TRH1 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

June 15, 2022

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

TRH - Agonist pubchem

PHYSIOLOGICAL LIGANDS

TRH



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
R02G.hns1R21Y23N24V26G.H5GproteinT4x38F34x55R3x50S-Q8x48GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.hns1G.H5GPCR segments:ICL2TM3TM4ICL4H8

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x382x392x433x463x493x503x533x5434x5034x5134x5434x5534x574x385x615x656x326x337x538x488x49G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.21G.H5.20G.H5.19G.H5.16G.H5.15G.H5.12G.H5.08G.S3.01G.S1.02G.hns1.03G.hns1.02Res. Pos.TRH1 (7WKD)- (7WKD)----------------------PTLFERAIPIQFCTILQVYQKPTLPIQFCFERAITILQVYQKSYENKILFVLRRLNLVR

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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