Structure information

κ receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8FEG

SPECIES

Homo sapiens

RESOLUTION

2.540

PREFERRED CHAIN

B

REFERENCE

10.1038/s41467-023-43718-w

PUBLICATION DATE

Dec. 6, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 V134 3.28x28 TM3 hydrophobic
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 L135 3.29x29 TM3 hydrophobic
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 Y139 3.33x33 TM3 hydrophobic
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 M142 3.36x36 TM3 hydrophobic
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 E209 ECL2 polar (charge-assisted hydrogen bond)
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 C210 45.50x50 ECL2 Van der Waals
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 C210 45.50x50 ECL2 polar (hydrogen bond with backbone)
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 S211 45.51x51 ECL2 Van der Waals
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 K227 5.39x40 TM5 Van der Waals
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 V230 5.42x43 TM5 hydrophobic
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 V230 5.42x43 TM5 Van der Waals
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 W287 6.48x48 TM6 hydrophobic
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 W287 6.48x48 TM6 Van der Waals
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 I290 6.51x51 TM6 Van der Waals
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 I290 6.51x51 TM6 hydrophobic
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 F293 6.54x54 TM6 Van der Waals
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 F293 6.54x54 TM6 hydrophobic
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 I294 6.55x55 TM6 hydrophobic
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 I294 6.55x55 TM6 Van der Waals
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 E297 6.58x58 TM6 polar (charge-assisted hydrogen bond)
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 T302 ECL3 Van der Waals
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 S303 ECL3 Van der Waals
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 S303 ECL3 polar (hydrogen bond with backbone)
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 S305 7.28x27 TM7 Van der Waals
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 S305 7.28x27 TM7 polar (hydrogen bond with backbone)
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 S305 7.28x27 TM7 polar (hydrogen bond)
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 L309 7.32x31 TM7 hydrophobic
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 L309 7.32x31 TM7 Van der Waals
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 Y312 7.35x34 TM7 polar (hydrogen bond)
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 I316 7.39x38 TM7 hydrophobic
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 Y320 7.43x42 TM7 Van der Waals
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 Y320 7.43x42 TM7 hydrophobic

Ligands

ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9

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Residue Diagrams

S N G V L G V V F V V S Y V A T I I V P 1 F N L A L A D A L V T T T M P F Q S T V 2 M T L T F I S T F M N Y Y D I S I V I K 3 A K I I N I C I W L L S S S V G I S A I 4 Y C V I I I L V P I V F A F I F V C I K M 5 L V V V A V F V V C W T P I H I F I L V 6 I P N L S S N T Y G L A I C F Y Y S S 7
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ICL1 T K M K ICL1ECL1 S W P F ECL1ICL2 P V K A L D F R ICL2ECL2 G T K V R E D V D V I E C S L Q F P D D ECL2ICL3 R L L S G ICL3ECL3 S T S H ECL3N-term M D S P I Q I F R G E P G P T C A P S A C L P P N S S A W F P G W A E P D S N G S A G S E D A Q L E P A H I S P N-termC-term P L K M R M E R Q S T S R V R N T V Q D P A Y L R D I D G M N K P V C-term A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P L K A K I I N I C I W L L S S S V G I S A I V L G D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F R D F K R C F C F
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Residue Table


GPCRdb(A)
GPCRdb(A)
κ receptor
TM3
3x28 3.28x28 V134
3x29 3.29x29 I135
3x33 3.33x33 Y139
3x36 3.36x36 M142
ECL2
45x50 45.50x50 C210
45x51 45.51x51 S211
TM5
5x40 5.39x40 K227
5x43 5.42x43 V230
TM6
6x48 6.48x48 W287
6x51 6.51x51 I290
6x54 6.54x54 F293
6x55 6.55x55 I294
6x58 6.58x58 E297
TM7
7x27 7.28x27 S305
7x31 7.32x31 L309
7x34 7.35x34 Y312
7x38 7.39x38 I316
7x42 7.43x42 Y320