-term polar (hydrogen bond)
adrenomedullin 2/intermedin K134 1.32x32 TM1 Van der Waals
adrenomedullin 2/intermedin V135 1.33x33 TM1 Van der Waals
adrenomedullin 2/intermedin V135 1.33x33 TM1 hydrophobic
adrenomedullin 2/intermedin A138 1.36x36 TM1 Van der Waals
adrenomedullin 2/intermedin A138 1.36x36 TM1 hydrophobic
adrenomedullin 2/intermedin L139 1.37x37 TM1 hydrophobic
adrenomedullin 2/intermedin L139 1.37x37 TM1 Van der Waals
adrenomedullin 2/intermedin L141 1.39x39 TM1 hydrophobic
adrenomedullin 2/intermedin L141 1.39x39 TM1 Van der Waals
adrenomedullin 2/intermedin F142 1.40x40 TM1 Van der Waals
adrenomedullin 2/intermedin F142 1.40x40 TM1 hydrophobic
adrenomedullin 2/intermedin T191 2.64x64 TM2 Van der Waals
adrenomedullin 2/intermedin L195 2.68x68 TM2 Van der Waals
adrenomedullin 2/intermedin L195 2.68x68 TM2 hydrophobic
adrenomedullin 2/intermedin A199 ECL1 polar (hydrogen bond with backbone)
adrenomedullin 2/intermedin A199 ECL1 Van der Waals
adrenomedullin 2/intermedin N200 ECL1 Van der Waals
adrenomedullin 2/intermedin Q202 ECL1 Van der Waals
adrenomedullin 2/intermedin Q216 3.33x33 TM3 polar (hydrogen bond)
adrenomedullin 2/intermedin H219 3.36x36 TM3 Van der Waals
adrenomedullin 2/intermedin L220 3.37x37 TM3 Van der Waals
adrenomedullin 2/intermedin Y227 3.44x44 TM3 Van der Waals
adrenomedullin 2/intermedin I284 45.52x52 ECL2 Van der Waals
adrenomedullin 2/intermedin I284 45.52x52 ECL2 hydrophobic
adrenomedullin 2/intermedin S285 ECL2 Van der Waals
adrenomedullin 2/intermedin S286 ECL2 Van der Waals
adrenomedullin 2/intermedin S286 ECL2 polar (hydrogen bond)
adrenomedullin 2/intermedin D287 ECL2 Van der Waals
adrenomedullin 2/intermedin H289 ECL2 Van der Waals
adrenomedullin 2/intermedin H289 ECL2 polar (hydrogen bond)
adrenomedullin 2/intermedin L291 5.36x37 TM5 hydrophobic
adrenomedullin 2/intermedin Y292 5.37x38 TM5 polar (hydrogen bond)
adrenomedullin 2/intermedin Y292 5.37x38 TM5 polar (hydrogen bond)
adrenomedullin 2/intermedin H295 5.40x40 TM5 Van der Waals
adrenomedullin 2/intermedin I298 5.43x43 TM5 Van der Waals
adrenomedullin 2/intermedin F349 6.53x53 TM6 Van der Waals
adrenomedullin 2/intermedin W354 ECL3 Van der Waals
adrenomedullin 2/intermedin W354 ECL3 polar (hydrogen bond with backbone)
adrenomedullin 2/intermedin M369 7.42x41 TM7 Van der Waals
adrenomedullin 2/intermedin M369 7.42x41 TM7 hydrophobic
adrenomedullin 2/intermedin H370 7.43x42 TM7 polar (hydrogen bond)
adrenomedullin 2/intermedin H370 7.43x42 TM7 Van der Waals
adrenomedullin 2/intermedin M373 7.46x45 TM7 hydrophobic
adrenomedullin 2/intermedin M373 7.46x45 TM7 Van der Waals

Ligands

adrenomedullin 2/intermedin

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Residue Diagrams

L L S A I S L G H G I I T L Y F L N L A 1 K N L F F S F V C N S V V T I I H L T A 2 C L M W F Y N C G M L Y L H I F Q S V K 3 H L M W Y Y F G L W G F P L I P A C I H A 4 L F F L N V L L A A C I P G H I I Y L L H 5 L I L V P L L G I E F V L I P W 6 T S V L L G Q F H M L I H M I Y D Y V 7
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ICL1 K S L S ICL1ECL1 A N N Q A L V A T N P ECL1ICL2 A V F A E K Q ICL2ECL2 N D N C W I S S D ECL2ICL3 V T H Q A E S N L ICL3ECL3 R P E G ECL3N-term M E K K C T L Y F L V L L P F F M I L V T A E L E E S P E D S I Q L G V T R N K I M T A Q Y E C Y Q K I M Q D P I Q Q A E G V Y C N R T W D G W L C W N D V A A G T E S M Q L C P D Y F Q D F D P S E K V T K I C D Q D G N W F R H P A S N R T W T N Y T Q C N V N-termC-term E A L R S A S Y T V S T I S D G P G Y S H D C P S E H L N G K S I H D I E N V L L K P E N L Y N C-term N T H E K V K T A L N L F Y L T I I G H G L S I A S L L I S L G I F F Y F C Q R I T L H K N L F F S F V C N S V V T I I H L T A V V S C K V S Q F I H L Y L M G C N Y F W M L C E G I Y L H T L I V V H L M W Y Y F L G W G F P L I P A C I H A I A R S L Y Y T H L L Y I I H G P I C A A L L V N L F F L L N I V R V L I T K L K Y M K A V R A T L I L V P L L G I E F V L I P W K I A E E V Y D Y I M H I L M H F Q G L L V S T I F C F F N G E L R R Y K I S F S V Q A I N W N Q Q F G N N S
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Residue Table


GPCRdb(A)
GPCRdb(B)
calcitonin receptor-like receptor
TM1
1x28 1.32x32 K134
1x29 1.33x33 V135
1x32 1.36x36 A138
1x33 1.37x37 L139
1x35 1.39x39 L141
1x36 1.40x40 F142
TM2
2x57 2.64x64 T191
2x61 2.68x68 L195
TM3
3x29 3.33x33 Q216
3x32 3.36x36 H219
3x33 3.37x37 L220
3x40 3.44x44 Y227
ECL2
45x52 45.52x52 I284
TM5
5x41 5.36x37 L291
5x42 5.37x38 Y292
5x44 5.40x40 H295
5x47 5.43x43 I298
TM6
6x48 6.53x53 F349
TM7
7x37 7.42x41 M369
7x38 7.43x42 H370
7x41 7.46x45 M373