TP receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8XJO

RESOLUTION

3.1 Å

REFERENCE

10.1016/J.CELREP.2024.113893

PUBLICATION DATE

Feb. 28, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

50 interactions (Click to see)

LIGANDS

U46619 - Agonist pubchem gtoplig chembl_ligand gtoplig

PHYSIOLOGICAL LIGANDS

PGF2α, PGH2, PGI2, PGD2, thromboxane A2, PGE2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 137 - G.H5 L 236 G.H5.16
Polar TM6 Q 246 6x36 G.H5 N 244 G.H5.24
Van-der-waals TM6 Q 246 6x36 G.H5 N 244 G.H5.24
Polar H8 R 318 8x53 G.H5 L 245 G.H5.25
Van-der-waals H8 R 318 8x53 G.H5 L 245 G.H5.25
Hydrophobic H8 V 315 8x50 G.H5 L 245 G.H5.25
Aromatic TM2 F 63 2x39 G.H5 Y 243 G.H5.23
Hydrophobic TM2 F 63 2x39 G.H5 Y 243 G.H5.23
Hydrophobic ICL1 H 58 - G.H5 L 245 G.H5.25
Hydrophobic ICL2 P 137 - G.H5 K 232 G.H5.12
Hydrophobic TM7 I 309 7x54 G.H5 L 245 G.H5.25
Hydrophobic H8 A 314 8x49 G.H5 L 245 G.H5.25
Polar TM6 S 239 6x29 G.H5 N 244 G.H5.24
Van-der-waals TM6 S 239 6x29 G.H5 N 244 G.H5.24
Hydrophobic TM6 M 243 6x33 G.H5 Y 243 G.H5.23
Van-der-waals TM6 M 243 6x33 G.H5 Y 243 G.H5.23
Polar TM3 E 129 3x49 G.H5 Y 243 G.H5.23
Hydrophobic TM3 E 129 3x49 G.H5 Y 243 G.H5.23
Van-der-waals TM3 E 129 3x49 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 P 137 - G.H5 I 235 G.H5.15
Van-der-waals ICL2 P 137 - G.H5 I 235 G.H5.15
Hydrophobic ICL2 F 138 - G.H5 F 228 G.H5.08
Van-der-waals ICL2 F 138 - G.H5 F 228 G.H5.08
Hydrophobic TM6 M 243 6x33 G.H5 L 240 G.H5.20
Hydrophobic TM6 R 235 6x25 G.h4s6 I 210 G.h4s6.20
Van-der-waals TM6 R 235 6x25 G.h4s6 I 210 G.h4s6.20
Hydrophobic TM5 L 222 5x65 G.H5 L 240 G.H5.20
Hydrophobic ICL2 F 138 - G.H5 K 232 G.H5.12
Van-der-waals ICL2 F 138 - G.H5 K 232 G.H5.12
Hydrophobic TM6 E 242 6x32 G.H5 N 244 G.H5.24
Hydrophobic ICL2 F 138 - G.H5 I 235 G.H5.15
Hydrophobic ICL1 S 61 - G.H5 Y 243 G.H5.23
Hydrophobic TM3 I 134 3x54 G.H5 L 236 G.H5.16
Hydrophobic TM2 L 64 2x40 G.H5 L 245 G.H5.25
Van-der-waals TM2 L 64 2x40 G.H5 L 245 G.H5.25
Hydrophobic TM2 L 67 2x43 G.H5 L 245 G.H5.25
Hydrophobic ICL2 F 138 - G.S3 V 79 G.S3.01
Van-der-waals ICL2 F 138 - G.S3 V 79 G.S3.01
Polar TM3 G 133 3x53 G.H5 Y 243 G.H5.23
Hydrophobic TM3 G 133 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 G 133 3x53 G.H5 Y 243 G.H5.23
Ionic TM6 R 235 6x25 G.H5 D 233 G.H5.13
Polar TM6 R 235 6x25 G.H5 D 233 G.H5.13
Hydrophobic TM6 R 235 6x25 G.H5 D 233 G.H5.13
Van-der-waals TM6 R 235 6x25 G.H5 D 233 G.H5.13
Hydrophobic ICL2 F 138 - G.H5 C 231 G.H5.11
Hydrophobic H8 R 312 8x47 G.H5 N 244 G.H5.24
Van-der-waals H8 R 312 8x47 G.H5 N 244 G.H5.24
Polar H8 R 318 8x53 G.H5 V 246 G.H5.26
Van-der-waals H8 R 318 8x53 G.H5 V 246 G.H5.26
Hydrophobic ICL2 F 138 - G.S1 L 34 G.S1.02
Van-der-waals ICL2 F 138 - G.S1 L 34 G.S1.02
Hydrophobic ICL1 H 58 - G.H5 V 246 G.H5.26
Van-der-waals ICL1 H 58 - G.H5 V 246 G.H5.26
Polar TM3 G 133 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM3 G 133 3x53 G.H5 N 239 G.H5.19
Van-der-waals TM3 G 133 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM6 E 240 6x30 G.H5 L 240 G.H5.20
Van-der-waals TM6 E 240 6x30 G.H5 L 240 G.H5.20
Hydrophobic ICL1 S 61 - G.H5 E 242 G.H5.22
Van-der-waals ICL1 S 61 - G.H5 E 242 G.H5.22
Hydrophobic ICL2 A 142 - G.hns1 R 31 G.hns1.02
Hydrophobic H8 A 314 8x49 G.H5 V 246 G.H5.26
Hydrophobic ICL2 V 143 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 V 143 - G.hns1 R 31 G.hns1.02
Polar TM6 Q 246 6x36 G.H5 Y 243 G.H5.23
Polar ICL1 R 60 - G.H5 N 239 G.H5.19
Van-der-waals ICL1 R 60 - G.H5 N 239 G.H5.19
Polar TM6 E 240 6x30 G.H5 Q 237 G.H5.17
Hydrophobic ICL1 R 60 - G.H5 E 242 G.H5.22
Van-der-waals ICL1 R 60 - G.H5 E 242 G.H5.22
Aromatic TM3 R 130 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 130 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 I 134 3x54 G.H5 L 240 G.H5.20
Hydrophobic TM3 I 134 3x54 G.H5 Y 243 G.H5.23
Ionic ICL1 H 58 - G.H5 E 242 G.H5.22
Polar ICL1 H 58 - G.H5 E 242 G.H5.22
Hydrophobic ICL1 H 58 - G.H5 E 242 G.H5.22
Van-der-waals ICL1 H 58 - G.H5 E 242 G.H5.22
Hydrophobic ICL1 R 60 - G.H5 M 238 G.H5.18
Polar TM6 M 243 6x33 G.H5 N 244 G.H5.24
Hydrophobic TM6 M 243 6x33 G.H5 N 244 G.H5.24
Van-der-waals TM6 M 243 6x33 G.H5 N 244 G.H5.24
Hydrophobic TM2 F 63 2x39 G.H5 L 245 G.H5.25
Hydrophobic TM6 R 235 6x25 G.H5 Q 237 G.H5.17
Van-der-waals TM6 R 235 6x25 G.H5 Q 237 G.H5.17