MT1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

D

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7DB6

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41594-021-00634-1

PUBLICATION DATE

Aug. 18, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

29 interactions (Click to see)

LIGANDS

ramelteon - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

ENDOGENOUS LIGANDS

melatonin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 R 220 - G.H5 F 334 G.H5.06
Hydrophobic TM3 I 129 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 129 3x54 G.H5 L 348 G.H5.20
Hydrophobic H8 Q 300 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 Q 300 8x48 G.H5 G 352 G.H5.24
Hydrophobic TM5 Y 207 5x58 G.H5 L 353 G.H5.25
Van-der-waals TM5 Y 207 5x58 G.H5 L 353 G.H5.25
Ionic ICL3 R 218 - G.H5 D 341 G.H5.13
Polar ICL3 R 218 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 218 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 218 - G.H5 D 341 G.H5.13
Polar H8 Q 300 8x48 G.H5 K 349 G.H5.21
Van-der-waals H8 Q 300 8x48 G.H5 K 349 G.H5.21
Polar TM3 Y 128 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 Y 128 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 R 125 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 217 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 V 217 5x68 G.H5 I 344 G.H5.16
Polar ICL3 R 220 - G.S6 I 319 G.S6.01
Hydrophobic ICL2 D 136 34x54 G.HN E 28 G.HN.52
Hydrophobic TM5 I 210 5x61 G.H5 L 353 G.H5.25
Polar TM6 T 239 6x36 G.H5 F 354 G.H5.26
Hydrophobic TM6 T 239 6x36 G.H5 F 354 G.H5.26
Van-der-waals TM6 T 239 6x36 G.H5 F 354 G.H5.26
Aromatic ICL3 R 220 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 R 220 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 220 - G.S6 Y 320 G.S6.02
Hydrophobic TM3 I 129 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 129 3x54 G.H5 N 347 G.H5.19
Ionic ICL2 D 136 34x54 G.hns1 R 32 G.hns1.03
Polar ICL2 D 136 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 D 136 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals TM6 R 235 6x32 G.H5 F 354 G.H5.26
Polar ICL3 Q 219 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 Q 219 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 Q 219 - G.H5 D 337 G.H5.09
Hydrophobic H8 N 299 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 299 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM5 W 211 5x62 G.H5 F 354 G.H5.26
Van-der-waals TM5 W 211 5x62 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 129 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 213 5x64 G.H5 I 344 G.H5.16
Polar TM3 R 125 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 125 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 V 214 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 V 214 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM3 Y 128 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 Y 128 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 I 210 5x61 G.H5 L 348 G.H5.20
Polar TM3 Y 128 3x53 G.H5 N 347 G.H5.19
Polar ICL2 S 132 34x50 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 S 132 34x50 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 S 132 34x50 G.hns1 R 32 G.hns1.03
Polar TM6 R 235 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 214 5x65 G.H5 F 354 G.H5.26
Polar TM6 T 239 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 239 6x36 G.H5 L 353 G.H5.25
Polar ICL2 S 132 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM5 I 210 5x61 G.H5 F 354 G.H5.26
Ionic ICL3 R 220 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 220 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 220 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL2 Y 135 34x53 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 V 214 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM3 I 129 3x54 G.H5 I 344 G.H5.16
Ionic ICL3 R 218 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 218 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 218 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 218 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 N 236 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 N 236 6x33 G.H5 F 354 G.H5.26