Structure information

BB1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8H0P

SPECIES

Homo sapiens

RESOLUTION

3.150

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-022-00743-6

PUBLICATION DATE

Aug. 9, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
NMB30 D100 2.61x60 TM2 polar (charge-assisted hydrogen bond)
NMB30 R103 2.64x63 TM2 polar (charge-assisted hydrogen bond)
NMB30 Y104 2.65x64 TM2 Van der Waals
NMB30 Y104 2.65x64 TM2 hydrophobic
NMB30 F106 2.67x66 TM2 Van der Waals
NMB30 D107 ECL1 polar (charge-assisted hydrogen bond)
NMB30 E108 23.49x49 ECL1 Van der Waals
NMB30 P120 3.29x29 TM3 Van der Waals
NMB30 P120 3.29x29 TM3 hydrophobic
NMB30 Q123 3.32x32 TM3 Van der Waals
NMB30 V127 3.36x36 TM3 Van der Waals
NMB30 V127 3.36x36 TM3 hydrophobic
NMB30 E178 4.60x61 TM4 Van der Waals
NMB30 S182 ECL2 polar (hydrogen bond)
NMB30 S182 ECL2 Van der Waals
NMB30 F195 ECL2 hydrophobic
NMB30 F195 ECL2 Van der Waals
NMB30 A197 ECL2 hydrophobic
NMB30 A197 ECL2 Van der Waals
NMB30 C198 45.50x50 ECL2 Van der Waals
NMB30 I199 45.51x51 ECL2 hydrophobic
NMB30 I199 45.51x51 ECL2 Van der Waals
NMB30 P200 45.52x52 ECL2 Van der Waals
NMB30 P200 45.52x52 ECL2 polar (hydrogen bond with backbone)
NMB30 I216 5.42x43 TM5 hydrophobic
NMB30 I216 5.42x43 TM5 Van der Waals
NMB30 N282 6.51x51 TM6 Van der Waals
NMB30 N282 6.51x51 TM6 polar (hydrogen bond)
NMB30 H283 6.52x52 TM6 aromatic (face-to-edge)
NMB30 H283 6.52x52 TM6 Van der Waals
NMB30 Y286 6.55x55 TM6 aromatic (face-to-edge)
NMB30 Y286 6.55x55 TM6 Van der Waals
NMB30 R289 6.58x58 TM6 polar (charge-assisted hydrogen bond)
NMB30 P298 ECL3 hydrophobic
NMB30 P298 ECL3 Van der Waals
NMB30 H302 7.31x30 TM7 Van der Waals
NMB30 M303 7.32x31 TM7 hydrophobic
NMB30 M303 7.32x31 TM7 Van der Waals
NMB30 T306 7.35x34 TM7 Van der Waals
NMB30 R310 7.39x38 TM7 polar (charge-assisted hydrogen bond)
NMB30 S313 7.42x41 TM7 Van der Waals
NMB30 F314 7.43x42 TM7 hydrophobic
NMB30 F314 7.43x42 TM7 Van der Waals

Ligands

NMB30

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Residue Diagrams

I N G L L G V T I I L L Y L S P I V C R 1 S N L A A G D L L L L T L C V P V D A S R 2 A T L T F V S V G V S T L Q I V P I L K 3 T C V K A M G I W V V S V L L A V P E 4 Y Y I S I I A L P I L F Y V L F I L V S H 5 L V F V G C F I F C W F P N H I L Y M Y 6 F P N V C S N G F S L V R A V L T V I 7
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ICL1 S A M R ICL1ECL1 D E W M F ECL1ICL2 P M D M Q T S G ICL2ECL2 E V A R I S S L D N S S F T A C I P Y P Q T ECL2ICL3 N L P G ICL3ECL3 Y N E I D P ECL3N-term M P S K S L S N L S V T T G A N E S G S V P E G W E R D F L P A N-termC-term G R K S Y Q E R G T S Y L L S S S A V R M T S L K S N A K N M V T N S V L L N G H S M K Q E M A L C-term S D G T T T E L V I R C V I P S L Y L L I I T V G L L G N I M L V K I F I T N S V P N I F I S N L A A G D L L L L L T C V P V D A S R Y F F G K V G C K L I P V I Q L T S V G V S V F T L T A L S A D R Y R A I V N A L L R T C V K A M G I W V V S V L L A V P E A V F S D E L H P K I H S V L I F L V Y F L I P L A I I S I Y Y Y H I A K T L I K S A H E Y N E H T K K Q M E T R K R L A K I V L V F V G C F I F C W F P N H I L Y M Y R S F N S L G H M I V T L V A R V L S F G N S C V N P F A L Y L L S E S F N S F R R H Q L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
BB1 receptor
TM2
2x60 2.61x60 D100
2x63 2.64x63 R103
2x64 2.65x64 Y104
2x66 2.67x66 F106
ECL1
23x49 23.49x49 E108
TM3
3x29 3.29x29 P120
3x32 3.32x32 Q123
3x36 3.36x36 V127
TM4
4x61 4.60x61 E178
ECL2
45x50 45.50x50 C198
45x51 45.51x51 I199
45x52 45.52x52 P200
TM5
5x43 5.42x43 I216
TM6
6x51 6.51x51 N282
6x52 6.52x52 H283
6x55 6.55x55 Y286
6x58 6.58x58 R289
TM7
7x30 7.31x30 H302
7x31 7.32x31 M303
7x34 7.35x34 T306
7x38 7.39x38 R310
7x41 7.42x41 S313
7x42 7.43x42 F314