Structure information

GLP-1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6X19

SPECIES

Homo sapiens

RESOLUTION

2.100

PREFERRED CHAIN

R

REFERENCE

10.1016/J.MOLCEL.2020.09.020

PUBLICATION DATE

Sept. 9, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHU-128 W33 N-term hydrophobic
CHU-128 P137 N-term hydrophobic
CHU-128 L141 1.36x36 TM1 hydrophobic
CHU-128 L144 1.39x39 TM1 hydrophobic
CHU-128 Y145 1.40x40 TM1 hydrophobic
CHU-128 L201 2.71x71 TM2 hydrophobic
CHU-128 Y220 ECL1 polar (hydrogen bond)
CHU-128 Y220 ECL1 Van der Waals
CHU-128 C226 3.29x29 TM3 Van der Waals
CHU-128 V229 3.32x32 TM3 hydrophobic
CHU-128 V229 3.32x32 TM3 Van der Waals
CHU-128 F230 3.33x33 TM3 hydrophobic
CHU-128 F230 3.33x33 TM3 Van der Waals
CHU-128 M233 3.36x36 TM3 hydrophobic
CHU-128 M233 3.36x36 TM3 Van der Waals
CHU-128 T298 45.52x52 ECL2 Van der Waals
CHU-128 L384 7.39x38 TM7 hydrophobic
CHU-128 L388 7.43x42 TM7 Van der Waals
CHU-128 L388 7.43x42 TM7 hydrophobic

Ligands

CHU-128

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Residue Diagrams

V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7
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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
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Residue Table


GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x32 1.36x36 L141
1x35 1.39x39 L144
1x36 1.40x40 Y145
TM2
2x64 2.71x71 L201
TM3
3x25 3.29x29 C226
3x28 3.32x32 V229
3x29 3.33x33 F230
3x32 3.36x36 M233
ECL2
45x52 45.52x52 T298
TM7
7x34 7.39x38 L384
7x38 7.43x42 L388