Structure information

QRFP receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8WZ2

SPECIES

Homo sapiens

RESOLUTION

2.730

PREFERRED CHAIN

R

REFERENCE

10.1038/S41421-024-00670-3

PUBLICATION DATE

June 19, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Orexigenic neuropeptide QRFP V35 N-term hydrophobic
Orexigenic neuropeptide QRFP C98 2.57x56 TM2 Van der Waals
Orexigenic neuropeptide QRFP C98 2.57x56 TM2 polar (hydrogen bond)
Orexigenic neuropeptide QRFP V101 2.60x59 TM2 Van der Waals
Orexigenic neuropeptide QRFP V101 2.60x59 TM2 hydrophobic
Orexigenic neuropeptide QRFP L104 2.63x62 TM2 Van der Waals
Orexigenic neuropeptide QRFP L104 2.63x62 TM2 hydrophobic
Orexigenic neuropeptide QRFP Q105 2.64x63 TM2 polar (hydrogen bond)
Orexigenic neuropeptide QRFP Q105 2.64x63 TM2 polar (hydrogen bond)
Orexigenic neuropeptide QRFP S108 2.67x66 TM2 Van der Waals
Orexigenic neuropeptide QRFP D109 ECL1 Van der Waals
Orexigenic neuropeptide QRFP N110 23.49x49 ECL1 Van der Waals
Orexigenic neuropeptide QRFP W111 23.50x50 ECL1 Van der Waals
Orexigenic neuropeptide QRFP W111 23.50x50 ECL1 aromatic (edge-to-face)
Orexigenic neuropeptide QRFP C118 3.25x25 TM3 Van der Waals
Orexigenic neuropeptide QRFP P122 3.29x29 TM3 hydrophobic
Orexigenic neuropeptide QRFP P122 3.29x29 TM3 Van der Waals
Orexigenic neuropeptide QRFP Q125 3.32x32 TM3 Van der Waals
Orexigenic neuropeptide QRFP S126 3.33x33 TM3 Van der Waals
Orexigenic neuropeptide QRFP V129 3.36x36 TM3 Van der Waals
Orexigenic neuropeptide QRFP V129 3.36x36 TM3 hydrophobic
Orexigenic neuropeptide QRFP Q184 4.64x64 TM4 Van der Waals
Orexigenic neuropeptide QRFP Q184 4.64x64 TM4 polar (hydrogen bond)
Orexigenic neuropeptide QRFP C200 ECL2 polar (hydrogen bond)
Orexigenic neuropeptide QRFP C201 45.50x50 ECL2 Van der Waals
Orexigenic neuropeptide QRFP C201 45.50x50 ECL2 polar (hydrogen bond with backbone)
Orexigenic neuropeptide QRFP L202 45.51x51 ECL2 Van der Waals
Orexigenic neuropeptide QRFP L202 45.51x51 ECL2 hydrophobic
Orexigenic neuropeptide QRFP E203 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
Orexigenic neuropeptide QRFP Y214 5.38x39 TM5 Van der Waals
Orexigenic neuropeptide QRFP Y214 5.38x39 TM5 hydrophobic
Orexigenic neuropeptide QRFP T215 5.39x40 TM5 polar (hydrogen bond)
Orexigenic neuropeptide QRFP F289 6.51x51 TM6 hydrophobic
Orexigenic neuropeptide QRFP F289 6.51x51 TM6 Van der Waals
Orexigenic neuropeptide QRFP H293 6.55x55 TM6 Van der Waals
Orexigenic neuropeptide QRFP Q318 7.39x38 TM7 polar (hydrogen bond)
Orexigenic neuropeptide QRFP Q318 7.39x38 TM7 Van der Waals
Orexigenic neuropeptide QRFP F322 7.43x42 TM7 Van der Waals

Ligands

Orexigenic neuropeptide QRFP

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Residue Diagrams

A N G F L A L A F I L V G T L V L A L K 1 C S L A L S D L L I T F F C I P V T M L Q 2 C T M T L I E T V V A T S Q V F P V M K 3 A F T M L G V V W L V A V I V G S P M W 4 Y L I L M V M L P L L F L I V L I F T T Y 5 V T V V A L F A V C W A P F H V V H M M 6 I P N C I S N S F G I I Q V I A F I M 7
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ICL1 K A M R ICL1ECL1 D N W L G G A ECL1ICL2 P F K M K W Q Y ICL2ECL2 Q L E I K Y D F L Y E K E H I C C L E E W T ECL2ICL3 H G K E ICL3ECL3 N F E K E Y D ECL3N-term M Q A L N I T P E Q F S R L L R D H N L T R E Q F I A L Y R L R P L V Y T P E L N-termC-term N K T F S P A Q R H G N S G I T M M R K K A K F S L R E N P V E E T K G E A F S D G N I E V K L C E Q T E E K K K L K R H L A L F R S E L A E N S P L D S G H C-term P G R A K L A L V L T G V L I F A L A L F G N A L V F Y V V T R S T V T N I F I C S L A L S D L L I T F F C I P V T M L Q N I S F I C K M V P F V Q S T A V V T E I L T M T C I A V E R H Q G L V H T N R R A F T M L G V V W L V A V I V G S P M W H V Q S P V H Q K I Y T T F I L V I L F L L P L M V M L I L Y S K I G Y E L W I K K R V G D G S V L R T I M S K I A R K K K R A V I M M V T V V A L F A V C W A P F H V V H M M I E Y S D V T I K M I F A I V Q I I G F S N S I C N P I V Y A F M N E N V L S C I V F K K N A V C Y
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Residue Table


GPCRdb(A)
GPCRdb(A)
QRFP receptor
TM2
2x56 2.57x56 C98
2x59 2.60x59 V101
2x62 2.63x62 L104
2x63 2.64x63 Q105
2x66 2.67x66 S108
ECL1
23x49 23.49x49 N110
23x50 23.50x50 W111
TM3
3x25 3.25x25 C118
3x29 3.29x29 P122
3x32 3.32x32 Q125
3x33 3.33x33 S126
3x36 3.36x36 V129
TM4
4x64 4.64x64 Q184
ECL2
45x50 45.50x50 C201
45x51 45.51x51 L202
45x52 45.52x52 E203
TM5
5x39 5.38x39 Y214
5x40 5.39x40 T215
TM6
6x51 6.51x51 F289
6x55 6.55x55 H293
TM7
7x38 7.39x38 Q318
7x42 7.43x42 F322