Structure information

TRH1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7WKD

SPECIES

Homo sapiens

RESOLUTION

3.010

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-022-00641-X

PUBLICATION DATE

June 15, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
TRH A78 2.57x56 TM2 polar (hydrogen bond)
TRH T102 3.29x29 TM3 polar (hydrogen bond)
TRH Q105 3.32x32 TM3 polar (hydrogen bond)
TRH Q105 3.32x32 TM3 polar (hydrogen bond)
TRH Y106 3.33x33 TM3 polar (hydrogen bond)
TRH I109 3.36x36 TM3 Van der Waals
TRH I109 3.36x36 TM3 hydrophobic
TRH L164 ECL2 polar (hydrogen bond)
TRH C179 45.50x50 ECL2 polar (charge-assisted hydrogen bond)
TRH C179 45.50x50 ECL2 polar (hydrogen bond)
TRH C179 45.50x50 ECL2 polar (hydrogen bond with backbone)
TRH G180 45.51x51 ECL2 polar (hydrogen bond with backbone)
TRH G180 45.51x51 ECL2 Van der Waals
TRH Y181 45.52x52 ECL2 polar (hydrogen bond)
TRH R185 5.32x32 TM5 polar (charge-assisted hydrogen bond)
TRH Y192 5.39x39 TM5 polar (hydrogen bond)
TRH Y282 6.51x51 TM6 polar (hydrogen bond)
TRH Y282 6.51x51 TM6 polar (hydrogen bond)
TRH L285 6.54x54 TM6 Van der Waals
TRH V286 6.55x55 TM6 polar (hydrogen bond)
TRH N289 6.58x58 TM6 polar (hydrogen bond)
TRH N289 6.58x58 TM6 polar (hydrogen bond)
TRH L302 7.35x34 TM7 Van der Waals
TRH L302 7.35x34 TM7 hydrophobic
TRH R306 7.39x38 TM7 polar (charge-assisted hydrogen bond)
TRH I309 7.42x41 TM7 polar (hydrogen bond)
TRH Y310 7.43x42 TM7 polar (hydrogen bond)

Ligands

TRH

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Residue Diagrams

I N G V I G L G C I I L V L L I T V V Q 1 V S L A V A D L M V L A V A G L P N I T D 2 A T I S C S S A N I G L Y Q L Y T I C L 3 A K K I I I F V W A F T S L Y C M L W F 4 Y L V T A L I M P V V Y F V G F D M L Y 5 A V V V I L F A L L W M P Y R T L V V V 6 V P N I A S N L Y I C I R C F L L F W 7
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ICL1 K H M R ICL1ECL1 G S W V Y ECL1ICL2 P I K A Q F L C ICL2ECL2 D L N I S T Y K D A I V I S C G Y K ECL2ICL3 N S K T W K N D S T H Q N T N L N V N T S N R C F ICL3ECL3 S S P F Q ECL3N-term M E N E T V S E L N Q T Q L Q P R A V V A N-termC-term C K Q K P T E K P A N Y S V A L N Y S V I K E S D H F S T E L D D I T V T D T Y L S A T K V S F D D T C L A S E V S F S Q S C-term L E Y Q V V T I L L V L I I C G L G I V G N I M V V L V V M R T T P T N C Y L V S L A V A D L M V L V A A G L P N I T D S I Y G Y V G C L C I T Y L Q Y L G I N A S S C S I T A F T I E R Y I A I C H T F S R A K K I I I F V W A F T S L Y C M L W F F L L I S R N Y Y S P I Y L M D F G V F Y V V P M I L A T V L Y G F I A R I L F L N P I P S D P K E N S T V S S R K Q V T K M L A V V V I L F A L L W M P Y R T L V V V N S F L E N W F L L F C R I C I Y L N S A I N P V I Y N L M S Q K F R K F R A A L C N
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Residue Table


GPCRdb(A)
GPCRdb(A)
TRH1 receptor
TM2
2x56 2.57x56 A78
TM3
3x29 3.29x29 T102
3x32 3.32x32 Q105
3x33 3.33x33 Y106
3x36 3.36x36 I109
ECL2
45x50 45.50x50 C179
45x51 45.51x51 G180
45x52 45.52x52 Y181
TM5
5x32 5.32x32 R185
5x39 5.39x39 Y192
TM6
6x51 6.51x51 Y282
6x54 6.54x54 L285
6x55 6.55x55 V286
6x58 6.58x58 N289
TM7
7x34 7.35x34 L302
7x38 7.39x38 R306
7x41 7.42x41 I309
7x42 7.43x42 Y310