Structure information

TP receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8XJO

SPECIES

Homo sapiens

RESOLUTION

3.110

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELREP.2024.113893

PUBLICATION DATE

Feb. 28, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
U46619 A31 1.39x39 TM1 hydrophobic
U46619 L78 2.54x54 TM2 hydrophobic
U46619 V85 2.61x61 TM2 hydrophobic
U46619 H89 2.65x65 TM2 Van der Waals
U46619 H89 2.65x65 TM2 polar (hydrogen bond)
U46619 M112 3.32x32 TM3 Van der Waals
U46619 M112 3.32x32 TM3 hydrophobic
U46619 G116 3.36x36 TM3 Van der Waals
U46619 S181 ECL2 polar (hydrogen bond)
U46619 S181 ECL2 Van der Waals
U46619 W182 ECL2 hydrophobic
U46619 W182 ECL2 Van der Waals
U46619 F184 45.51x51 ECL2 Van der Waals
U46619 F184 45.51x51 ECL2 hydrophobic
U46619 F200 5.43x43 TM5 hydrophobic
U46619 F200 5.43x43 TM5 Van der Waals
U46619 W258 6.48x48 TM6 hydrophobic
U46619 W258 6.48x48 TM6 Van der Waals
U46619 L261 6.51x51 TM6 Van der Waals
U46619 L291 7.36x35 TM7 Van der Waals
U46619 L294 7.39x38 TM7 hydrophobic
U46619 L294 7.39x38 TM7 Van der Waals
U46619 R295 7.40x39 TM7 polar (charge-assisted hydrogen bond)
U46619 T298 7.43x42 TM7 Van der Waals
U46619 Q301 7.46x46 TM7 polar (hydrogen bond)
U46619 Q301 7.46x46 TM7 Van der Waals

Ligands

U46619

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Residue Diagrams

L N S A L G V V C F S A A F W P S 1 C G L V L T D F L G L L V T G T I V V S 2 A A G L L L P S L G F F I M V V G M F R 3 A W A T V G L V W A A A L A L G L L P L 4 N L L F S L G V S L G G L M S F L L G F 5 L G I M V V A S V C W L P L L V F I A Q 6 W P D L I Q N W T A V R L Y I L L E K 7
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ICL1 G G S H T R ICL1ECL1 L F E W H A V D P G ECL1ICL2 P F S R P A V A ICL2ECL2 V G R Y T V Q Y P G S W C F L T L G A ECL2ICL3 E A A Q ICL3ECL3 N P P A M S P A G Q L ECL3N-term M W P N G S S L G P C F R P T N I T L E E R R L I A N-termC-term L Q P Q L T Q R S G L Q C-term S P W F A A S F C V V G L A S N L L A L S V L A G A R Q S S F L T F L C G L V L T D F L G L L V T G T I V V S Q H A A C R L C R F M G V V M I F F G L S P L L L G A A M A S E R Y L G I T R S Q R R A W A T V G L V W A A A L A L G L L P L L G E S G D V A F G L L F S M L G G L S V G L S F L L N T V S V A T L C H V Y H G Q Q R P R D S E V E M M A Q L L G I M V V A S V C W L P L L V F I A Q T V L R S R T T E K E L L I Y L R V A T W N Q I L D P W V Y I L F R R A L Q P R P R V L R R R L S T S L S
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Residue Table


GPCRdb(A)
GPCRdb(A)
TP receptor
TM1
1x39 1.39x39 A31
TM2
2x54 2.54x54 L78
2x61 2.61x61 V85
2x65 2.65x65 H89
TM3
3x32 3.32x32 M112
3x36 3.36x36 G116
ECL2
45x51 45.51x51 F184
TM5
5x43 5.43x43 F200
TM6
6x48 6.48x48 W258
6x51 6.51x51 L261
TM7
7x35 7.36x35 L291
7x38 7.39x38 L294
7x39 7.40x39 R295
7x42 7.43x42 T298
7x46 7.46x46 Q301