calcitonin receptor-like receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

6UVA

RESOLUTION

2.3 Å

REFERENCE

10.1021/ACSPTSCI.9B00080

PUBLICATION DATE

April 1, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

140 interactions (Click to see)

LIGANDS

adrenomedullin 2/intermedin - Agonist gtoplig

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 246 - G.hns1 A 39 G.hns1.03
Hydrophobic TM5 L 316 5x61 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 316 5x61 G.H5 L 388 G.H5.20
Aromatic TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 173 2x46 G.H5 Y 391 G.H5.23
Ionic TM5 K 319 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 319 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 319 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 319 5x64 G.H5 D 381 G.H5.13
Polar TM3 V 242 3x59 G.H5 R 380 G.H5.12
Polar TM5 K 319 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 319 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 319 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 316 5x61 G.H5 L 394 G.H5.26
Van-der-waals ICL2 E 248 - G.HN Q 35 G.HN.52
Hydrophobic TM6 L 341 6x45 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 241 3x58 G.H5 L 393 G.H5.25
Polar H8 N 388 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 N 388 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 388 8x47 G.H5 E 392 G.H5.24
Polar TM3 L 240 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 240 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 240 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM2 H 177 2x50 G.H5 Y 391 G.H5.23
Polar TM3 V 242 3x59 G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 316 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL2 A 244 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 A 244 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 K 249 - G.hns1 A 39 G.hns1.03
Polar TM6 R 336 6x40 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 336 6x40 G.H5 E 392 G.H5.24
Hydrophobic TM6 A 337 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 241 3x58 G.H5 H 387 G.H5.19
Hydrophobic TM3 I 241 3x58 G.H5 L 388 G.H5.20
Van-der-waals ICL2 V 245 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 F 246 - G.H5 I 383 G.H5.15
Hydrophobic TM3 L 237 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 237 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM6 I 340 6x44 G.H5 L 393 G.H5.25
Polar TM3 I 241 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 241 3x58 G.H5 Q 384 G.H5.16
Polar ICL2 K 249 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 K 249 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 K 249 - G.HN Q 35 G.HN.52
Polar TM5 K 319 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 319 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 319 5x64 G.H5 R 385 G.H5.17
Hydrophobic ICL3 V 322 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 V 322 - G.H5 R 385 G.H5.17
Polar TM2 R 173 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 173 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 173 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM3 Y 236 3x53 G.H5 Y 391 G.H5.23
Polar H8 G 389 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 G 389 8x48 G.H5 E 392 G.H5.24
Polar TM6 R 336 6x40 G.H5 L 393 G.H5.25
Hydrophobic TM6 R 336 6x40 G.H5 L 393 G.H5.25
Van-der-waals TM6 R 336 6x40 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 241 3x58 G.H5 Y 391 G.H5.23
Polar ICL2 A 247 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 A 247 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 F 246 - G.S3 V 217 G.S3.01
Hydrophobic TM5 L 320 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 320 5x65 G.H5 L 394 G.H5.26
Hydrophobic ICL2 E 248 - G.hns1 R 38 G.hns1.02
Aromatic ICL2 F 246 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 246 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 246 - G.S1 H 41 G.S1.02