QRFP receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8WZ2

RESOLUTION

2.7 Å

REFERENCE

10.1038/S41421-024-00670-3

PUBLICATION DATE

June 19, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

78 interactions (Click to see)

LIGANDS

Orexigenic neuropeptide QRFP - Agonist

PHYSIOLOGICAL LIGANDS

QRFP26 (26RFa), QRFP43, QRFP43 (43RFa)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic ICL2 Y 157 34x57 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 Y 157 34x57 G.H5 Y 358 G.H5.23
Van-der-waals ICL2 Y 157 34x57 G.H5 Y 358 G.H5.23
Hydrophobic TM4 T 158 4x38 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 T 158 4x38 G.hns1 R 31 G.hns1.02
Hydrophobic TM6 M 275 6x37 G.H5 L 360 G.H5.25
Van-der-waals TM6 M 275 6x37 G.H5 L 360 G.H5.25
Hydrophobic TM3 L 147 3x54 G.H5 L 355 G.H5.20
Hydrophobic ICL2 F 151 34x51 G.S1 L 34 G.S1.02
Van-der-waals ICL2 F 151 34x51 G.S1 L 34 G.S1.02
Hydrophobic TM2 I 84 2x43 G.H5 N 359 G.H5.24
Van-der-waals TM2 I 84 2x43 G.H5 N 359 G.H5.24
Hydrophobic ICL2 Y 157 34x57 G.H5 E 357 G.H5.22
Van-der-waals ICL2 Y 157 34x57 G.H5 E 357 G.H5.22
Hydrophobic TM6 K 267 6x29 G.H5 V 361 G.H5.26
Van-der-waals TM6 K 267 6x29 G.H5 V 361 G.H5.26
Polar TM2 T 80 2x39 G.H5 E 357 G.H5.22
Van-der-waals TM2 T 80 2x39 G.H5 E 357 G.H5.22
Hydrophobic TM6 K 263 6x25 G.h4s6 G 322 G.h4s6.11
Van-der-waals TM6 K 263 6x25 G.h4s6 G 322 G.h4s6.11
Hydrophobic H8 E 337 8x48 G.H5 V 361 G.H5.26
Van-der-waals H8 E 337 8x48 G.H5 V 361 G.H5.26
Hydrophobic ICL2 K 154 34x54 G.S1 L 34 G.S1.02
Van-der-waals ICL2 K 154 34x54 G.S1 L 34 G.S1.02
Hydrophobic TM2 T 80 2x39 G.H5 N 359 G.H5.24
Van-der-waals TM2 T 80 2x39 G.H5 N 359 G.H5.24
Polar H8 N 336 8x47 G.H5 N 359 G.H5.24
Hydrophobic H8 N 336 8x47 G.H5 N 359 G.H5.24
Van-der-waals H8 N 336 8x47 G.H5 N 359 G.H5.24
Hydrophobic H8 N 336 8x47 G.H5 V 361 G.H5.26
Polar TM3 G 146 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 G 146 3x53 G.H5 N 354 G.H5.19
Aromatic ICL2 F 151 34x51 G.H5 F 343 G.H5.08
Hydrophobic ICL2 F 151 34x51 G.H5 F 343 G.H5.08
Van-der-waals ICL2 F 151 34x51 G.H5 F 343 G.H5.08
Hydrophobic TM6 R 270 6x32 G.H5 V 361 G.H5.26
Hydrophobic ICL2 F 151 34x51 G.S3 F 196 G.S3.03
Hydrophobic TM3 L 147 3x54 G.H5 N 354 G.H5.19
Hydrophobic ICL2 F 151 34x51 G.H5 I 350 G.H5.15
Van-der-waals ICL2 F 151 34x51 G.H5 I 350 G.H5.15
Hydrophobic ICL2 P 150 34x50 G.H5 K 347 G.H5.12
Hydrophobic ICL2 F 151 34x51 G.H5 K 347 G.H5.12
Van-der-waals ICL2 F 151 34x51 G.H5 K 347 G.H5.12
Polar ICL2 W 155 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 W 155 34x55 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 W 155 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 P 150 34x50 G.H5 L 351 G.H5.16
Van-der-waals ICL2 P 150 34x50 G.H5 L 351 G.H5.16
Ionic TM5 E 240 5x64 G.H5 K 347 G.H5.12
Polar TM5 E 240 5x64 G.H5 K 347 G.H5.12
Van-der-waals TM5 E 240 5x64 G.H5 K 347 G.H5.12
Polar TM6 K 268 6x30 G.H5 Q 352 G.H5.17
Hydrophobic TM6 K 268 6x30 G.H5 Q 352 G.H5.17
Van-der-waals TM6 K 268 6x30 G.H5 Q 352 G.H5.17
Aromatic ICL2 W 155 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 W 155 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 W 155 34x55 G.hns1 R 32 G.hns1.03
Polar TM3 E 142 3x49 G.H5 Y 358 G.H5.23
Hydrophobic TM3 E 142 3x49 G.H5 Y 358 G.H5.23
Polar TM3 G 146 3x53 G.H5 Y 358 G.H5.23
Hydrophobic TM3 G 146 3x53 G.H5 Y 358 G.H5.23
Van-der-waals TM3 G 146 3x53 G.H5 Y 358 G.H5.23
Hydrophobic TM2 T 80 2x39 G.H5 Y 358 G.H5.23
Hydrophobic TM3 R 143 3x50 G.H5 Y 358 G.H5.23
Van-der-waals TM3 R 143 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM3 R 143 3x50 G.H5 L 360 G.H5.25
Van-der-waals TM3 R 143 3x50 G.H5 L 360 G.H5.25
Hydrophobic TM6 A 271 6x33 G.H5 L 360 G.H5.25
Hydrophobic TM3 L 147 3x54 G.H5 Y 358 G.H5.23
Hydrophobic TM6 K 268 6x30 G.H5 L 355 G.H5.20
Hydrophobic TM6 A 271 6x33 G.H5 V 361 G.H5.26
Polar H8 N 338 8x49 G.H5 R 356 G.H5.21
Van-der-waals H8 N 338 8x49 G.H5 R 356 G.H5.21
Hydrophobic ICL2 P 150 34x50 G.H5 I 350 G.H5.15
Van-der-waals ICL2 P 150 34x50 G.H5 I 350 G.H5.15
Hydrophobic ICL2 F 151 34x51 G.S3 V 194 G.S3.01
Van-der-waals ICL2 F 151 34x51 G.S3 V 194 G.S3.01
Hydrophobic ICL2 F 151 34x51 G.H5 C 346 G.H5.11
Hydrophobic TM3 L 147 3x54 G.H5 L 351 G.H5.16
Van-der-waals TM3 L 147 3x54 G.H5 L 351 G.H5.16
Hydrophobic TM3 L 147 3x54 G.H5 L 360 G.H5.25
Van-der-waals TM3 L 147 3x54 G.H5 L 360 G.H5.25
Polar ICL2 K 154 34x54 G.S1 T 33 G.S1.01
Polar ICL2 K 154 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 K 154 34x54 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 K 154 34x54 G.hns1 R 31 G.hns1.02