Structure information

MRGPRX2

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7VDM

SPECIES

Homo sapiens

RESOLUTION

2.980

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-021-04077-Y

PUBLICATION DATE

Dec. 1, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
substance P C168 4.64x64 TM4 hydrophobic
substance P F170 ECL2 hydrophobic
substance P W243 6.55x55 TM6 polar (hydrogen bond with backbone)
substance P W243 6.55x55 TM6 polar (hydrogen bond)
substance P L247 6.59x59 TM6 Van der Waals
substance P W248 6.60x60 TM6 Van der Waals
substance P W248 6.60x60 TM6 hydrophobic

Ligands

substance P

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Residue Diagrams

G N G V L G V L A I F L I L F V P I L T 1 L S L A G A D F L F L C F Q I I N C L V 2 T S L M S L G A L Y A C T M V T T F F S 3 S A V V C V L L W A L S L L L S I L E G 4 S S G C L V M F L F I L W A A T I F D F 5 L L T V L V F L L C G L P F G I Q W F L 6 I P N A S S N L S S L V V S V P H I H 7
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ICL1 R R ICL1ECL1 I S I N F ECL1ICL2 P I W Y R C R R ICL2ECL2 G F L F S D G ECL2ICL3 S R G L ICL3ECL3 K D S D V ECL3N-term M D P T T P A W G T E S T T V N G N D Q A L L L L C G K E N-termC-term R K Q W R L Q Q P I L K L A L Q R A L Q D I A E V D H S E G C F R Q G T P E M S R S S L V C-term T L I P V F L I L F I A L V G L V G N G F V L W L L G F R M N A F S V Y V L S L A G A D F L F L C F Q I I N C L V Y L S N F F C S P S F F T T V M T C A Y L A G L S M L S T V S T E R C L S V L W P R H L S A V V C V L L W A L S L L L S I L E G K F C D S G W C Q T F D F I T A A W L I F L F M V L C G S S L A L L V R I L C G P L T R L Y L T I L L T V L V F L L C G L P F G I Q W F L I L W I W L F C H I H P V S V V L S S L N S S A N P I I Y F F V G S F
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Residue Table


GPCRdb(A)
GPCRdb(A)
MRGPRX2
TM4
4x64 4.64x64 C168
TM6
6x55 6.55x55 W243
6x59 6.59x59 L247
6x60 6.60x60 W248