GLP-1 receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

6X19

RESOLUTION

2.1 Å

REFERENCE

10.1016/J.MOLCEL.2020.09.020

PUBLICATION DATE

Sept. 9, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

45 interactions (Click to see)

LIGANDS

CHU-128 - Agonist pubchem

PHYSIOLOGICAL LIGANDS

glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
Q52G.HNR17H19Q22E24L26G.H5GproteinR6x37L3x57R2x46N5x68E4x39N8x47GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.HNG.H5GPCR segments:TM2TM3TM4TM5TM6H8

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
Res. Pos.

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.