Structure information

VPAC1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

8E3Z

SPECIES

Homo sapiens

RESOLUTION

2.700

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-34629-3

PUBLICATION DATE

Nov. 23, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Vasoactive intestinal polypeptide V40 N-term hydrophobic
Vasoactive intestinal polypeptide F90 N-term hydrophobic
Vasoactive intestinal polypeptide Y118 N-term polar (hydrogen bond)
Vasoactive intestinal polypeptide Y118 N-term Van der Waals
Vasoactive intestinal polypeptide D126 N-term Van der Waals
Vasoactive intestinal polypeptide D132 1.29x29 TM1 Van der Waals
Vasoactive intestinal polypeptide T136 1.33x33 TM1 Van der Waals
Vasoactive intestinal polypeptide Y139 1.36x36 TM1 polar (hydrogen bond)
Vasoactive intestinal polypeptide Y146 1.43x43 TM1 Van der Waals
Vasoactive intestinal polypeptide Y146 1.43x43 TM1 hydrophobic
Vasoactive intestinal polypeptide Y150 1.47x47 TM1 Van der Waals
Vasoactive intestinal polypeptide R188 2.60x60 TM2 polar (charge-assisted hydrogen bond)
Vasoactive intestinal polypeptide K195 2.67x67 TM2 polar (charge-assisted hydrogen bond)
Vasoactive intestinal polypeptide F200 2.72x72 TM2 aromatic (face-to-edge)
Vasoactive intestinal polypeptide F200 2.72x72 TM2 Van der Waals
Vasoactive intestinal polypeptide F200 2.72x72 TM2 polar (hydrogen bond with backbone)
Vasoactive intestinal polypeptide E204 ECL1 polar (charge-assisted hydrogen bond)
Vasoactive intestinal polypeptide F222 3.36x36 TM3 hydrophobic
Vasoactive intestinal polypeptide F222 3.36x36 TM3 Van der Waals
Vasoactive intestinal polypeptide Q223 3.37x37 TM3 polar (hydrogen bond)
Vasoactive intestinal polypeptide V226 3.40x40 TM3 hydrophobic
Vasoactive intestinal polypeptide V226 3.40x40 TM3 Van der Waals
Vasoactive intestinal polypeptide D287 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
Vasoactive intestinal polypeptide T288 ECL2 polar (hydrogen bond)
Vasoactive intestinal polypeptide I289 ECL2 hydrophobic
Vasoactive intestinal polypeptide I289 ECL2 Van der Waals
Vasoactive intestinal polypeptide N290 ECL2 Van der Waals
Vasoactive intestinal polypeptide W294 5.36x37 TM5 hydrophobic
Vasoactive intestinal polypeptide W294 5.36x37 TM5 Van der Waals
Vasoactive intestinal polypeptide M370 7.39x38 TM7 Van der Waals
Vasoactive intestinal polypeptide M370 7.39x38 TM7 polar (hydrogen bond with backbone)
Vasoactive intestinal polypeptide E373 7.42x41 TM7 Van der Waals
Vasoactive intestinal polypeptide L374 7.43x42 TM7 Van der Waals
Vasoactive intestinal polypeptide L374 7.43x42 TM7 hydrophobic

Ligands

Vasoactive intestinal polypeptide

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Residue Diagrams

L L T A L S L G Y G I T Y G T K V S G Y 1 M H L F I S F I L R A A A V F I K D L A 2 V L L W F F N A M V C Y Q F F V M A A K 3 Y F W G Y I L G I W G V P S T F T M V W T 4 F L I F N V L I S T L I P G K I I W W L S 5 L L L I P L F G V H Y I M F A F F 6 I A V V F G Q F S G V V L E F V M K V 7
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ICL1 R K L H ICL1ECL1 F D S G E S D Q C S E G ECL1ICL2 S F F ICL2ECL2 D Y G C W D T I ECL2ICL3 R P P D I R K ICL3ECL3 P D N F K ECL3N-term M R P P S P L P A R W L C V L A G A L A W A L G P A G G Q A A R L Q E E C D Y V Q M I E V Q H K Q C L E E A Q L E N E T I G C S K M W D N L T C W P A T P R G Q V V V L A C P L I F K L F S S I Q G R N V S R S C T D E G W T H L E P G P Y P I A C G L D D K A N-termC-term Y R H P S G G S N G A T C S T Q V S M L T R V S P G A R R S S S F Q A E V S L V C-term A S L D E Q Q T M F Y G S V K T G Y T I G Y G L S L A T L L V A T A I L S L F C T R N Y I H M H L F I S F I L R A A A V F I K D L A L S V G C K A A M V F F Q Y C V M A N F F W L L V E G L Y L Y T L L A V S E R K Y F W G Y I L I G W G V P S T F T M V W T I A R I H F E N S S L W W I I K G P I L T S I L V N F I L F I C I I R I L L Q K L S D S S P Y S R L A R S T L L L I P L F G V H Y I M F A F F P E V K M V F E L V V G S F Q G F V V A I L Y C F L N G E L R R W H L G W N V Q A E K W R R Q G V L P K
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Residue Table


GPCRdb(A)
GPCRdb(B)
VPAC1 receptor
TM1
1x25 1.29x29 D132
1x29 1.33x33 T136
1x32 1.36x36 Y139
1x39 1.43x43 Y146
1x43 1.47x47 Y150
TM2
2x53 2.60x60 R188
2x60 2.67x67 K195
TM3
3x32 3.36x36 F222
3x33 3.37x37 Q223
3x36 3.40x40 V226
ECL2
45x52 45.52x52 D287
TM5
5x41 5.36x37 W294
TM7
7x34 7.39x38 M370
7x37 7.42x41 E373
7x38 7.43x42 L374