Structure information

MT1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7DB6

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

D

REFERENCE

10.1038/S41594-021-00634-1

PUBLICATION DATE

Aug. 18, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ramelteon I112 3.37x37 TM3 hydrophobic
ramelteon L163 4.61x62 TM4 hydrophobic
ramelteon F179 45.52x52 ECL2 hydrophobic
ramelteon Q181 ECL2 polar (hydrogen bond)
ramelteon Q181 ECL2 Van der Waals
ramelteon V191 5.42x43 TM5 hydrophobic
ramelteon V191 5.42x43 TM5 Van der Waals
ramelteon W251 6.48x48 TM6 Van der Waals
ramelteon W251 6.48x48 TM6 hydrophobic
ramelteon L254 6.51x51 TM6 Van der Waals
ramelteon G258 6.55x55 TM6 Van der Waals

Ligands

ramelteon

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Residue Diagrams

L N G L I D V V I T F I L V C A L A S A 1 V S L A V A D L V V A Y I P Y P L V L M S 2 G T I N F I S G I V S L G M L F G S V Q 3 S L C Y V L L I W L L T L A A V L P N 4 Y C F I V I I M P V L F H F V V V A I T Y 5 F V V F V L F A I C W A P L N F I G L A 6 I A N L C S N F Y A M Y Y S A V F L W 7
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ICL1 K K L R ICL1ECL1 G W N L ECL1ICL2 S L K Y D K L Y ICL2ECL2 T L Q Y D P R I Y S C T F A Q S V ECL2ICL3 K P D R K ICL3ECL3 P A S M V P R I ECL3N-term M Q G N G S A L P N A S Q P V L R G D G A R N-termC-term A R V F F V D S S N D V A D R V K W K P S P L M T N N N V V K V D S V C-term P S W L A S A L A C V L I F T I V V D I L G N L L V I L S V Y R N N A G N I F V V S L A V A D L V V A I Y P Y P L V L M S I F N N G Y L H C Q V S G F L M G L S V I G S I F N I T G I A I N R Y C Y I C H S S K N S L C Y V L L I W L L T L A A V L P N L R A G S S A Y T I A V V V F H F L V P M I I V I F C Y L R I W I L V L Q V R Q R V P K L K P Q D F R N F V T M F V V F V L F A I C W A P L N F I G L A V A S D P E W L F V A S Y Y M A Y F N S C L N A I I Y G L L N Q N Y R R L C T F R K E I I V S
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Residue Table


GPCRdb(A)
GPCRdb(A)
MT1 receptor
TM3
3x37 3.37x37 I112
TM4
4x62 4.61x62 L163
ECL2
45x52 45.52x52 F179
TM5
5x43 5.42x43 V191
TM6
6x48 6.48x48 W251
6x51 6.51x51 L254
6x55 6.55x55 G258