Structure information

CT receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7TYI

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIENCE.ABM9609

PUBLICATION DATE

March 30, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Amylin rat W79 N-term aromatic (face-to-edge)
Amylin rat F99 N-term hydrophobic
Amylin rat P100 N-term Van der Waals
Amylin rat P100 N-term polar (hydrogen bond with backbone)
Amylin rat D101 N-term polar (charge-assisted hydrogen bond)
Amylin rat F102 N-term Van der Waals
Amylin rat F102 N-term hydrophobic
Amylin rat H121 N-term Van der Waals
Amylin rat W128 N-term polar (hydrogen bond)
Amylin rat W128 N-term Van der Waals
Amylin rat S129 N-term Van der Waals
Amylin rat S129 N-term polar (hydrogen bond with backbone)
Amylin rat Y131 N-term Van der Waals
Amylin rat Y131 N-term hydrophobic
Amylin rat T132 N-term Van der Waals
Amylin rat F137 N-term aromatic (edge-to-face)
Amylin rat F137 N-term Van der Waals
Amylin rat K141 1.32x32 TM1 Van der Waals
Amylin rat L142 1.33x33 TM1 hydrophobic
Amylin rat L142 1.33x33 TM1 Van der Waals
Amylin rat A145 1.36x36 TM1 hydrophobic
Amylin rat A145 1.36x36 TM1 Van der Waals
Amylin rat Y146 1.37x37 TM1 Van der Waals
Amylin rat Y146 1.37x37 TM1 polar (hydrogen bond)
Amylin rat L148 1.39x39 TM1 Van der Waals
Amylin rat L148 1.39x39 TM1 hydrophobic
Amylin rat V206 ECL1 polar (hydrogen bond with backbone)
Amylin rat V206 ECL1 Van der Waals
Amylin rat G209 ECL1 Van der Waals
Amylin rat V212 ECL1 hydrophobic
Amylin rat V212 ECL1 Van der Waals
Amylin rat R213 ECL1 polar (charge-assisted hydrogen bond)
Amylin rat H226 3.36x36 TM3 polar (hydrogen bond)
Amylin rat Q227 3.37x37 TM3 polar (hydrogen bond)
Amylin rat Y234 3.44x44 TM3 hydrophobic
Amylin rat N288 ECL2 Van der Waals
Amylin rat L291 45.52x52 ECL2 Van der Waals
Amylin rat L291 45.52x52 ECL2 polar (hydrogen bond with backbone)
Amylin rat S292 ECL2 Van der Waals
Amylin rat V293 ECL2 Van der Waals
Amylin rat V293 ECL2 polar (hydrogen bond with backbone)
Amylin rat E294 ECL2 polar (hydrogen bond with backbone)
Amylin rat E294 ECL2 Van der Waals
Amylin rat H296 ECL2 polar (hydrogen bond)
Amylin rat L298 5.36x37 TM5 Van der Waals
Amylin rat Y299 5.37x38 TM5 polar (hydrogen bond)
Amylin rat Y299 5.37x38 TM5 Van der Waals
Amylin rat H302 5.40x40 TM5 Van der Waals
Amylin rat H302 5.40x40 TM5 polar (hydrogen bond)
Amylin rat M306 5.44x44 TM5 Van der Waals
Amylin rat F356 6.53x53 TM6 hydrophobic
Amylin rat F356 6.53x53 TM6 Van der Waals
Amylin rat P360 ECL3 polar (hydrogen bond with backbone)
Amylin rat P360 ECL3 Van der Waals
Amylin rat H377 7.43x42 TM7 Van der Waals
Amylin rat I380 7.46x45 TM7 Van der Waals
Amylin rat H381 7.47x46 TM7 Van der Waals

Ligands

Amylin rat

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Residue Diagrams

V L T F I S L S H G V I A L Y Y L V Y A 1 K N M F L T Y I L N S M I I I I H L V E 2 C L M W F Y N C A M M Y Q H F F H L I K 3 R L R W Y Y L G L W G F P L V P T T I H A 4 L F F F N V V L A A M V P G H I I Y L 5 M I L V P L L G I Q F V V F P W 6 T A V F F G Q F H I L S H M V Y D Y I 7
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ICL1 R S L G ICL1ECL1 V P N G E L V R R D ECL1ICL2 A V F T E K Q ICL2ECL2 N D N C W L S V E T H L ECL2ICL3 E ICL3ECL3 R P S ECL3N-term M R F T F T S R C L A L F L L L N H P T P I L P A F S N Q T Y P T I E P K P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y N-termC-term P S N R S A R A A A A A A E A G D I P I Y I C H Q E L R N E P A N N Q G E E S A E I I P L N I I E Q E S S A C-term T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V K R F K I R W G V Q T T Q W A Q Q W N Q R R
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Residue Table


GPCRdb(A)
GPCRdb(B)
CT receptor
TM1
1x28 1.32x32 K141
1x29 1.33x33 L142
1x32 1.36x36 A145
1x33 1.37x37 Y146
1x35 1.39x39 L148
TM3
3x32 3.36x36 H226
3x33 3.37x37 Q227
3x40 3.44x44 Y234
ECL2
45x52 45.52x52 L291
TM5
5x41 5.36x37 L298
5x42 5.37x38 Y299
5x44 5.40x40 H302
5x48 5.44x44 M306
TM6
6x48 6.53x53 F356
TM7
7x38 7.43x42 H377
7x41 7.46x45 I380
7x42 7.47x46 H381